High Strength Red Clover 1000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking High Strength Red Clover 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
High Strength Red Clover 1000 mg is a dietary supplement by Simply Supplements with 1 active ingredient. Its ingredients are commonly taken for menopause symptoms (hot flashes), high cholesterol, bone health/osteoporosis.Based on those ingredients, 867 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Red Clover extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against High Strength Red Clover 1000 mg by Simply Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with High Strength Red Clover 1000 mg by Simply Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of High Strength Red Clover 1000 mg by Simply Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: red clover extract at 1000 mg per dose. Red clover is a plant that supplies isoflavones — compounds with mild estrogen-like activity in your body.
The extract also contains inactive ingredients (microcrystalline cellulose, dicalcium phosphate, magnesium stearate, and silica) that help form and stabilize the tablet.
Does it work?
Not established
The evidence we hold doesn't establish that red clover works for any of its proposed uses. For menopausal symptoms, osteoporosis, osteoarthritis, and male-pattern hair loss, the data shows insufficient reliable evidence to rate it.
If you're considering red clover for one of these reasons, that's worth discussing with your doctor or pharmacist — they can tell you what the broader research suggests and whether it fits your situation.
How safe is it?
Well-documented data
Red clover is generally well tolerated in the short term for healthy adults, but its estrogen-like effects mean some people need to be cautious. The most common side effects reported are muscle pain, nausea, and vaginal spotting.
There's also a concern from lab studies that red clover's isoflavones might slightly increase breast density in premenopausal people, though the real-world meaning of this isn't clear. During pregnancy, red clover is rated possibly unsafe because of its estrogen-like activity and lack of safety data — the safety data advises against it.
While breastfeeding, there isn't enough information to know if it's safe, so it's best avoided. Anyone concerned about breast tissue changes or who has a history of estrogen-sensitive cancers should talk with their doctor before taking it.
Meds to double-check
Moderate interaction found
Before taking this red clover product, double-check with your pharmacist or doctor if you take estrogens (including birth control or hormone replacement), methotrexate, or tamoxifen — these carry Moderate-severity interaction concerns. You should also confirm any blood thinners or antiplatelet drugs (like warfarin or aspirin), as well as any medications your liver metabolizes through CYP1A2, CYP2C19, CYP2C9, or CYP3A4 enzymes, though the clinical significance of those interactions is less clear.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Red clover may be worth considering for some people, but the evidence for its effectiveness isn't established in our data. More importantly, it interacts with a large number of medications — especially hormonal therapies, methotrexate, tamoxifen, and drugs your liver processes through certain pathways.
If you take any prescription medications, check them against the interaction tool here or talk with your pharmacist before you start. It's not safe in pregnancy and best avoided while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 24, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about High Strength Red Clover 1000 mg, straight from the product label.
| Brand | Simply Supplements |
|---|---|
| Barcode (UPC) | 5060370562626 |
| Net contents | 120 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Feb 24, 2017 |
| DSLD ID | 70496 |
| Product type | Botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for High Strength Red Clover 1000 mg by Simply Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Red Clover extract | 83.5 mg | -- |
Other ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
A rich source of isoflavones
Product information A perennial herb that grows wild throughout Europe and Asia, Red Clover contains the isoflavones daidzein and genistein.
Seals/Symbols
Quality Assured
V Vegetarian
Suggested/Recommended/Usage/Directions
Suggested daily intake Take two tablets daily as a food supplement or as directed by a healthcare professional.
Precautions
Important information If you are taking any prescription medication, you have a medical condition or you have specific concerns about the suitability of any of our products in relation to these, you should always consult your GP or Pharmacist prior to taking supplements. Pregnant or lactating women should consult a GP before taking supplements.
Do not exceed the recommended daily dosage.
Keep out of reach of children.
Supplements should not be taken as a substitute for a varied diet. Always read the label before use.
General Statements
Image is for illustration purposes only.
AutoDespatch Save 10% and get free P&P on all repeat orders by having your favourite supplements conveniently scheduled and delivered automatically with our unique AutoDespatch system. Same Day Despatch We will ensure your order is despatched on the day of receipt (when placed before 12.30pm) and that all orders placed after 12.30pm are despatched on the next working day. All sent 1st class!
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Isoflavones are phyto-estrogens naturally found in plants. During the menopause natural levels of oestrogen are low.
Each tablet contains:
Formulation
Suitable for vegetarians.
General
E474
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
High Strength Red Clover 1000 mg by Simply Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in High Strength Red Clover 1000 mg by Simply Supplements
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Red Clover extract
Interacts with867 drugs
Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms like hot f...
Red Clover extract monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
High Strength Red Clover 1000 mg by Simply Supplements Drug Interactions
HelloPharmacist Interaction Report
Simply Supplements High Strength Red Clover 1000 mg interacts with several medication types through its red clover extract content.
The most serious concerns are with estrogens, methotrexate, and tamoxifen — all rated Moderate severity. Red clover contains phytoestrogens (plant compounds with estrogen-like activity) that might interfere with estrogen therapy or compete for how your body uses these hormones.
There's also a case report of someone taking red clover alongside methotrexate who developed severe nausea, vomiting, and stomach pain — symptoms of methotrexate toxicity. With tamoxifen, lab evidence suggests red clover's genistein content might work against the drug's cancer-fighting effects, though animal studies are mixed.
Read the full breakdown — every affected drug type, severity by severity
Minor interactions are documented with several drug-metabolizing enzyme systems (CYP1A2, CYP2C19, CYP2C9, and CYP3A4 substrates) — these are drugs your liver processes in specific ways, and red clover might theoretically raise their blood levels. However, small clinical studies haven't confirmed this effect in real people.
Red clover also has theoretical anticoagulant and antiplatelet activity based on lab work, but clinical evidence doesn't bear this out.
Altogether, these interactions span 868 individual medications. You'll want to check your exact prescriptions with the search tool on this page before starting red clover, especially if you take hormonal therapy, methotrexate, tamoxifen, or any blood thinners or antiplatelet drugs.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against High Strength Red Clover 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in High Strength Red Clover 1000 mg interact with 867 drugs. Click any drug to see the details.
1 of the 1 ingredient in High Strength Red Clover 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Red Clover extract
Bazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Red Clover Extract + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Red Clover Extract + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Conjugated Estrogens, Methyltestosterone interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Red Clover Extract + Cyproterone Acetate, Ethinyl Estradiol interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Red Clover Extract + Desogestrel, Ethinyl Estradiol interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Red Clover Extract + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Red Clover Extract + Drospirenone, Ethinyl Estradiol interactionEsterified EstrogensEstratab, Menest
How Esterified Estrogens interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Esterified Estrogens interactionEsterified Estrogens, MethyltestosteroneEstratest
How Esterified Estrogens, Methyltestosterone interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Red Clover Extract + Esterified Estrogens, Methyltestosterone interactionEstradiolDivigel, Elestrin, Estrace, Estraderm, Estring, Evamist +6 more
How Estradiol interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Estradiol interactionEstradiol, MedroxyprogesteroneDivitren
How Estradiol, Medroxyprogesterone interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Red Clover Extract + Estradiol, Medroxyprogesterone interactionEstradiol, Norethindrone AcetateActivella
How Estradiol, Norethindrone Acetate interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Red Clover Extract + Estradiol, Norethindrone Acetate interactionEstradiol, NorgestimateOrtho-Prefest
How Estradiol, Norgestimate interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Estradiol, Norgestimate interactionEstradiol, ProgesteroneBijuvanda
How Estradiol, Progesterone interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Red Clover Extract + Estradiol, Progesterone interactionEstrogenEstrogen
How Estrogen interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Estrogen interactionEstroneOrtho-Est
How Estrone interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Estrone interactionEstropipateOgen, Ortho EST
How Estropipate interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Estropipate interactionEthiny Estradiol, LevonorgestrelLogynon, Microgynon 30 ED
How Ethiny Estradiol, Levonorgestrel interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Red Clover Extract + Ethiny Estradiol, Levonorgestrel interactionEthinyl EstradiolEstinyl
How Ethinyl Estradiol interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Red Clover Extract + Ethinyl Estradiol interactionEthinyl Estradiol, DesogestrelApri, Cesia, Cyclessa, Gedarel, Kariva, Linessa +4 more
How Ethinyl Estradiol, Desogestrel interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Estrogens +2 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP2C9; however, a small clinical study found no effect.
Read the full Red Clover Extract + Ethinyl Estradiol, Desogestrel interactionEthinyl Estradiol, DrospirenoneYaz
How Ethinyl Estradiol, Drospirenone interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Red Clover Extract + Ethinyl Estradiol, Drospirenone interactionEthinyl Estradiol, Ethynodiol DiacetateDemulen 1/35, Demulen 1/50, Demulen Compack, Kelnor 1/35, Zovia, Zovia 1/35 +1 more
How Ethinyl Estradiol, Ethynodiol Diacetate interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Ethinyl Estradiol, Ethynodiol Diacetate interactionEthinyl Estradiol, LevonorgestrelAlesse, Alesse 21, Alesse 28, Aviane, Enpresse, Jolessa +18 more
How Ethinyl Estradiol, Levonorgestrel interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Red Clover Extract + Ethinyl Estradiol, Levonorgestrel interactionEthinyl Estradiol, NorethindroneAranelle, Brevicon, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Brevicon 1/35 21 day, Brevicon 1/35 28 day +50 more
How Ethinyl Estradiol, Norethindrone interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Ethinyl Estradiol, Norethindrone interactionEthinyl Estradiol, Norethindrone, Ferrous FumarateEstrostep Fe, Femcon FE, Junel Fe 1.5/30, Loestrin Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20 +3 more
How Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Red Clover Extract + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionEthinyl Estradiol, NorgestimateCilest, Mononessa, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho Tri-Cylcen, Ortho-Cyclen +5 more
How Ethinyl Estradiol, Norgestimate interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Ethinyl Estradiol, Norgestimate interactionEthinyl Estradiol, NorgestrelCryselle, Lo/Ovral, Low-Ogestrel, Ogestrel 0.5/50, Ovral
How Ethinyl Estradiol, Norgestrel interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Red Clover Extract + Ethinyl Estradiol, Norgestrel interactionEthinyl Estradiol, LevonogestrelLybrel
How Ethinyl Estradiol, Levonogestrel interacts with High Strength Red Clover 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Red Clover ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Red Clover Extract + Ethinyl Estradiol, Levonogestrel interactionEach ingredient & the kinds of drugs it affects
For each ingredient in High Strength Red Clover 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Red Clover extract
Estrogens
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Red clover contains phytoestrogens which might have estrogenic activity in some people. Theoretically, red clover might compete for estrogen receptors and interfere with estrogen-containing drug therapy.
Methotrexate (Trexall, Others)
Theoretically, red clover might increase the risk of methotrexate toxicity.
In a case report, a 52-year-old female receiving weekly methotrexate injections for psoriasis developed symptoms of methotrexate toxicity, including severe vomiting and epigastric pain, after three days of taking red clover 430 mg daily. Toxicity resolved after red clover was discontinued. However, no liver function tests or methotrexate levels were reported.
Tamoxifen (Nolvadex)
Theoretically, the phytoestrogens in red clover might interfere with tamoxifen.
In vitro and animal research suggests that genistein, a constituent of red clover, might antagonize the antitumor effects of tamoxifen. However, there is some evidence from an animal study that red clover does not reduce the efficacy of tamoxifen. Until more is known, tell patients taking tamoxifen to avoid red clover.
Anticoagulant/Antiplatelet Drugs
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
In vitro research suggests that genistein in red clover has antiplatelet effects, and historically, red clover was thought to have anticoagulant effects due to its coumarin content. However, some experts state that this is unlikely as most natural coumarins have not been shown to have anticoagulant effects, and their content in red clover is low. Additionally, some clinical research in postmenopausal patients found no effect on coagulation or prothrombin time with the use of red clover flowering tops 378 mg daily for 12 months or red clover isoflavone (Rimostil) 50 mg daily for 2 years.
Caffeine
Theoretically, soy might reduce the clearance of caffeine; however, a small clinical study found no effect.
Red clover contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. However, this effect does not seem to occur with the lower amounts of genistein found in red clover. A clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
In vitro evidence shows that red clover inhibits CYP1A2. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine, a CYP1A2 probe substrate.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, red clover might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that red clover weakly inhibits CYP2C19. This interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, red clover might increase levels of drugs metabolized by CYP2C9; however, a small clinical study found no effect.
In vitro evidence suggests that red clover might inhibit CYP2C9. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of tolbutamide, a CYP2C9 probe substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
In vitro evidence shows that red clover might inhibit CYP3A4 isoenzymes. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of alprazolam, a CYP3A4 probe substrate.
Brand information
Manufacturer and brand details for High Strength Red Clover 1000 mg, from the product label.
Simply Supplements
See all Simply Supplements products- Name
- Simply Supplements
- Street Address
- PO Box 1330
- City
- Peterborough
- ZipCode
- PE2 2PW
- Phone Number
- 0800 988 0292
High Strength Red Clover 1000 mg by Simply Supplements: Common Questions
Does High Strength Red Clover 1000 mg by Simply Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take red clover if I'm on birth control or hormone replacement therapy?
What are the most common side effects?
Is red clover safe to take while pregnant or breastfeeding?
Does red clover actually help with hot flashes or other menopausal symptoms?
Should I worry about it raising my risk of breast cancer?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind High Strength Red Clover 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
High Strength Red Clover 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 24 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Red Clover 24 references
- Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. PubMed
- Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
- Ingram DM, Hickling C, West L, et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 2002;11:170-4. PubMed
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
- Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
- Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156-66. PubMed
- Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
- Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr 2004;58(1):173-179. PubMed
- Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. PubMed
- Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 2002;455(1):53-57. PubMed
- Polini N, Rauschemberger MB, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 2007;267(1-2):55-62. PubMed
- Wuttke W, Jarry H, Seidlova-Wuttke D. Plant-derived alternative treatments for the aging male: facts and myths. Aging Male 2010;13(2):75-81. PubMed
- Villaseca P. Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Climacteric 2012;15(2):115-124. PubMed
- Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed
- Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
- Hooper, L., Madhavan, G., Tice, J. A., Leinster, S. J., and Cassidy, A. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Hum.Reprod.Update. 2010;16(6):745-7 PubMed
- Orr A and Parker R. Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. Menopause Int. 2013;19(3):133-134. PubMed
- Clifton-Bligh PB, et al. Red cover isoflavones enriched with formononetin lower serum LDL cholesterol- a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2015;69(1):134-142.
- Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). 2015. DOI
- Ferraris C, Ballestra B, Listorti C, et al. Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. Breast Cancer Res Treat 2020;180(1):157-65. doi: 10.1007/s1054 PubMed
- Chen L, Choi J, Leonard SW, et al. No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women. J Agric Food Chem. 2020;68(47):13929-13939. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC