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Dietary supplement

Tongkat Ali Fadogia Ingredients & Drug Interactions

by Unbound

Tongkat Ali Fadogia label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tongkat Ali Fadogia against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tongkat Ali Fadogia is a dietary supplement by Unbound with 2 active ingredients. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are LJ100. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tongkat Ali Fadogia by Unbound

Ask about any prescription or over-the-counter medication and we check it for interactions with Tongkat Ali Fadogia by Unbound — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tongkat Ali Fadogia by Unbound

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: LJ100, a water extract of Eurycoma longifolia root (also called Tongkat Ali), and Fadogia agrestis stem extract. Both are plant-based ingredients traditionally used to support male vitality and athletic performance.

The capsule itself is made from gelatin and water.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: male sexual function and testosterone support.
  • We looked for evidence on: Age-related testosterone deficiency, Erectile dysfunction (ED), Male Infertility, Sexual desire, Muscle strength, Athletic performance — and 3 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Muscle strength, Age-related testosterone deficiency, Male Infertility.

LJ100 is possibly effective for sexual desire based on the evidence we hold. For athletic performance, the data suggests it's possibly ineffective.

The product hasn't accumulated enough reliable evidence for us to rate it on back pain, osteoporosis, or diabetes. Fadogia agrestis has insufficient evidence to rate on athletic performance, erectile dysfunction, or malaria — so we don't know yet whether it works for any of those.

The evidence, ingredient by ingredient Eurycoma Longifolia Fadogia Agrestis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Eurycoma longifolia is generally well tolerated in short-term studies, but long-term safety is uncertain and product quality can vary. One concern: the herb may increase testosterone, and if your levels climb too high, you could develop acne, insulin resistance, liver stress, or other testosterone-related side effects.

Fadogia agrestis poses a bigger safety question — human data are scarce, and animal studies hint at possible harm to the testicles, liver, and kidneys, so caution is warranted here. The product should be avoided during pregnancy and while breastfeeding due to insufficient safety information for both ingredients.

Side effects, ingredient by ingredient Eurycoma Longifolia Fadogia Agrestis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take propranolol (Inderal) for blood pressure or heart rhythm, this product could weaken it — Moderate concern. Also check any medications your liver metabolizes using CYP1A2, CYP2C19, or CYP2A6 enzymes, since this product might raise their levels.

And if you're on testosterone therapy, discuss whether adding this will push your levels too high.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in this for sexual desire and your medications don't include propranolol or liver-metabolized drugs, ask your pharmacist to run a quick check. Anyone taking blood pressure or heart medications, or testosterone therapy, should double-check before starting.

Pregnant women and those breastfeeding should skip it. Talk to your pharmacist about your full medication list first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tongkat Ali Fadogia, straight from the product label.

Brand Unbound
Barcode (UPC) 649908602369
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 329464
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tongkat Ali Fadogia by Unbound, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
649908602369
IngredientAmount% DV
LJ100200 mg--
Fadogia Agrestis Stem Extract600 mg--

Other ingredients: Gelatin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules daily as needed.

Precautions

Warnings: Keep out of reach of children. Not for use by individuals under the age of 18 years.

Do not use if pregnant or nursing. Consult a physician before use if you have a medical condition or are taking any medication.

Discontinue use two weeks prior to surgery.

Processed in a facility that also processes milk and tree nuts.

General Statements

"We let our E.T.H.I.C.s be our guide" Mark Glazier President | CEO

From our facility to your shaker since 1996

Be Unequaled.

Formulation

NB ETHICS Efficacy Transparency Honesty Innovation Commitment

Libido Testosterone booster

Made without gluten, lactose and GMOs.

Formula

LJ100

Brand IP Statement(s)

LJ-100 is a registered trademark of HP Ingredients Corp.

Seals/Symbols

Manufactured in our GMP & FDA Inspected Facility Made in USA with ingredients sourced worldwide

FDA Statement of Identity

Botanical Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tongkat Ali Fadogia by Unbound label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tongkat Ali Fadogia label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tongkat Ali Fadogia by Unbound

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

LJ100

Interacts with
248 drugs
200 mg per serving Form: Tongkat Ali Root Extract

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

LJ100 monograph & interactions

Fadogia Agrestis Stem Extract

No known
interactions
600 mg per serving Form: Vangueria agrestis Stem Extract

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes most...

Fadogia Agrestis Stem Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tongkat Ali Fadogia by Unbound Drug Interactions

Want to check YOUR meds against Tongkat Ali Fadogia?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

LJ100 248

Individual Drug Interactions

The ingredients in Tongkat Ali Fadogia interact with 248 drugs. Click any drug to see the details.

1 of the 2 ingredients in Tongkat Ali Fadogia interact with drugs. Each result below shows which ingredient is responsible. LJ100

Each ingredient & the kinds of drugs it affects

For each ingredient in Tongkat Ali Fadogia with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

LJ1005 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
LJ100 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tongkat Ali Fadogia, from the product label.

Unbound

Name
NutraBio Labs, Inc.
Pharmacist Counseling Corner

Tongkat Ali Fadogia by Unbound: Common Questions

Does Tongkat Ali Fadogia by Unbound interact with any medications?
Yes. Based on its ingredients, Tongkat Ali Fadogia has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tongkat Ali Fadogia contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually boost testosterone?
LJ100 has shown in clinical studies that it can increase testosterone levels in aging men whose baseline levels were low — roughly an 8% gain over 12 weeks. Whether that translates to noticeable changes depends on where you're starting. If your testosterone is already normal or high, pushing it higher could trigger side effects like acne or liver stress.
Can I take this while pregnant or breastfeeding?
No. There isn't enough safety data for either ingredient during pregnancy or breastfeeding, so the guidance is to avoid it in both situations. Talk to your OB/GYN or midwife if you're considering it before or after pregnancy.
What's LJ100, and why is it in this product?
LJ100 is a water extract of Tongkat Ali root (Eurycoma longifolia). It's included because it's possibly effective for sexual desire based on clinical evidence, and it may also support athletic performance — though the data on that is mixed.
Are there any side effects I should watch for?
If this product raises your testosterone too much, you might notice acne, changes in mood or aggression, or insulin resistance. Fadogia agrestis is less well-studied, but animal data hint at possible liver, kidney, and testicle concerns, so use caution and watch for unusual fatigue, pain, or changes in urination.
Is this product safe to use long-term?
The short-term safety data for LJ100 look okay, but we don't have strong evidence on long-term use. Product quality can also vary. If you're thinking of staying on it for months, check in with your pharmacist or doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tongkat Ali Fadogia is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tongkat Ali Fadogia label
Go deeper

The Full Monographs Behind Tongkat Ali Fadogia’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Fadogia Agrestis

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes mostly from a few small rat studies. Animal...

Read the full Fadogia Agrestis monograph →
Sources

Sources & How We Checked

Tongkat Ali Fadogia's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Fadogia Agrestis 2 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

See these in context on the Fadogia Agrestis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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