Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Serralase Ingredients & Drug Interactions

by Klaire Labs

Serralase label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serralase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serralase is a dietary supplement by Klaire Labs with 4 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serralase by Klaire Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Serralase by Klaire Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Serralase by Klaire Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proteolytic Enzyme Blend” is a proprietary blend — the label gives one combined amount (390 mg) without saying how much of each component you get.

Serralase has four active ingredients: bromelain (an enzyme from pineapple), papain (an enzyme from papaya), Serratia Peptidase (a bacterial protease), and catalase (an enzyme that breaks down hydrogen peroxide). These are all proteolytic enzymes — they're designed to break down proteins.

The product also contains common inactive ingredients like microcrystalline cellulose (a binder), silicon dioxide (an anti-caking agent), and an enteric coating that helps the tablet survive stomach acid and release in the small intestine.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Systemic proteolytic enzyme support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Exercise-induced muscle soreness, Postoperative pain, Postoperative swelling, Rhinosinusitis, Sprains — and 4 related terms.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing, Tonsillopharyngitis.
  • Also on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), Exercise-induced muscle soreness, Rhinosinusitis, Wound healing.

The evidence for bromelain is currently insufficient to rate it for conditions like hay fever, burns, cancer, nerve pain, chronic venous insufficiency, or diabetes. Similarly, papain is rated as having insufficient evidence for cancer, cavities, radiation burns, exercise soreness, shingles, and parasitic infections.

We don't hold effectiveness data for Serratia Peptidase or catalase in the facts provided.

The evidence, ingredient by ingredient Bromelain Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated short-term, though long-term safety data is limited. The most common side effects are diarrhea, flatulence, stomach upset, and headache when taken by mouth.

Some people may have allergic reactions — including rash, hives, or in rare cases respiratory symptoms if inhaled. Papain is generally tolerated as a food but supplements may irritate the digestive tract and trigger allergic reactions in sensitive individuals, especially at high doses; rare serious effects include severe stomach inflammation or esophageal perforation.

During pregnancy, bromelain's safety data advises against it. Concentrated papain and unripe papaya products should also be avoided in pregnancy.

For breastfeeding, safety data on bromelain is unknown, and concentrated papain is best avoided — but there isn't enough reliable information on papain as a supplement while nursing. Talk with your pharmacist or doctor about your personal situation.

Side effects, ingredient by ingredient Bromelain Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, dabigatran, rivaroxaban, and others) — bromelain and papain may increase bleeding risk. If you're on tetracycline antibiotics (doxycycline, minocycline, tetracycline), bromelain might affect absorption, though real-world impact is unclear.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serralase is a proteolytic enzyme blend that may appeal to people looking for digestive support, but it's not a routine product — it has a couple of meaningful interactions with blood thinners and one antibiotic class. If you take warfarin, any other blood thinner, or tetracycline antibiotics, you need to check with your pharmacist first.

Pregnant or breastfeeding? Talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serralase, straight from the product label.

Brand Klaire Labs
Barcode (UPC) 828054005426
Net contents 90 Vegetarian Tablet(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 322454
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serralase by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
UPC/BARCODE
828054005426
IngredientAmount% DV
Bromelain0 NP--
Proteolytic Enzyme Blend390 mg--
Papain0 NP--
Serratia Peptidase0 NP--
Catalase0 NP--

Other ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Silicon Dioxide, Stearic Acid, Magnesium Stearate, enteric copolymer dispersion Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Enzyme units as defined by FCC.

SFI

Formulation

Free of the following common allergens: milk/casein, eggs, fish, shellfish, peanuts, and soybeans. Contains no artificial colors, flavors or preservatives. Tablet coating is derived from highly refined coconut oil and/or palm kernel oil that contains no protein.

Formulated to be hypoallergenic.

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Formula

Tablet coating is derived from highly refined coconut oil and/or palm kernel oil that contains no protein.

Serralase contains systemic proteolytic enzymes (proteases) which work synergistically to assist protein breakdown. Enteric tablet coating protects enzyme activity against degradation by stomach acid.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 tablet, 1 to 3 times daily between meals. Intensive support: 3 to 6 tablets daily between meals or as directed by a healthcare professional.

Brand IP Statement(s)

Peptizyme SP is a registered trademark of Specialty Enzymes and Biotechnologies.

Precautions

Do not use if shrinkwrap is broken or missing.

Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place (59 degrees F - 85 degrees F) away from direct light.

FDA Statement of Identity

Enzyme Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serralase by Klaire Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serralase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serralase by Klaire Labs

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proteolytic Enzyme Blend

390 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Silicon Dioxide, Stearic Acid, Magnesium Stearate, Enteric copolymer dispersion Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serralase by Klaire Labs Drug Interactions

Want to check YOUR meds against Serralase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141
Papain 2

Individual Drug Interactions

The ingredients in Serralase interact with 141 drugs. Click any drug to see the details.

2 of the 4 ingredients in Serralase interact with drugs. Each result below shows which ingredient is responsible. Bromelain Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Serralase with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serralase, from the product label.

Klaire Labs

See all Klaire Labs products
Name
SFI USA
City
Reno
State
NV
ZipCode
89521
Web Address
Klaire.com
Pharmacist Counseling Corner

Serralase by Klaire Labs: Common Questions

Does Serralase by Klaire Labs interact with any medications?
Yes. Based on its ingredients, Serralase has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serralase contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the most common side effects of Serralase?
When taken by mouth, bromelain and papain most commonly cause diarrhea, flatulence, stomach upset, and headache. Allergic reactions (like rash or hives) can occur in sensitive people. High doses of papain may cause more serious stomach irritation.
Can I take Serralase while pregnant?
No — the safety data for bromelain advises against it during pregnancy, and concentrated papain and unripe papaya products should also be avoided. Talk with your doctor or pharmacist about whether this product is right for you.
Can I take Serralase while breastfeeding?
There isn't enough data to know either way for bromelain, and safety on concentrated papain while nursing isn't well established. Talk with your pharmacist or doctor for personalized advice before starting.
Is Serralase proven to work?
The evidence for its main active enzymes is currently insufficient to rate them for most conditions. That means the science hasn't established whether it's truly effective — not that it doesn't work, just that reliable proof isn't yet in the data we hold.
What if I'm allergic to pineapple or papaya?
Bromelain (from pineapple) and papain (from papaya) may trigger IgE-mediated allergic reactions in sensitive individuals. If you have a known pineapple or papaya allergy, avoid this product and talk with your pharmacist about alternatives.
How long is it safe to take Serralase?
Short-term use of bromelain appears generally well tolerated, but evidence on long-term safety is limited. If you plan to take it beyond a few weeks, check in with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serralase label
Go deeper

The Full Monographs Behind Serralase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Serralase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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