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Dietary supplement

Super Charge! Xtreme 4.0 Orange Flavor Ingredients & Drug Interactions

by Labrada Nutrition

Super Charge! Xtreme 4.0 Orange Flavor label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Charge! Xtreme 4.0 Orange Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Super Charge! Xtreme 4.0 Orange Flavor is a dietary supplement by Labrada Nutrition with 4 active ingredients.Based on those ingredients, 789 medications have a known interaction with it, the most serious rated major. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super Charge! Xtreme 4.0 Orange Flavor by Labrada Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Charge! Xtreme 4.0 Orange Flavor by Labrada Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Super Charge! Xtreme 4.0 Orange Flavor by Labrada Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 11 of its 11 active ingredients.
  • “Super Charge(R) Performance Blend” is a proprietary blend — the label gives one combined amount (7.20 Gram(s)) without saying how much of each component you get.
  • “Energy/Hemo-Dilation Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Strength & Endurance Complex” is a proprietary blend — the label doesn't break down how much of each component you get.

Super Charge! Xtreme 4.0 is a powder with 11 active ingredients designed to support workout performance and recovery.

The main components are taurine (an amino acid and cellular regulator), L-tyrosine (an amino acid precursor to thyroid and brain chemicals), beta-alanine (for muscular endurance), L-arginine (for blood vessel function), creatine (for muscle energy), caffeine (a stimulant), and several amino acid blends and performance compounds including picamilon, nitrous malate, and other proprietary complexes. The product also contains inactive ingredients like maltodextrin, citric acid, silica, sucralose, and riboflavin.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Enhance strength, energy, endurance and mental focus.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle breakdown, Exercise-induced muscle soreness, Mental alertness, Muscle strength, Fatigue — and 4 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance, Muscle strength.

Evidence for this product's ingredients is mixed. Caffeine is likely effective for mental alertness and athletic performance.

Creatine and beta-alanine are possibly effective for athletic and physical performance. L-tyrosine is possibly effective for cognitive function and memory, and is effective for a rare genetic condition (phenylketonuria).

Taurine is possibly effective for congestive heart failure but possibly ineffective for weight loss. L-arginine, picamilon, and the blend components have either insufficient evidence or no established effectiveness ratings in our data for most of their proposed uses.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine is generally well tolerated in moderate amounts but high doses can cause anxiety, insomnia, tremors, and rarely, stroke. L-tyrosine is generally well tolerated but larger doses can cause headache and fatigue.

Taurine is generally well tolerated short-term at typical doses, though long-term safety is less certain; common side effects are constipation, diarrhea, and indigestion. Beta-alanine commonly causes harmless tingling and flushing of the skin (paresthesia), usually starting on the scalp within 20 minutes and lasting about an hour — intensity depends on dose.

Creatine is generally well tolerated but can cause dehydration, diarrhea, muscle cramps, and water retention; those with kidney problems should be careful. L-arginine can cause abdominal pain, bloating, nausea, diarrhea, headache, and insomnia.

Picamilon has limited human safety data. Regarding pregnancy and nursing: caffeine is possibly safe in pregnancy at limited doses but possibly unsafe at higher amounts — discuss safe limits with your doctor.

Beta-alanine and creatine should be avoided in pregnancy and while breastfeeding due to insufficient safety data. Picamilon should be avoided in pregnancy and while nursing.

Taurine is rated likely safe in pregnancy and lactation. L-tyrosine and L-arginine have insufficient data for pregnancy and lactation — talk to your doctor or pharmacist.

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 7 matched ingredients can interact with medications — L-arginine, Caffeine, Taurine, Tyrosine, Picamilon.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 789 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications if you take: ephedrine (Major risk with caffeine), blood pressure medications (taurine and L-arginine), blood thinners or antiplatelet drugs (L-arginine), diabetes drugs (L-arginine), levodopa for Parkinson's (L-tyrosine), thyroid hormones (L-tyrosine), barbiturates or other seizure medications (caffeine), quinolone antibiotics (caffeine), clozapine or other antipsychotics (caffeine), or cimetidine (caffeine). Also check if you take potassium-sparing diuretics, ACE inhibitors, ARBs, or sildenafil (all with L-arginine), or niacin (with picamilon).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is an intense pre- or post-workout formula, best suited for healthy adults engaged in serious training who don't take blood pressure, diabetes, or seizure medications, and who tolerate caffeine well. If you're on any prescription drug — especially for blood pressure, diabetes, heart rhythm, seizures, or mental health — check your medications against this product with the tool below before you start.

Pregnant or nursing? Talk to your pharmacist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Charge! Xtreme 4.0 Orange Flavor, straight from the product label.

Brand Labrada Nutrition
Barcode (UPC) 710779444621
Net contents 1.76 lbs; 800 Gram(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 41146
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Charge! Xtreme 4.0 Orange Flavor by Labrada Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
16 Gram(s)
Maximum serving Sizes:
32 Gram(s)
Servings per container
25
UPC/BARCODE
710779444621
IngredientAmount% DV
Calories32 {Calories}, 64 {Calories}--
Total Carbohydrates8 Gram(s), 16 Gram(s)3%, 6%
Sugar1 Gram(s), 1 Gram(s)--
Taurine1000 mg, 2000 mg--
L-Tyrosine250 mg, 500 mg--
CarnoSyn750 mg, 1500 mg--
Arginine Alpha-Ketoglutarate871 mg, 1742 mg--
N-Acetyl-L-Glutamine250 mg, 500 mg--
instantized BCAA1000 mg, 2000 mg--
Pikatropin25 mg, 50 mg--
Nitrous Malate1125 mg, 2250 mg--
Super Charge(R) Performance Blend7.2 Gram(s), 14.5 Gram(s)--
Energy/Hemo-Dilation Complex0 NP, 0 NP--
Methylxanthines225 mg, 450 mg--
Strength & Endurance Complex0 NP, 0 NP--
CreaLean1000 mg, 2000 mg--
Post-Workout Recovery Complex0 NP, 0 NP--
Pepform(R) BCAA250 mg, 500 mg--

Other ingredients: Power Carb(TM), Maltodextrin, Citric Acid, Natural & Artificial flavors, Silica, Sucralose, Riboflavin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Servings Per Container: 25 50

University Tested 110% Greater Power Increase in 8 Weeks. Feel the Power with the 1st Dose!

Get Xplosive Workouts! Enhance Strength, Energy, Endurance & Mental Focus MUSCLE SIZE, ENERGY & STRENGTH 110% MORE POWER** 82% MORE FOCUS*** 39% MORE REPS*** Enough for 50 WORKOUTS!

Recover Faster!

Workout longer!

Safe for High School and College Athletes.

Super Charge(R) is made in a steroid and prohormone free, FDA-inspected, pharmaceutical-grade manufacturing facility. This product is pure and unadulaterated, and will not cause a positive test result for banned substances.

UNIVERSITY TESTED>>>**8 week study conducted at the University of Kansas in 2010. 30 trained male subjects, were separated into two groups. Both groups were put on an effective weight training program and made significant gains.

The SCX! group experienced significantly GREATER gains. The SCX! group showed increases in squat power that were 110% greater than the control group. The SCX! group also experienced bench press max increases that were 70% greater than the control group.

***Clinical study conducted by Human Performance Specialists, Tempe, Arizona, in 2008. Study conducted on test subjects taking one dose of Super Charge!(R) before one workout, compared to control group. The SCX! group enjoyed an 82% increase in pre-workout mental energy and a 39% increase in bench press reps. ****Jour. ISSN, Feb 2009, Smith et al.

10 PERFORMANCE PRODUCTS IN ONE DAILY DOSE! Enhance Strength, Energy, Endurance & Mental Focus

PRE-WORKOUT PERFORMANCE ENHANCER DRINK MIX

Natural & Artificial

Learn How to Get the Best Results at www.labrada.com/superchargeresults

SCAN ME {QR Code}

Brand IP Statement(s)

Supercharge(R) provides you will all of the best performance-enhancing supplements, in one easy-to-use, concentrated daily dose! ~ Increases Strength and Power - Super Charge(R) has been shown in a University study to increase power by up to 110%** and exercise repetitions performed by up to 39%.***

What's NEW in Super Charge(R) Extreme 4.0:

~ PepForm(R) BCAA 2:1:1 are free form branched chain amino acids (BCAA) bound to BCAA peptides.

CreaLean(R) is pure, pharmaceutical-grade creatine monohydrate to help you build strength faster!

~ PowerCarb(R) is an engineered carbohydrate that supports nutrient transport and sustains energy.

However, one group used Super Charge!(R) Extreme (SCX!) prior to training, the other did not.

Power Carb(TM) contains licensed, patented Karbo-Lyn(R) technology. Karbo-Lyn(R) is a registered trademark of All American Pharmaceutical.

Copyright (C) 2013 LBN, Inc.

PepForm(R) is a trademark of Glandia, plc.

Licensed under one or more of U.S. Pat. Nos. 5,965,596, 6,426,361, 7,504,376 and 8,067,381, each of which is owned by Natural Alternatives International, Inc. (NAI). NAI is also the owner of the registered trademark CarnoSyn(R)

Formula

~ Increases Blood Flow to Muscles - Super Charge(R) contains powerful nitric acid (N.O.) boosters to dilate arteries and increase muscle pumps. ~ Increases Endurance - Super Charge(R) contains CarnoSyn(R) to increase muscle carnosine stores, resulting in up to a 29% increase in endurance performance.**** ~ Enhances mental focus during exercise - Super Charge(R) contains tyrosine and caffeine to improve mental focus up to 82%, for peak performance.*** ~ Delays Fatigue - Super Charge(R) contains Pikatropin(TM) to fight fatigue, so you can exercise longer. ~ Jump Starts Recovery - Super Charge(R) contains PepForm(R) branched chain amino acids and n-acetyl-l-glutamine to protect against muscle breakdown and improve post workout recovery.

with N.O. Boosters & BCAAs

Formulation

~ Super Charge(R) is Now Artificial Color FREE

STEROID FREE.

NO ARTIFICIAL COLORS

Seals/Symbols

NO BANNED SUBSTANCES CERTIFIED cGMP(TM) STEROID-FREE Current Good Manufacturing Practices

"Compare and Make the Smart Choice!" Unlike competing products, Super Charge!(R) ingredient amounts are not hidden in a "proprietary blend." When you buy Labrada, you know exactly what you are paying for - ingredients that work, in amounts that work. Labrada Nutrition is the smart choice! LEE LABRADA’S QUALITY GUARANTEE “If it’s on the label, it’s in the bottle!”(TM) This product is independent lab assayed for purity.

2:1:1 PepForm(R) 2:1:1 BCAA Peptides

CarnoSyn(R) Carnosine Synthesizer

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Use daily for best results. Mix 2 scoops (Super Intense Workout) or 1 scoop (Intense Workout) with 10-16 ounces of water and drink 30 minutes prior to exercise.

Precautions

To avoid sleeplessness, do not consume in the evening. Do not exceed 2 scoops per day.

WARNING: Not for use by individuals under the age of 18.

Consult a physician or licensed qualified health care professional before using this product if you have or have a family history of, heart disease, thyroid disease, diabetes, high blood pressure, recurrent headaches, depression or other psychiatric condition, glaucoma, difficulty in urinating, prostate enlargement, or seizure disorder, if you are using a monoamine oxidase inhibitor (MAOI) or any other dietary supplement, prescription drug or over-the-counter drug containing ephedrine, pseudoephedrine or phenylpropanolamine (ingredients found in certain allergy, cough/cold, and weight control products).

Exceeding recommended serving may cause serious adverse health effects including heart attack and stroke. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, headache, shortness of breath, or other similar symptoms. Individuals who consume caffeine with this product may experience serious adverse health effects. Improper use of product may be hazardous to a person's health.

KEEP OUT OF REACH OF CHILDREN

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Charge! Xtreme 4.0 Orange Flavor by Labrada Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Charge! Xtreme 4.0 Orange Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Charge! Xtreme 4.0 Orange Flavor by Labrada Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size16 Gram(s) Dosage formPowder Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Super Charge(R) Performance Blend

7.2 Gram(s) per serving
  • › Energy/Hemo-Dilation Complex
  • › Strength & Endurance Complex
  • › Post-Workout Recovery Complex

Other (inactive) ingredients: Power Carb(TM), Maltodextrin, Citric Acid, Natural & Artificial flavors, Silica, Sucralose, Riboflavin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Charge! Xtreme 4.0 Orange Flavor by Labrada Nutrition Drug Interactions

Want to check YOUR meds against Super Charge! Xtreme 4.0 Orange Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
789Drugs
8 Major 698 Moderate 83 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Super Charge! Xtreme 4.0 Orange Flavor interact with 789 drugs. Click any drug to see the details.

0 of the 4 ingredients in Super Charge! Xtreme 4.0 Orange Flavor interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Charge! Xtreme 4.0 Orange Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Super Charge! Xtreme 4.0 Orange Flavor, from the product label.

Labrada Nutrition

See all Labrada Nutrition products
Phone Number
1.800.832.9948
Web Address
www.labrada.com
Pharmacist Counseling Corner

Super Charge! Xtreme 4.0 Orange Flavor by Labrada Nutrition: Common Questions

Does Super Charge! Xtreme 4.0 Orange Flavor by Labrada Nutrition interact with any medications?
Yes. Based on its ingredients, Super Charge! Xtreme 4.0 Orange Flavor has a known interaction with 789 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Charge! Xtreme 4.0 Orange Flavor contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the tingling and flushing I might feel?
That's the beta-alanine, one of the active ingredients. It causes harmless skin tingling (paresthesia) and flushing that usually starts on your scalp 20 minutes after you take it and lasts about an hour. The intensity depends on dose — higher doses cause more noticeable tingling. It's not dangerous, just a sensation some people find uncomfortable.
Is this safe if I have kidney problems?
Creatine, one of the main ingredients, requires caution if you have kidney issues. Talk to your doctor or pharmacist before using this product if you have any kidney condition or are on medications that affect kidney function.
Can I take this while pregnant or breastfeeding?
This product contains ingredients with conflicting safety ratings. Beta-alanine and creatine should be avoided — there isn't enough safety data. Caffeine is possibly safe at limited doses but possibly unsafe at higher amounts. Taurine is rated likely safe. For L-tyrosine and L-arginine, there isn't enough data either way. Talk to your doctor or pharmacist about what's right for you.
Will this help me build muscle or improve my workout?
Creatine and beta-alanine are possibly effective for athletic and physical performance. Caffeine is likely effective for mental alertness and athletic performance. The other ingredients have either limited evidence or no clear established effectiveness for most of their claimed uses in our data.
What's in the 'blends' — are they just fillers?
The blends listed (Super Charge Performance Blend, Energy/Hemo-Dilation Complex, Strength & Endurance Complex, and Post-Workout Recovery Complex) contain active ingredients whose interactions and effects we can't check separately because they're not broken out individually on the label. We hold no interaction data for those proprietary blends.
How much caffeine is in this?
The product facts don't specify the caffeine dose, so check the label or contact the manufacturer. That matters because caffeine's side effects and interactions depend on how much you're taking.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super Charge! Xtreme 4.0 Orange Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Charge! Xtreme 4.0 Orange Flavor label
Sources

Sources & How We Checked

Super Charge! Xtreme 4.0 Orange Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 429 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Taurine 21 references
  1. Ahmad S, Robertson HT, Golper TA, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 1990;38:912-8. PubMed
  2. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  3. Obermann M, Schorn CF, Mummel P, et al. Taurine induced toxic encephalopathy? Clin Neurol Neurosurg 2006;108:812-3. PubMed
  4. Bichler, A., Swenson, A., and Harris, M. A. A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids 2006;31(4):471-476. PubMed
  5. Iyadurai, S. J. and Chung, S. S. New-onset seizures in adults: possible association with consumption of popular energy drinks. Epilepsy Behav 2007;10(3):504-508. PubMed
  6. Berger, A. J. and Alford, K. Cardiac arrest in a young man following excess consumption of caffeinated "energy drinks". Med J Aust. 1-5-2009;190(1):41-43. PubMed
  7. Worthley, M. I., Prabhu, A., De, Sciscio P., Schultz, C., Sanders, P., and Willoughby, S. R. Detrimental effects of energy drink consumption on platelet and endothelial function. Am J Med 2010;123(2):184-187. PubMed
  8. Morchon, Simon D. and Perez Castrillon, J. L. [Hypoglycemia by intake of taurine]. Rev.Clin Esp. 2010;210(1):49.
  9. Livshits, Z., Hoffman, R. S., Hymes, K. B., and Nelson, L. S. If vitamins could kill: massive hemolysis following naturopathic vitamin infusion. J Med Toxicol. 2011;7(3):224-226. PubMed
  10. Schoffl, I., Kothmann, J. F., Schoffl, V., Rupprecht, H. D., and Rupprecht, T. "Vodka energy": too much for the adolescent nephron? Pediatrics 2011;128(1):e227-e231. PubMed
  11. Calabro, R. S., Italiano, D., Gervasi, G., and Bramanti, P. Single tonic-clonic seizure after energy drink abuse. Epilepsy Behav 2012;23(3):384-385. PubMed
  12. Fujita, T., Ando, K., Noda, H., Ito, Y., and Sato, Y. Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 1987;75(3):525-532. PubMed
  13. Darling, P. B., Lepage, G., Leroy, C., Masson, P., and Roy, C. C. Effect of taurine supplements on fat absorption in cystic fibrosis. Pediatr Res 1985;19(6):578-582. PubMed
  14. Fukuyama, Y. and Ochiai, Y. Therapeutic trial by taurine for intractable childhood epilepsies. Brain Dev. 1982;4(1):63-69. PubMed
  15. Franconi, F., Bennardini, F., Mattana, A., Miceli, M., Ciuti, M., Mian, M., Gironi, A., Anichini, R., and Seghieri, G. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am.J. DOI
  16. Stohs SJ, Miller M. A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides. Food Chem Toxicol. 2014 Jan;63:240-3. PubMed
  17. Sun Q, Wang B, Li Y, Sun F, et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study. Hypertension 2016 Mar;67(3):541-9. PubMed
  18. Jang ES, Hwang SH, Kim JW, Jeong SH. Effectiveness of 4-week oral taurine treatment for muscle cramps in patients with liver cirrhosis: a single-arm pilot study. Yonsei Med J 2021;62(1):21-8. PubMed
  19. Guan L, Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials. Eur J Pharmacol 2020;885:173533. PubMed
  20. Higgins JP, Liras GN, Liras IN, et al. Energy Drink Effects on Hemodynamics and Endothelial Function in Young Adults. Cardiology. 2021;146(2):258-262. PubMed
  21. Pallangyo P, Bhalia SV, Komba M, et al. Acute Myocardial Infarction Following the Consumption of Energy Drink in a 28-Year-Old Male: A Case Report. J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231168811. PubMed

See these in context on the Taurine monograph →

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Beta-alanine 13 references
  1. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30:279-89.
  2. Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007;32:225-33.
  3. Bellinger PM, Minahan CL. The effect of ß-alanine supplementation on cycling time trials of different length. Eur J Sport Sci 2016;16(7):829-36.
  4. Chung W, Shaw G, Anderson ME, et al. Effect of 10 week beta-alanine supplementation on competition and training performance in elite swimmers. Nutrients 2012;4(10):1441-53. PubMed
  5. Glenn JM, Gray M, Stewart R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids 2015;47(12):2593-600. PubMed
  6. Gross M, Bieri K, Hoppeler H, Norman B, Vogt M. Beta-alanine supplementation improves jumping power and affects severe-intensity performance in professional alpine skiers. Int J Sport Nutr Exerc Metab 2014;24(6):665-73. PubMed
  7. Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab 2013;23(6):562-70. PubMed
  8. Sweeney KM, Wright GA, Glenn Brice A, Doberstein ST. The effect of beta-alanine supplementation on power performance during repeated sprint activity. J Strength Cond Res 2010;24(1):79-87.
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See these in context on the Caffeine monograph →

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See these in context on the Creatine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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