Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Serretia 250,000 SPUs Ingredients & Drug Interactions

by Arthur Andrew Medical

Serretia 250,000 SPUs label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serretia 250,000 SPUs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serretia 250,000 SPUs is a dietary supplement by Arthur Andrew Medical with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Serretia 250,000 SPUs by Arthur Andrew Medical

Ask about any prescription or over-the-counter medication and we check it for interactions with Serretia 250,000 SPUs by Arthur Andrew Medical — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Serretia 250,000 SPUs by Arthur Andrew Medical

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Serretia contains one active ingredient: serrapeptase, an enzyme extracted from the bacterium Serratia marcescens. The product delivers 250,000 SPUs (serrapeptase protease units) per capsule.

The only other ingredient listed is cellulose, an inactive filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: break down mucus and promote normal inflammatory response.
  • We looked for evidence on: Asthma, Bronchiectasis, Chronic bronchitis, Laryngitis, Otitis media, Pharyngitis — and 4 related terms.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Chronic bronchitis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Asthma, Otitis media, Pharyngitis, Rhinosinusitis, and more.

The evidence for serrapeptase is limited. For chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis—conditions it's often marketed for—we don't have reliable evidence to rate whether it actually works.

That doesn't mean it's ineffective; it means the research to prove it either way hasn't been done or isn't solid enough for us to rely on.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated in short-term use. The most common side effects people report are epigastric pain (upper stomach discomfort), general gastrointestinal upset, and nausea—though these occur at about the same rate as placebo in trials.

A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported. Long-term safety hasn't been well studied, so we don't know what happens if you take it for months or years.

The safety data advises against use during pregnancy and breastfeeding because there isn't enough reliable information to know it's safe. If you're pregnant, nursing, or planning to, talk with your doctor or pharmacist before taking this supplement.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Serretia, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs—such as warfarin, aspirin, clopidogrel, or heparin. Serrapeptase may increase your risk of bleeding or bruising when combined with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serretia is an enzyme supplement with limited evidence for the conditions it's marketed for. The main concern is its potential to increase bleeding risk if you take blood thinners or antiplatelet medications.

If you're on any blood-thinning drugs, check with your doctor or pharmacist before starting. For everyone else, short-term use appears generally tolerated, though long-term safety data is sparse.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serretia 250,000 SPUs, straight from the product label.

Brand Arthur Andrew Medical
Barcode (UPC) 855571001600
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 21307
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serretia 250,000 SPUs by Arthur Andrew Medical, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
UPC/BARCODE
855571001600
IngredientAmount% DV
Serrapeptase250000 SPU--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Serrapeptase is clinically shown to break down mucus and promote a normal inflammatory response.

Pharmaceutical Grade

Accelerated Healing Healthy Sinus Activity Normal Fluid Retention (swelling) Free Joint Mobility Post Surgical Recovery

0692 MFG 12/11

Brand IP Statement(s)

ACID ARMOR(TM) Acid Resistant Capsule Technology

Acid Armor(TM) Capsules

Copyright (c) 2005-2011 Arthur Andrew Medical, Inc.

SERRETIA is pure serrapeptase in natural Acid Armor(TM) capsules. Acid Armor(TM) capsules have enteric properties that protect the enzymes from stomach acid without the use of chemicals and plastics commonly found in traditional enteric coatings. Acid Armor(TM) capsules delay the release of their contents for up to an hour in low pH environments.

Suggested/Recommended/Usage/Directions

SUGGESTED USE: Take 2 capsules 1 to 3 times daily between meals or as recommended by your physician. Serretia can be safely taken with other dietary supplements.

Precautions

WARNING: Serrapeptase may thin the blood; consult your physician if you are currently taking anticoagulants.

KEEP OUT OF REACH OF CHILDREN.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

60 {symbol}

Storage

STORE IN A COOL, DRY PLACE WITH LID TIGHTLY CLOSED

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serretia 250,000 SPUs by Arthur Andrew Medical label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serretia 250,000 SPUs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serretia 250,000 SPUs by Arthur Andrew Medical

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
250000 SPU per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serretia 250,000 SPUs by Arthur Andrew Medical Drug Interactions

Want to check YOUR meds against Serretia 250,000 SPUs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serretia 250,000 SPUs interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serretia 250,000 SPUs interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serretia 250,000 SPUs with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serretia 250,000 SPUs, from the product label.

Arthur Andrew Medical

See all Arthur Andrew Medical products
Phone Number
800-448-5015
Pharmacist Counseling Corner

Serretia 250,000 SPUs by Arthur Andrew Medical: Common Questions

Does Serretia 250,000 SPUs by Arthur Andrew Medical interact with any medications?
Yes. Based on its ingredients, Serretia 250,000 SPUs has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serretia 250,000 SPUs contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Serretia if I'm on aspirin or another blood thinner?
You need to check with your doctor or pharmacist first. Serrapeptase may increase bleeding risk when combined with blood thinners and antiplatelet drugs like aspirin, warfarin, and clopidogrel. Your prescriber can weigh the benefit against the risk for your situation.
Is Serretia safe to take long-term?
We don't have good long-term safety data for serrapeptase. It's generally well tolerated in the short run, but we simply don't know what happens if you take it for months or years. Talk with your doctor before using it indefinitely.
Can I take Serretia while pregnant or breastfeeding?
The safety data advises against it—there isn't enough reliable information to know whether it's safe during pregnancy or breastfeeding. Discuss it with your doctor or pharmacist if you're pregnant, nursing, or planning to be.
What side effects does Serretia cause?
Most people who experience side effects report mild stomach discomfort, upset stomach, or nausea—at about the same rate as placebo. Rarely, a blistering skin condition called bullous pemphigoid has been reported. If you develop unusual symptoms, stop and tell your pharmacist or doctor.
Does Serretia actually work for back pain or chronic bronchitis?
The evidence isn't solid enough to say. We don't have reliable studies showing whether serrapeptase works for back pain, chronic bronchitis, asthma, atherosclerosis, or osteoporosis. If you're considering it for one of those conditions, ask your doctor what the science actually supports.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serretia 250,000 SPUs is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serretia 250,000 SPUs label
Go deeper

The Full Monographs Behind Serretia 250,000 SPUs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serretia 250,000 SPUs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team