Similase GFCF Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Similase GFCF against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Similase GFCF is a dietary supplement by Integrative Therapeutics with 7 active ingredients. Its ingredients are commonly taken for improving mineral absorption, breaking down phytic acid (phytate) in grains and legumes, supporting digestion of plant-based foods.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Similase GFCF by Integrative Therapeutics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Similase GFCF contains seven active digestive enzymes: amylase, phytase, lipase, sucrase, lactase, cellulase, and a DPP IV protease blend. These are all natural enzymes that help break down different components of food—starches, proteins, fats, sugars, and plant fiber.
The product is formulated to be gluten-free and casein-free, as the name suggests. The inactive ingredients are a plant-derived capsule, cellulose, inulin, calcium laurate, and silica—common binders and fillers that help hold the capsule together.
Does it work?
Strong evidence
The evidence for most of these enzymes is thin. Lactase—the enzyme that breaks down milk sugar—is rated effective for lactose intolerance.
For the other six active ingredients, the evidence we hold is insufficient to establish whether they work for their intended digestive purposes. That doesn't mean they don't work; it means reliable human studies haven't been done yet or the data aren't in our system.
How safe is it?
Well-documented data
Lactase is generally well tolerated as a supplement. Phytase and lipase are considered low-risk in the foods we eat, but human safety data on them as supplements are limited.
We hold little safety information on amylase, sucrase, cellulase, or the DPP IV protease blend in supplement form. One rare concern: occupational exposure to powdered phytase has triggered allergic reactions and lung inflammation in some workers in the animal-feed industry, though this is a workplace exposure concern rather than a typical supplement user concern.
A case of allergic rhinitis from powdered lactase has also been reported. For anyone with serious digestive conditions, lipase should be used only under medical guidance.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, we could not verify amylase, sucrase, cellulase, or the DPP IV protease blend against our interaction database.
If you take any regular medications, check them against the search tool on this page.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Similase GFCF is a digestive enzyme blend that's generally well tolerated. It's most clearly supported for lactose intolerance.
If you have a serious digestive condition, a food allergy or sensitivity, or take any medications, talk with your doctor or pharmacist before starting it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Similase GFCF, straight from the product label.
| Brand | Integrative Therapeutics |
|---|---|
| Barcode (UPC) | 871791003866 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 19, 2022 |
| DSLD ID | 265963 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Similase GFCF by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Lipase | 0 NP | -- |
| Sucrase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Microbial Enzymes | 621 mg | -- |
| DPP IV Protease Blend | 0 NP | -- |
Other ingredients: plant-derived Capsule, Cellulose, Inulin, Calcium Laurate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Caution: If you are pregnant, nursing, have diabetes, or if you are taking prescription drugs, consult a healthcare professional before use.
While Similase GFCF will reduce the level of reactive gliadin and gluten proteins in a meal, it is advised that celiac disease sufferers continue with their normal gluten exclusion diet as even small amounts of gliadin can cause adverse reactions in the most sensitized individuals.
Keep out of reach of children.
Safety sealed with inner seal. Do not use if seal is broken or missing.
General Statements
For more information, please visit integrativepro.com.
Storage
Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.
Formulation
Vegan
Contains no dairy, or artificial colors, flavors, or preservatives.
Seals/Symbols
Quality Global Sourcing Bottled & Tested in the USA
Brand IP Statement(s)
Copyright 2021 Distributed by Integrative Therapeutics, LLC
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formula
Gluten and casein digestive enzymes
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommendation: Adults take 2 capsules with each meal or as recommended by a healthcare professional.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Similase GFCF by Integrative Therapeutics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Similase GFCF by Integrative Therapeutics
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Plant-derived Capsule, Cellulose, Inulin, Calcium Laurate, Silica. These complete the product’s ingredient list but are not active constituents.
Similase GFCF by Integrative Therapeutics Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Similase GFCF. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Similase GFCF, from the product label.
Integrative Therapeutics
See all Integrative Therapeutics products- Name
- Integrative Therapeutics, LLC
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 800.931.1709
- Web Address
- integrativepro.com
Similase GFCF by Integrative Therapeutics: Common Questions
Does Similase GFCF by Integrative Therapeutics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to take during pregnancy or while breastfeeding?
What does each enzyme in this product do?
Does this actually work for digestive problems?
Can I be allergic to the enzymes in this product?
Is this product gluten-free and casein-free?
Are there any fillers or other ingredients I should know about?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Similase GFCF is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Similase GFCF’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Phytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
Similase GFCF's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 9 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC