Interactions on record — worth a quick check against your medications. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Superior Antioxidant Ingredients & Drug Interactions

by dotFIT

Superior Antioxidant label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Superior Antioxidant against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Superior Antioxidant is a dietary supplement by dotFIT with 7 active ingredients. Its ingredients are commonly taken for heart health, prostate health, antioxidant support.Based on those ingredients, 430 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Alpha Lipoic Acid, Coenzyme Q10, Lycopene. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Superior Antioxidant by dotFIT

Ask about any prescription or over-the-counter medication and we check it for interactions with Superior Antioxidant by dotFIT — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Superior Antioxidant by dotFIT

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Superior Antioxidant contains 7 active ingredients, most of them plant-derived antioxidants. Lycopene (from tomatoes) and the mixed carotenoids from Dunaliella salina give the formula its red and yellow pigments and free-radical-fighting power.

Lutein and zeaxanthin are carotenoids that concentrate in the eye. Alpha-lipoic acid is a compound your cells naturally produce to help turn food into energy and fight oxidative stress.

Coenzyme Q10 (CoQ10) is another naturally occurring antioxidant that your mitochondria use for energy production. The formula also includes OpriBerry, an ingredient we have no interaction data for.

The softgel capsule also contains inactive ingredients: soybean oil, gelatin, glycerin, beeswax, lecithin, caramel color, titanium dioxide, and silicon dioxide.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“antioxidant support for healthy aging”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Coenzyme Q10 deficiency — rated "Likely Effective" (Coenzyme Q10) (Natural Medicines).
  • On file: Age-related macular degeneration (AMD) — rated "Possibly Effective" (Lutein) (Natural Medicines).
  • On file: Cataracts — rated "Possibly Effective" (Lutein) (Natural Medicines).
  • On file: Migraine headache — rated "Possibly Effective" (Coenzyme Q10) (Natural Medicines).
  • On file: Congestive heart failure (CHF) — rated "Possibly Effective" (Coenzyme Q10) (Natural Medicines).

The evidence for this product's ingredients is mixed. Lycopene is possibly effective for prostate cancer but possibly ineffective for bladder cancer and diabetes.

Alpha-lipoic acid is possibly effective for diabetic nerve damage, high cholesterol, and obesity. Lutein and zeaxanthin are both possibly effective for age-related macular degeneration and cataracts — the eye conditions they're most commonly used for.

Coenzyme Q10 is likely effective for CoQ10 deficiency itself and possibly effective for heart failure, migraines, diabetic nerve damage, and fibromyalgia. For most other conditions these ingredients are used for, the evidence is insufficient or shows they're possibly ineffective.

The evidence, ingredient by ingredient Lycopene Alpha-lipoic Acid Lutein Coenzyme Q10 Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at typical supplement doses. Lycopene supplements can cause gastrointestinal side effects like diarrhea, nausea, and indigestion.

Alpha-lipoic acid may cause headache, nausea, dizziness, and rash — and because it can lower blood sugar, it's best used under medical guidance. CoQ10 most commonly causes mild gastrointestinal upset in less than 1% of users.

Lutein and zeaxanthin have minimal reported side effects at normal doses. Regarding pregnancy and breastfeeding: lycopene, lutein, zeaxanthin, and CoQ10 are all rated Likely Safe, though supplement doses of lutein and zeaxanthin haven't been well studied.

Alpha-lipoic acid, however, should be avoided in pregnancy and while breastfeeding due to insufficient safety data — talk with your doctor or pharmacist if you're pregnant or nursing and considering this product.

Side effects, ingredient by ingredient Lycopene Alpha-lipoic Acid Lutein Coenzyme Q10 Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Lycopene, Alpha-lipoic Acid, Coenzyme Q10, Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 430 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners (warfarin, aspirin, clopidogrel) or antiplatelet drugs — lycopene and alpha-lipoic acid may increase bleeding risk. If you're on thyroid hormone medication, diabetes medication, or any chemotherapy (especially alkylating agents or antitumor antibiotics), you need to discuss this product first, as alpha-lipoic acid and coenzyme Q10 may interfere with how they work.

Blood pressure medications may also need review with your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This antioxidant formula may appeal to you if you're interested in eye health, cardiovascular support, or general antioxidant protection. However, it's not for everyone — especially if you take blood thinners, thyroid medication, diabetes drugs, or chemotherapy.

If you're pregnant, breastfeeding, or taking any prescription medications, check with your own doctor or pharmacist before starting. The ingredients are mostly well tolerated, but the interaction profile is substantial enough to warrant a conversation with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Superior Antioxidant, straight from the product label.

Brand dotFIT
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Oct 25, 2012
DSLD ID 12982
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Superior Antioxidant by dotFIT, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
IngredientAmount% DV
Lycopene10 mg--
Alpha Lipoic Acid200 mg--
Lutein6 mg--
Coenzyme Q10100 mg--
Zeaxanthin4 mg--
OpriBerry(R)30 mg--
D. Salina natural mixed carotenoids1.5 mg--

Other ingredients: Soybean Oil, Gelatin, Glycerin, Bee's Wax, Lecithin, Caramel color, Titanium Dioxide, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Triggers your body's natural ability to protect cells against free radicals.

New softgels for improved absorptin of C0Q-10, mixed carotenoids, lutein & zeaxanthin.

SUPPORTS HEALTHY AGING

OPTIMIZES CELLULAR HEALTH

Warm Weather Advisory: Products Containing Chocolate & Softgels We do our best to ensure that you receive your items in good condition. However, we can't control the hot weather! Here are handling tips for products and food items during the summer months: - Do not store items in your car. - Store food, chocolate, or softgels products in a cool place or take them with you. - Place items in a cooled environment for at least 2 hours before opening. - Choose expedited shipping to your daytime location.

Intense exercisers, in particular, to reduce the increased free radical production and damage associate with intense and prolonged training bouts.

health

For more complete product information : watch video / read product brief

Brand IP Statement(s)

All rights reserved.

The dotFIT Superior Antioxidant(TM) is for everyone, exercisers and non-exercisers, interested in reducing the ravages of free radical damage, achieving optimal health and functioning, and reducing the risk of chronic disease such as cancers and heart disease.

OpriBerry(R) is a registered trademark of InterHealth N.I. OpriBerry(R) brand anthocyanin extract (patent pending).

Seals/Symbols

df(R)

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 softgel daily with a main meal.

Formulation

Contains No Dairy, Fish, Crustacean Shellfish, Tree Nuts, Peanuts or Gluten. No Sugar, Salt, Starch, Yeast, Artificial flavors, Coloring or Preservatives added.

Formula

WITH LYCOPENE & CO-Q10

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Superior Antioxidant by dotFIT label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Superior Antioxidant label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Superior Antioxidant by dotFIT

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lycopene

Interacts with
122 drugs
10 mg per serving

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

Alpha Lipoic Acid

Interacts with
263 drugs
200 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha Lipoic Acid monograph & interactions

Lutein

No known
interactions
6 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Coenzyme Q10

Interacts with
198 drugs
100 mg per serving

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q10 monograph & interactions

Zeaxanthin

Interacts with
86 drugs
4 mg per serving Form: Marigold

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

OpriBerry(R)

30 mg per serving Form: cranberry, Elderberry, Raspberry, Strawberry, wild Bilberry, Wild Blueberry

D. Salina natural mixed carotenoids

1.5 mg per serving

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Bee's Wax, Lecithin, Caramel color, Titanium Dioxide, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Superior Antioxidant by dotFIT Drug Interactions

Want to check YOUR meds against Superior Antioxidant?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
430Drugs
263 Moderate 167 Minor

Ingredients driving the most interactions

Alpha Lipoic Acid 263
Coenzyme Q10 198
Lycopene 122
Zeaxanthin 86

Individual Drug Interactions

The ingredients in Superior Antioxidant interact with 430 drugs. Click any drug to see the details.

4 of the 7 ingredients in Superior Antioxidant interact with drugs. Each result below shows which ingredient is responsible. Alpha Lipoic Acid Coenzyme Q10 Lycopene Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Superior Antioxidant with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha Lipoic Acid full monograph & interactions

Coenzyme Q103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Coenzyme Q10 full monograph & interactions

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Superior Antioxidant, from the product label.

dotFIT

See all dotFIT products
Name
dotFIT, LLC
Pharmacist Counseling Corner

Superior Antioxidant by dotFIT: Common Questions

Does Superior Antioxidant by dotFIT interact with any medications?
Yes. Based on its ingredients, Superior Antioxidant has a known interaction with 430 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Superior Antioxidant contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my eyesight?
Lutein and zeaxanthin are possibly effective for age-related macular degeneration and cataracts — they're the main eye-support ingredients here. The evidence is promising for those two conditions specifically, though it's not a guarantee. For other eye problems, the data is less clear.
Can I take this while I'm pregnant?
Lycopene, lutein, and zeaxanthin are rated Likely Safe in pregnancy. However, alpha-lipoic acid should be avoided — there isn't enough safety data. Since this product contains alpha-lipoic acid, talk with your doctor or pharmacist for personalized advice before starting.
Is this safe if I'm breastfeeding?
Lycopene, lutein, and zeaxanthin are rated Likely Safe while breastfeeding. Coenzyme Q10 and alpha-lipoic acid haven't been well studied in that setting, though. Since this is a multi-ingredient formula, check with your doctor or pharmacist about whether it's right for you.
What side effects might I see?
Most people tolerate this well. Lycopene and CoQ10 can cause mild stomach upset — diarrhea, nausea, or heartburn — in some people. Alpha-lipoic acid may cause headache, nausea, or dizziness. Rash is rare but has been reported. If side effects don't settle in a few days, stop and talk to your pharmacist.
Does this really work for antioxidant protection?
The ingredients here are well-studied antioxidants, and several have solid evidence for specific uses — lycopene for prostate health, alpha-lipoic acid for nerve damage and cholesterol, and lutein and zeaxanthin for eye health. For general 'antioxidant protection,' the science is less clear-cut.
Can I take this with my blood pressure medication?
Coenzyme Q10 in this product has a minor interaction with blood pressure drugs — it may add to their effect and theoretically lower your blood pressure further. Talk with your doctor or pharmacist to see if you need blood pressure monitoring or a dose adjustment.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Superior Antioxidant label
Go deeper

The Full Monographs Behind Superior Antioxidant’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Superior Antioxidant's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 104 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lycopene 10 references
  1. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
  2. Hsiao, G., Wang, Y., Tzu, N. H., Fong, T. H., Shen, M. Y., Lin, K. H., Chou, D. S., and Sheu, J. R. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med 2005;146(4):216-226. PubMed
  3. Clark, P. E., Hall, M. C., Borden, L. S., Jr., Miller, A. A., Hu, J. J., Lee, W. R., Stindt, D., D'Agostino, R., Jr., Lovato, J., Harmon, M., and Torti, F. M. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse o
  4. O'Kennedy, N., Crosbie, L., Whelan, S., Luther, V., Horgan, G., Broom, J. I., Webb, D. J., and Duttaroy, A. K. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am.J.Clin.Nutr. 2006;84(3):561-569. PubMed
  5. Jatoi, A., Burch, P., Hillman, D., Vanyo, J. M., Dakhil, S., Nikcevich, D., Rowland, K., Morton, R., Flynn, P. J., Young, C., and Tan, W. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II stu
  6. Schwenke, C., Ubrig, B., Thurmann, P., Eggersmann, C., and Roth, S. Lycopene for advanced hormone refractory prostate cancer: a prospective, open phase II pilot study. J.Urol. 2009;181(3):1098-1103. PubMed
  7. Banerjee, S., Jeyaseelan, S., and Guleria, R. Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J.Obstet.Gynaecol.Res. 2009;35(3):477-482. PubMed
  8. Haseen, F., Cantwell, M. M., O'Sullivan, J. M., and Murray, L. J. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic.Dis. 2009;12(4):325-332. PubMed
  9. Ilic, D., Forbes, K. M., and Hassed, C. Lycopene for the prevention of prostate cancer. Cochrane.Database.Syst.Rev. 2011;(11):CD008007. PubMed
  10. Sawardekar SB, Patel TC, Uchil D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: an in vitro study. Indian J Pharmacol 2016;48:26-31. PubMed

See these in context on the Lycopene monograph →

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
  10. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
  11. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21.
  12. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  13. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  14. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
  15. Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. PubMed
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Lutein 2 references
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Coenzyme Q10 40 references
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Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
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See these in context on the Zeaxanthin monograph →

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