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Dietary supplement

Serracor-NK Ingredients & Drug Interactions

by AST Enzymes

Serracor-NK label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serracor-NK against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Serracor-NK is a dietary supplement by AST Enzymes with 2 active ingredients.Based on those ingredients, 537 medications have a known interaction with it, the most serious rated major. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Serracor-NK by AST Enzymes

Ask about any prescription or over-the-counter medication and we check it for interactions with Serracor-NK by AST Enzymes — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Serracor-NK by AST Enzymes

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “Serracor-NK Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.
  • “SEBkinase Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Enzyme and Cofactor Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Serracor-NK contains 10 ingredients, including several active enzymes and plant compounds. Magnesium is a mineral that supports nerve and muscle function and helps with digestion and blood sugar control.

Rutin is a plant compound; papain and bromelain are digestive enzymes from papaya and pineapple respectively. Lipase breaks down dietary fats.

Amla (Indian gooseberry) is a fruit extract. Coenzyme Q-10 is an antioxidant your body makes naturally.

Nattokinase is an enzyme derived from fermented soybeans. Proteases are additional protein-digesting enzymes.

The product also contains enzyme blends (Serracor-NK Blend, SEBkinase Blend, and Enzyme and Cofactor Blend) whose individual component ingredients are listed separately. Inactive ingredients include cellulose, maltodextrin, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy cardiovascular circulatory and respiratory systems.
  • We looked for evidence on: Cardiovascular disease (CVD), Coronary heart disease (CHD), Congestive heart failure (CHF), Arrhythmia, Angina, Atherosclerosis — and 4 related terms.
  • The strongest evidence on file: Indian Gooseberry is rated "Possibly Effective" for Dyslipidemia (Natural Medicines).
  • Also on file: Coenzyme Q10 is rated "Possibly Effective" for Congestive heart failure (CHF).
  • Also on file: Magnesium is rated "Possibly Effective" for Vasospastic angina, Arrhythmia.

The evidence for most of Serracor-NK's ingredients is limited. Magnesium is effective for dyspepsia (indigestion), constipation, magnesium deficiency, and pre-eclampsia in pregnancy.

Amla is possibly effective for acid reflux (GERD) and high cholesterol. Coenzyme Q-10 is likely effective for coenzyme Q-10 deficiency and possibly effective for fibromyalgia, migraine headache, heart failure, and diabetic nerve pain.

For rutin, bromelain, lipase, nattokinase, proteases, and the enzyme blends, we hold no evidence establishing effectiveness — these ingredients are not yet rated in the data we have.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Magnesium is generally well tolerated at recommended doses but can cause diarrhea, nausea, vomiting, and gastrointestinal irritation orally. Rare cases of stomach blockage (bezoar) have been reported with high daily doses.

Rutin is generally well tolerated but may cause headache, flushing, or rash in some people; long-term safety data are limited. Papain is normally tolerated as food but may cause allergic reactions, digestive upset, or in rare cases serious stomach injury at high doses.

Bromelain is generally well tolerated short-term but may cause diarrhea, gas, nausea, or headache. Coenzyme Q-10 is generally well tolerated; fewer than 1% of users report mild stomach upset, nausea, or diarrhea.

Nattokinase carries rare reports of bleeding, including one case of brain hemorrhage when combined with aspirin. For pregnancy, magnesium is needed but supplements should be used only under doctor guidance; amla and bromelain lack sufficient safety data so avoid them; papain concentrates should be avoided; rutin, lipase, nattokinase, and proteases also lack adequate pregnancy safety data.

For breastfeeding, magnesium at normal dietary amounts is acceptable but check with your doctor before supplements; rutin, bromelain, nattokinase, and proteases are best avoided; papain safety is unknown so avoid it; lipase and coenzyme Q-10 safety has not been well studied.

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 9 matched ingredients can interact with medications — Papain, Rutin, Indian Gooseberry, Bromelain, Coenzyme Q10, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; Parkinson's medications.
  • For scale: 537 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Serracor-NK, double-check your medications for: levodopa/carbidopa (Sinemet) — a Major interaction with magnesium; then blood thinners and antiplatelet drugs (warfarin, aspirin, clopidogrel), anticoagulants, blood pressure medications, diabetes drugs, quinolone or tetracycline antibiotics, bisphosphonates, skeletal muscle relaxants, potassium-sparing diuretics, acid reducers, sulfonylurea diabetes drugs, and chemotherapy drugs — all Moderate interactions. No interactions are documented for ingredients we could fully check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Serracor-NK may help with indigestion and constipation through its magnesium and enzyme content, but it carries significant interaction risks — especially for people on Parkinson's medications, blood thinners, diabetes drugs, antibiotics, or blood pressure medication. If you take any prescription drugs, check your exact medications with the tool below before starting.

Talk to your pharmacist about whether this product fits your medication routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serracor-NK, straight from the product label.

Brand AST Enzymes
Barcode (UPC) 850213002045
Net contents 300 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 338356
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serracor-NK by AST Enzymes, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
300
UPC/BARCODE
850213002045
IngredientAmount% DV
Magnesium0 NP--
Rutin0 NP--
Papain0 NP--
Bromelain0 NP--
Lipase0 NP--
Amla0 NP--
Coenzyme Q-100 NP--
Nattokinase0 NP--
Proteases0 NP--
Peptizyme SP EN0 NP--
Serracor-NK Blend500 mg--
SEBkinase Blend0 NP--
Enzyme and Cofactor Blend0 NP--

Other ingredients: Cellulose, Maltodextrin, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Serracor-NK promotes healthy cardiovascular, circulatory, and respiratory systems. A powerful systemic enzyme blend, Serracor-NK supports a healthy response to inflammation

Serrapeptase & Nattokinase Formula

Suggested/Recommended/Usage/Directions

Directions: Take with a large glass of water. Maintenance: 1-2 capsules, 3 times a day. Therapeutic: 3 capsules, 3 times a day. Must be taken on an empty stomach (30 minutes before or 2 hours after meals).

Precautions

Keep out of reach of children.

Caution: If taking anticoagulant drugs, do not use this product before consulting your physician. Consult your doctor before use if pregnant, nursing, or taking medicaiton.

Discontinue if adverse conditions occur.

Free of: What, egg, milk, soy, tree nuts, peanuts, fish, shellfish and sesame. Manufactured in cGMP facilities that also process wheat, milk, eggs, and soy.

Storage

Storage: Closed in a cool, dry place. Avoid excessive heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Supports healthy inflammatory response Supports respiratory & cardiovascular health; promotes Fibrin metabolism. Professional strength

Free of: What, egg, milk, soy, tree nuts, peanuts, fish, shellfish and sesame.

Manufactured and laboratory tested in the USA.

Seals/Symbols

BPPS Technology Laboratory Tested

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serracor-NK by AST Enzymes label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serracor-NK label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serracor-NK by AST Enzymes

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container300 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Serracor-NK Blend

500 mg per serving
  • › SEBkinase Blend
  • › Enzyme and Cofactor Blend

Other (inactive) ingredients: Cellulose, Maltodextrin, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serracor-NK by AST Enzymes Drug Interactions

Want to check YOUR meds against Serracor-NK?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
537Drugs
6 Major 529 Moderate 2 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Serracor-NK interact with 537 drugs. Click any drug to see the details.

0 of the 2 ingredients in Serracor-NK interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Serracor-NK with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Serracor-NK, from the product label.

AST Enzymes

See all AST Enzymes products
Name
AST Enzymes
Street Address
13591 Yorba Ave.
City
Chino
State
CA
ZipCode
91710
Web Address
www.ASTenzymes.com
Pharmacist Counseling Corner

Serracor-NK by AST Enzymes: Common Questions

Does Serracor-NK by AST Enzymes interact with any medications?
Yes. Based on its ingredients, Serracor-NK has a known interaction with 537 medications, including 6 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serracor-NK contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Serracor-NK if I'm pregnant?
It depends on the ingredient. Magnesium is needed in pregnancy but supplements should be used only under your doctor's guidance. Rutin, papain, bromelain, nattokinase, and the enzyme blends lack enough safety data — talk with your doctor or pharmacist before using this product in pregnancy, as it may not be suitable.
What is magnesium doing in a digestive enzyme product?
Magnesium helps support digestion and is effective for constipation and indigestion. It's also a mineral your body needs for nerve and muscle function. In this formula, it works alongside the digestive enzymes to support your digestive system.
Is Serracor-NK safe for people taking blood thinners?
No — this product carries moderate bleeding risk if you take blood thinners, antiplatelet drugs like aspirin, or anticoagulants. Papain, bromelain, amla, and nattokinase all may increase bleeding. Talk to your pharmacist before starting if you're on any of these drugs.
Does coenzyme Q-10 in this product interact with my blood pressure or heart medications?
Yes, theoretically. Coenzyme Q-10 might lower blood pressure further if you're already on blood pressure medication, and it may reduce the effectiveness of warfarin if you take it. Check your exact medications with the interaction tool on this page before starting.
What side effects are most common with Serracor-NK?
Magnesium commonly causes diarrhea, nausea, or stomach irritation. Bromelain may cause gas, diarrhea, or headache. Rutin might cause headache or rash in some people. These side effects tend to be mild and affect a small number of users.
Can I breastfeed while taking Serracor-NK?
Magnesium at normal dietary amounts is generally okay, but check with your doctor before taking supplements. Rutin, papain, bromelain, nattokinase, and the enzyme blends either lack safety data or are best avoided while breastfeeding — talk with your healthcare provider first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serracor-NK is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serracor-NK label
Sources

Sources & How We Checked

Serracor-NK's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 173 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Magnesium 82 references
  1. Rodin SM, Johnson BF. Pharmacokinetic interactions with digoxin. Clin Pharmacokinet 1988;15:227-44.
  2. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  3. Dahle LO, Berg G, Hammar M, et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol 1995;173:175-80. PubMed
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia 1996;16:257-63. PubMed
  6. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1999. Available at: http://books.nap.edu/books/0309063507/html/index.html.
  7. Birrer RB, Shallash AJ, Totten V. Hypermagnesemia-induced fatality following epsom salt gargles. J Emerg Med 2002;22:185-8. PubMed
  8. Ryan MP. Diuretics and potassium/magnesium depletion. Directions for treatment. Am J Med 1987;82:38-47.. PubMed
  9. Hollifield JW. Magnesium depletion, diuretics, and arrhythmias. Am J Med 1987;82:30-7.. PubMed
  10. Heidenreich O. Mode of action of conventional and potassium-sparing diuretics--aspects with relevance to Mg-sparing effects. Magnesium 1984;3:248-56..
  11. Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the prophylaxis of migraine--a double-blind placebo-controlled study. Cephalalgia 1996;16:436-40.. PubMed
  12. Wang F, Van Den Eeden SK, Ackerson LM, et al. Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache 2003;43:601-10.. PubMed
  13. Sompolinsky D, Samra Z. Influence of magnesium and manganese on some biological and physical properties of tetracycline. J Bacteriol 1972;110:468-76.. PubMed
  14. Jeyabalan A, Caritis SN. Pharmacologic inhibition of preterm labor. Clin Obstet Gynecol 2002;45:99-113. PubMed
  15. Mittendorf R, Dambrosia J, Pryde PG, et al. Association between the use of antenatal magnesium sulfate in preterm labor and adverse health outcomes in infants. Am J Obstet Gynecol 2002;186:1111-8.. PubMed
  16. Witlin AG, Sibai BM. Magnesium sulfate therapy in preeclampsia and eclampsia. Obstet Gynecol 1998;92:883-9.. DOI
  17. Crowther CA, Hiller JE, Doyle LW. Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev 2002;4:CD001060. . PubMed
  18. Davey MJ, Teubner D. A randomized controlled trial of magnesium sulfate, in addition to usual care, for rate control in atrial fibrillation. Ann Emerg Med 2005;45:347-53.. PubMed
  19. L'Hommedieu CS, Nicholas D, Armes DA, et al. Potentiation of magnesium sulfate--induced neuromuscular weakness by gentamicin, tobramycin, and amikacin. J Pediatr 1983;102:629-31..
  20. Dunn CJ, Goa KL. Risedronate: a review of its pharmacological properties and clinical use in resorptive bone disease. Drugs 2001;61:685-712..
  21. Kass L, Weekes J, Carpenter L. Effect of magnesium supplementation on blood pressure: a meta-analysis. Eur J Clin Nutr 2012;66:411-8. PubMed
  22. Koontz SL, Friedman SA, Schwartz ML. Symptomatic hypocalcemia after tocolytic therapy with magnesium sulfate and nifedipine. Am J Obstet Gynecol. 2004;190(6):1773-6. PubMed
  23. Snyder SW, Cardwell MS. Neuromuscular blockade with magnesium sulfate and nifedipine. Am J Obstet Gynecol. 1989;161(1):35-6. PubMed
  24. Waisman GD, Mayorga LM, Cámera MI, et al. Magnesium plus nifedipine: potentiation of hypotensive effect in preeclampsia? Am J Obstet Gynecol. 1988;159(2):308-9. PubMed
  25. Brown DD, Juhl RP. Decreased bioavailability of digoxin due to antacids and kaolin-pectin. N Engl J Med. 1976;295(19):1034-7. PubMed
  26. Allen MD, Greenblatt DJ, Harmatz JS, et al. Effect of magnesium--aluminum hydroxide and kaolin--pectin on absorption of digoxin from tablets and capsules. J Clin Pharmacol. 1981;21(1):26-30. PubMed
  27. Ravn HB, Vissinger H, Kristensen SD, et al. Magnesium inhibits platelet activity--an in vitro study. Thromb Haemost. 1996;76(1):88-93. DOI
  28. Ravn HB, Kristensen SD, Vissinger H, et al. Magnesium inhibits human platelets. Blood Coagul Fibrinolysis. 1996;7(2):241-4. PubMed
  29. Ravn HB, Vissinger H, Kristensen SD, et al. Magnesium inhibits platelet activity--an infusion study in healthy volunteers. Thromb Haemost. 1996;75(6):939-44. DOI
  30. Neuvonen PJ, Kivistö KT. The effects of magnesium hydroxide on the absorption and efficacy of two glibenclamide preparations. Br J Clin Pharmacol. 1991;32(2):215-20. PubMed
  31. Kivistö KT, Neuvonen PJ. Enhancement of absorption and effect of glipizide by magnesium hydroxide. Clin Pharmacol Ther. 1991;49(1):39-43. PubMed
  32. Neuvonen PJ, Kivistö KT. Enhancement of drug absorption by antacids. An unrecognised drug interaction. Clin Pharmacokinet. 1994;27(2):120-8. PubMed
  33. Shechter, M., Merz, C. N., Paul-Labrador, M., Meisel, S. R., Rude, R. K., Molloy, M. D., Dwyer, J. H., Shah, P. K., and Kaul, S. Beneficial antithrombotic effects of the association of pharmacological oral magnesium therapy with aspirin in coronary heart
  34. Ganzevoort, J. W., Hoogerwaard, E. M., and van der Post, J. A. [Hypocalcemic delirium due to magnesium sulphate therapy in a pregnant woman with pre-eclampsia]. Ned.Tijdschr.Geneeskd. 8-3-2002;146(31):1453-1456.
  35. Horner, S. M. Efficacy of intravenous magnesium in acute myocardial infarction in reducing arrhythmias and mortality. Meta-analysis of magnesium in acute myocardial infarction. Circulation 1992;86(3):774-779. PubMed
  36. Azria, E., Tsatsaris, V., Goffinet, F., Kayem, G., Mignon, A., and Cabrol, D. [Magnesium sulfate in obstetrics: current data]. J Gynecol.Obstet.Biol.Reprod.(Paris) 2004;33(6 Pt 1):510-517.
  37. Magee, L. A., Miremadi, S., Li, J., Cheng, C., Ensom, M. H., Carleton, B., Cote, A. M., and von Dadelszen, P. Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with p
  38. Henyan, N. N., Gillespie, E. L., White, C. M., Kluger, J., and Coleman, C. I. Impact of intravenous magnesium on post-cardiothoracic surgery atrial fibrillation and length of hospital stay: a meta-analysis. Ann.Thorac.Surg. 2005;80(6):2402-2406. PubMed
  39. Li, J., Zhang, Q., Zhang, M., and Egger, M. Intravenous magnesium for acute myocardial infarction. Cochrane.Database.Syst.Rev. 2007;(2):CD002755. PubMed
  40. Doyle, L. W., Crowther, C. A., Middleton, P., Marret, S., and Rouse, D. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane.Database.Syst.Rev. 2009;(1):CD004661. PubMed
  41. Han, S., Crowther, C. A., and Moore, V. Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour. Cochrane.Database.Syst.Rev. 2010;(7):CD000940. PubMed
  42. Duley, L., Gulmezoglu, A. M., Henderson-Smart, D. J., and Chou, D. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane.Database.Syst.Rev. 2010;(11):CD000025. PubMed
  43. Conde-Agudelo, A., Romero, R., and Kusanovic, J. P. Nifedipine in the management of preterm labor: a systematic review and metaanalysis. Am J Obstet.Gynecol. 2011;204(2):134-20. PubMed
  44. Wong, G. K., Boet, R., Poon, W. S., Chan, M. T., Gin, T., Ng, S. C., and Zee, B. C. Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage: an updated systemic review and meta-analysis. Crit Care 2011;15(1):R52. PubMed
  45. Magee, L., Sawchuck, D., Synnes, A., and von, Dadelszen P. SOGC Clinical Practice Guideline. Magnesium sulphate for fetal neuroprotection. J Obstet.Gynaecol.Can. 2011;33(5):516-529.
  46. Doyle, L. W. Antenatal magnesium sulfate and neuroprotection. Curr Opin Pediatr 2012;24(2):154-159. PubMed
  47. McDonald, S. D., Lutsiv, O., Dzaja, N., and Duley, L. A systematic review of maternal and infant outcomes following magnesium sulfate for pre-eclampsia/eclampsia in real-world use. Int J Gynaecol.Obstet. 2012;118(2):90-96. PubMed
  48. Gordon, M., Naidoo, K., Akobeng, A. K., and Thomas, A. G. Osmotic and stimulant laxatives for the management of childhood constipation. Cochrane.Database.Syst.Rev. 2012;7:CD009118. PubMed
  49. Dodd, J. M., Crowther, C. A., and Middleton, P. Oral betamimetics for maintenance therapy after threatened preterm labour. Cochrane.Database.Syst.Rev. 2012;12:CD003927. PubMed
  50. Wu, X., Wang, C., Zhu, J., Zhang, C., Zhang, Y., and Gao, Y. Meta-analysis of randomized controlled trials on magnesium in addition to beta-blocker for prevention of postoperative atrial arrhythmias after coronary artery bypass grafting. BMC.Cardiovasc.D PubMed
  51. Thorp, J. M., Jr., Katz, V. L., Campbell, D., and Cefalo, R. C. Hypersensitivity to magnesium sulfate. Am.J.Obstet.Gynecol. 1989;161(4):889-890. PubMed
  52. Duley L and Gulmezoglu AM. Magnesium sulphate versus lytic cocktail for eclampsia. Cochrane Database of Systematic Reviews 2000;(3) PubMed
  53. Gibbins KJ, Browning KR, Lopes VV, Anderson BL, Rouse DJ. Evaluation of the clinical use of magnesium sulfate for cerebral palsy prevention. Obstet Gynecol 2013;121(2 Pt 1):235-40. PubMed
  54. Ji D. Oral magnesium sulfate causes perforation during bowel preparation for fiberoptic colonoscopy in patients with colorectal cancer. J Emerg Med 2012;43(4):716-7. PubMed
  55. Yagi T, Naito T, Mino Y, Umemura K, Kawakami J. Impact of concomitant antacid administration on gabapentin plasma exposure and oral bioavailability in healthy adult subjects. Drug Metab Pharmacokinet 2012;27(2):248-54. PubMed
  56. Yamasaki M, Funakoshi S, Matsuda S, Imazu T, Takeda Y, Murakami T, Maeda Y. Interaction of magnesium oxide with gastric acid secretion inhibitors in clinical pharmacotherapy. Eur J Clin Pharmacol 2014;70(8):921-4. PubMed
  57. Choi ES, Jeong WJ, Ahn SH, Oh AY, Jeon YT, Do SH. Magnesium sulfate accelerates the onset of low-dose rocuronium in patients undergoing laryngeal microsurgery. J Clin Anesth. 2017 Feb;36:102-106. PubMed
  58. Ikee R, Toyoyama T, Endo T, Tsunoda M, Hashimoto N. Impact of sevelamer hydrochloride on serum magnesium concentrations in hemodialysis patients. Magnes Res. 2016 Apr 1;29(4):184-90. PubMed
  59. Miller ES, Sakowicz A, Leger E. Lange E, Yee LM. The association between receipt of intrapartum magnesium and postpartum hemorrhage. Am J Obstet Gynecol 2018;218(1 Suppl):S165.
  60. Rodríguez-Rubio L, Solis Garcia Del Pozo J, Nava E, Jordán J. Interaction between magnesium sulfate and neuromuscular blockers during the perioperative period. A systematic review and meta-analysis. J Clin Anesth. 2016;34:524-34. PubMed
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Rutin 2 references
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Papain 11 references
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Bromelain 19 references
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Lipase 1 reference
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Indian Gooseberry 6 references
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Coenzyme Q10 40 references
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Nattokinase 9 references
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Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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