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Dietary supplement

Vital-Dophilus Plus Ingredients & Drug Interactions

by Klaire Labs

Vital-Dophilus Plus label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vital-Dophilus Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vital-Dophilus Plus is a dietary supplement by Klaire Labs with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vital-Dophilus Plus by Klaire Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Vital-Dophilus Plus by Klaire Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vital-Dophilus Plus by Klaire Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Probiotic Blend” is a proprietary blend — the label gives one combined amount (60 mg) without saying how much of each component you get.

Vital-Dophilus Plus contains two active probiotic ingredients: Lactobacillus acidophilus and Lactobacillus rhamnosus. Both are live beneficial bacteria designed to support digestive and gut health.

The powder also contains inulin as an inactive ingredient, which serves as a prebiotic fiber to help feed the probiotics.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and immune support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance, Necrotizing enterocolitis (NEC).

Lactobacillus acidophilus has the strongest evidence for irritable bowel syndrome (IBS), antibiotic-associated diarrhea, bacterial vaginosis, and Helicobacter pylori infection — all rated possibly effective based on available research. It is rated possibly ineffective for atopic disease (allergic and immune conditions), and there isn't enough reliable evidence to rate it for acute respiratory distress syndrome.

We don't have effectiveness data on file for Lactobacillus rhamnosus.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Mild gastrointestinal side effects like bloating, gas, abdominal discomfort, or diarrhea can occur when taking it with other probiotics, but these are uncommon.

Because these are live organisms, there is a theoretical concern about infection in certain vulnerable patients — most cases documented have been in people with underlying translocation risk or severe immune compromise. Check with your doctor before using this product, especially if you have a weakened immune system or serious illness.

We don't have safety or adverse-effect data on file for Lactobacillus rhamnosus.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, check your exact medication below before starting — you'll need to separate the timing of your antibiotic and this probiotic to protect the live organisms. We could not check Lactobacillus rhamnosus because we don't hold interaction data for it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic is worth considering if you have IBS, antibiotic-associated diarrhea, or certain infections and want a possibly effective option. If you're on antibiotics, space out the timing — don't take them together.

Talk to your pharmacist or doctor before starting, especially if you're immunocompromised or seriously ill.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vital-Dophilus Plus, straight from the product label.

Brand Klaire Labs
Barcode (UPC) 709616203026
Net contents 2 oz.; 56 Gram(s)
Market status On market
Date entered into DSLD Apr 25, 2014
DSLD ID 32541
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vital-Dophilus Plus by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 tsp
Maximum serving Sizes:
0.25 tsp
Servings per container
56
UPC/BARCODE
709616203026
IngredientAmount% DV
Probiotic Blend60 mg--
Lactobacillus acidophilus0 NP--
Lactobacillus rhamnosus0 NP--

Other ingredients: Inulin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat/gluten, corn, yeast, and soybeans. No sugar, magnesium stearate, maltodextrin, artificial sweeteners, colors, flavors, salicylates, or preservatives.

NON-DAIRY MALTODEXTRIN-FREE CERTIFIED STRAINS

General Statements

All ingredients are of the highest quality and purity available. Formulated for the most sensitive individual.

This product was made in a GMP and ISO 9001:2000 registered facility.

EXP 04 11

10+ BILLION CFUs

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement take 1/4 teaspoon daily with food or as directed by a healthcare practitioner.

Precautions

Do not use if full-bottle shrinkwrap is broken or missing.

KEEP OUT OF REACH OF CHILDREN.

Storage

Storage: Refrigerate and keep tightly closed to maintain product potency.

General

V203-02 rev080917

FDA Statement of Identity

MULTI-SPECIES PROBIOTIC SUPPLEMENT

Brand IP Statement(s)

Klaire Labs(TM) is a division of: ProThera, Inc

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vital-Dophilus Plus by Klaire Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vital-Dophilus Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vital-Dophilus Plus by Klaire Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.25 tsp Dosage formPowder Servings per container56 Amounts shown are per serving.

Probiotic Blend

Interacts with
182 drugs
60 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions

Other (inactive) ingredients: Inulin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vital-Dophilus Plus by Klaire Labs Drug Interactions

Want to check YOUR meds against Vital-Dophilus Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Probiotic Blend 182

Individual Drug Interactions

The ingredients in Vital-Dophilus Plus interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vital-Dophilus Plus interact with drugs. Each result below shows which ingredient is responsible. Probiotic Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Vital-Dophilus Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vital-Dophilus Plus, from the product label.

Klaire Labs

See all Klaire Labs products
Name
ProThera Inc.
City
Reno
State
NV
ZipCode
89521
Phone Number
888-488-2488
Pharmacist Counseling Corner

Vital-Dophilus Plus by Klaire Labs: Common Questions

Does Vital-Dophilus Plus by Klaire Labs interact with any medications?
Yes. Based on its ingredients, Vital-Dophilus Plus has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vital-Dophilus Plus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Do I take this at the same time as my antibiotic?
No — the antibiotic will kill off the live bacteria in this probiotic. Space them out by a few hours so the probiotic can do its job. Your pharmacist can help you work out the best timing.
Will this help with my IBS?
Lactobacillus acidophilus is possibly effective for IBS based on current research, which means there's some evidence it may help, but it's not guaranteed to work for everyone. Talk with your doctor about whether it's right for you.
Can I take this if I have a weak immune system?
Check with your doctor first. While these probiotics are generally well tolerated, there's a theoretical concern about infection in people with weakened immunity. Your doctor knows your full medical picture and can advise you safely.
What are the side effects?
Most people tolerate it well. Mild gas, bloating, abdominal discomfort, or diarrhea can happen when taking probiotics together, but these are uncommon. A rash and itching were reported rarely in one trial, though it's unclear if they were caused by this ingredient or something else.
Is there enough information about this during pregnancy or breastfeeding?
We don't have safety data on file for these ingredients during pregnancy or breastfeeding. Talk with your obstetrician or pharmacist to figure out what's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vital-Dophilus Plus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vital-Dophilus Plus label
Go deeper

The Full Monographs Behind Vital-Dophilus Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Vital-Dophilus Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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