Tangerine Fruit 4:1 Extract Powder Ingredients & Drug Interactions
by TerraVita Premium Collection
What is this page for?
First and foremost: checking Tangerine Fruit 4:1 Extract Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Tangerine Fruit 4:1 Extract Powder is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for source of vitamin c, digestive support, aromatherapy and relaxation.Based on those ingredients, 645 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Tangerine Fruit Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Tangerine Fruit 4:1 Extract Powder by TerraVita Premium Collection
Ask about any prescription or over-the-counter medication and we check it for interactions with Tangerine Fruit 4:1 Extract Powder by TerraVita Premium Collection — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Tangerine Fruit 4:1 Extract Powder by TerraVita Premium Collection
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Tangerine Fruit Extract in a 4:1 powder form, meaning the extract has been concentrated. There are no other inactive ingredients listed.
The extract is derived from tangerine fruit and retains the compounds—including tangeretin—that make tangerines what they are.
Does it work?
Couldn't assess
The evidence we hold does not establish whether this product works for any health condition. Our data rates tangerine for cancer as having insufficient reliable evidence to rate.
If you're considering this supplement for a specific reason, talk it over with your doctor or pharmacist about whether the science supports its use for your particular situation.
How safe is it?
Well-documented data
Tangerine fruit is generally well tolerated when eaten as food. However, our safety data advises caution with concentrated extracts and supplements—the same form this product is in.
The concentrated extract hasn't been studied as thoroughly as the whole fruit, so safety outcomes aren't fully characterized. Very few adverse effects have been reported with medicinal use of tangerine, though a complete safety evaluation hasn't been done.
Topically, tangerine essential oil has caused contact dermatitis in some people. Our data does not include pregnancy or lactation safety information for this ingredient.
Meds to double-check
Minor interactions only
Check with your own doctor or pharmacist before adding this product if you take midazolam (Versed) or any other drug metabolized by the CYP3A4 liver enzyme—that includes many sedatives, blood pressure medications, statins, and others. The human evidence suggests real-world risk is lower than laboratory findings implied, but it's still worth confirming your specific medications are in the clear.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
If you eat tangerines regularly, you're fine—the fruit itself is safe. But moving to a concentrated extract is a different story, and the evidence for what it actually does for your health isn't established in our data.
Before you start, check with your own doctor or pharmacist, especially if you take any medications your liver processes, and discuss whether this supplement makes sense for what you're hoping to accomplish.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Tangerine Fruit 4:1 Extract Powder, straight from the product label.
| Brand | TerraVita Premium Collection |
|---|---|
| Barcode (UPC) | 064435215125 |
| Net contents | 4 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Apr 21, 2023 |
| DSLD ID | 289857 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Tangerine Fruit 4:1 Extract Powder by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Tangerine Fruit Extract, Powder | 1000 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
A Dietary Supplement
Brand IP Statement(s)
Copyright 2017 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Suggested/Recommended/Usage/Directions
Directions Stir 1/4 of a teaspoon into a glass of water and consume 3 times daily, with meals.
General Statements
TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.
Please recycle!
FDA Disclaimer Statement
Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Tangerine Fruit 4:1 Extract Powder by TerraVita Premium Collection label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Tangerine Fruit 4:1 Extract Powder by TerraVita Premium Collection
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.25 Teaspoon(s) Dosage formPowder Servings per container113 Amounts shown are per serving.
Tangerine Fruit Extract, Powder
Interacts with645 drugs
Tangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food. While the peel and essential...
Tangerine Fruit Extract, Powder monograph & interactionsTangerine Fruit 4:1 Extract Powder by TerraVita Premium Collection Drug Interactions
HelloPharmacist Interaction Report
TerraVita Premium Collection's Tangerine Fruit 4:1 Extract Powder contains tangerine extract, which has documented interactions with CYP3A4 substrates and midazolam.
The most serious concern is Minor in severity. In laboratory studies, tangeretin (a compound in tangerine) appeared to speed up how your liver breaks down midazolam by up to 52%.
However, human studies tell a different story: when people drank 200 mL of tangerine juice, it slightly delayed how quickly midazolam was absorbed into the bloodstream but did not actually change how fast the body metabolized it.
Read the full breakdown — every affected drug type, severity by severity
The interaction data focuses on midazolam (Versed, a sedative) and other drugs metabolized by the same liver enzyme (CYP3A4 substrates). While laboratory findings suggested tangeretin might rev up this enzyme, the human evidence shows that effect didn't happen in practice.
Altogether, these interactions span 644 individual medications.
Before you start this supplement, run your exact medications through the interaction checker on this page—especially if you take sedatives, blood pressure medications, statins, or any drug you know is broken down by your liver.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Tangerine Fruit 4:1 Extract Powder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Tangerine Fruit 4:1 Extract Powder interact with 645 drugs. Click any drug to see the details.
1 of the 1 ingredient in Tangerine Fruit 4:1 Extract Powder interact with drugs. Each result below shows which ingredient is responsible. Tangerine Fruit Extract, Powder
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Abiraterone Acetate interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acalabrutinib interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Tangerine Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Tangerine Fruit Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Fruit Extract, Powder + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Tangerine Fruit 4:1 Extract Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Tangerine Fruit Extract, Powder
Cytochrome P450 3A4 (Cyp3A4) Substrates
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4). This suggests that tangeretin may stimulate CYP3A4 activity. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam, a CYP3A4 substrate. Theoretically, tangerine juice might increase CYP3A4 activity and decrease levels of drugs metabolized by this enzyme. However, this effect is unlikely.
Some drugs metabolized by CYP3A4 include amitriptyline (Elavil), amiodarone (Cordarone), citalopram (Celexa), felodipine (Plendil), lansoprazole (Prevacid), ondansetron (Zofran), prednisone (Deltasone, Orasone), sertraline (Zoloft), sibutramine (Meridia), and many others.
Midazolam (Versed)
In vitro, tangeretin, a constituent of tangerine, appears to increase the metabolism of midazolam in human liver microsomes by up to 52%. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam. Theoretically, tangerine juice might increase the metabolism and reduce the effects of midazolam. However, this effect is unlikely.
Brand information
Manufacturer and brand details for Tangerine Fruit 4:1 Extract Powder, from the product label.
TerraVita Premium Collection
See all TerraVita Premium Collection products- Name
- TerraVita Fine Whole Herbs
- City
- Brampton
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Tangerine Fruit 4:1 Extract Powder by TerraVita Premium Collection: Common Questions
Does Tangerine Fruit 4:1 Extract Powder by TerraVita Premium Collection interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is tangerine extract safe to take if I eat tangerines regularly?
What does this extract actually do?
Can I use this if I take sedatives like midazolam?
Are there any side effects I should know about?
Is this safe during pregnancy or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Tangerine Fruit 4:1 Extract Powder is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Tangerine Fruit 4:1 Extract Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Tangerine Fruit 4:1 Extract Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Tangerine 3 references
- Yuan, J. M., Wang, X. L., Xiang, Y. B., Gao, Y. T., Ross, R. K., and Yu, M. C. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer 2000;85(3):358-363. DOI
- Backman, J. T., Maenpaa, J., Belle, D. J., Wrighton, S. A., Kivisto, K. T., and Neuvonen, P. J. Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. Clin Pharmacol Ther 2000; PubMed
- Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC