Major interaction on record — check this product against your medications before combining. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Trac Orange Ingredients & Drug Interactions

by MHP

Trac Orange label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Trac Orange against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Trac Orange is a dietary supplement by MHP with 7 active ingredients. Its ingredients are commonly taken for high blood pressure, erectile dysfunction, athletic performance.Based on those ingredients, 420 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Arginine, L-Phenylalanine, L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Trac Orange by MHP

Ask about any prescription or over-the-counter medication and we check it for interactions with Trac Orange by MHP — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Trac Orange by MHP

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Trac Orange is a powder with six active ingredients designed to support muscle and athletic performance. It contains L-arginine and L-phenylalanine, both amino acids that play roles in circulation and neurotransmitter production; creatine monohydrate, which supports muscle strength and energy; L-lysine, an amino acid used for immune and tissue support; folate, a B vitamin; and NADH, a coenzyme form of vitamin B3.

The product also contains inactive ingredients—maltodextrin, citric acid, guar gum, orange flavoring, sweeteners (sucralose and acesulfame potassium), vegetable oil, egg lecithin, and beta-carotene—that serve as fillers, thickeners, and flavorings.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Herpes labialis (cold sores) — rated "Possibly Effective" (Lysine) (Natural Medicines).
  • On file: Vitiligo — rated "Possibly Effective" (Phenylalanine) (Natural Medicines).
  • On file: Athletic performance — rated "Possibly Effective" (Creatine) (Natural Medicines).
  • On file: Muscle strength — rated "Possibly Effective" (Creatine) (Natural Medicines).
  • On file: Sarcopenia — rated "Possibly Effective" (Creatine) (Natural Medicines).

The evidence for Trac Orange's active ingredients is mixed and incomplete. Creatine monohydrate is possibly effective for muscle strength, athletic performance, and sarcopenia (age-related muscle loss), though it is possibly ineffective for Huntington disease and osteopenia.

L-lysine is possibly effective for cold sores. L-phenylalanine is possibly effective for vitiligo but possibly ineffective for ADHD.

NADH is possibly effective for chronic fatigue syndrome. For L-arginine, folate, and several other uses of the other ingredients, the data we hold does not establish effectiveness.

Talk with your doctor or pharmacist about whether this product matches your goals.

The evidence, ingredient by ingredient L-arginine Creatine Phenylalanine Lysine Nadh

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at typical doses. L-arginine can lower blood pressure and should only be used under medical supervision because its safety for self-treatment is not well established.

Creatine is generally well tolerated in healthy adults but requires caution in people with kidney disease; dehydration, diarrhea, muscle cramps, and water retention are common side effects. L-phenylalanine can cause anxiety, insomnia, headache, nausea, and constipation.

L-lysine is generally well tolerated but high amounts may cause stomach upset and diarrhea. NADH is generally well tolerated short-term, though long-term safety data are limited.

Creatine should be avoided during pregnancy and lactation. L-phenylalanine supplements should be avoided during pregnancy and breastfeeding.

L-lysine supplement safety during pregnancy and breastfeeding is not well studied—talk with your doctor first. NADH should be avoided in pregnancy and while breastfeeding.

We have no pregnancy or breastfeeding data on file for folate in this context.

Side effects, ingredient by ingredient L-arginine Creatine Phenylalanine Lysine Nadh

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Lysine, Phenylalanine, L-arginine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; Parkinson's medications.
  • For scale: 420 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Trac Orange, double-check with your doctor or pharmacist if you take any of these: levodopa (Parkinson disease)—L-phenylalanine can reduce its effectiveness; blood pressure medications, ACE inhibitors, ARBs, or sildenafil (Viagra)—L-arginine may increase low blood pressure risk; blood thinners or antiplatelet drugs—L-arginine may increase bleeding risk; potassium-sparing diuretics or ACE inhibitors/ARBs—L-arginine may raise potassium dangerously; diabetes medications—L-arginine may lower blood sugar further; older antidepressants (MAOIs)—L-phenylalanine may trigger a dangerous blood pressure spike; baclofen—L-phenylalanine may reduce how well it works; or 5-HT4 agonists (digestive medications)—L-lysine may reduce their effects. No interactions are documented for NADH or folate in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Trac Orange may support muscle strength and athletic performance through creatine and amino acids, but it is not for everyone. If you take levodopa for Parkinson disease, blood pressure medications, blood thinners, diabetes drugs, heart medications, or older antidepressants (MAOIs), check with your doctor or pharmacist before starting—the interactions could be serious.

If you're pregnant, breastfeeding, or have kidney disease, talk it over with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Trac Orange, straight from the product label.

Brand MHP
Barcode (UPC) 666222054025
Net contents 425 g; 15 oz.
Market status On market
Date entered into DSLD Feb 23, 2012
DSLD ID 5721
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Trac Orange by MHP, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
17 Gram(s)
Maximum serving Sizes:
17 Gram(s)
Servings per container
25
UPC/BARCODE
666222054025
IngredientAmount% DV
Calories35 {Calories}--
Total Carbohydrates4 None2%
Sugar0 None--
L-Arginine4 g--
Creatine Monohydrate4 g--
L-Phenylalanine200 mg--
L-Lysine600 mg--
Folate400 mcg100%
NADH2.5 mg--

Other ingredients: Maltodextrin, Maltodextrin, Citric Acid, Guar Gum, natural and artificial Orange flavor, Sucralose, Acesulfame Potassium, Vegetable oil, Vegetable Oil, Egg Lecithin, Beta-Carotene

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take one serving (17 grams) daily, preferably pre-workout. Mix with 8 oz. of water and stir vigorously or mix in a shaker bottle.

Due to TRAC's micro-encapsulated Time Release Technology contents may suspend when mixed in water. Additional stirring may be required.

Precautions

Do not purchase if seal is broken.

Keep out of reach of children.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Protect from heat, light and moisture.

Store at 15-30(0)C (59-86(0)F).

General

89044201

General Statements

Increases Muscle Pumps* Enhances Strength* Improves Muscle Endurance* Increases Energy* Improves Blood Flow & Vascularity*

Naturally and Artificially Flavored

No Loading - No Bloating

ORANGE

Pump and Strength Maximizing Pre-Workout Formula*

Stimulant-Free ENERGY!

Sugar Free!

Time Release Technology-Patents Pending

Time-Released Nitric Oxide/Creatine

TRAC also contains the powerful stimulant-free energizer NADH (nicotinamide adenine dinucleotide), which works in conjuction with Creatine to produce ATP-the energy source for all living cells and cellular processes, including muscle contraction, metabolic reactions and the transmission of nerve impulses.

Brand IP Statement(s)

TRAC's Nitro-Loading transport is a revolutionary breakthrough in Creatine supplementation. TRAC(R) uses Arginine for the production of Nitric Oxide for maximum muscle pumps to help mediate insulin and improve Creatine transport. This patent pending combination of Arginine and Creatine helps increase Creatine transport without using excessive amounts of carbohydrates (sugar).

TRAC's patent pending pharmaceutical time-released delivery system, TRT(R), ensures optimum transport and bioavailability of Creatine, Arginine and other active substrate ingredients, and is released in the bloodstream to muscle tissue for up to 8 hours. This sustained release improves nutrient delivery to muscles as it is needed, so you can maintain peak power energy and pumps throughout your workout and continue to feed your muscles for maximum recovery.*

TRT(R) and Time Release Technology(R) are registered trademarks of Maxmimum Human Performance, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Trac Orange by MHP label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Trac Orange label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Trac Orange by MHP

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size17 Gram(s) Dosage formPowder Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 None per serving

L-Arginine

Interacts with
403 drugs
4 g per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine monograph & interactions

Creatine Monohydrate

No known
interactions
4 g per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine Monohydrate monograph & interactions

L-Phenylalanine

Interacts with
16 drugs
200 mg per serving

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitilig...

L-Phenylalanine monograph & interactions

L-Lysine

Interacts with
1 drug
600 mg per serving

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...

L-Lysine monograph & interactions

Folate

400 mcg per serving Form: Folic Acid

NADH

No known
interactions
2.5 mg per serving

NADH is the active, electron-carrying form of niacin (vitamin B3) that your body uses to make energy in cells. Some people take it as a supplement for...

NADH monograph & interactions

Other (inactive) ingredients: Maltodextrin, Maltodextrin, Citric Acid, Guar Gum, Natural and artificial Orange flavor, Sucralose, Acesulfame Potassium, Vegetable oil, Vegetable Oil, Egg Lecithin, Beta-Carotene. These complete the product’s ingredient list but are not active constituents.

Interaction report

Trac Orange by MHP Drug Interactions

Want to check YOUR meds against Trac Orange?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
420Drugs
5 Major 406 Moderate 9 Minor

Ingredients driving the most interactions

L-Arginine 403
L-Phenylalanine 16
L-Lysine 1

Individual Drug Interactions

The ingredients in Trac Orange interact with 420 drugs. Click any drug to see the details.

3 of the 7 ingredients in Trac Orange interact with drugs. Each result below shows which ingredient is responsible. L-Arginine L-Phenylalanine L-Lysine

Each ingredient & the kinds of drugs it affects

For each ingredient in Trac Orange with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

L-Phenylalanine3 drug types · 16 drugs

Levodopa

Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.

Likelihood Probable Evidence B
Baclofen

Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.

Likelihood Possible Evidence D
L-Phenylalanine full monograph & interactions

L-Lysine1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Trac Orange, from the product label.

MHP

See all MHP products
Name
Maximum Human Performance, Inc.
Street Address
21 Dwight Place
City
Fairfield
State
NJ
ZipCode
07004
Phone Number
1.888.783.8844
Web Address
www.getMHP.com
Pharmacist Counseling Corner

Trac Orange by MHP: Common Questions

Does Trac Orange by MHP interact with any medications?
Yes. Based on its ingredients, Trac Orange has a known interaction with 420 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Trac Orange contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is creatine safe if I have kidney problems?
Those with kidney issues should be careful with creatine. The facts list it as generally well tolerated in healthy adults, but caution is specifically advised for people with kidney disease. Talk with your doctor or pharmacist before taking it if you have kidney concerns.
Can I take this while pregnant or breastfeeding?
Several ingredients raise safety concerns in pregnancy and breastfeeding. Creatine should be avoided during both; L-phenylalanine supplements should be avoided during both; L-lysine and NADH lack enough safety data—check with your doctor first. We have no pregnancy or breastfeeding data on file for folate in this context either. Your doctor or pharmacist can give you personalized advice.
What side effects might I notice?
Common side effects from creatine include dehydration, diarrhea, muscle cramps, and water retention. L-phenylalanine may cause anxiety, insomnia, headache, nausea, or constipation. L-arginine can cause abdominal pain, bloating, nausea, diarrhea, headache, or flushing. L-lysine might cause abdominal pain, diarrhea, or digestive upset.
Will this help me build muscle or improve my workout?
Creatine monohydrate is possibly effective for muscle strength and athletic performance, so that ingredient may help. L-arginine has no established effectiveness rating in our data for muscle or exercise. For personalized advice on whether this product fits your fitness goals, talk with your doctor or pharmacist.
What is NADH, and what's it supposed to do?
NADH is a coenzyme form of vitamin B3 that helps your body produce energy. In this product, it is possibly effective for chronic fatigue syndrome. Long-term safety data are limited, so talk with your doctor if you have questions about long-term use.
Can I take this if I have PKU (phenylketonuria)?
No. This product contains L-phenylalanine, and people with PKU cannot safely metabolize phenylalanine. Avoid this product and talk with your doctor or pharmacist about alternatives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Trac Orange label
Go deeper

The Full Monographs Behind Trac Orange’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Phenylalanine

Interacts with 16 drugs

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...

Read the full Phenylalanine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Nadh

NADH is the active, electron-carrying form of niacin (vitamin B3) that your body uses to make energy in cells. Some people take it as a supplement for fatigue, mental sharpness, and athletic...

Read the full Nadh monograph →
Sources

Sources & How We Checked

Trac Orange's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 183 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
  15. Facchinetti, F., Longo, M., Piccinini, F., Neri, I., and Volpe, A. L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol.Investig. 1999;6(4):202-207. DOI
  16. de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
  17. Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
  18. Cartledge, J. J., Davies, A. M., and Eardley, I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU.Int. 2000;85(4):421-426.
  19. Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72(8):24-27.
  20. Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmona
  21. Stokes, G. S., Barin, E. S., Gilfillan, K. L., and Kaesemeyer, W. H. Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave. Am J Hypertens. 2003;16(9 Pt 1):719-724.
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See these in context on the L-arginine monograph →

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Phenylalanine 23 references
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Lysine 7 references
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See these in context on the Lysine monograph →

Nadh 1 reference
  1. Niacin - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source

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