Interactions on record — worth a quick check against your medications. Based on 4 of 12 ingredients. Check your meds →
Dietary supplement

T5 To T9 HCl Ingredients & Drug Interactions

by Chiro-Zyme

T5 To T9 HCl label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking T5 To T9 HCl against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

T5 To T9 HCl is a dietary supplement by Chiro-Zyme with 12 active ingredients. Its ingredients are commonly taken for high blood pressure, exercise and athletic performance, heart and circulation support.Based on those ingredients, 883 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beet, Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against T5 To T9 HCl by Chiro-Zyme

Ask about any prescription or over-the-counter medication and we check it for interactions with T5 To T9 HCl by Chiro-Zyme — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of T5 To T9 HCl by Chiro-Zyme

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 12 active ingredients.
  • “Proprietary Plant Enzyme Blend” is a proprietary blend — the label gives one combined amount (278 mg) without saying how much of each component you get.

Chiro-Zyme T5 To T9 HCl contains 12 active ingredients, most of them digestive enzymes that help break down food: protease (breaks protein), lipase (breaks fat), cellulase, invertase, glucoamylase, alpha-galactosidase, hemicellulase, diastase, pepsin (another protein-digesting enzyme), and amylase. It also includes beet (a vegetable with nitrates and antioxidants) and betaine HCl (a compound that increases stomach acid).

The product also contains inactive ingredients: vegetable capsules and phytase.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: pH balancing system.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for this product's ingredients is mostly thin. Beet shows possibly effective ratings for athletic performance and exercise-induced muscle soreness, but the evidence for cognitive function and cholesterol support is insufficient to rate.

The digestive enzymes—protease, lipase, and pepsin—lack established effectiveness ratings in our data. Betaine HCl similarly has insufficient evidence for the conditions it's been studied in, including indigestion, low thyroid function, diarrhea, and food allergies.

You'd want to talk with your pharmacist about whether the specific uses you have in mind are backed by reliable evidence.

The evidence, ingredient by ingredient Beet Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beet is generally well tolerated as a food, though concentrated supplements lack robust safety data, so use caution with the supplement form. The main side effect is red or sometimes black stools, which is harmless—though there's one case report of black stools in an older adult on blood thinners after taking beet pills.

Rare serious effects from large amounts include low calcium (hypocalcemia) and kidney damage. Betaine HCl can irritate the stomach and isn't safe for people with ulcers, gastritis, or true acid reflux disease.

The proteolytic enzymes (protease and pepsin) are generally well tolerated but may cause digestive upset or allergic reactions in some people. Lipase is generally well tolerated in adults, though safety data in pregnancy and breastfeeding is limited.

Side effects, ingredient by ingredient Beet Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Beet, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • For scale: 884 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any medications, double-check them before starting. The main concerns are drugs that depend on CYP3A4 metabolism (Moderate severity), acid-reducing medications like H2-blockers, antacids, or PPIs (Minor), drugs that use CYP1A2 metabolism (Minor), and blood pressure medications (Minor).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take any acid-reducing medication (H2-blockers, antacids, or PPIs) or drugs metabolized through the CYP3A4 pathway, check your exact medications with the tool on this page before starting. People with stomach ulcers, gastritis, or active acid reflux should avoid this product because of the betaine HCl.

If you're pregnant or breastfeeding, talk with your pharmacist or doctor first—safety data is thin for most ingredients here.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about T5 To T9 HCl, straight from the product label.

Brand Chiro-Zyme
Barcode (UPC) 697706002508
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2018
DSLD ID 176451
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for T5 To T9 HCl by Chiro-Zyme, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
697706002508
IngredientAmount% DV
Beet100 mg--
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Cellulase0 NP--
Invertase0 NP--
Betaine HCl180 mg--
Glucoamylase0 NP--
Alpha-Galactosidase0 NP--
Hemicellulase0 NP--
Diastase0 NP--
Proprietary Plant Enzyme Blend278 mg--
Pepsin50 mg--

Other ingredients: Vegetable Capsule, Phytase

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

pHBS ph balancing system

EFI Enzyme Formulations, Inc.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Keep out of reach of children

Note: Consult your physician before using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Do not use if inner or outer seal is broken, torn, or missing.

Storage

To ensure freshness and potency, keep bottle tightly closed and store in a cool, dry place.

General

H-63995-5

FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions for use: Take 2 capsules, 3 times daily with meals or as directed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

T5 To T9 HCl by Chiro-Zyme label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

T5 To T9 HCl label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in T5 To T9 HCl by Chiro-Zyme

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beet

Interacts with
861 drugs
100 mg per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet monograph & interactions

Betaine HCl

Interacts with
36 drugs
180 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine HCl monograph & interactions

Proprietary Plant Enzyme Blend

278 mg per serving
  • › Amylase
  • › Protease
  • › Lipase
  • › Cellulase
  • › Invertase
  • › Glucoamylase
  • › Alpha-Galactosidase
  • › Hemicellulase
  • › Diastase

Pepsin

No known
interactions
50 mg per serving Form: Porcine

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Other (inactive) ingredients: Vegetable Capsule, Phytase. These complete the product’s ingredient list but are not active constituents.

Interaction report

T5 To T9 HCl by Chiro-Zyme Drug Interactions

Want to check YOUR meds against T5 To T9 HCl?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
883Drugs
643 Moderate 240 Minor

Ingredients driving the most interactions

Beet 861
Betaine HCl 36

Individual Drug Interactions

The ingredients in T5 To T9 HCl interact with 883 drugs. Click any drug to see the details.

2 of the 12 ingredients in T5 To T9 HCl interact with drugs. Each result below shows which ingredient is responsible. Beet Betaine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in T5 To T9 HCl with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beet3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Beet full monograph & interactions

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for T5 To T9 HCl, from the product label.

Chiro-Zyme

See all Chiro-Zyme products
Name
Enzyme Formulations, Inc.
City
Madison
State
Wisconsin
ZipCode
53719
Phone Number
1-800-614-4400
Web Address
www.enzymeformulations.com
Pharmacist Counseling Corner

T5 To T9 HCl by Chiro-Zyme: Common Questions

Does T5 To T9 HCl by Chiro-Zyme interact with any medications?
Yes. Based on its ingredients, T5 To T9 HCl has a known interaction with 883 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
T5 To T9 HCl contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What do the enzymes in this product actually do?
They're designed to help your digestive system break down food. Protease breaks down protein, lipase breaks down fat, and the others target different carbohydrates and fiber. Most of these enzymes aren't well studied for their effectiveness in supplement form, but they're commonly used in digestive aids.
Is it safe to take if I have an ulcer or reflux?
No. The betaine HCl in this product increases stomach acid, which can irritate ulcers and worsen reflux. It's not safe for people with these conditions unless your doctor says otherwise.
Can I take this if I'm on antacids or an acid-reflux medication?
Probably not without checking first. Betaine HCl works against what those drugs do, so it may reduce how well they work. Talk to your pharmacist before combining them.
What's the red-colored poop I might see?
That's from the beet in the formula. It's completely harmless—just beet pigment passing through. You might also occasionally see black stools, which is also from the beet and not dangerous.
Is this safe during pregnancy or breastfeeding?
We don't have enough safety data for most ingredients in this product during pregnancy or breastfeeding. Betaine HCl is best avoided in pregnancy, and protease safety isn't established. Talk with your doctor or pharmacist for personalized advice.
Can this cause allergic reactions?
Rarely, the proteolytic enzymes (protease and pepsin) may trigger allergic reactions or digestive upset in some people. People with enzyme sensitivities should be cautious.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if T5 To T9 HCl is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

T5 To T9 HCl label
Go deeper

The Full Monographs Behind T5 To T9 HCl’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

T5 To T9 HCl's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beet 14 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
  3. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  4. Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
  5. Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
  6. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
  7. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
  8. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
  9. Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
  10. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
  11. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  12. Hemmatinafar M, Zaremoayedi L, Koushkie Jahromi M, et al. Effect of Beetroot Juice Supplementation on Muscle Soreness and Performance Recovery after Exercise-Induced Muscle Damage in Female Volleyball Players. Nutrients 2023;15(17):3763. PubMed
  13. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
  14. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed

See these in context on the Beet monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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