Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Testo-Quench Ingredients & Drug Interactions

by Douglas Laboratories

Testo-Quench label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Testo-Quench against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Testo-Quench is a dietary supplement by Douglas Laboratories with 6 active ingredients. Its ingredients are commonly taken for digestive upset and bloating, infant colic, menstrual cramps.Based on those ingredients, 978 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fennel, Trigonella foenum-graecum, Ocimum sanctum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Testo-Quench by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Testo-Quench by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Testo-Quench by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Testo-Quench(TM) Herbal Proprietary Blend” is a proprietary blend — the label gives one combined amount (2,160 mg) without saying how much of each component you get.

Testo-Quench contains six active ingredients: fennel, fenugreek (Trigonella foenum-graecum), saw palmetto, stinging nettle (Urtica dioica), holy basil (Ocimum sanctum), and pygeum (Pygeum africanum). The product also includes a proprietary herbal blend labeled as Testo-Quench, which functions as a container for component ingredients listed separately.

The capsule itself is made from gelatin, dicalcium phosphate (a binder), and vegetable stearate (a flow agent).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Benign prostatic hyperplasia (BPH) — rated "Likely Effective" (Pygeum) (Natural Medicines).
  • On file: Dysmenorrhea — rated "Possibly Effective" (Fennel) (Natural Medicines).
  • On file: Diabetes — rated "Possibly Effective" (Stinging Nettle) (Natural Medicines).
  • On file: Sexual dysfunction — rated "Possibly Effective" (Fenugreek) (Natural Medicines).
  • On file: Sexual arousal — rated "Possibly Effective" (Fenugreek) (Natural Medicines).

The evidence for most ingredients in this product is limited. Fennel is possibly effective for menstrual pain (dysmenorrhea), but evidence is insufficient for its use in bronchitis, anxiety, bedwetting, or cholera.

Fenugreek is possibly effective for sexual dysfunction, sexual arousal, menstrual pain, and diabetes. Saw palmetto is possibly effective for one specific prostate condition (transurethral resection of the prostate) but possibly ineffective for benign prostate enlargement; evidence is insufficient for chronic bronchitis, hair loss, and urinary symptoms.

Stinging nettle is possibly effective for diabetes but has insufficient evidence for hay fever, anemia, asthma, prostate enlargement, and gum disease. Holy basil and pygeum have insufficient evidence for their claimed uses in anxiety, asthma, headache, infections, dental plaque, and diabetes (holy basil), or Alzheimer's disease, malaria, sexual desire, and psychosis (pygeum).

Pygeum is likely effective for benign prostate enlargement.

The evidence, ingredient by ingredient Fennel Fenugreek Saw Palmetto Stinging Nettle Holy Basil Pygeum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated in short-term use. Fennel can cause stomach discomfort, sun sensitivity, and allergic reactions in sensitive people; seizures are rare.

Fenugreek commonly causes abdominal pain, bloating, diarrhea, and nausea, and rare severe allergic reactions are possible. Saw palmetto is mild and usually reversible, with common side effects including stomach pain, constipation, decreased sex drive, diarrhea, dizziness, fatigue, headache, nausea, and stuffy nose; rare heart effects have been reported.

Stinging nettle causes constipation or diarrhea; liver injury is rare. Holy basil may cause loose stools and nausea.

Pygeum sometimes causes nausea and abdominal pain at similar rates to placebo. Fennel, saw palmetto, and stinging nettle should be avoided during pregnancy due to hormone concerns or lack of safety data.

Fenugreek and holy basil are possibly unsafe in pregnancy. Safety during breastfeeding is not established for fennel, saw palmetto, stinging nettle, and holy basil; fenugreek is sometimes used to boost milk supply but evidence is limited—discuss with your provider.

Side effects, ingredient by ingredient Fennel Fenugreek Saw Palmetto Stinging Nettle Holy Basil Pygeum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Fennel, Stinging Nettle, Fenugreek, Saw Palmetto, Holy Basil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 979 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Testo-Quench, double-check with your pharmacist if you use blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), diabetes medications, birth control or hormone replacement therapy, theophylline, phenytoin, lithium, diuretics, or barbiturates. Fennel may reduce the effectiveness of ciprofloxacin and tamoxifen as well.

These are Moderate-severity interactions documented across the product's ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines multiple herbal ingredients with potential interactions, especially with blood thinners, diabetes medications, and hormone-based drugs. If you take any regular medications, check your specific drugs with the tool on this page before starting.

Talk to your pharmacist or doctor if you have questions about whether this product fits your health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Testo-Quench, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539022474
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2014
DSLD ID 31045
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult Male (18-50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Testo-Quench by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
310539022474
IngredientAmount% DV
Fennel0 NP--
Trigonella foenum-graecum0 NP--
Testo-Quench(TM) Herbal Proprietary Blend2160 mg--
Saw Palmetto0 NP--
Urtica dioica0 NP--
Ocimum sanctum0 NP--
Pygeum africanum0 NP--

Other ingredients: Gelatin, Dicalcium Phosphate, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

This product contains NO yeast, gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.

Precautions

WARNING: Not to be used by pregnant or nursing women.

Tamper resistant package, do not use if outer seal is missing.

KEEP OUT OF REACH OF CHILDREN.

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 3 capsules daily with food or as directed by your healthcare professional.

FDA Statement of Identity

A Dietary Supplement

Storage

For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)

General

Formula #99093

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Testo-Quench by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Testo-Quench label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Testo-Quench by Douglas Laboratories

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Testo-Quench(TM) Herbal Proprietary Blend

2160 mg per serving

Other (inactive) ingredients: Gelatin, Dicalcium Phosphate, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Testo-Quench by Douglas Laboratories Drug Interactions

Want to check YOUR meds against Testo-Quench?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
978Drugs
908 Moderate 70 Minor

Ingredients driving the most interactions

Fennel 740
Trigonella foenum-graecum 389
Ocimum sanctum 212
Saw Palmetto 174
Urtica dioica 164

Individual Drug Interactions

The ingredients in Testo-Quench interact with 978 drugs. Click any drug to see the details.

5 of the 6 ingredients in Testo-Quench interact with drugs. Each result below shows which ingredient is responsible. Fennel Trigonella foenum-graecum Ocimum sanctum Saw Palmetto Urtica dioica

Each ingredient & the kinds of drugs it affects

For each ingredient in Testo-Quench with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel full monograph & interactions

Trigonella foenum-graecum9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Trigonella foenum-graecum full monograph & interactions

Ocimum sanctum3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
Ocimum sanctum full monograph & interactions

Saw Palmetto3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto full monograph & interactions

Urtica dioica4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Urtica dioica full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Testo-Quench, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Testo-Quench by Douglas Laboratories: Common Questions

Does Testo-Quench by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, Testo-Quench has a known interaction with 978 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Testo-Quench contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control?
Two ingredients—fennel and saw palmetto—may theoretically interfere with how birth control works due to estrogenic or antiestrogenic effects. Talk to your pharmacist or doctor before taking this product alongside any hormone-based medication, including contraceptives.
Is this safe to take while pregnant?
No, several ingredients should be avoided in pregnancy. Fennel, saw palmetto, and stinging nettle should not be used due to hormone concerns or insufficient safety data. Fenugreek and holy basil are possibly unsafe as well. Talk with your doctor before taking any supplement during pregnancy.
What's the most common side effect of these ingredients?
Stomach upset—including bloating, gas, diarrhea, nausea, and abdominal pain—is most common across fenugreek, saw palmetto, and stinging nettle. Most side effects are mild and temporary.
Does this product actually work?
Evidence is weak or missing for most uses. Fenugreek is possibly effective for sexual function and diabetes, and pygeum is likely effective for prostate enlargement, but the other ingredients lack strong research support for their claimed effects.
Can I take this with my blood thinner?
Probably not without talking to your doctor first. Fennel, fenugreek, saw palmetto, and holy basil may all increase bleeding risk when used with anticoagulants or antiplatelet drugs. Stinging nettle may also interfere with warfarin due to its vitamin K content. Check with your pharmacist before starting.
What happens if I'm allergic to one of these herbs?
Allergic reactions range from mild (itching, rash, sneezing) to severe (trouble breathing, swelling of the mouth or throat, bronchospasm). If you have a known allergy to any of these plants, avoid this product. If you experience difficulty breathing or severe swelling, seek emergency help.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Testo-Quench label
Go deeper

The Full Monographs Behind Testo-Quench’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph → Herb & supplement monograph

Holy Basil

Interacts with 212 drugs

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...

Read the full Holy Basil monograph → Herb & supplement monograph

Pygeum

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some studies suggest modest benefit for these s...

Read the full Pygeum monograph →
Sources

Sources & How We Checked

Testo-Quench's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 103 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
  4. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
  5. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  6. Rosti L, Nardini A, Bettinelli ME, Rosti D. Toxic effects of a herbal tea mixture in two newborns. Acta Paediatrica 1994;83:683. PubMed
  7. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
  8. Tognolini, M., Ballabeni, V., Bertoni, S., Bruni, R., Impicciatore, M., and Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol.Res 2007;56(3):254-260. PubMed
  9. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
  10. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  11. Subehan, Zaidi, S. F., Kadota, S., and Tezuka, Y. Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. J Agric.Food Chem. 12-12-2007;55(25):101 PubMed
  12. LEVY, S. B. Bronchial asthma due to ingestion of fennel and fennel seed. Ann.Allergy 1948;6(4):415.
  13. Ottolenghi, A., De Chiara, A., Arrigoni, S., Terracciano, L., and De Amici, M. [Diagnosis of food allergy caused by fruit and vegetables in children with atopic dermatitis]. Pediatr Med Chir 1995;17(6):525-530.
  14. Trabace L, Tucci P, Ciuffreda L, et al. "Natural" relief of pregnancy-related symptoms and neonatal outcomes: above all do no harm. J Ethnopharmacol. 2015;174:396-402. PubMed
  15. Denaxa D, Arkwright PD. Fennel as a cause of immediate hypersensitivity to toothpaste. Ann Allergy Asthma Immunol. 2020;125(1):99-100. PubMed
  16. Lee HW, Ang L, Lee MS, Alimoradi Z, Kim E. Fennel for reducing pain in primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. Nutrients 2020;12(11):3438. PubMed
  17. Mathew T, John SK, Javali M, Vasireddy M, Nadig R, Sarma GRK. Substance use related cluster headache: A case series. Headache 2022;62(7):908-910. PubMed

See these in context on the Fennel monograph →

Fenugreek 30 references
  1. Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
  2. Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
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Saw Palmetto 22 references
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Stinging Nettle 23 references
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Holy Basil 8 references
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Pygeum 3 references
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