Interactions on record — worth a quick check against your medications. Based on 5 of 19 ingredients. Check your meds →
Dietary supplement

Supreme Digestive Enzymes Ingredients & Drug Interactions

by Altrum

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Supreme Digestive Enzymes is a dietary supplement by Altrum with 19 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Supreme Digestive Enzymes by Altrum

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 19 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (460 mg) without saying how much of each component you get.

This product contains 19 active ingredients, most of them digestive enzymes designed to help break down different parts of food. Bromelain is an enzyme from pineapple that breaks down protein; the protease enzymes (four different types) do similar work.

Lactase breaks down lactose (milk sugar) and is effective for lactose intolerance. Lipase breaks down fats, while amylase, glucoamylase, and several others break down carbohydrates and plant fibers.

Phytase helps release minerals like iron and zinc from food. The product also contains inactive ingredients (cellulose and MCT) as fillers and capsule materials—these are not active and play no digestive role.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Full-spectrum digestive enzyme support.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Exercise-induced muscle soreness, Postoperative pain, Postoperative swelling, Allergic rhinitis (hay fever) — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), Exercise-induced muscle soreness, Rhinosinusitis, Postoperative swelling, and more.

The evidence supporting these enzymes is limited. Lactase is the one ingredient with established effectiveness for lactose intolerance.

For bromelain, the data we have rates its usefulness for conditions like hay fever, burns, and diabetes as insufficient—meaning we don't yet have enough reliable evidence to say it works. The same holds true for the proteases (lipase, phytase, and others): the evidence for their use in digestive support or other conditions has not been established in our data.

The evidence, ingredient by ingredient Bromelain Proteolytic Enzymes (proteases) Lactase Phytase Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated when taken by mouth short-term, though long-term safety data are limited. Common side effects include diarrhea, flatulence, stomach upset, and headache.

Allergic reactions are possible, especially in people sensitive to pineapple. The proteases, lactase, phytase, and lipase are also generally well tolerated for most adults, though they may occasionally cause digestive upset or allergic reactions.

Rare allergic reactions to powdered enzymes (occupational exposure in workers) have included asthma and difficulty swallowing. For pregnancy: bromelain should be avoided—not enough safety data exists.

The proteases, phytase, and lipase are best avoided in pregnancy unless prescribed by your doctor. Lactase is likely safe in pregnancy but check with your doctor before regular use.

For breastfeeding: bromelain and the proteases are not recommended without medical advice. Phytase and lipase safety has not been well studied—talk to your doctor or pharmacist first.

Lactase is safer; limited data suggest it acts only in the gut, but still ask your healthcare provider.

Side effects, ingredient by ingredient Bromelain Proteolytic Enzymes (proteases) Lactase Phytase Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 5 matched ingredients can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Supreme Digestive Enzymes, double-check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin)—bromelain may increase bleeding risk. Also mention if you're on tetracycline antibiotics, where bromelain may theoretically raise drug levels.

No other documented interactions exist in our data for the other checked ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This enzyme blend is primarily for digestive support, and lactase is the one ingredient proven to help with lactose intolerance. If you take blood thinners (anticoagulants), antiplatelet drugs, or tetracycline antibiotics, talk to your pharmacist before starting—bromelain may affect how these work.

If you're pregnant or breastfeeding, check with your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 19 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Supreme Digestive Enzymes, straight from the product label.

Brand Altrum
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 331470
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Supreme Digestive Enzymes by Altrum, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
60
IngredientAmount% DV
Bromelain0 NP--
Amylase0 NP--
Glucoamylase0 NP--
Invertase0 NP--
Protease 4.50 NP--
Lactase0 NP--
Hemicellulase0 NP--
Proprietary Blend460 mg--
Alpha-Galactosidase0 NP--
Protease 60 NP--
Peptidase0 NP--
Phytase0 NP--
Acid Maltase0 NP--
Cellulase0 NP--
Pectinase0 NP--
Beta-Glucanase0 NP--
Xylanase0 NP--
Lipase0 NP--
Neutral Protease0 NP--
Acid-Stable Protease 3.00 NP--

Other ingredients: Cellulose, MCT

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 capsule with each meal.

Formula

This product is a potent proprietary combination of digestive enzymes produced through controlled fermentation of select microbial species and is stable throughout the PH range of the GI tract. This full-spectrum digestive support formula helps to optimize nutrient absorption by assisting in the breakdown of protein, carbohydrate and fat, as well as dairy, grains and indigestible fibers found in foods such as vegetables and beans.

Formulation

In addition, this product is suitable for vegetarians.

Natural color variation may occur in this product

Supports healthy digestion

GMP

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or sesame ingredients.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool, dry place after opening.

General Statements

This bottle is made from 100% PCR (post-consumer recycled) resin.

FDA Statement of Identity

A Dietary Supplement

See for yourself

Supreme Digestive Enzymes by Altrum label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Supreme Digestive Enzymes by Altrum

These are the 19 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

460 mg per serving

Other (inactive) ingredients: Cellulose, MCT. These complete the product’s ingredient list but are not active constituents.

Interaction report

Supreme Digestive Enzymes by Altrum Drug Interactions

Want to check YOUR meds against Supreme Digestive Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141

Each ingredient & the kinds of drugs it affects

For each ingredient in Supreme Digestive Enzymes with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Supreme Digestive Enzymes, from the product label.

Altrum

See all Altrum products
Name
ALTRUM Nutrition Div. of AMSOIL INC.
City
Superior
State
WI
ZipCode
54880
Phone Number
(715) 392-7101
Pharmacist Counseling Corner

Supreme Digestive Enzymes by Altrum: Common Questions

Does Supreme Digestive Enzymes by Altrum interact with any medications?
Yes. Based on its ingredients, Supreme Digestive Enzymes has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Supreme Digestive Enzymes contains 19 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me digest food better?
The product contains multiple digestive enzymes—bromelain, proteases, lipase, and carbohydrate-breaking enzymes—designed to help break down different foods. However, evidence supporting their effectiveness for general digestion has not been established in our data. If you have lactose intolerance specifically, the lactase in this product is effective.
Can I take this if I'm pregnant?
Bromelain should be avoided during pregnancy—there isn't enough safety data. The proteases, phytase, and lipase are also best avoided unless prescribed by your doctor. Lactase is likely safe but talk with your doctor before regular use during pregnancy.
What side effects might I experience?
Most common are digestive complaints: diarrhea, flatulence, stomach upset, and headache. Allergic reactions are possible, particularly if you're sensitive to pineapple (bromelain comes from pineapple). Occupational exposure to these enzymes in powdered form has caused asthma and respiratory symptoms in workers, but this is rare in people taking the supplement by mouth.
Is this safe if I'm breastfeeding?
Bromelain and the proteases are not recommended without medical advice—safety data are lacking. Phytase and lipase also have limited breastfeeding data; check with your healthcare provider. Lactase is safer and acts only in the gut, but still ask your doctor or pharmacist first.
What's bromelain, and why is it in here?
Bromelain is an enzyme from pineapple that breaks down protein. It's included to help your digestive system process protein-rich foods. It does interact with certain medications—blood thinners and some antibiotics—so mention it to your pharmacist.
Why are there so many different enzymes in one product?
Each enzyme breaks down a different type of nutrient: proteases handle protein, lipase handles fat, and others handle various carbohydrates and fibers. Together they're meant to work across the range of foods you eat, though evidence specifically supporting this combination is not established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Supreme Digestive Enzymes is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Supreme Digestive Enzymes label
Go deeper

The Full Monographs Behind Supreme Digestive Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Supreme Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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