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Dietary supplement

Stress Escape Ingredients & Drug Interactions

by Sundown Organics

Stress Escape label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stress Escape against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Stress Escape is a dietary supplement by Sundown Organics with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, restlessness.Based on those ingredients, 836 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Passion Flower. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Stress Escape by Sundown Organics

Ask about any prescription or over-the-counter medication and we check it for interactions with Stress Escape by Sundown Organics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Stress Escape by Sundown Organics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Stress Escape has one active ingredient: organic passion flower. This is a plant extract traditionally used to ease anxiety and support sleep.

The tablet also contains inactive ingredients—fillers and binders like tapioca dextrose, rice extract, bamboo extract, and guar gum—that hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: stress and nervous tension relief.
  • We looked for evidence on: Stress, Pre-procedural anxiety, Insomnia, Adjustment disorders, anxiety, restlessness — and 1 related terms.
  • The strongest evidence on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety (Natural Medicines).
  • Also on file: Passion Flower is rated "Possibly Effective" for Insomnia.
  • Also on file: Passion Flower is rated "Insufficient Reliable Evidence To Rate" for Adjustment disorders, Stress.

Passion flower is rated possibly effective for insomnia and for easing anxiety before a procedure or medical event. For alcohol use disorder and help with benzodiazepine (anti-anxiety medication) withdrawal, the evidence isn't strong enough yet to make a clear call.

If you're looking at this for sleep or pre-procedure jitters, the data suggests it may help—but talk to your pharmacist or doctor about whether it fits your situation.

The evidence, ingredient by ingredient Passion Flower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Passion flower is generally well tolerated when used short-term. The most common side effects are drowsiness, dizziness, confusion, and sensitivity reactions.

A small number of people have reported allergy-like symptoms such as sinus irritation. There is a single case report of severe nausea, vomiting, and heart rhythm changes at very high doses (1500–2000 mg); symptoms resolved once the product was stopped.

Do not use during pregnancy—there isn't enough safety data, and passion flower may affect the uterus. While breastfeeding, there also isn't enough safety information, so it's best to avoid it.

Talk with your doctor or pharmacist before using if you are pregnant or nursing.

Side effects, ingredient by ingredient Passion Flower

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Passion Flower.
  • The most serious interaction on file is rated Moderate.
  • For scale: 837 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Stress Escape, check your medications, especially if you take any sedative or anti-anxiety drugs, sleep aids, or benzodiazepines—passion flower can amplify their drowsy effects (Moderate severity). Also double-check any medications that are broken down by your liver's CYP3A4 enzyme or transported into cells by OATP carriers, as passion flower may theoretically alter how they work (Minor severity).

Use the medication checker below with your full list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Stress Escape may help with short-term sleep trouble or anxiety before a medical procedure. If you take any sedative medication, blood pressure drugs, or other prescriptions, check them against the interaction tool below first—passion flower can interact with a wide range of medications.

Skip it if you're pregnant or breastfeeding. Ask your pharmacist if this fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stress Escape, straight from the product label.

Brand Sundown Organics
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 240885
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stress Escape by Sundown Organics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
organic Passion Flower500 mg--

Other ingredients: Tapioca Dextrose, organic Bamboo extract, organic Rice extract Blend, Maltodextrin, organic Sunflower Lecithin, organic Palm Oil, organic Guar Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) tablet daily, preferably with a meal or at bedtime.

Once daily

Precautions

As a reminder, discuss the supplements and medications you take with your health care providers.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by person under the age of 18. Keep out of reach of children.

Tamper Resistant: Do not use if seal under cap is broken or missing.

Storage

Store at room temperature and avoid excessive heat.

Formulation

Non-GMO No gluten No wheat No milk No lactose No artificial color No artificial flavor No artificial sweetener No preservatives No soy No yeast No peanuts No tree nuts No fish Sodium free

Made in the USA with select ingredients from around the world

Gluten free Dairy free Non-GMO

USDA Organic

Organic, clean nutrition

In a world of choice, living your best becomes a collaboration between you...and you. When your well-being is important, living clean is a conscious choice you make. Sundown believes in living clean...and being transparent. That's why you won't find genetically modified ingredients, gluten, wheat, dairy, lactose or artificial flavors in any of our products. Now, we're going one step further with our USDA certified Organic Supplements that are 100% free of synthetic dyes. Now there's a clean, organic choice you can feel good about.

General Statements

Tree-free carton Made from 100% sugar cane fiber

Eliminates wood-based processes Renewable resource Removes carbon dioxide from the atmosphere

How2recycle.info Coated paper Box US only

Sundown's Whole Herb products utilize ground plant parts.

Seals/Symbols

Quality Assurance International Certified Organic Certified Organic by Quality Assurance International

USDA Organic

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Whole herb Passion Flower Traditionally used to soothe and relax

Our Stress Escape provides you with 500 mg of Passion Flower to help soothe and relax. This tropical herb has been traditionally used for centuries and is a great choice to help with occasional stress. Traditional use claims are based on historical or traditional practices. The use of passion flower for its soothing properties dates back to the ancient Aztecs.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stress Escape by Sundown Organics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stress Escape label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stress Escape by Sundown Organics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Organic Passion Flower

Interacts with
836 drugs
500 mg per serving

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Organic Passion Flower monograph & interactions

Other (inactive) ingredients: Tapioca Dextrose, Organic Bamboo extract, Organic Rice extract Blend, Maltodextrin, Organic Sunflower Lecithin, Organic Palm Oil, Organic Guar Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stress Escape by Sundown Organics Drug Interactions

Want to check YOUR meds against Stress Escape?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
836Drugs
248 Moderate 588 Minor

Ingredients driving the most interactions

organic Passion Flower 836

Individual Drug Interactions

The ingredients in Stress Escape interact with 836 drugs. Click any drug to see the details.

1 of the 1 ingredient in Stress Escape interact with drugs. Each result below shows which ingredient is responsible. organic Passion Flower

Each ingredient & the kinds of drugs it affects

For each ingredient in Stress Escape with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Passion Flower3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
organic Passion Flower full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stress Escape, from the product label.

Sundown Organics

See all Sundown Organics products
Name
Rexall Sundown, Inc.
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-888-848-2435
Web Address
www.sundownorganics.com
Pharmacist Counseling Corner

Stress Escape by Sundown Organics: Common Questions

Does Stress Escape by Sundown Organics interact with any medications?
Yes. Based on its ingredients, Stress Escape has a known interaction with 836 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stress Escape contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Yes, drowsiness is the most common side effect. Dizziness and confusion can also happen. If you drive or operate machinery, be cautious, especially when first starting it.
Can I take this if I'm pregnant or breastfeeding?
No. During pregnancy, passion flower should be avoided due to lack of safety data and possible effects on the uterus. While breastfeeding, there isn't enough information to know if it's safe, so it's best avoided. Talk with your doctor or pharmacist for personalized guidance.
Does passion flower actually help with sleep and anxiety?
The evidence suggests it may help with insomnia and with anxiety before a medical procedure—that's why it's rated possibly effective for those uses. Results vary person to person, and it's not a replacement for professional treatment if you have serious sleep or anxiety issues.
What's in this besides the passion flower?
The tablet contains inactive ingredients like tapioca dextrose, rice extract, bamboo extract, guar gum, and sunflower lecithin—these are fillers and binders that help form the tablet. The only active ingredient is the organic passion flower.
What side effects should I watch for?
The most common are drowsiness, dizziness, confusion, and sensitivity reactions like sinus irritation or, rarely, hives. There is one reported case of severe nausea, vomiting, and heart rhythm changes at very high doses; stop taking it and call your doctor if anything feels wrong.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stress Escape label
Go deeper

The Full Monographs Behind Stress Escape’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph →
Sources

Sources & How We Checked

Stress Escape's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Passion Flower 19 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
  4. Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
  5. Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
  6. Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
  7. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
  8. Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91.
  9. Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. PubMed
  10. Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
  11. Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
  12. Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
  13. Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
  14. Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
  15. Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017;22(1):e95-e101. PubMed
  16. Ozturk Z, Kalayci CC. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement Ther Med. 2018 Feb;36:30-32. PubMed
  17. da Cunha RS, Amorim KS, Gercina AC, et al. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2020. PubMed
  18. Schäfer AM, Gilgen PM, Spirgi C, et al. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021. PubMed
  19. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Passion Flower monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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