Shoden Ashwagandha Extract Powder Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Shoden Ashwagandha Extract Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Shoden Ashwagandha Extract Powder is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Shoden Ashwagandha (Withania somnifera) root & leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Shoden Ashwagandha Extract Powder by Nootropics Depot
Ask about any prescription or over-the-counter medication and we check it for interactions with Shoden Ashwagandha Extract Powder by Nootropics Depot — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Shoden Ashwagandha Extract Powder by Nootropics Depot
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Shoden Ashwagandha Extract Powder contains one active ingredient: Shoden Ashwagandha (Withania somnifera) root and leaf extract — a concentrated form of an herb traditionally used in Ayurvedic medicine. The product has no listed inactive ingredients.
Does it work?
Moderate evidence
Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD) based on the evidence we have on file. The research suggesting benefit for attention deficit-hyperactivity disorder (ADHD) is insufficient to rate at this time.
How safe is it?
Well-documented data
Ashwagandha is generally well tolerated when taken by mouth in the short term by healthy adults, but long-term safety data are limited and product quality can vary. The most common side effects — diarrhea, nausea, vomiting, and gastrointestinal upset — don't typically occur at standard doses.
Rare but serious concerns include acute liver damage and a case report of reversible cerebral vasoconstriction syndrome (a narrowing of blood vessels in the brain). Drowsiness has also been reported.
Do not take ashwagandha during pregnancy — the safety data advise against it due to a traditional concern about miscarriage risk. There isn't enough safety information to know whether it's safe while breastfeeding, so avoid it unless your doctor or pharmacist has advised otherwise.
If you're pregnant, planning to become pregnant, or breastfeeding, talk with your healthcare provider before using this product.
Meds to double-check
Moderate interaction found
Before taking Shoden Ashwagandha, double-check with your doctor or pharmacist if you're on hepatotoxic drugs (medications that can damage the liver), CNS depressants (sedatives, anxiolytics, barbiturates), benzodiazepines, antihypertensive drugs (blood pressure medications), antidiabetes drugs, thyroid hormones, or immunosuppressants. All of these carry Moderate-severity interactions with ashwagandha.
You should also mention any drugs that your liver breaks down via CYP1A2 (a Minor interaction).
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Ashwagandha may help with insomnia, anxiety, stress, and general worry — but it interacts with a significant range of medications, especially those that sedate, lower blood pressure, manage blood sugar, or affect the immune system. If you take any prescription medication or have liver concerns, check your specific drugs with the tool on this page and talk with your doctor or pharmacist before starting.
It's not for use during pregnancy or while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Shoden Ashwagandha Extract Powder, straight from the product label.
| Brand | Nootropics Depot |
|---|---|
| Net contents | 1.05 oz; 30 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2021 |
| DSLD ID | 251275 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Shoden Ashwagandha Extract Powder by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Shoden Ashwagandha (Withania somnifera) root & leaf extract | 120 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Minimum withanolides content: 35%
FDA Statement of Identity
Dietary Supplement
General Statements
Disclaimer: Transfer scoops are not accurate forms of measurement. A milligram scale is needed to accurately measure dosages.
Precautions
Always consult with a qualified health physician before taking any new dietary supplement.
Warning: Keep out of reach of children.
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s)
FDA Disclaimer Statement
This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the Food & Drug Administration.
Brand IP Statement(s)
Shoden is a registered trademark of Arjuna Natural Pvt. Ltd. Use of Shoden is protected by U.S. Trademark Registration No. 5,634,394.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 120mg 1-2 times daily.
Storage
Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Shoden Ashwagandha Extract Powder by Nootropics Depot label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Shoden Ashwagandha Extract Powder by Nootropics Depot
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size120 mg Dosage formPowder Servings per container250 Amounts shown are per serving.
Shoden Ashwagandha (Withania somnifera) root & leaf extract
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Shoden Ashwagandha (Withania somnifera) root & leaf extract monograph & interactionsShoden Ashwagandha Extract Powder by Nootropics Depot Drug Interactions
HelloPharmacist Interaction Report
Shoden Ashwagandha Extract Powder by Nootropics Depot interacts with medications through its Withania somnifera root and leaf extract.
The most serious documented concern is with hepatotoxic drugs — ashwagandha has been linked to rare cases of acute liver damage, liver failure, and hepatic encephalopathy, which means you need to be cautious if you're taking any medication known to stress the liver.
Read the full breakdown — every affected drug type, severity by severity
Ashwagandha can increase the sedative effects of CNS depressants (drugs that slow your central nervous system), including benzodiazepines like Valium and Klonopin, barbiturates, and other sedatives or anti-anxiety medications. It may also lower blood pressure, so if you're on antihypertensive drugs, there's a risk of blood pressure dropping too far.
Additionally, ashwagandha can theoretically lower blood sugar, raising the risk of low blood sugar (hypoglycemia) if you take antidiabetes drugs, and it may boost thyroid hormone effects, which could intensify both benefits and side effects if you're on thyroid medication.
Ashwagandha has immune-stimulating properties, so it might reduce the effectiveness of immunosuppressants — drugs taken to prevent organ rejection or manage autoimmune conditions. On the minor side, it may decrease the levels of certain medications that your liver breaks down via a specific enzyme pathway (CYP1A2 substrates), potentially making those drugs less effective.
Altogether, these interactions span 1,373 individual medications. Use the medication checker on this page to look up your specific drugs before starting ashwagandha, and talk with your doctor or pharmacist about whether this product is right for you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Shoden Ashwagandha Extract Powder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Shoden Ashwagandha Extract Powder interact with 1,372 drugs. Click any drug to see the details.
1 of the 1 ingredient in Shoden Ashwagandha Extract Powder interact with drugs. Each result below shows which ingredient is responsible. Shoden Ashwagandha (Withania somnifera) root & leaf extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Abacavir, Lamivudine interactionAbiraterone
How Abiraterone interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractAntihypertensive Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acebutolol interactionAcepromazineAtravet
How Acepromazine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs, Cns Depressants +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Serotonergic Drugs +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +3 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Shoden Ashwagandha Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Shoden Ashwagandha (withania Somnifera) Root & Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Shoden Ashwagandha (withania Somnifera) Root & Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Shoden Ashwagandha Extract Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Shoden Ashwagandha (Withania somnifera) root & leaf extract
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Brand information
Manufacturer and brand details for Shoden Ashwagandha Extract Powder, from the product label.
Nootropics Depot
See all Nootropics Depot products- Name
- Nootropics Depot
- Street Address
- 8380 S. Kyrene Rd. Ste. 110
- City
- Tempe
- State
- AZ
- ZipCode
- 85284
- Web Address
- nootropicsdepot.com
Shoden Ashwagandha Extract Powder by Nootropics Depot: Common Questions
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The Full Monographs Behind Shoden Ashwagandha Extract Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Shoden Ashwagandha Extract Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ashwagandha 32 references
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- Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
- Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
- Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
- Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
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- Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
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- Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
- Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
- Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
- Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
- Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
- Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
- Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med 2021;1 PubMed
- Ireland PJ, Hardy T, Burt AD, Donnelly MC. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. J R Coll Physicians Edinb. 2021;51(4):363-365. PubMed
- Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Cureus. 2022 Mar 25;14(3):e23494. PubMed
- Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Am J Ther 2023;30(1):e80-e83. PubMed
- Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Cureus 2022;14(10):e30433. PubMed
- Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus 2022;14(10):e30787. PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Lubarska M, Halasinski P, Hryhorowicz S, et al. Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury. Int J Environ Res Public Health 2023;20(5):3921. PubMed
- Tóth M, Benedek AE, Longerich T, Seitz HK. Ashwagandha-induced acute liver injury: A case report. Clin Case Rep 2023;11(3):e7078.
- Bokan G, Glamocanin T, Mavija Z, et al. Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause. Pharmaceuticals (Basel) 2023;16(8):1129. PubMed
- Patel PA, Sanborn E, Then R, Williams DM. Recurrent Reversible Cerebral Vasoconstriction Syndrome: A Report of Two Cases. Cureus 2023;15(8):e42992. PubMed
- Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L. A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomize
- Philips CA, Valsan A, Theruvath AH, et al. Ashwagandha-induced liver injury-A case series from India and literature review. Hepatol Commun 2023;7(10):e0270. PubMed
- Hayashi M, Hamada H, Azuma SI, Hayashi K. Painless Thyroiditis by Withania somnifera (Ashwagandha). Cureus 2024;16(3):e55352. PubMed
- Vazirani S, Kothari A, Fujimoto J, Gomez M. Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha. Fed Pract 2023;40(9):315-319. PubMed
- Patel M, Newell R, Hillier M, Ramalingam R. Herbal remedies as a potential cause of hypoadrenalism. Br J Hosp Med (Lond) 2024;85(6):1-4. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC