Slippery Elm 400 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Slippery Elm 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Slippery Elm 400 mg is a dietary supplement by Nature's Harmony with 1 active ingredient. Its ingredients are commonly taken for sore throat and cough, heartburn and acid reflux, digestive upset and ibs.Based on those ingredients, 2,022 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Slippery Elm. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Slippery Elm 400 mg by Nature's Harmony
Ask about any prescription or over-the-counter medication and we check it for interactions with Slippery Elm 400 mg by Nature's Harmony — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Slippery Elm 400 mg by Nature's Harmony
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: slippery elm inner bark at 400 mg per capsule. Slippery elm is a tree bark that's traditionally been used to coat and soothe the digestive tract.
The capsule itself is filled out with inactive ingredients — microcrystalline cellulose, magnesium stearate, silicon dioxide, and gelatin — which are standard binders and fillers.
Does it work?
Not established
The evidence we hold doesn't establish that slippery elm works for cancer, constipation, cough, inflammatory bowel disease, or diarrhea — all of these conditions have insufficient reliable evidence to rate. If you're thinking about it for one of these reasons, that's worth talking through with your doctor, who can point you toward remedies with stronger data behind them.
How safe is it?
Well-documented data
Slippery elm is generally well tolerated for short-term use, but high-quality safety data are limited. Adverse effects we know about include contact dermatitis from topical contact with the bark or its pollen, and urticaria (hives) in people sensitive to it.
The pollen itself is an allergen, so if you're prone to pollen allergies, you may want to be cautious. There isn't enough reliable safety data to know whether it's safe in pregnancy; some sources advise caution.
Similarly, safety while breastfeeding isn't well established, so caution is advised. If you're pregnant or nursing, talk with your doctor or pharmacist before starting this supplement.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist about any oral medications you're taking — slippery elm's mucilage may slow their absorption and reduce how well they work. Because this concern spans over 2,000 individual medications, it's not practical to list them all here; use the search tool on this page to check your specific drugs, or ask your pharmacist to review your list.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Slippery Elm 400 mg may be worth considering if you're looking for a traditional digestive soother, but the evidence for its effectiveness isn't established. The main thing to watch is that it can interfere with how your body absorbs other oral medications — spacing doses apart or checking with your own doctor or pharmacist beforehand is important.
Because safety data are limited and the pollen can trigger allergies in some people, this isn't a grab-and-go supplement.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Slippery Elm 400 mg, straight from the product label.
| Brand | Nature's Harmony |
|---|---|
| Barcode (UPC) | 063047008323 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 24, 2013 |
| DSLD ID | 21798 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Slippery Elm 400 mg by Nature's Harmony, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Slippery Elm | 400 mg | -- |
Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Gelatin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Recommended Use: Traditionally used in Herbal Medicine as a demulcent to soothe the stomach. Recommended Dose (Adults): Take 5 capsules twice daily.
Precautions
Risk Information: Do not use if pregnant or breastfeeding.
KEEP OUT OF REACH OF CHILDREN.
DO NOT USE IF SEAL UNDER CAP IS BROKEN.
Consult a health care practitioner for prolonged use.
Formulation
This product does not contain corn, dairy, egg, gluten, shellfish, soy, sulfites, or artificial colours, flavours or preservatives.
Storage
STORE IN A COOL, DRY PLACE.
General Statements
Soothes the Stomach
{Capsule} Actual Size
A Proud Canadian Company
General
400832.01-01
Seals/Symbols
SunOpta A healthy products company
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Slippery Elm 400 mg by Nature's Harmony label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Slippery Elm 400 mg by Nature's Harmony
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size5 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Slippery Elm
Interacts with2,022 drugs
Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated di...
Slippery Elm monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Gelatin. These complete the product’s ingredient list but are not active constituents.
Slippery Elm 400 mg by Nature's Harmony Drug Interactions
HelloPharmacist Interaction Report
Slippery Elm 400 mg by Nature's Harmony may slow how your body absorbs oral medications through its mucilage content, which can reduce drug levels in your bloodstream.
This is a Moderate interaction that affects a broad range of oral drugs — we've documented this concern across 2,023 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Because slippery elm's mucilage can coat your digestive tract and interfere with how pills dissolve and get absorbed, you'll want to space out doses: take your medications at least 2 hours apart from this supplement, or better yet, check with your doctor or pharmacist about the specific drugs you're on.
To see whether any of your exact medications are on the list, run them through the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Slippery Elm 400 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Slippery Elm 400 mg interact with 2,022 drugs. Click any drug to see the details.
1 of the 1 ingredient in Slippery Elm 400 mg interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm
"phentolamineOraVerse, Rogitine, Ryzumvi
How "phentolamine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + "phentolamine interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + 6-mercaptopurine interactionAbacavirZiagen
How Abacavir interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Abacavir interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acalabrutinib interactionAcamprosateCampral
How Acamprosate interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acamprosate interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Slippery Elm 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Caffeine, Isometheptene interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Slippery Elm 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Slippery Elm
Oral Drugs
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.
Brand information
Manufacturer and brand details for Slippery Elm 400 mg, from the product label.
Nature's Harmony
See all Nature's Harmony products- Name
- SunOpta Inc.
- Street Address
- 6 Commerce Crescent
- City
- Acton
- State
- ON
- ZipCode
- L7J 2X3
Slippery Elm 400 mg by Nature's Harmony: Common Questions
Does Slippery Elm 400 mg by Nature's Harmony interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this with my other medications?
Is slippery elm safe during pregnancy?
Is it safe while breastfeeding?
Does slippery elm actually work for constipation or diarrhea?
Can slippery elm cause allergic reactions?
How long is it safe to use slippery elm?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Slippery Elm 400 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Slippery Elm 400 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Slippery Elm 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Slippery Elm 3 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC