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Dietary supplement

Spearmint Extract Ingredients & Drug Interactions

by BulkSupplements.com

Spearmint Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Spearmint Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Spearmint Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, nausea, hormonal acne and unwanted hair (pcos-related).Based on those ingredients, 579 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Spearmint Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Spearmint Extract by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Spearmint Extract by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Spearmint Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Spearmint Leaf Extract. There are no other inactive ingredients listed.

Spearmint is a plant commonly used as a flavoring and in traditional herbal preparations, and this extract concentrates its compounds into powder form.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Spearmint product and its label doesn't state a use — see Spearmint's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that spearmint extract works for any of the uses sometimes suggested for it—cognitive decline, cognitive function, flatulence, irritable bowel syndrome, postoperative nausea, or osteoarthritis. Each of these has insufficient reliable evidence to rate.

That doesn't mean it doesn't work; it means the research data we have isn't strong enough to say either way.

The evidence, ingredient by ingredient Spearmint

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Spearmint is generally well tolerated when taken by mouth. The main caution is that this is a concentrated supplement, not the small amount you'd get from spearmint tea or food.

The safety data we have is limited for supplement doses specifically, so the manufacturer and our data recommend sticking to food or tea amounts unless your doctor approves otherwise. Allergic reactions are possible but uncommon.

They've included allergic skin reactions from topical spearmint oil, swelling in the soft palate of the mouth from eating spearmint, and allergic reactions in people chewing spearmint gum. One person in a trial taking 600 mg daily reported anxiety, though it's unclear if spearmint caused it.

Side effects, ingredient by ingredient Spearmint

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Spearmint.
  • The most serious interaction on file is rated Moderate.
  • For scale: 580 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check this product with your pharmacist before taking it if you use any sedative, sleep aid, or anti-anxiety medication—spearmint might unpredictably alter how they work. Also check if you take any medication your doctor has told you can affect your liver.

No other medication types are documented to interact with the ingredient we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take sedative or sleep medications, or anything that stresses your liver, check this product with your pharmacist before you start. The evidence for what spearmint extract does isn't established in our data, and we have limited safety information on supplement doses.

A short conversation with your pharmacist will tell you whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Spearmint Extract, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X0018W6A7R
Net contents 250 Gram(s); 8.8 Ounce(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 311634
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Spearmint Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
500
UPC/BARCODE
X0018W6A7R
IngredientAmount% DV
Spearmint Leaf Extract500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & pure bulk supplements

Formulation

Color may vary

Free of: Added sugar, soy, dairy, yeast, gluten, additives

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 500 mg (about 1/5 tsp) once or twice times daily, or as directed by a physician.

Storage

Store in a dry, cool place Contents are sold by weight, not volume. Settling may occur.

General Statements

New Use an accurate milligram scale.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Spearmint Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Spearmint Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Spearmint Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container500 Amounts shown are per serving.

Spearmint Leaf Extract

Interacts with
579 drugs
500 mg per serving Form: Mentha spicata Leaf Extract

Spearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild horm...

Spearmint Leaf Extract monograph & interactions
Interaction report

Spearmint Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Spearmint Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
579Drugs
579 Moderate

Ingredients driving the most interactions

Spearmint Leaf Extract 579

Individual Drug Interactions

The ingredients in Spearmint Extract interact with 579 drugs. Click any drug to see the details.

1 of the 1 ingredient in Spearmint Extract interact with drugs. Each result below shows which ingredient is responsible. Spearmint Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Spearmint Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Spearmint Leaf Extract2 drug types · 579 drugs

Cns Depressants

Theoretically, spearmint might alter the sedative effects of CNS depressants.
Animal research suggests that (-)-carvone, a major constituent of spearmint, has sedative effects. However, in humans, chewing spearmint-flavored gum induced arousal effects.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Animal research suggests that drinking spearmint tea for 30 days can increase markers of liver damage, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and cause liver degeneration and necrosis, in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Spearmint Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Spearmint Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Spearmint Extract by BulkSupplements.com: Common Questions

Does Spearmint Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Spearmint Extract has a known interaction with 579 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Spearmint Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will spearmint extract help with bloating or IBS?
The evidence we hold doesn't establish that spearmint extract works for flatulence or irritable bowel syndrome. You might see it marketed for these uses, but the research backing isn't there yet.
Is it safe to take if I have a sensitive stomach?
Spearmint is well tolerated by mouth in general. If you have a known allergy to spearmint or related plants (like mint), avoid it. For other stomach conditions, your doctor or pharmacist is the best source—we don't have specific data on how this supplement affects particular digestive issues.
Can I take this if I'm pregnant or breastfeeding?
We don't have safety data on file for spearmint extract in pregnancy or breastfeeding. Talk with your doctor or pharmacist before taking it—they can weigh the individual factors in your situation.
What does spearmint extract actually do?
The evidence we hold doesn't show spearmint extract works reliably for any particular condition. It's used in teas and food flavoring traditionally, but the supplement form hasn't been proven effective for cognitive health, digestive issues, or other common uses.
Will it make me drowsy?
Animal research suggests spearmint has some sedative activity, but humans who chewed spearmint gum actually felt more alert. We don't have clear data on how the extract affects alertness in people, so it's hard to say. If you're sensitive to sedatives, mention this product to your pharmacist.
Can I get allergic reactions from this?
Yes—allergic reactions to spearmint are possible but uncommon. They've included skin reactions, swelling in the mouth, and reactions to spearmint oil. If you have a known mint allergy, skip this product. If you develop any unusual rash or swelling of your mouth or throat after starting it, stop and contact your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Spearmint Extract label
Go deeper

The Full Monographs Behind Spearmint Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Spearmint

Interacts with 579 drugs

Spearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild hormone-related issues (such as excess facia...

Read the full Spearmint monograph →
Sources

Sources & How We Checked

Spearmint Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Spearmint 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Akdogan M, Ozguner M, Aydin G, Gokalp O. Investigation of biochemical and histopathological effects of Mentha piperita Labiatae and Mentha spicata Labiatae on liver tissue in rats. Hum Exp Toxicol 2004;23:21-8.
  3. Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. PubMed
  4. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  5. de Sousa, D. P., Farias Nobrega, F. F., and de Almeida, R. N. Influence of the chirality of (R)-(-)- and (S)-(+)-carvone in the central nervous system: a comparative study. Chirality 5-5-2007;19(4):264-268.
  6. Larsen, W., Nakayama, H., Fischer, T., Elsner, P., Frosch, P., Burrows, D., Jordan, W., Shaw, S., Wilkinson, J., Marks, J., Jr., Sugawara, M., Nethercott, M., and Nethercott, J. Fragrance contact dermatitis: a worldwide multicenter investigation (Part II PubMed
  7. Guney, M., Oral, B., Karahanli, N., Mungan, T., and Akdogan, M. The effect of Mentha spicata Labiatae on uterine tissue in rats. Toxicol.Ind.Health 2006;22(8):343-348.
  8. Masumoto, Y., Morinushi, T., Kawasaki, H., Ogura, T., and Takigawa, M. Effects of three principal constituents in chewing gum on electroencephalographic activity. Psychiatry Clin.Neurosci. 1999;53(1):17-23. PubMed
  9. Bulat, R., Fachnie, E., Chauhan, U., Chen, Y., and Tougas, G. Lack of effect of spearmint on lower oesophageal sphincter function and acid reflux in healthy volunteers. Aliment.Pharmacol Ther. 1999;13(6):805-812. PubMed
  10. Francalanci, S., Sertoli, A., Giorgini, S., Pigatto, P., Santucci, B., and Valsecchi, R. Multicentre study of allergic contact cheilitis from toothpastes. Contact Dermatitis 2000;43(4):216-222. PubMed
  11. Bonamonte, D., Mundo, L., Daddabbo, M., and Foti, C. Allergic contact dermatitis from Mentha spicata (spearmint). Contact Dermatitis 2001;45(5):298.
  12. Tomson, N., Murdoch, S., and Finch, T. M. The dangers of making mint sauce. Contact Dermatitis 2004;51(2):92-93. PubMed
  13. Clayton, R. and Orton, D. Contact allergy to spearmint oil in a patient with oral lichen planus. Contact Dermatitis 2004;51(5-6):314-315. PubMed
  14. Dal Sacco, D., Gibelli, D., and Gallo, R. Contact allergy in the burning mouth syndrome: a retrospective study on 38 patients. Acta Derm.Venereol. 2005;85(1):63-64. PubMed
  15. Goncalves, J. C., Oliveira, Fde S., Benedito, R. B., de Sousa, D. P., de Almeida, R. N., and de Araujo, D. A. Antinociceptive activity of (-)-carvone: evidence of association with decreased peripheral nerve excitability. Biol Pharm Bull. 2008;31(5):1017- PubMed
  16. Ormerod, A. D. and Main, R. A. Sensitisation to "sensitive teeth" toothpaste. Contact Dermatitis 1985;13(3):192-193. PubMed
  17. Skrebova, N., Brocks, K., and Karlsmark, T. Allergic contact cheilitis from spearmint oil. Contact Dermatitis 1998;39(1):35. PubMed
  18. Damiani E, Aloia AM, Priore MG, et al. Allergy to mint (Mentha spicata). J Investig Allergol Clin Immunol 2012;22:309-10.
  19. Connelly AE, Tucker AJ, Tulk H, et al. High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms. J Med Food 2014;17:1361-7. PubMed
  20. Lasrado JA, Nieman KM, Fonseca BA, et al. Safety and tolerability of a dried aqueous spearmint extract. Regul Toxicol Pharmacol 2017;86:167-176. PubMed

See these in context on the Spearmint monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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