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Dietary supplement

SinuCheck Ingredients & Drug Interactions

by Enzymatic Therapy

SinuCheck label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SinuCheck against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SinuCheck is a dietary supplement by Enzymatic Therapy with 1 active ingredient. Its ingredients are commonly taken for cough and chest congestion, colds and flu symptoms, stuffy nose.Based on those ingredients, 878 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Soledum brand Eucalyptus globulus oil extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against SinuCheck by Enzymatic Therapy

Ask about any prescription or over-the-counter medication and we check it for interactions with SinuCheck by Enzymatic Therapy — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of SinuCheck by Enzymatic Therapy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

SinuCheck contains one active ingredient: Soledum brand eucalyptus oil extract. Eucalyptus is used traditionally to support sinus and respiratory function.

The product is packaged in a softgel capsule and includes inactive ingredients (gelatin, medium chain triglycerides, vegetable glycerin, sorbitol, modified cellulose, sodium alginate, oleic acid, candelilla wax, and stearic acid) to form and stabilize the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Eucalyptus's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: soothing sinus support and clear-headed comfort.
  • We looked for evidence on: Rhinosinusitis, nasal congestion, sinus congestion, sinusitis.
  • The closest evidence on file: Eucalyptus is rated "Insufficient Reliable Evidence To Rate" for Rhinosinusitis (Natural Medicines).

The evidence we have for eucalyptus doesn't yet establish whether it works for acne, bronchitis, asthma, burns, or cancer. Our data shows insufficient reliable evidence to rate it for any of these uses.

If you're thinking about using SinuCheck for a specific condition, talk it over with your doctor — they can help you weigh what's known and what isn't, and consider what's best for your situation.

The evidence, ingredient by ingredient Eucalyptus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Eucalyptus oil is generally well tolerated when used in small amounts for inhalation or diluted on skin, but undiluted oil can be poisonous if swallowed. If you take this product orally, the most common side effects are diarrhea, nausea, and vomiting; on skin, you might see burning, itching, redness, or stinging.

Rarely, especially at higher doses, eucalyptus oil can cause serious toxicity — central nervous system depression, shallow breathing, rapid pulse, seizures, coma, and in severe cases, death. Some people have had allergic reactions or worsening of asthma and sinus symptoms after exposure to eucalyptus.

For pregnancy and breastfeeding, the data we hold rates eucalyptus as likely safe, but other safety notes caution against internal use and recommend keeping the oil away from babies. Because the product itself should not be taken internally (given the toxicity risk of undiluted oil), talk with your doctor or pharmacist about whether it's right for you during pregnancy or while nursing.

Side effects, ingredient by ingredient Eucalyptus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Eucalyptus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 879 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking SinuCheck, double-check your medications against the tool on this page — especially any drugs your liver processes (Moderate severity). If you take diabetes medications, amphetamines, or the sedative pentobarbital, those warrant a conversation with your doctor or pharmacist too.

No interactions are documented for ingredients we could not check — this product contains only eucalyptus extract, which we have data for.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

SinuCheck may appeal to someone looking for a traditional eucalyptus product for sinus support, but it carries real interaction risks with a very large number of medications — especially those your liver processes. If you take any prescription drugs or regular over-the-counter medications, check them carefully against the interaction tool below before starting.

Pregnant or breastfeeding, or allergic to eucalyptus? Talk it over with your doctor or pharmacist to see if this is the right fit for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SinuCheck, straight from the product label.

Brand Enzymatic Therapy
Barcode (UPC) 763948094141
Net contents 40 Softgel(s)
Market status On market
Date entered into DSLD Mar 24, 2016
DSLD ID 58191
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SinuCheck by Enzymatic Therapy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
20
UPC/BARCODE
763948094141
IngredientAmount% DV
Soledum brand Eucalyptus globulus oil extract200 mg--

Other ingredients: Gelatin, Medium Chain Triglycerides, Vegetable Glycerin, Sorbitol, Modified Cellulose, Sodium Alginate, Oleic Acid, Candelilla Wax, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Herbal Relief

Clear-headed comfort ~ Soothing sinus support ~ Non-drowsy

When you need respiratory support, get clear-headed comfort with SinuCheck sinus formula.

Product of Germany

SinuCheck: ~ Soothes and supports mucous membranes and sinus cavities* ~ Maintains healthy sinus drainage* ~ Relieves occasional irritation* ~ Promotes clear respiratory comfort* ~ Delivers real relief—powered by real eucalyptus*

Brand IP Statement(s)

SinuCheck by Soledum

Breath easy with SinuCheck

Distributed by Enzymatic Therapy, LLC (part of Nature’s Way Brands, LLC)

Soledum is a trademark of the KLOSTERFRAU Healthcare Group.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General

LBX09414.B02 (BLK941B)

Precautions

This product has a tamper-evident blister sheet. Do not use if foil or plastic is punctured!

Caution: Keep out of the reach of children.

Do not exceed recommended dosage. If symptoms persist beyond 10 days or worsen, consult your healthcare professional.

If pregnant, nursing or taking any medications, consult a healthcare professional before use.

Suggested/Recommended/Usage/Directions

Recommendations: Take 2 softgels three times daily.

Formula

Made with a unique form of eucalyptus oil extract, SinuCheck is sinus support that works in harmony with your body.*

Formulation

Gluten free. No sugar, salt, yeast, wheat, corn, soy, dairy products, artificial colors, artificial flavors, or preservatives.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SinuCheck by Enzymatic Therapy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SinuCheck label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SinuCheck by Enzymatic Therapy

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container20 Amounts shown are per serving.

Soledum brand Eucalyptus globulus oil extract

Interacts with
878 drugs
200 mg per serving

Eucalyptus is best known for its strong-smelling oil used in vapor rubs, inhalants, and lozenges to ease coughs and congestion. It may provide mild, s...

Soledum brand Eucalyptus globulus oil extract monograph & interactions

Other (inactive) ingredients: Gelatin, Medium Chain Triglycerides, Vegetable Glycerin, Sorbitol, Modified Cellulose, Sodium Alginate, Oleic Acid, Candelilla Wax, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

SinuCheck by Enzymatic Therapy Drug Interactions

Want to check YOUR meds against SinuCheck?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
878Drugs
878 Moderate

Ingredients driving the most interactions

Soledum brand Eucalyptus globulus oil extract 878

Individual Drug Interactions

The ingredients in SinuCheck interact with 878 drugs. Click any drug to see the details.

1 of the 1 ingredient in SinuCheck interact with drugs. Each result below shows which ingredient is responsible. Soledum brand Eucalyptus globulus oil extract

Each ingredient & the kinds of drugs it affects

For each ingredient in SinuCheck with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Soledum brand Eucalyptus globulus oil extract7 drug types · 878 drugs

Amphetamines

Theoretically, inhaling eucalyptol may reduce the effectiveness of amphetamines.
Animal research suggests that inhaling eucalyptol may reduce the levels of amphetamines in the blood.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, eucalyptus leaf might increase the risk of hypoglycemia.
Animal research suggests that eucalyptus leaf might have hypoglycemic activity, and might have additive effects when used with antidiabetes drugs.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP1A2, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, eucalyptus might increase the levels of CYP2C19 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP2C19, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, eucalyptus might increase the levels of CYP2C9 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP2C9, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP3A4, although this has not been reported in humans.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, inhaling eucalyptol might reduce the effectiveness of pentobarbital.
Animal research suggests that inhaling eucalyptol reduces the level of pentobarbital that reaches the brain.

Likelihood Possible Evidence D
Soledum brand Eucalyptus globulus oil extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SinuCheck, from the product label.

Enzymatic Therapy

Name
Enzymatic Therapy, LLC (Part of Nature’s Way Brands, LLC)
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-783-2286
Web Address
enzy.com
Pharmacist Counseling Corner

SinuCheck by Enzymatic Therapy: Common Questions

Does SinuCheck by Enzymatic Therapy interact with any medications?
Yes. Based on its ingredients, SinuCheck has a known interaction with 878 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SinuCheck contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Our data rates eucalyptus as likely safe during pregnancy and breastfeeding, but other safety notes advise against taking the oil internally and to keep it away from babies. The best move is to talk with your doctor or pharmacist — they know your full picture and can give you personalized advice.
What are the side effects?
If you take it orally, expect possible diarrhea, nausea, or vomiting. On skin, you might see burning, itching, redness, or stinging. Rarely, especially at higher doses, eucalyptus oil can cause serious effects like seizures, breathing problems, or coma — which is why the undiluted oil should never be swallowed.
Does this actually work for sinus issues?
We don't have reliable evidence yet to confirm whether eucalyptus works for sinus problems — or for acne, bronchitis, asthma, burns, or cancer. If you're using it for a specific condition, talk with your doctor about what the research shows and what might be the best choice for you.
Is this the same as eucalyptus oil I can buy at a health store?
SinuCheck contains Soledum brand eucalyptus oil extract in a softgel capsule — so it's a prepared supplement, not raw oil. The key difference: never take undiluted eucalyptus oil by mouth, as it can be poisonous. Always follow the product label and talk with your pharmacist about how to use it safely.
Can I use this if I have asthma?
Eucalyptus can trigger or worsen asthma and sinus symptoms in some people, including allergic reactions. If you have asthma, check with your doctor before starting SinuCheck — they can help you weigh the risks and benefits for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SinuCheck is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SinuCheck label
Go deeper

The Full Monographs Behind SinuCheck’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eucalyptus

Interacts with 878 drugs

Eucalyptus is best known for its strong-smelling oil used in vapor rubs, inhalants, and lozenges to ease coughs and congestion. It may provide mild, short-term relief of cold symptoms, but t...

Read the full Eucalyptus monograph →
Sources

Sources & How We Checked

SinuCheck's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eucalyptus 23 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  3. De Vincenzi M, Silano M, De Vincenzi A, et al. Constituents of aromatic plants: eucalyptol. Fitoterapia 2002;73:269-75. PubMed
  4. Gray AM, Flatt PR. Antihyperglycemic actions of Eucalyptus globulus (Eucalyptus) are associated with pancreatic and extra-pancreatic effects in mice. J Nutr 1998;128:2319-23. PubMed
  5. Whitman BW, Ghazizadeh H. Eucalyptus oil: therapeutic and toxic aspects of pharmacology in humans and animals. J Paediatr Child Health 1994;30:190-1. PubMed
  6. Barker SC and Altman PM. An ex vivo, assessor blind, randomised, parallel group, comparative efficacy trial of the ovicidal activity of three pediculicides after a single application--melaleuca oil and lavender oil, eucalyptus oil and lemon tea tree oil,
  7. Vilaplana, J. and Romaguera, C. Allergic contact dermatitis due to eucalyptol in an anti-inflammatory cream. Contact Dermatitis 2000;43(2):118.
  8. Juergens, U. R. [Reducing the need for cortisone. Does eucalyptus oil work in asthma? (interview by Brigitte Moreano]. MMW.Fortschr Med 3-29-2001;143(13):14.
  9. Tascini, C., Ferranti, S., Gemignani, G., Messina, F., and Menichetti, F. Clinical microbiological case: fever and headache in a heavy consumer of eucalyptus extract. Clin Microbiol.Infect. 2002;8(7):437, 445-437, 446. PubMed
  10. Galdi, E., Perfetti, L., Calcagno, G., Marcotulli, M. C., and Moscato, G. Exacerbation of asthma related to Eucalyptus pollens and to herb infusion containing Eucalyptus. Monaldi Arch.Chest Dis. 2003;59(3):220-221.
  11. Spoerke, D. G., Vandenberg, S. A., Smolinske, S. C., Kulig, K., and Rumack, B. H. Eucalyptus oil: 14 cases of exposure. Vet Hum.Toxicol 1989;31(2):166-168.
  12. Jori, A., Bianchetti, A., Prestini, P. E., and Gerattini, S. Effect of eucalyptol (1,8-cineole) on the metabolism of other drugs in rats and in man. Eur.J Pharmacol 1970;9(3):362-366. PubMed
  13. Tibballs, J. Clinical effects and management of eucalyptus oil ingestion in infants and young children. Med J Aust 8-21-1995;163(4):177-180. PubMed
  14. Webb, N. J. and Pitt, W. R. Eucalyptus oil poisoning in childhood: 41 cases in south-east Queensland. J Paediatr.Child Health 1993;29(5):368-371. PubMed
  15. Gyldenløve M, Menné T, Thyssen JP. Eucalyptus contact allergy. Contact Dermatitis. 2014;71(5):303-304. PubMed
  16. Higgins C, Palmer A, Nixon R. Eucalyptus oil: contact allergy and safety. Contact Dermatitis. 2015;72(5):344-346. PubMed
  17. de Groot AC, Schmidt E. Eucalyptus oil and tea tree oil. Contact Dermatitis. 2015;73(6):381-386. PubMed
  18. Greive KA, Barnes TM. The efficacy of Australian essential oils for the treatment of head lice infestation in children: A randomised controlled trial. Australas J Dermatol. 2018;59(2):e99-e105. PubMed
  19. Paulsen E, Thormann H, Vestergaard L. Eucalyptus species as a cause of airborne allergic contact dermatitis. Contact Dermatitis. 2018;78(4):301-303.
  20. Mathew T, John SK, Kamath V, et al. Essential oil related seizures (EORS): A multi-center prospective study on essential oils and seizures in adults. Epilepsy Res. 2021;173:106626. PubMed
  21. Dudipala SC, Mandapuram P, Ch LK. Eucalyptus Oil-Induced Seizures in Children: Case Reports and Review of the Literature. J Neurosci Rural Pract 2021;12(1):112-115. PubMed
  22. Panda PK, Sharawat IK, Panda P, Dawman L, Kasinathan A. Clinico-laboratory characteristics and outcome of patients with eucalyptus oil-induced/provoked seizures: A case series and systematic review of the published patients. Trop Doct 2021;51(4):518-522. PubMed
  23. Sai Chandar D, Prashanthi M, Laxman Kumar C, Amith Kumar C. Eucalyptus Oil-Induced Seizures in Children: A Single-Center Prospective Study. Cureus 2021;13(3):e14109. PubMed

See these in context on the Eucalyptus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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