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Dietary supplement

Serrapeptase 40,000 SPU Ingredients & Drug Interactions

by Sunergetic

Serrapeptase 40,000 SPU label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase 40,000 SPU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase 40,000 SPU is a dietary supplement by Sunergetic with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase 40,000 SPU by Sunergetic

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase 40,000 SPU by Sunergetic — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Serrapeptase 40,000 SPU by Sunergetic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: serrapeptase, a fibrinolytic enzyme—a protein that breaks down fibrin, a material involved in blood clotting and inflammation. The capsule also holds inactive ingredients (rice flour, hypromellose, gellan gum, purified water, and vegetable magnesium stearate) that serve as fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Serrapeptase product and its label doesn't state a use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for serrapeptase isn't established in the data we hold. Chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis all show insufficient reliable evidence to rate whether this ingredient works for them.

If you're considering serrapeptase for a specific condition, talk with your doctor about what the research actually supports for your situation.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated in the short term, though long-term safety hasn't been well studied. The most common side effects in trials—epigastric pain (upper stomach discomfort), general gastrointestinal upset, and nausea—occurred at about the same rate as placebo.

A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported. The safety data advises against taking this product during pregnancy or while breastfeeding.

If you're pregnant, planning to become pregnant, or nursing, talk with your doctor before considering serrapeptase.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start serrapeptase, double-check with your pharmacist or doctor if you take any blood thinners or antiplatelet drugs (anticoagulants or antiplatelets). Serrapeptase's ability to break down clots combined with these medications could raise your risk of bruising and bleeding.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase may be worth considering if you're exploring options for conditions like chronic bronchitis or back pain—though the evidence for it isn't solid yet. If you take blood thinners or antiplatelet medications, you'll need to check with your pharmacist or doctor first, because this enzyme can theoretically increase your bleeding risk.

Long-term safety is unclear, so a conversation with your healthcare provider about whether it fits your situation is important.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase 40,000 SPU, straight from the product label.

Brand Sunergetic
Barcode (UPC) X000ZS4TT1
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 276832
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase 40,000 SPU by Sunergetic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
X000ZS4TT1
IngredientAmount% DV
Serrapeptase18 mg--

Other ingredients: Rice Flour, Hypromellose, Gellan Gum, Water, Purified, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule daily with 8 ounces of water on an empty stomach or as directed by a healthcare professional. For best results, avoid eating for 30 minutes after use.

Precautions

Caution: Do not exceed recommended dose.

Do not use this product if you are taking blood platelet inhibitors such as Ticlid, Plavix or Coumadin. Pregnant or nursing mothers, children under 18, and individuals with a known medical condition or taking medication should consult a physician before using this or any dietary supplement.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Contains milk

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

40,000 SPU per capsule

Completely vegetarian with both Kosher and Vegetarian certifications, these innovative acid-resistant capsule shells also offer an effective means of helping mask odor and taste without the use of chemicals and solvents.

Formulation

Non GMO formula

DRcaps Acid-Resistant Capsules

DRcaps offer a safe and effective means of protecting ingredients from destruction within the stomach.

Completely vegetarian with both Kosher and Vegetarian certifications, these innovative acid-resistant capsule shells also offer an effective means of helping mask odor and taste without the use of chemicals and solvents.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

DRcaps is a registered trademark of Capsugel.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase 40,000 SPU by Sunergetic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase 40,000 SPU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase 40,000 SPU by Sunergetic

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
18 mg per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Rice Flour, Hypromellose, Gellan Gum, Water, Purified, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase 40,000 SPU by Sunergetic Drug Interactions

Want to check YOUR meds against Serrapeptase 40,000 SPU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase 40,000 SPU interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase 40,000 SPU interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase 40,000 SPU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase 40,000 SPU, from the product label.

Sunergetic

See all Sunergetic products
Name
Sunergized LLC
City
Woodbury
State
NY
ZipCode
11797
Phone Number
(866) 839-5329
Web Address
www.sunergeticproducts.com
Pharmacist Counseling Corner

Serrapeptase 40,000 SPU by Sunergetic: Common Questions

Does Serrapeptase 40,000 SPU by Sunergetic interact with any medications?
Yes. Based on its ingredients, Serrapeptase 40,000 SPU has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase 40,000 SPU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does serrapeptase do?
Serrapeptase is an enzyme that breaks down fibrin, a protein involved in blood clotting and inflammation. It's theorized to help reduce inflammation and improve circulation, though solid evidence for specific conditions is lacking in the data we hold.
Will this help my back pain or arthritis?
Back pain shows insufficient reliable evidence to rate whether serrapeptase works for it. There's not enough established data to say whether it will help your situation—your doctor is the best person to discuss whether it's worth trying.
What side effects should I watch for?
Most commonly, people report upper stomach discomfort, general digestive upset, and nausea—though these occurred at the same rate as placebo in trials. A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported.
Can I take this long-term?
Long-term safety of serrapeptase hasn't been well studied. It's generally tolerated in the short term, so talk with your doctor about how long it's safe for you to take it.
Can I take this while pregnant or breastfeeding?
The safety data advises against using serrapeptase during pregnancy or while breastfeeding. If you're pregnant, nursing, or planning either, talk with your doctor before considering this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase 40,000 SPU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase 40,000 SPU label
Go deeper

The Full Monographs Behind Serrapeptase 40,000 SPU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase 40,000 SPU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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