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Dietary supplement

Serrapeptase Ingredients & Drug Interactions

by Source Naturals

Serrapeptase label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase by Source Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Serrapeptase by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This single-ingredient product contains serrapeptase, a protease enzyme derived from the digestive tract of silkworms. The capsule also includes inactive ingredients: maltodextrin, hypromellose, pectin, purified water, and medium chain triglycerides.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: healthy inflammation response and mucus viscosity.
  • We looked for evidence on: Asthma, Back pain, Bronchiectasis, Chronic bronchitis, Laryngitis, Osteoarthritis — and 4 related terms.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Chronic bronchitis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Asthma, Back pain, Osteoarthritis, Pharyngitis, and more.

The evidence behind serrapeptase remains insufficient for most uses we have data on—including chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis. We don't have reliable evidence backing its effectiveness for these conditions, so claims about what it can do aren't yet supported by the research available to us.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated in the short term, though long-term safety hasn't been well studied. The most common side effects reported are epigastric pain (upper abdominal discomfort), gastrointestinal upset, and nausea—though when compared head-to-head with placebo, these side effects appear at similar rates.

A rare serious effect, bullous pemphigoid (a blistering skin condition), has been reported. During pregnancy, there isn't enough safety data, so it's best avoided.

While breastfeeding, reliable safety information is lacking, so it's also best to avoid it. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding before taking serrapeptase.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking serrapeptase, double-check with your doctor or pharmacist if you use any blood thinners or antiplatelet drugs—including aspirin, warfarin, clopidogrel, and others. Serrapeptase can theoretically increase bleeding risk when combined with these medications (Moderate severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase may appeal to people looking for enzyme-based support, but the evidence for what it actually does isn't yet established in our data. Its main concern is with blood thinners and antiplatelet medications, where it could theoretically raise bleeding risk.

If you take any blood-thinning drug, clear it with your doctor or pharmacist first. And if you're pregnant or breastfeeding, avoid it until you've talked with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078019497
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 296174
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
021078019497
IngredientAmount% DV
Serrapeptase0 NP--

Other ingredients: Maltodextrin, Hypromellose, Pectin, Water, Purified, Medium Chain Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Delayed release

Whole body systemic vegetarian and delayed release enzyme

Serrapeptase is provided as a delayed release vegetarian capsule, designed to provide the most benefit.

Suitable for Vegetarians.

Contains no yeast, egg, gluten or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

Formula

Whole body systemic vegetarian and delayed release enzyme

Serrapeptase is an enzyme that preliminary evidence suggests is active systemically and may support a healthy inflammation response. Preliminary evidence also suggests that when taken orally, this enzyme may reduce the viscosity of mucus in the respiratory tract.

FDA Statement of Identity

Dietary Supplement

Precautions

Contains milk and soy.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Caution: Do not take if you are pregnant, may become pregnant, breastfeeding, or if you suffer from any gastrointestinal disorders such as ulcers. Consult your health care professional before taking this product if you are taking any drug that affects blood coagulation such as prescription vitamin K, heparin, warfarin (Coumadin), or aspirin.

Discontinue use if nausea, diarrhea, or other intestinal discomfort occurs.

Suggested/Recommended/Usage/Directions

Suggested use: 1 to 2 capsules twice daily as needed on an empty stomach with at least 8 ounces of water.

General Statements

Not all inflammation is associated with disease states. Inflammation is the body's healthy immune response to life's occasional, normal stressors and is important for optimal health.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright Source Naturals, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase by Source Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
0 NP per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Maltodextrin, Hypromellose, Pectin, Water, Purified, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase by Source Naturals Drug Interactions

Want to check YOUR meds against Serrapeptase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

Serrapeptase by Source Naturals: Common Questions

Does Serrapeptase by Source Naturals interact with any medications?
Yes. Based on its ingredients, Serrapeptase has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is serrapeptase?
Serrapeptase is a protease enzyme—a protein-digesting enzyme—originally found in silkworms. It's marketed as a dietary supplement for various conditions, though the evidence backing most of its claimed benefits is insufficient at this time.
Can I take serrapeptase if I'm on aspirin or other blood thinners?
Not without checking first with your doctor or pharmacist. Serrapeptase has fibrinolytic activity and might increase your bleeding risk when combined with blood thinners or antiplatelet drugs. Your healthcare provider needs to weigh the pros and cons for your situation.
What side effects might I experience?
The most common ones are epigastric pain, gastrointestinal upset, and nausea—though these appear at about the same rate as placebo in studies. A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported.
Is serrapeptase safe long-term?
It's generally well tolerated in the short term, but long-term safety hasn't been well studied. If you're considering using it regularly, talk with your doctor or pharmacist about what we do and don't know.
Can I take serrapeptase while pregnant or breastfeeding?
No—there isn't enough safety data. During pregnancy and while breastfeeding, it's best avoided. Speak with your doctor or pharmacist for personalized guidance if you're in either situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase label
Go deeper

The Full Monographs Behind Serrapeptase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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