Major interaction on record — check this product against your medications before combining. Based on 6 of 9 ingredients. Check your meds →
Dietary supplement

Super-Digestive with Ox Bile & Activated Charcoal Ingredients & Drug Interactions

by Sunshine Naturals

Super-Digestive with Ox Bile & Activated Charcoal label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super-Digestive with Ox Bile & Activated Charcoal against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Super-Digestive with Ox Bile & Activated Charcoal is a dietary supplement by Sunshine Naturals with 9 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 2,042 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Activated Charcoal, Calcium, Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super-Digestive with Ox Bile & Activated Charcoal by Sunshine Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Super-Digestive with Ox Bile & Activated Charcoal by Sunshine Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Super-Digestive with Ox Bile & Activated Charcoal by Sunshine Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 9 of its 9 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 9 ingredients, of which several are digestive enzymes and bile compounds. Calcium supports bone health and other body functions.

Papain and pepsin are proteolytic enzymes (they break down proteins). Lipase breaks down fats.

Pancreatin is an enzyme blend. Ox bile and betaine HCl support stomach acid and fat digestion.

Activated charcoal is included for its traditional use in absorbing substances in the gut. The product also contains inactive ingredients—stearic acid, silicon dioxide, magnesium stearate, croscarmellose sodium, and pharmaceutical glaze—which are standard tablet binders and flow agents.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support digestion of carbohydrates proteins and fats.
  • We looked for evidence on: Dyspepsia, Flatulence, Diarrhea, Constipation, Indigestion, Bloating — and 2 related terms.
  • The strongest evidence on file: Calcium is rated "Effective" for Dyspepsia (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Activated Charcoal is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced diarrhea, Constipation, Dyspepsia, Flatulence.

Calcium in this product is effective for preventing low blood calcium (hypocalcemia), supporting bone health in osteoporosis (rated Likely Effective), managing high potassium levels (hyperkalemia), and addressing indigestion (dyspepsia) and kidney failure. Activated charcoal is rated Possibly Effective for poisoning.

The other active ingredients—papain, lipase, betaine HCl, pepsin, pancreatin, ox bile, and mycozyme—lack established evidence in our data. Papain has been studied for various uses including cancer, herpes zoster, and parasitic infection, but the evidence is insufficient to rate it.

Lipase and betaine HCl similarly show insufficient evidence for dyspepsia and other conditions.

The evidence, ingredient by ingredient Calcium Papain Lipase Betaine Hydrochloride Activated Charcoal Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended doses, though high amounts can cause problems—constipation, diarrhea, and stomach upset are common. There's some concern that very high intake (over 2,000 mg daily from all sources) may increase the risk of prostate cancer and possibly cardiovascular disease, though research is mixed.

Papain may irritate the digestive tract and cause allergic reactions in sensitive people; concentrated papain and unripe papaya are not safe in pregnancy. Activated charcoal causes constipation commonly and can lead to black stools, bloating, and flatulence.

Lipase, pepsin, and betaine HCl carry cautions: lipase and pepsin are not well studied in pregnancy or breastfeeding, and betaine HCl may irritate the stomach and isn't safe if you have ulcers or reflux. Pepsin occupational exposure can trigger respiratory allergies.

Side effects, ingredient by ingredient Calcium Papain Lipase Betaine Hydrochloride Activated Charcoal Proteolytic Enzymes (proteases)

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 6 matched ingredients can interact with medications — Papain, Activated Charcoal, Betaine Hydrochloride, Calcium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications; lithium.
  • For scale: 2,043 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use: HIV integrase inhibitors (dolutegravir, elvitegravir), the antibiotic ceftriaxone (especially intravenously), blood thinners (warfarin), thyroid medication (levothyroxine), heart medications (diltiazem, sotalol), or acid-reducing drugs (PPIs, H2-blockers, antacids). If you take oral contraceptives, activated charcoal may reduce their effectiveness.

The product's calcium content can interfere with absorption of several of these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is a digestive enzyme and bile blend with calcium—useful if you're looking for digestive support and calcium intake. However, the calcium and activated charcoal create significant interaction risks with HIV drugs, blood thinners, thyroid medication, heart drugs, acid-reducing medications, and oral contraceptives.

If you take any prescription medications, check them carefully with your doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super-Digestive with Ox Bile & Activated Charcoal, straight from the product label.

Brand Sunshine Naturals
Barcode (UPC) 789939101155
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 271239
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super-Digestive with Ox Bile & Activated Charcoal by Sunshine Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
50
UPC/BARCODE
789939101155
IngredientAmount% DV
Calcium40 mg--
Papain100 mcg--
Lipase30 mg--
Betaine HCl200 mg--
Activated Charcoal120 mg--
Pepsin200 mcg--
Pancreatin100 mg--
Ox Bile80 mg--
Mycozyme100 mg--

Other ingredients: Stearic Acid, Silicon Dioxide, Magnesium Stearate, Croscarmellose Sodium, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Adults take two tablets with or before meals as a dietary supplement.

Formula

Our formula which includes Digestive Enzymes, Ox Bile, and Activated Charcoal, is a natural help for digestion of carbohydrates, proteins, and fats.

A help for those suffering digestive discomfort, slow digestion, and intestinal flatulence.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Storage

Store in a cool dry place.

Formulation

Helps the digestion of carbohydrates, protein, and fats For better digestion

Proudly Made in the USA.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Proudly Made in the USA.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super-Digestive with Ox Bile & Activated Charcoal by Sunshine Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super-Digestive with Ox Bile & Activated Charcoal label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super-Digestive with Ox Bile & Activated Charcoal by Sunshine Naturals

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
40 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Papain

Interacts with
2 drugs
100 mcg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Lipase

No known
interactions
30 mg per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Betaine HCl

Interacts with
36 drugs
200 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine HCl monograph & interactions

Activated Charcoal

Interacts with
2,027 drugs
120 mg per serving

Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some poisonings...

Activated Charcoal monograph & interactions

Pepsin

No known
interactions
200 mcg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Pancreatin

100 mg per serving

Ox Bile

80 mg per serving

Mycozyme

100 mg per serving

Other (inactive) ingredients: Stearic Acid, Silicon Dioxide, Magnesium Stearate, Croscarmellose Sodium, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super-Digestive with Ox Bile & Activated Charcoal by Sunshine Naturals Drug Interactions

Want to check YOUR meds against Super-Digestive with Ox Bile & Activated Charcoal?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,042Drugs
2,023 Major 19 Moderate

Ingredients driving the most interactions

Activated Charcoal 2,027
Calcium 168
Betaine HCl 36
Papain 2

Individual Drug Interactions

The ingredients in Super-Digestive with Ox Bile & Activated Charcoal interact with 2,042 drugs. Click any drug to see the details.

4 of the 9 ingredients in Super-Digestive with Ox Bile & Activated Charcoal interact with drugs. Each result below shows which ingredient is responsible. Activated Charcoal Calcium Betaine HCl Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Super-Digestive with Ox Bile & Activated Charcoal with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Activated Charcoal3 drug types · 2,027 drugs

Oral Drugs

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Activated charcoal adsorbs various drugs and may reduce their absorption and/or half-life. Examples of affected drugs include acetaminophen, aminophylline, amiodarone, atenolol, carbamazepine, dapsone, digoxin, disopyramide, fluoxetine, indomethacin, moxifloxacin, nadolol, phenytoin, phenobarbital, piroxicam, quinine, sotalol, theophylline, tricyclic antidepressants, valproate, and verapamil. Avoid co-administration, except after drug overdose.

Likelihood Probable Evidence B
Alcohol (Ethanol)

The binding action of activated charcoal may be reduced by alcohol.
Alcohol may lower the adsorptive capacity of activated charcoal.

Likelihood Probable Evidence D
Contraceptive Drugs

Activated charcoal may reduce the clinical effects of oral contraceptives.
Activated charcoal, taken in a dose of 5 grams four times daily for 3 days, may bind to, and reduce the absorption of, oral contraceptives, thereby limiting their effectiveness and increasing the risk of contraceptive failure. However, some clinical research shows that the risk for this interaction is minimal when activated charcoal is taken either 3 hours after or at least 12 hours before oral contraceptives.

Likelihood Possible Evidence B
Activated Charcoal full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super-Digestive with Ox Bile & Activated Charcoal, from the product label.

Sunshine Naturals

See all Sunshine Naturals products
Name
American Naturavit Inc.
City
Miami
State
FL
ZipCode
33166
Phone Number
305-593-5417
Web Address
www.sunshinenaturals.com
Pharmacist Counseling Corner

Super-Digestive with Ox Bile & Activated Charcoal by Sunshine Naturals: Common Questions

Does Super-Digestive with Ox Bile & Activated Charcoal by Sunshine Naturals interact with any medications?
Yes. Based on its ingredients, Super-Digestive with Ox Bile & Activated Charcoal has a known interaction with 2,042 medications, including 2023 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super-Digestive with Ox Bile & Activated Charcoal contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product help with digestion?
The enzymes and bile compounds are meant to support digestion, but the evidence isn't well established for most ingredients. Calcium is rated effective for indigestion (dyspepsia), though this product is one part of a complex blend.
Can I take this if I'm pregnant?
The data is mixed. Calcium is likely safe in recommended amounts during pregnancy, but papain is possibly unsafe and concentrated papain should be avoided. Betaine HCl is best avoided, and there isn't enough safety information on the other ingredients. Talk with your doctor before starting it.
Can I take this while breastfeeding?
Calcium is generally safe in recommended amounts. However, there isn't enough safety data on pepsin, lipase, pancreatin, or betaine HCl during breastfeeding, and papain is best avoided. Check with your healthcare provider.
What side effects should I expect?
The most common are gastrointestinal: constipation, bloating, flatulence, black stools, and abdominal discomfort. Some people sensitive to papain may have allergic reactions like itchy eyes or sneezing. Serious side effects are rare.
Does this product interact with oral contraceptives?
Yes. The activated charcoal in this product may reduce how well birth control pills work by binding to them and reducing their absorption, which could increase your risk of unintended pregnancy. Discuss with your doctor or pharmacist.
Why can't this be taken with thyroid medication?
The calcium in this product binds to levothyroxine and blocks its absorption, which weakens how well your thyroid medication works. You'd need to take them at least 4 hours apart to avoid the problem.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super-Digestive with Ox Bile & Activated Charcoal is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super-Digestive with Ox Bile & Activated Charcoal label
Go deeper

The Full Monographs Behind Super-Digestive with Ox Bile & Activated Charcoal’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Activated Charcoal

Interacts with 2,027 drugs

Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some poisonings and overdoses. For everyday uses like g...

Read the full Activated Charcoal monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Super-Digestive with Ox Bile & Activated Charcoal's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 93 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
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Papain 11 references
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Lipase 1 reference
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Betaine Hydrochloride 2 references
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Activated Charcoal 14 references
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Proteolytic Enzymes (proteases) 3 references
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See these in context on the Proteolytic Enzymes (proteases) monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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