Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Senolytic Activator Ingredients & Drug Interactions

by Life Extension

Senolytic Activator label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Senolytic Activator against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Senolytic Activator is a dietary supplement by Life Extension with 5 active ingredients. Its ingredients are commonly taken for seasonal allergies, antioxidant support, heart and blood pressure health.Based on those ingredients, 1,169 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bio-Quercetin Phytosome, Theaflavins. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Senolytic Activator by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Senolytic Activator by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Senolytic Activator by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 6 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (312 mg) without saying how much of each component you get.
  • “Bio-Quercetin Phytosome” is listed as a grouped ingredient — the label gives one combined amount (74 mg) without saying how much of each component you get.

Senolytic Activator is a six-ingredient product combining compounds thought to target aging cells. The active ingredients are apigenin and fisetin (both in the Bio-Quercetin Phytosome and the proprietary blend), theaflavins (from green tea), galactomannans, quercetin (supplied as Bio-Quercetin Phytosome and separately), and phosphatidylcholine complex.

The product also contains inactive ingredients — cellulose, sunflower lecithin, microcrystalline cellulose, silica, and stearate — which are fillers and binders that give the capsule its form and stability.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Support cellular aging and senescent cell clearance.
  • We looked for evidence on: Aging, Age-related cognitive decline, Dementia, Alzheimer disease, Cardiovascular disease (CVD), Obesity — and 4 related terms.
  • The closest evidence on file: Quercetin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Quercetin is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Cardiovascular disease (CVD), Obesity, Metabolic syndrome.
  • Also on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Dementia.

The effectiveness evidence for these ingredients is sparse in our data. Quercetin is rated possibly ineffective for athletic performance and has insufficient evidence for age-related cognitive decline, hay fever, Alzheimer's disease, asthma, and atherosclerosis.

Theaflavins show insufficient evidence for lowering cholesterol (hyperlipidemia). Phosphatidylcholine is rated possibly effective for ulcerative colitis, but insufficient for nonalcoholic fatty liver disease, alcohol-related liver disease, Alzheimer's disease, and anxiety.

For the senolytic (aging-cell-targeting) claim at the heart of this product, evidence ratings are not provided in our data.

The evidence, ingredient by ingredient Quercetin Phosphatidylcholine Theaflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Quercetin is generally well tolerated in food and typical supplement amounts, but high doses and long-term safety are not well studied. Oral quercetin may cause headache and tingling in hands or feet.

During pregnancy, the safety data advises against supplemental doses of quercetin; the same applies to breastfeeding. Theaflavins, derived from black tea, are generally safe in normal amounts, but concentrated extracts are less studied.

Because they contain caffeine, which passes into breast milk, you should limit intake and avoid high-dose extracts without your doctor's approval, especially while breastfeeding. Phosphatidylcholine is generally well tolerated orally, though high doses (30 grams per day) can cause bloating, diarrhea, and digestive upset.

There isn't enough reliable data on supplement use beyond food sources during pregnancy or breastfeeding; speak with your healthcare provider first. Apigenin, fisetin, and galactomannans have no safety notes on file.

Side effects, ingredient by ingredient Quercetin Phosphatidylcholine Theaflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Quercetin, Theaflavin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,170 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications before you start, especially: blood thinners (warfarin), blood pressure drugs (losartan), cholesterol medications (pravastatin and other OATP substrates), blood sugar medications (antidiabetes drugs), immunosuppressants (cyclosporine), anti-inflammatories for bowel disease (sulfasalazine), certain antibiotics (quinolones), and chemotherapy drugs (mitoxantrone). All interactions listed are Moderate severity.

We could not check apigenin, fisetin, and galactomannans for drug interactions, so unknown interactions are possible with those.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Senolytic Activator is designed to support cellular aging pathways, but the evidence for that specific claim isn't established in our data. If you take blood thinners, diabetes medications, statins, blood pressure drugs, or immunosuppressants, you'll need to check this product against your exact list before starting — quercetin and theaflavins carry documented moderate-severity interactions with several of these drug types.

Talk to your pharmacist before adding it to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Senolytic Activator, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870230120
Net contents 36 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 328654
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Senolytic Activator by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
12
UPC/BARCODE
737870230120
IngredientAmount% DV
Proprietary Blend312 mg--
Bio-Quercetin Phytosome74 mg--
Apigenin50 mg--
Fisetin56 mg--
Theaflavins275 mg--
Galactomannans109 mg--
Quercetin25 mg--
Phosphatidylcholine Complex0 NP--

Other ingredients: Cellulose, Sunflower Lecithin, Microcrystalline Cellulose, Silica, Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Precautions

Read the entire label and follow the directions carefully prior to use.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Directions: Take three (3) capsules once weekly, or as recommended by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

Formulation

Gluten free Non GMO LE Certified

Seals/Symbols

Non GMO LE Certified

Formula

Advanced Bio-Quercetin - Theaflavin - Apigenin - Bio-Fisetin formula

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Senolytic Activator by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Senolytic Activator label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Senolytic Activator by Life Extension

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container12 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

312 mg per serving
  • › Fisetin
  • › Galactomannans

Bio-Quercetin Phytosome

Interacts with
1,169 drugs
74 mg per serving

Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties found in many common foods and sold as a supplement. While early rese...

Bio-Quercetin Phytosome monograph & interactions

Apigenin

50 mg per serving

Theaflavins

Interacts with
130 drugs
275 mg per serving Form: Black Tea Leaf Extract, Decaffeinated

Theaflavins are antioxidant compounds formed when tea leaves are oxidized to make black tea. Early research suggests they may help with cholesterol an...

Theaflavins monograph & interactions

Other (inactive) ingredients: Cellulose, Sunflower Lecithin, Microcrystalline Cellulose, Silica, Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Senolytic Activator by Life Extension Drug Interactions

Want to check YOUR meds against Senolytic Activator?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,169Drugs
1,169 Moderate

Ingredients driving the most interactions

Bio-Quercetin Phytosome 1,169
Theaflavins 130

Individual Drug Interactions

The ingredients in Senolytic Activator interact with 1,169 drugs. Click any drug to see the details.

2 of the 5 ingredients in Senolytic Activator interact with drugs. Each result below shows which ingredient is responsible. Bio-Quercetin Phytosome Theaflavins

Each ingredient & the kinds of drugs it affects

For each ingredient in Senolytic Activator with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bio-Quercetin Phytosome21 drug types · 1,169 drugs

Antidiabetes Drugs

Theoretically, concomitant use of quercetin and antidiabetes drugs might increase the risk of hypoglycemia.

Clinical research suggests that a combination of quercetin, myricetin, and chlorogenic acid reduce levels of fasting glucose in patients with type 2 diabetes, including those already taking antidiabetes agents. The effect of quercetin alone is unknown.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking quercetin with antihypertensive drugs might increase the risk of hypotension.

Quercetin can modestly decrease blood pressure in people with mild hypertension. Theoretically, it might have additive blood pressure lowering effects when used with antihypertensive drugs.

Likelihood Possible Evidence B
Cyclosporine (Neoral, Sandimmune)

Theoretically, concomitant use might increase the levels and adverse effects of cyclosporine.

A small study in healthy volunteers shows that pretreatment with quercetin increases plasma levels and prolongs the half-life of a single dose of cyclosporine, possibly due to inhibition of p-glycoprotein or cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporin.

Likelihood Possible Evidence B
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, concomitant use might increase the levels and adverse effects of CYP2C8 substrates.

In vitro research shows that quercetin inhibits CYP2C8. Inhibition of paclitaxel (Taxol) metabolism via CYP2C8 has been reported in vitro. However, a small study in humans found no effect of quercetin on rosiglitazone (Avandia), which is also a CYP2C8 substrate.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use might increase the levels and adverse effects of CYP2C9 substrates.

A small clinical study in healthy volunteers shows that taking quercetin 500 mg twice daily for 10 days prior to taking diclofenac, a CYP2C9 substrate, increases diclofenac plasma levels by 75% and prolongs the half-life by 32.5%. Animal research also shows that pretreatment with quercetin increases plasma levels and prolongs the half-life of losartan (Cozaar), a substrate of CYP2C9. Furthermore, laboratory research shows that quercetin inhibits CYP2C9.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use might increase the levels and adverse effects of CYP2D6 substrates.

In vitro research show that quercetin inhibits CYP2D6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.
A small clinical study in healthy volunteers shows that pretreatment with quercetin increases plasma levels and prolongs the half-life of a single dose of cyclosporine (Neoral, Sandimmune), a substrate of CYP3A4. Animal research also shows that pretreatment with quercetin increases plasma levels and prolongs the half-life of losartan (Cozaar) and quetiapine (Seroquel), substrates of CYP3A4. Other laboratory research also shows that quercetin inhibits CYP3A4. However, one clinical study shows that quercetin can increase the metabolism of midazolam, a substrate of CYP3A4, and decrease serum concentrations of midazolam by about 24% in some healthy individuals, suggesting possible induction of CYP3A4.

Likelihood Possible Evidence D
Diclofenac (Voltaren, Others)

Theoretically, concomitant use might increase the levels and adverse effects of diclofenac.

A small clinical study in healthy volunteers shows that taking quercetin 500 mg twice daily for 10 days prior to taking diclofenac increases diclofenac plasma levels by 75% and prolongs the half-life by 32.5%. This is thought to be due to inhibition of CYP2C9 by quercetin.

Likelihood Probable Evidence B
Losartan (Cozaar)

Theoretically, concomitant use might increase the effects and adverse effects of losartan and decrease the effects of its active metabolite.

Animal research shows that pretreatment with quercetin increases plasma levels and prolongs the half-life of losartan (Cozaar) while decreasing plasma levels of losartan's active metabolite. This metabolite, which is around 10-fold more potent than losartan, is the result of cytochrome P450 (CYP) 2C9- and CYP3A4-mediated transformation of losartan. Additionally, in vitro research shows that quercetin may inhibit P-glycoprotein-mediated efflux of losartan from the intestines, resulting in increased absorption of losartan. These results suggest that concomitant use of quercetin and losartan might increase systemic exposure to losartan while also decreasing plasma concentrations of losartan's active and more potent metabolite.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, concomitant use might decrease the levels and effects of midazolam.

A small clinical study in healthy volunteers shows that quercetin can increase the metabolism of midazolam, with a decrease in AUC of about 24%.

Likelihood Possible Evidence B
Mitoxantrone

Theoretically, quercetin might increase the effects and adverse effects of mitoxantrone.
In vitro research shows that quercetin increases the intracellular accumulation and cytotoxicity of mitoxantrone, possibly through inhibition of breast cancer resistance protein (BCRP), of which mitoxantrone is a substrate. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Organic Anion Transporter 1 (Oat1) Substrates

Theoretically, concomitant use might increase the effects and adverse effects of OAT1 substrates.

In vitro research shows that quercetin is a strong non-competitive inhibitor of OAT1, with half-maximal inhibitory concentration (IC50) values less than 10 mcM. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Organic Anion Transporter 3 (Oat3) Substrates

Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.

In vitro research shows that quercetin is a strong non-competitive inhibitor of OAT3, with half-maximal inhibitory concentration (IC50) values as low as 0.75 mcM. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, concomitant use might increase the effects and adverse effects of OATP substrates.

In vitro evidence shows that quercetin can inhibit organic anion-transporting peptide (OATP) 1B1-mediated uptake of estrone-3-sulfate and pravastatin. Furthermore, clinical research in healthy males shows that intake of quercetin along with pravastatin increases the AUC of pravastatin by 24%, prolongs its half-life by 14%, and decreases its apparent clearance by 18%, suggesting that quercetin modestly inhibits the uptake of pravastatin in hepatic cells.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Theoretically, concomitant use might alter the effects and adverse effects of P-glycoprotein substrates.

There is preliminary evidence that quercetin inhibits the gastrointestinal P-glycoprotein efflux pump, which might increase the bioavailability and serum levels of drugs transported by the pump. A small study in healthy volunteers reported that pretreatment with quercetin increased bioavailability and plasma levels after a single dose of cyclosporine (Neoral, Sandimmune). Also, two small studies have shown that quercetin might decrease the absorption of talinolol, a substrate transported by the gastrointestinal P-glycoprotein efflux pump. However, in another small study, several days of quercetin treatment did not significantly affect the pharmacokinetics of saquinavir (Invirase). The reason for these discrepancies is not entirely clear. Until more is known, use quercetin cautiously in combination with P-glycoprotein substrates.

Likelihood Possible Evidence B
Pravastatin (Pravachol)

Theoretically, concomitant use might increase the effects and adverse effects of pravastatin.
In vitro evidence shows that quercetin can inhibit OATP 1B1-mediated uptake of pravastatin. Also, preliminary clinical research in healthy males shows that intake of quercetin along with pravastatin increases the maximum concentration of pravastatin by 24%, prolongs its half-life by 14%, and decreases its apparent clearance by 18%, suggesting that quercetin modestly inhibits the uptake of pravastatin in hepatic cells.

Likelihood Possible Evidence B
Prazosin (Minipress)

Theoretically, quercetin might increase the effects and adverse effects of prazosin.
In vitro research shows that quercetin inhibits the transcellular efflux of prazosin, possibly through inhibition of breast cancer resistance protein (BCRP), of which prazosin is a substrate. BCRP is an ATP-binding cassette efflux transporter in the intestines, kidneys, and liver. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Quetiapine (Seroquel)

Theoretically, concomitant use might increase the effects and adverse effects of quetiapine.
Animal research shows that pretreatment with quercetin can increase plasma levels of quetiapine and prolong its clearance, possibly due to inhibition of cytochrome P450 3A4 (CYP3A4) by quercetin. Additionally, the brain-to-plasma ratio of quetiapine concentrations increased, possibly due to inhibition of P-glycoprotein at the blood-brain barrier. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, concomitant use might inhibit the effects of quinolone antibiotics.
In vitro, quercetin binds to the DNA gyrase site on bacteria, which may interfere with the activity of quinolone antibiotics.

Likelihood Possible Evidence B
Sulfasalazine (Azulfidine)

Theoretically, quercetin might increase the effects and adverse effects of sulfasalazine.
Animal research shows that quercetin increases the maximum serum concentration (Cmax) and area under the curve (AUC) of sulfasalazine, possibly through inhibition of breast cancer resistance protein (BCRP), of which sulfasalazine is a substrate. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, quercetin may increase the risk of bleeding if used with warfarin.
Animal and in vitro studies show that quercetin might increase serum levels of warfarin. Quercetin and warfarin have the same human serum albumin (HSA) binding site, and in vitro research shows that quercetin has stronger affinity for the HSA binding site and can theoretically displace warfarin, causing higher serum levels of warfarin. Animal research shows that taking quercetin for 2 weeks before initiating warfarin increases the maximum serum level of warfarin by 30%, the half-life by 10%, and the overall exposure by 63% when compared with control. Concomitant administration of quercetin and warfarin, without quercetin pre-treatment, also increased these measures, but to a lesser degree. Researchers theorize that inhibition of CYP3A4 by quercetin may explain these effects. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Bio-Quercetin Phytosome full monograph & interactions

Theaflavins2 drug types · 130 drugs

Antidiabetes Drugs

In an animal diabetic model, giving theaflavin reduced fasting blood glucose, with an effect comparable to metformin. A fermented green tea product containing theaflavin also appears to reduce blood glucose levels in healthy humans and in an animal model. Theoretically, concomitant use with antidiabetes drugs might cause additive hypoglycemic effects. Use with caution.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

In vitro, theaflavin inhibits organic anion-transporting polypeptide (OATP)2B1. OATP2B1 is expressed in the small intestine and liver and is responsible for the uptake of drugs and other compounds. This interaction has not been shown in humans. However, theaflavin might reduce the absorption of drugs that are OATP2B1 substrates. Use with caution.

Likelihood Possible Evidence D
Theaflavins full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Senolytic Activator, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Senolytic Activator by Life Extension: Common Questions

Does Senolytic Activator by Life Extension interact with any medications?
Yes. Based on its ingredients, Senolytic Activator has a known interaction with 1,169 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Senolytic Activator contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against quercetin supplements during pregnancy and breastfeeding. Theaflavins contain caffeine, which passes into breast milk, so you'd need to limit intake. There isn't enough data on phosphatidylcholine supplements during these periods either. Talk with your doctor or pharmacist about whether this product is right for you.
What are theaflavins, and where do they come from?
Theaflavins are compounds found in black tea and fermented green tea. In this product, they're included for their potential effects on blood sugar and other health markers, though they're also a source of caffeine.
What's phosphatidylcholine, and does this product contain a lot of it?
Phosphatidylcholine is a fat compound that supports cell membranes and is found naturally in foods. The product facts don't specify the dose, so check the label. At very high doses (30 grams a day), it can cause digestive upset; smaller doses may cause bloating, nausea, or diarrhea in some people.
Does this product have any side effects?
Quercetin may cause headache and tingling in your hands or feet. Theaflavins contain caffeine, which can cause jitters or sleep issues. Phosphatidylcholine commonly causes bloating, diarrhea, nausea, or altered taste. Most people tolerate these ingredients well at typical doses.
What is a senolytic, and does this product remove aging cells?
A senolytic is a compound thought to target and clear out aging cells that accumulate with time. The ingredients in this product are selected for that purpose, but the evidence supporting the senolytic claim specifically is not rated in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Senolytic Activator label
Go deeper

The Full Monographs Behind Senolytic Activator’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Quercetin

Interacts with 1,169 drugs

Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties found in many common foods and sold as a supplement. While early research is interesting for allergies, blood...

Read the full Quercetin monograph → Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph → Herb & supplement monograph

Theaflavin

Interacts with 130 drugs

Theaflavins are antioxidant compounds formed when tea leaves are oxidized to make black tea. Early research suggests they may help with cholesterol and provide antioxidant effects, but high-...

Read the full Theaflavin monograph →
Sources

Sources & How We Checked

Senolytic Activator's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 45 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Quercetin 26 references
  1. Shoskes DA, Zeitlin SI, Shahed A, Rajfer J. Quercetin in men with category III chronic prostatitis: A preliminary prospective, double-blind, placebo-controlled trial. Urol 1999;54:960-3. PubMed
  2. Starvic B. Quercetin in our diet: from potent mutagen to probable anticarcinogen. Clin Biochem 1994;27:245-8. PubMed
  3. Ferry DR, Smith A, Malkhandi J, et al. Phase I clinical trial of the flavonoid quercetin: Pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res 1996;2:659-67..
  4. Obach RS. Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 2000;294:88-95. DOI
  5. Edwards RL, Lyon T, Litwin SE, et al. Quercetin reduces blood pressure in hypertensive subjects. J Nutr 2007;137:2405-11.
  6. Kim KA, Park PW, Kim HK, et al. Effect of quercetin on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in healthy subjects. J Clin Pharmacol 2005;45:941-6. PubMed
  7. DiCenzo R, Frerichs V, Larppanichpoonphol P, et al. Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults. Pharmacotherapy 2006;26:1255-61. PubMed
  8. Choi JS, Choi BC, Choi KE. Effect of quercetin on the pharmacokinetics of oral cyclosporine. Am J Health Syst Pharm 2004;61:2406-9. PubMed
  9. Choi JS, Jo BW, Kim YC. Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin. Eur J Pharm Biopharm 2004;57:313-8. PubMed
  10. Vaclavikova R, Horsky S, Simek P, Gut I. Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants. Naunyn Schmiedebergs Arch Pharmacol 2003;368:200-9. PubMed
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Phosphatidylcholine 15 references
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See these in context on the Phosphatidylcholine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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