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Dietary supplement

Siberian Cocklebur Ingredients & Drug Interactions

by Hawaii Pharm

Siberian Cocklebur label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Siberian Cocklebur against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Siberian Cocklebur is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for nasal congestion and sinus problems, allergic rhinitis (hay fever), headache.Based on those ingredients, 662 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Siberian Cocklebur Fruit Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Siberian Cocklebur by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Siberian Cocklebur by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Siberian Cocklebur by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Siberian Cocklebur Fruit Extract, Dry. The inactive ingredients are alcohol, water, and glycerin.

We should note upfront that the product facts flag serious safety concerns about this ingredient itself, separate from drug interactions. The fruit contains toxic compounds and has caused poisoning in people, which is why the safety data advises against use in pregnancy and breastfeeding.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Siberian Cocklebur product and its label doesn't state a use — see Siberian Cocklebur's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

No effectiveness ratings are on file in our data for Siberian Cocklebur. We don't hold information about what this ingredient is claimed to do or how well it works.

The evidence, ingredient by ingredient Siberian Cocklebur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Here's where we need to be direct: Siberian cocklebur is flagged in the safety data as generally regarded as unsafe for use. The ingredient can cause a long list of serious adverse effects — abdominal pain, nausea, vomiting, severe low blood sugar, liver damage (elevated liver enzymes), increased bleeding risk, drowsiness, dizziness, shortness of breath, sweating, fever, and heart palpitations.

Heart rhythm problems can happen within a few hours of taking it, and in the most severe cases, poisoning has led to metabolic acidosis, worsening blood sugar swings, and fatal outcomes. The ingredient is rated likely unsafe during pregnancy and while breastfeeding because of potential toxicity and lack of safety data.

Do not use if you're pregnant, nursing, or planning to become pregnant without talking to your doctor first.

Side effects, ingredient by ingredient Siberian Cocklebur

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Siberian Cocklebur.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 663 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes medication, any drug that can damage your liver, or any drug that can damage your kidneys, do not start this product without checking with your pharmacist first. The risks of low blood sugar, liver damage, and kidney damage are documented as Major.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product carries Major interaction risks with blood sugar drugs, liver-damaging drugs, and kidney-damaging drugs. Beyond interactions, the safety data describes this ingredient as unsafe for general use due to serious toxicity risks and a track record of poisoning.

If you're considering it, talk with your pharmacist or doctor about whether the risks are acceptable for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Siberian Cocklebur, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253649096
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 332073
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Siberian Cocklebur by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253649096
IngredientAmount% DV
Siberian Cocklebur Fruit Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR code to get more info or reorder

Formula

Xanthium strumarium

Organic alcohol based

Formulation

Only natural ingredients Identity and purity is laboratory verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Organic alcohol based

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Siberian Cocklebur by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Siberian Cocklebur label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Siberian Cocklebur by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Siberian Cocklebur Fruit Extract, Dry

Interacts with
662 drugs
983 mg per serving

Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and allergies. H...

Siberian Cocklebur Fruit Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Siberian Cocklebur by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Siberian Cocklebur?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
662Drugs
662 Major

Ingredients driving the most interactions

Siberian Cocklebur Fruit Extract, Dry 662

Individual Drug Interactions

The ingredients in Siberian Cocklebur interact with 662 drugs. Click any drug to see the details.

1 of the 1 ingredient in Siberian Cocklebur interact with drugs. Each result below shows which ingredient is responsible. Siberian Cocklebur Fruit Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Siberian Cocklebur with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Siberian Cocklebur Fruit Extract, Dry3 drug types · 662 drugs

Antidiabetes Drugs

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans. Hypoglycemia occurs soon after consumption and worsens with time in most cases. Do not use Siberian cocklebur in people taking medications that also lower blood glucose.
Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Likely Evidence B
Hepatotoxic Drugs

Siberian cocklebur can adversely affect the liver. It has been linked to many cases of hepatotoxicity and some cases of liver failure. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (TriCor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo).

Likelihood Likely Evidence B
Nephrotoxic Drugs

Siberian cocklebur can adversely affect the kidney. Theoretically, combining Siberian cocklebur with potentially nephrotoxic drugs might have additive harmful effects on kidney function.
Some potentially nephrotoxic drugs include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others.

Likelihood Likely Evidence B
Siberian Cocklebur Fruit Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Siberian Cocklebur, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Siberian Cocklebur by Hawaii Pharm: Common Questions

Does Siberian Cocklebur by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Siberian Cocklebur has a known interaction with 662 medications, including 662 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Siberian Cocklebur contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Siberian Cocklebur safe to take?
The safety data describes Siberian cocklebur as unsafe for use. It contains toxic compounds and has caused serious poisoning in people, with a long list of potential adverse effects including severe low blood sugar, liver and kidney damage, heart rhythm problems, and in severe cases, fatal outcomes. Talk to your pharmacist or doctor before considering it.
Can I take this if I'm pregnant or breastfeeding?
No. The ingredient is rated likely unsafe during pregnancy and breastfeeding due to potential toxicity and lack of safety data. Do not use if you're pregnant, nursing, or planning to become pregnant.
What are the main side effects I should watch for?
Adverse effects can include abdominal pain, nausea, vomiting, severe low blood sugar, liver damage, increased bleeding, drowsiness, dizziness, shortness of breath, sweating, fever, and heart palpitations. Heart rhythm problems can start within a few hours of taking it. In severe cases, poisoning can progress to life-threatening changes.
What's in this liquid?
The active ingredient is Siberian Cocklebur Fruit Extract, Dry. The inactive ingredients are alcohol, water, and glycerin.
How quickly can side effects happen?
Effects can be fast. Heart palpitations have been reported as little as 3 hours after ingestion, and heart rhythm problems can follow a few hours after that. Low blood sugar typically occurs soon after consumption and worsens with time.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Siberian Cocklebur is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Siberian Cocklebur label
Go deeper

The Full Monographs Behind Siberian Cocklebur’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Siberian Cocklebur

Interacts with 662 drugs

Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and allergies. Human evidence is very limited, and the p...

Read the full Siberian Cocklebur monograph →
Sources

Sources & How We Checked

Siberian Cocklebur's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Siberian Cocklebur 4 references
  1. Wu, M. L., Wang, C. P., and Deng, J. F. Fatal hepatic failure due to fructus xanthii in a child. Abstracts of the 2005 North American Congress of Clinical Toxicology Annual Meeting. Clin Toxicol 2005;43:639. DOI
  2. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756. PubMed
  3. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
  4. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.

See these in context on the Siberian Cocklebur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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