Super Strength Garlic 5000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Super Strength Garlic 5000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Super Strength Garlic 5000 mg is a dietary supplement by Simply Supplements with 1 active ingredient. Its ingredients are commonly taken for high blood pressure, high cholesterol, heart health.Based on those ingredients, 989 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Garlic extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Super Strength Garlic 5000 mg by Simply Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with Super Strength Garlic 5000 mg by Simply Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Super Strength Garlic 5000 mg by Simply Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: garlic extract at 5000 mg per capsule. The extract is standardized from whole garlic to give you a concentrated dose.
The inactive ingredients are microcrystalline cellulose (a binder), gelatin (capsule material), and magnesium stearate (a lubricant) — these help the capsule hold together and go down smoothly.
Does it work?
Moderate evidence
Garlic extract in this strength is possibly effective for a few conditions based on the evidence we hold: hypertension (high blood pressure), diabetes, periodontitis (gum disease), atherosclerosis (plaque buildup in arteries), and nonalcoholic fatty liver disease. That said, 'possibly effective' means the research is suggestive but not conclusive, so results can vary from person to person.
How safe is it?
Well-documented data
Taken by mouth, garlic is generally well tolerated, though a small number of people report stomach upset, nausea, bloating, or body odor — these are the most common side effects. Allergic reactions are uncommon but possible, especially with raw garlic; cooking seems to reduce the allergen load for sensitive individuals.
Serious side effects like increased bleeding are rare but have been reported, chiefly when garlic is combined with blood thinners. At food amounts, garlic is considered safe; the data on concentrated supplement doses like this one is less robust, so talk with your doctor before starting if you have any bleeding tendency or are pregnant or breastfeeding.
Meds to double-check
Moderate interaction found
Double-check this product if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), blood pressure medications, diabetes drugs, HIV protease inhibitors, tacrolimus (Prograf), or any medications processed through your liver's CYP3A4 or CYP2E1 pathways. Garlic can amplify or reduce their effects, so your dose or monitoring may need adjustment.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you're interested in garlic extract for blood pressure, blood sugar, or liver health, this product is generally well tolerated at typical doses. Anyone on blood thinners, blood pressure medication, diabetes pills, or HIV drugs must check with their pharmacist first — garlic can meaningfully change how these work.
A brief conversation with your doctor or pharmacist is worth it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 24, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Super Strength Garlic 5000 mg, straight from the product label.
| Brand | Simply Supplements |
|---|---|
| Barcode (UPC) | 5060370562688 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 24, 2017 |
| DSLD ID | 70644 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Super Strength Garlic 5000 mg by Simply Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Garlic extract | 50 mg | -- |
Other ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Helps to maintain healthy heart and circulation
Product information Allicin is the predominant chemical within garlic which is thought to hold the key to its beneficial properties and is believed may help to support the maintenance of normal heart function.
Each capsule contains:
Image is for illustration purposes only.
EasyGest capsules Easy to swallow Easy to absorb Easy to digest No product odour No bad taste
AutoDespatch Save 10% and get free P&P on all repeat orders by having your favourite supplements conveniently scheduled and delivered automatically with our unique AutoDespatch system. Same day despatch We will ensure your order is despatched on the day of receipt (when placed before 12.30pm) and that all orders placed after 12.30pm are despatched on the next working day. All sent 1st class!
PriceMatch guarantee! If you buy from us and then see the same product cheaper elsewhere we will refund the difference plus 10%!
Seals/Symbols
Quality Assured
Suggested/Recommended/Usage/Directions
Suggested daily intake Take one to two capsules daily as a food supplement or as directed by a healthcare professional.
Precautions
Important information If you are taking any prescription medication, you have a medical condition or you have specific concerns about the suitability of our products, always consult your GP or pharmacist prior to taking supplements.
Do not exceed stated dose.
Keep away from children at all times.
Do not use if seal is broken.
Pregnant or lactating women should consult a doctor before using this product.
Allergy Advice: Contains an ingredient derived from Beef.
Food supplement: This product should not be used as a substitute for a varied diet.
Storage
Store in a cool dry place.
General
E534
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Super Strength Garlic 5000 mg by Simply Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Super Strength Garlic 5000 mg by Simply Supplements
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Garlic extract
Interacts with989 drugs
Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usuall...
Garlic extract monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Super Strength Garlic 5000 mg by Simply Supplements Drug Interactions
HelloPharmacist Interaction Report
Super Strength Garlic 5000 mg by Simply Supplements contains garlic extract, which interacts with a number of medications.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs — garlic can increase bleeding risk. This includes warfarin (Coumadin), where there's a documented case of patients' blood-thinning levels becoming too strong when they added garlic supplement.
Read the full breakdown — every affected drug type, severity by severity
Garlic also affects blood pressure medications (antihypertensives) and diabetes drugs, potentially making them work stronger than expected — meaning your blood pressure or blood sugar could drop lower than intended. It may change how your liver and intestines process certain medications metabolized through CYP3A4 and CYP2E1 pathways, which includes HIV protease inhibitors and the immunosuppressant tacrolimus (Prograf).
Altogether, these interactions span 977 individual medications. If you take any prescription medication — especially blood thinners, blood pressure pills, diabetes drugs, or antiretroviral therapy — check your exact medications with the tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Super Strength Garlic 5000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Super Strength Garlic 5000 mg interact with 989 drugs. Click any drug to see the details.
1 of the 1 ingredient in Super Strength Garlic 5000 mg interact with drugs. Each result below shows which ingredient is responsible. Garlic extract
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Garlic Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Super Strength Garlic 5000 mg — through 1 ingredient. Tap an ingredient for the detail:
Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Super Strength Garlic 5000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Garlic extract
Anticoagulant/Antiplatelet Drugs
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time.
Antidiabetes Drugs
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research suggests that garlic and garlic extract lower blood glucose levels in healthy and diabetic individuals.
Antihypertensive Drugs
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
In human research, both garlic and garlic extracts have blood pressure-lowering effects.
Atazanavir (Reyataz)
Theoretically, garlic might decrease levels and effects of atazanavir.
In a case report, a patient consuming six stir-fried garlic cloves three times weekly developed suboptimal atazanavir levels and increases in HIV viral load. While the exact cause of this interaction is unclear, there is speculation that garlic might decrease the intestinal absorption of atazanavir or increase its metabolism by inducing cytochrome P450 3A4 (CYP3A4). Until more is known, advise patients not to consume large amounts of garlic while taking atazanavir.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Garlic might increase levels of drugs metabolized by CYP2E1.
Clinical research suggests garlic oil can inhibit the activity of CYP2E1 by 39%. Use garlic oil cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Some human research suggests that garlic may induce INTESTINAL CYP3A4, reducing levels of drugs metabolized by this enzyme. This is primarily based on a study showing that taking a specific allicin-containing garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induced CYP3A4 in the gut mucosa. Another study shows that giving docetaxel intravenously, bypassing the CYP3A4 enzymes in the gut mucosa, along with the same specific garlic product for 12 consecutive days, does not affect docetaxel levels. Conversely, there is concern that garlic may inhibit HEPATIC CYP3A4. In a single case report, increased tacrolimus levels and liver injury occurred in a liver transplant patient after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. Several other studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Isoniazid
Theoretically, garlic might decrease levels of isoniazid.
Animal research suggests that an aqueous extract of garlic reduces isoniazid levels by about 65%. Garlic reduced the maximum concentration (Cmax) and area under the curve (AUC), but not the half-life, of isoniazid. This suggests that garlic extract might inhibit isoniazid absorption across the intestinal mucosa; however, the exact mechanism of this potential interaction is not known.
Protease Inhibitors (Pis)
Theoretically, garlic products containing allicin might decrease levels of PIs.
Protease inhibitors are metabolized by cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4, reducing plasma levels of protease inhibitors. This is primarily based on a study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces levels of saquinavir, a PI, by approximately 50%. It is speculated that the allicin constituent induce CYP3A4 in the gut mucosa. Several studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Saquinavir (Fortovase, Invirase)
Theoretically, garlic containing allicin might decrease levels of saquinavir.
Saquinavir is a substrate of cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4 and cause subtherapeutic levels of saquinavir. This is primarily based on a pharmacokinetic study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induces CYP3A4 in the gut mucosa. Several pharmacokinetic studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin. Until more is known about this potential interaction, use garlic containing allicin cautiously in patients taking saquinavir.
Sofosbuvir (Sovaldi)
Theoretically, taking garlic with sofosbuvir might decrease its effectiveness.
Animal research in rats shows that giving aged garlic extract 120 mg/kg orally daily for 14 days decreases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 36%, increases the clearance by 63%, and decreases the plasma concentrations at 1 and 8 hours by 35% and 58%, respectively. This interaction is hypothesized to be due to induction of intestinal P-glycoprotein expression by garlic.
Tacrolimus (Prograf)
Theoretically, garlic might increase levels of tacrolimus.
In one case report, a liver transplant patient taking tacrolimus experienced increased tacrolimus levels and liver injury after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. It is speculated that garlic inhibited hepatic cytochrome P450 3A4 (CYP3A4), which increased plasma levels of tacrolimus.
Warfarin (Coumadin)
Theoretically, garlic might increase the risk of bleeding with warfarin.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time. In addition, there is a report of two patients who experienced an increase in a previously stabilized international normalized ratio (INR) with concomitant garlic and warfarin use. However, this report has been subsequently debated due to limited clinical information. Other clinical studies have not identified an effect of garlic on INR, warfarin pharmacokinetics, or bleeding risk. More evidence is needed to determine the safety of using garlic with warfarin.
Brand information
Manufacturer and brand details for Super Strength Garlic 5000 mg, from the product label.
Simply Supplements
See all Simply Supplements products- Name
- Simply Supplements
- Street Address
- PO Box 204
- City
- Guernsey
- ZipCode
- GY1 5SS
- Phone Number
- 0800 988 0292
- Web Address
- www.simplysupplements.co.uk
Super Strength Garlic 5000 mg by Simply Supplements: Common Questions
Does Super Strength Garlic 5000 mg by Simply Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will garlic extract lower my blood pressure if I'm already on blood pressure medication?
Can I take this if I'm on warfarin or aspirin?
What are the most common side effects?
Does this actually work for high blood pressure or diabetes?
Is this safe to take while pregnant or breastfeeding?
What's the difference between garlic supplement and eating raw garlic in food?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Super Strength Garlic 5000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Super Strength Garlic 5000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 154 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Garlic 154 references
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