Interactions on record — worth a quick check against your medications. Based on 8 of 9 ingredients. Check your meds →
Dietary supplement

SpectraFiber Ingredients & Drug Interactions

by Klaire Labs

SpectraFiber label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SpectraFiber against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SpectraFiber is a dietary supplement by Klaire Labs with 9 active ingredients. Its ingredients are commonly taken for digestive upset and bloating, infant colic, menstrual cramps.Based on those ingredients, 2,129 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glucomannan, Slippery Elm, Fennel. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SpectraFiber by Klaire Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with SpectraFiber by Klaire Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of SpectraFiber by Klaire Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “Plant Concentrate Blend” is a proprietary blend — the label gives one combined amount (750 mg) without saying how much of each component you get.

SpectraFiber contains nine active ingredients: fennel, glucomannan, sodium alginate, prune, carrot, slippery elm, celery, apple pectin, and citrus pectin. These are combined in a plant-based capsule alongside inactive ingredients including hydroxypropylmethylcellulose, ascorbyl palmitate, and silicon dioxide.

The formula blends fiber sources (glucomannan, sodium alginate, apple pectin, citrus pectin, and slippery elm) with herbal and plant components (fennel, prune, carrot, and celery). Each ingredient is listed for its traditional or studied contribution to digestive and general wellness support.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Broad spectrum natural soluble fiber support.
  • We looked for evidence on: Constipation, Diarrhea, Dyslipidemia, Hypercholesterolemia, Hyperlipidemia, Impaired glucose tolerance (Prediabetes) — and 4 related terms.
  • The strongest evidence on file: Glucomannan is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Glucomannan is rated "Possibly Effective" for Diabetes, Hyperlipidemia.
  • Also on file: Pectin is rated "Possibly Effective" for Hypercholesterolemia.

Glucomannan is possibly effective for constipation, diabetes, and high cholesterol. Fennel is possibly effective for dysmenorrhea (painful periods), though evidence for its use with bronchitis, anxiety, or bedwetting is insufficient.

Prune and carrot are each possibly effective for constipation. Apple and citrus pectin are possibly effective for high cholesterol.

Carrot is also possibly effective for vitamin A deficiency. For most other uses—including fennel for bronchitis or anxiety, slippery elm for constipation or inflammatory bowel disease, and celery for any condition listed—the evidence in our data is insufficient to rate.

We hold no effectiveness data for sodium alginate in this product's context.

The evidence, ingredient by ingredient Fennel Glucomannan Sodium Plum Carrot Slippery Elm Celery Pectin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fennel, glucomannan, slippery elm, celery, prune, carrot, apple pectin, and citrus pectin are generally well tolerated when used orally. The most common adverse effects are gastrointestinal: bloating, gas, diarrhea, constipation, nausea, and abdominal discomfort.

Fennel and carrot carry allergy risk; celery can trigger allergic reactions including anaphylaxis in sensitive people. Celery may cause photosensitivity (increased sun sensitivity).

Rare serious events include seizures (fennel), airway obstruction (glucomannan if taken dry), and aspiration or bowel obstruction (prune, slippery elm pollen is an allergen). Pregnancy and breastfeeding safety varies by ingredient.

Fennel should be avoided in medicinal amounts during pregnancy due to hormone-like effects and limited safety data; food amounts are likely fine. Glucomannan, slippery elm, celery, apple pectin, and citrus pectin lack sufficient pregnancy data—talk to your doctor or pharmacist.

Carrot as food is likely safe in pregnancy. Sodium alginate ratings are mixed (one entry says likely safe, another says possibly unsafe); avoid excess.

Prune and carrot have insufficient breastfeeding data; celery, slippery elm, and the pectins are not well studied while breastfeeding.

Side effects, ingredient by ingredient Fennel Glucomannan Sodium Plum Carrot Slippery Elm Celery Pectin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 8 matched ingredients can interact with medications — Glucomannan, Fennel, Pectin, Celery, Slippery Elm, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications; lithium.
  • For scale: 2,130 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking SpectraFiber, check with your pharmacist if you take contraceptive drugs, blood thinners (anticoagulants or antiplatelets), hormone replacement therapy, drugs metabolized by liver enzyme CYP3A4, corticosteroids, lithium, levothyroxine (Synthroid), venlafaxine (Effexor), blood pressure medication, ciprofloxacin (Cipro), tamoxifen, lovastatin, tetracycline antibiotics, digoxin (Lanoxin), acetaminophen (Tylenol), or sodium-containing medications. No interactions are documented for carrot alone among the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

SpectraFiber is a fiber blend that may help with constipation, blood sugar, or cholesterol in some people. Before you start, check your exact medications with the tool on this page—especially if you take birth control, blood thinners, thyroid medication, antidepressants, or heart drugs.

If you have a celery or fennel allergy, skip this product. Talk to your pharmacist if you're pregnant, breastfeeding, or unsure whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SpectraFiber, straight from the product label.

Brand Klaire Labs
Barcode (UPC) 828054005303
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 281214
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SpectraFiber by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
120
UPC/BARCODE
828054005303
IngredientAmount% DV
Fennel0 NP--
Glucomannan0 NP--
Sodium Alginate0 NP--
Prune0 NP--
Carrot0 NP--
Slippery Elm0 NP--
Plant Concentrate Blend750 mg--
Celery0 NP--
Apple Pectin0 NP--
Citrus Pectin0 NP--

Other ingredients: Hydroxypropylmethylcellulose, Water, Ascorbyl Palmitate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product.

Keep out of reach of children.

Warning: This product can expose you to chemicals including lead, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food

Do not use if shrinkwrap is broken or missing.

Formulation

Free of the following common allergens: Milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and corn. Contains no artificial colors, flavors, or preservatives.

SpectraFiber combines purified and whole food plant concentrates containing a broad spectrum of natural soluble fiber components including pectic substances, mucilages, algal polysaccharides, cellulose, hemicellulose, lignan, and other naturally-occurring fiber-related substances.

This product is free of cereal grains.

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 capsule, 1 to 6 times daily with meals or as directed by a healthcare professional.

Storage

Store in a cool, dry place (59 degrees F - 85 degrees F) away from direct light.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

SFI

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SpectraFiber by Klaire Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SpectraFiber label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SpectraFiber by Klaire Labs

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Plant Concentrate Blend

750 mg per serving

Other (inactive) ingredients: Hydroxypropylmethylcellulose, Water, Ascorbyl Palmitate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

SpectraFiber by Klaire Labs Drug Interactions

Want to check YOUR meds against SpectraFiber?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,129Drugs
2,110 Moderate 19 Minor

Ingredients driving the most interactions

Glucomannan 2,022
Slippery Elm 2,022
Fennel 740
Celery 651
Sodium Alginate 205

Individual Drug Interactions

The ingredients in SpectraFiber interact with 2,129 drugs. Click any drug to see the details.

7 of the 9 ingredients in SpectraFiber interact with drugs. Each result below shows which ingredient is responsible. Glucomannan Slippery Elm Fennel Celery Sodium Alginate Prune Apple Pectin

Each ingredient & the kinds of drugs it affects

For each ingredient in SpectraFiber with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Glucomannan1 drug type · 2,022 drugs

Oral Drugs

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.

Likelihood Probable Evidence B
Glucomannan full monograph & interactions

Slippery Elm1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm full monograph & interactions

Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel full monograph & interactions

Celery8 drug types · 651 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Celery root contains the constituents falcarinol and falcarindiol. Laboratory research suggests that these constituents can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, celery seed extract might have additive effects with antihypertensive drugs.
Clinical research suggests that taking celery seed extract may reduce daytime systolic blood pressure by about 12 mmHg compared to less than 1 mmHg with placebo.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggests that constituents of celery can inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Levothyroxine (Synthroid, Others)

Theoretically, celery seed might decrease the effects of levothyroxine.
Several cases of hypothyroidism with low T4 levels have been reported in people who were previously stabilized on levothyroxine and then started taking celery seed tablets. They presented with symptoms such as lethargy, bloating, and dry skin, and recovered when celery seed was stopped. However, celery stem and leaf has been associated with case reports of hyperthyroidism in patients with no pre-existing thyroid disorders.

Likelihood Possible Evidence D
Lithium

Theoretically, celery might reduce excretion and increase levels of lithium due to potential diuretic effects.
Celery is thought to have diuretic properties. However, this effect has not been confirmed in humans.

Likelihood Probable Evidence D
Venlafaxine (Effexor)

Theoretically, celery root extract might increase blood levels of venlafaxine.
There is one case report of a patient who experienced medication-induced bipolar disorder after beginning to take celery root extract 1000 mg daily along with venlafaxine 75 mg and St. John's wort 600 mg daily. Symptoms included confusion, speech abnormalities, manic affect, and visual hallucinations. The plasma level of venlafaxine was 476.8 ng/mL (normal range 195-400 ng/mL). It is theorized that celery root increased venlafaxine levels by inhibiting cytochrome P450 2D6.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Animal research suggests that concomitant use of celery juice plus acetaminophen prolongs the effects of acetaminophen. This effect has been attributed to a decrease in hepatic cytochrome P450 activity. However, other animal research shows that pretreatment with celery root extract protects against acetaminophen-induced acute liver failure. These effects have not been reported in humans.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Laboratory research shows that celery contains photosensitizing agents such as phenols and psoralens.

Likelihood Possible Evidence D
Celery full monograph & interactions

Sodium Alginate7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium Alginate full monograph & interactions

Prune1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, plum juice might have antiplatelet effects.
Consuming plum juice while taking anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding. In healthy volunteers, drinking plum juice 200 mL daily for 28 days prolonged clotting time and inhibited platelet aggregation.

Likelihood Possible Evidence B
Prune full monograph & interactions

Apple Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
Apple Pectin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SpectraFiber, from the product label.

Klaire Labs

See all Klaire Labs products
Name
SFI USA
City
Reno
State
NV
ZipCode
89521
Web Address
Klaire.com
Pharmacist Counseling Corner

SpectraFiber by Klaire Labs: Common Questions

Does SpectraFiber by Klaire Labs interact with any medications?
Yes. Based on its ingredients, SpectraFiber has a known interaction with 2,129 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SpectraFiber contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take SpectraFiber if I'm pregnant or breastfeeding?
Safety varies by ingredient. Fennel should be avoided in medicinal amounts during pregnancy. Glucomannan, slippery elm, celery, apple pectin, and citrus pectin lack enough pregnancy data—talk to your doctor. Carrot as food is likely safe in pregnancy, but concentrated forms are not well studied. Breastfeeding safety is similarly unclear for most ingredients. Check with your pharmacist or doctor for personalized advice.
What's the most common side effect I might notice?
Gastrointestinal effects are most common: bloating, gas, diarrhea, constipation, nausea, or abdominal discomfort. These typically happen when people take fiber supplements without drinking enough water. Make sure to take SpectraFiber with plenty of liquid.
Does fennel in this product really work for period pain?
Fennel is possibly effective for dysmenorrhea (painful periods) according to the evidence we hold. That said, most other uses of fennel—like for cough or anxiety—lack reliable evidence, so results vary person to person.
What's the sodium alginate in here, and why is it included?
Sodium alginate is a natural fiber derived from seaweed. It's added for its bulking and stool-softening properties to support digestive function. The concern is that if you're sensitive to sodium or take blood pressure or heart medications, extra sodium intake can matter—that's why we flag those interactions.
Can I take SpectraFiber with my other supplements or medicines?
That depends on what you take. SpectraFiber has interactions with dozens of medication types—especially blood thinners, birth control, thyroid drugs, and heart medications. Use the medication checker on this page to look up your specific prescriptions and over-the-counter drugs, then talk to your pharmacist.
Is anyone allergic to the ingredients in SpectraFiber?
Yes. Celery, fennel, carrot, and prune can trigger allergies in sensitive people. Celery in particular can cause severe reactions including anaphylaxis. If you have a known allergy to any plant in the carrot family (celery, fennel, carrot) or to other ingredients here, do not use this product and talk to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SpectraFiber label
Go deeper

The Full Monographs Behind SpectraFiber’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Glucomannan

Interacts with 2,022 drugs

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is gener...

Read the full Glucomannan monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Plum

Interacts with 122 drugs

Plums and their dried form (prunes) are common, nutritious foods that are best known for helping relieve constipation thanks to their fiber and sorbitol content. They are generally safe as f...

Read the full Plum monograph → Herb & supplement monograph

Carrot

Carrot is a common food vegetable that is a rich source of beta-carotene (which the body turns into vitamin A) and other nutrients. Eating carrots is safe and nutritious for most people, but...

Read the full Carrot monograph → Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

Celery

Interacts with 651 drugs

Celery is a common vegetable that is also taken as a seed extract or oil supplement, mainly for blood pressure, fluid retention, and joint discomfort. Human evidence for these supplement use...

Read the full Celery monograph → Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph →
Sources

Sources & How We Checked

SpectraFiber's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 156 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
  4. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
  5. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  6. Rosti L, Nardini A, Bettinelli ME, Rosti D. Toxic effects of a herbal tea mixture in two newborns. Acta Paediatrica 1994;83:683. PubMed
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  47. Azimi M, Zahedi MJ, Raeiszadeh M, Iraji A, Cramer H, Pasalar M. Efficacy and Safety of a Persian Medicine Formula on Functional Dyspepsia Symptoms: A Randomized Double-Blind Active-Control Clinical Trial. Complement Med Res 2023;30(3):238-247. PubMed
  48. Ukleja-Sokolowska N, Lis K, Graczyk M, Bartuzi M, Bartuzi Z. The use of inhibition assay in Api g 7 suspected allergy in a female patient with anaphylaxis: A case report. Int J Immunopathol Pharmacol 2024;38:3946320231223004. PubMed

See these in context on the Celery monograph →

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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