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Dietary supplement

TeaCrine 5 grams Ingredients & Drug Interactions

by Nootropics Depot

TeaCrine 5 grams label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TeaCrine 5 grams against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TeaCrine 5 grams is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for energy and reduced fatigue, focus and mental alertness, mood support.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Theacrine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against TeaCrine 5 grams by Nootropics Depot

Ask about any prescription or over-the-counter medication and we check it for interactions with TeaCrine 5 grams by Nootropics Depot — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of TeaCrine 5 grams by Nootropics Depot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

TeaCrine is a single-ingredient powder containing 5 grams of theacrine per serving. Theacrine is a purine alkaloid structurally similar to caffeine; it's found naturally in some plants and is being studied as a potential cognitive and physical performance enhancer.

The only other ingredient is calcium silicate, an inert filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Theacrine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Energy, focus and mental alertness.
  • We looked for evidence on: Athletic performance, Cognitive function, Fatigue, Mental alertness, Endurance, Physical performance.
  • The closest evidence on file: Theacrine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Theacrine is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Fatigue, Mental alertness.

We don't have reliable evidence yet to confirm that theacrine works for athletic performance, cognitive function, fatigue, mental alertness, or muscle strength. The research simply isn't established in our data.

If you're considering this product for one of those reasons, talk to your pharmacist about what the current science actually supports.

The evidence, ingredient by ingredient Theacrine

How safe is it?

Limited data
Safety Information · database check
Limited information

Little studied safety information is available for these ingredients — that is not the same as being safe.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of theacrine appears generally well tolerated in the studies we have, but long-term safety isn't well established — so if you're thinking of taking this regularly, that's worth discussing with your doctor. The safety data isn't sufficient during pregnancy or while breastfeeding, so those are times to avoid it.

We don't have adverse-effect reports on file, but that doesn't mean they don't occur.

Side effects, ingredient by ingredient Theacrine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Theacrine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check any CNS depressants you take — sedatives, sleep aids, anti-anxiety medications, and narcotic pain relievers — before starting TeaCrine. Theacrine might increase or decrease their effects depending on the dose you take, and this interaction is rated Moderate.

Use the medication checker below with your exact drug names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is limited.

TeaCrine is a single-ingredient supplement that may appeal to people exploring theacrine for potential focus or energy support, though the evidence isn't solid yet. If you take any sedating medication — including prescription sleep aids, anxiety meds, or narcotic pain relievers — you'll want to check with us or your pharmacist before adding this.

Long-term safety data is limited, so talk to your doctor if you plan regular use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TeaCrine 5 grams, straight from the product label.

Brand Nootropics Depot
Net contents 0.17 Ounce(s); 5 Gram(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232643
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TeaCrine 5 grams by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.1 mg
Maximum serving Sizes:
0.1 mg
Servings per container
50
IngredientAmount% DV
Theacrine100 mg--

Other ingredients: Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

General Statements

Disclaimer: Transfer scoops are not accurate. A mg scale is needed to measure dosages.

Precautions

Always consult with a qualified health physician before taking any new dietary supplement.

Warning: Keep out of reach of children. Do not take if under 18, pregnant/nursing, have any medical conditions or taking Rx/OTC drugs.

Do not take if under 18, pregnant/nursing, have any medical conditions or taking Rx/OTC drugs.

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the FDA.

Storage

Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.

Brand IP Statement(s)

TeaCrine is a registered trademark and protected by Patents Pending, Serial No. 61/903,362;under exclusive global distribution by Compound Solutions, Inc.

Suggested/Recommended/Usage/Directions

Suggested Use: Take 100mg once daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TeaCrine 5 grams by Nootropics Depot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TeaCrine 5 grams label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TeaCrine 5 grams by Nootropics Depot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.1 mg Dosage formPowder Servings per container50 Amounts shown are per serving.

Theacrine

Interacts with
248 drugs
100 mg per serving

Theacrine is a caffeine-like compound found naturally in certain tea plants and is sold in supplements for energy, focus, and mood. Early human studie...

Theacrine monograph & interactions

Other (inactive) ingredients: Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

TeaCrine 5 grams by Nootropics Depot Drug Interactions

Want to check YOUR meds against TeaCrine 5 grams?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Theacrine 248

Individual Drug Interactions

The ingredients in TeaCrine 5 grams interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in TeaCrine 5 grams interact with drugs. Each result below shows which ingredient is responsible. Theacrine

Each ingredient & the kinds of drugs it affects

For each ingredient in TeaCrine 5 grams with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Theacrine1 drug type · 248 drugs

Cns Depressants

Theoretically, theacrine might alter the effects of CNS depressants.
Animal research shows that low doses of theacrine have sedating effects, whereas high doses might have stimulant effects. Depending on the dose of theacrine used, it might increase or decrease the effects of CNS depressants. However, these effects have not yet been reported in humans.

Likelihood Possible Evidence D
Theacrine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TeaCrine 5 grams, from the product label.

Nootropics Depot

See all Nootropics Depot products
Name
Nootropics Depot
Street Address
8380 S. Kyrene Rd. Ste. 110
City
Tempe
State
AZ
ZipCode
85284
Pharmacist Counseling Corner

TeaCrine 5 grams by Nootropics Depot: Common Questions

Does TeaCrine 5 grams by Nootropics Depot interact with any medications?
Yes. Based on its ingredients, TeaCrine 5 grams has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TeaCrine 5 grams contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does theacrine actually improve focus or energy?
The research isn't established yet. We have insufficient reliable evidence to confirm that theacrine works for mental alertness, fatigue, or cognitive function. It's being studied, but we can't say it's proven to do those things based on the data we hold.
Is theacrine safe to take long term?
Short-term use appears well tolerated in studies, but long-term safety hasn't been well established. If you're planning to take this regularly, talk to your doctor about what we know and don't know yet.
Can I take TeaCrine if I'm pregnant or breastfeeding?
The safety data isn't sufficient to know either way, so the guidance is to avoid it during pregnancy and while breastfeeding. Talk to your doctor or pharmacist about what's right for your situation.
What is theacrine exactly?
Theacrine is a purine alkaloid similar in structure to caffeine. It's found naturally in some plants and is being researched for potential cognitive and athletic benefits, though the evidence isn't yet solid.
Does this powder have any fillers or other stuff in it?
Yes — besides the 5 grams of theacrine, it contains calcium silicate, which is an inert filler used to improve the powder's texture and handling.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TeaCrine 5 grams is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TeaCrine 5 grams label
Go deeper

The Full Monographs Behind TeaCrine 5 grams’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theacrine

Interacts with 248 drugs

Theacrine is a caffeine-like compound found naturally in certain tea plants and is sold in supplements for energy, focus, and mood. Early human studies suggest it may give a stimulant-like b...

Read the full Theacrine monograph →
Sources

Sources & How We Checked

TeaCrine 5 grams's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theacrine 1 reference
  1. Xu JK, Kurihara H, Zhao L, Yao XS. Theacrine, a special purine alkaloid with sedative and hypnotic properties from Cammelia assamica var. kucha in mice. J Asian Nat Prod Res 2007;9(6-8):665-72.

See these in context on the Theacrine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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