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Dietary supplement

Transmax Trans-Resveratrol 500 mg Ingredients & Drug Interactions

by Biotivia

Transmax Trans-Resveratrol 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Transmax Trans-Resveratrol 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Transmax Trans-Resveratrol 500 mg is a dietary supplement by Biotivia with 1 active ingredient. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, anti-aging.Based on those ingredients, 822 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 98% Trans-Resveratrol Polygonum cuspidatum rhizome extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Transmax Trans-Resveratrol 500 mg by Biotivia

Ask about any prescription or over-the-counter medication and we check it for interactions with Transmax Trans-Resveratrol 500 mg by Biotivia — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Transmax Trans-Resveratrol 500 mg by Biotivia

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “98% Trans-Resveratrol Polygonum cuspidatum rhizome extract” is listed as a grouped ingredient — the label gives one combined amount (510 mg) without saying how much of each component you get.

This product contains one active ingredient: 500 mg of trans-resveratrol, extracted from Polygonum cuspidatum rhizome and standardized to 98% purity. Resveratrol is a polyphenol — a plant compound — that's also found naturally in red grapes and red wine.

The inactive ingredient is hydroxypropyl methyl cellulose, a common capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Resveratrol's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Antioxidant support and heart health.
  • We looked for evidence on: Cardiovascular disease (CVD), Hypercholesterolemia, Hypertension, Metabolic syndrome, Diabetes, Aging skin — and 2 related terms.
  • The closest evidence on file: Resveratrol is rated "Possibly Ineffective" for Cardiovascular disease (CVD) (Natural Medicines).
  • Also on file: Resveratrol is rated "Possibly Ineffective" for Hypercholesterolemia, Metabolic syndrome.
  • Also on file: Resveratrol is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Diabetes, Hypertension.

The evidence for resveratrol is mixed. It's rated possibly effective for obesity and allergic rhinitis (hay fever), meaning there's some promising early research but not yet solid proof.

For cardiovascular disease and high cholesterol, the data suggests it's possibly ineffective — studies haven't shown meaningful benefit so far.

The evidence, ingredient by ingredient Resveratrol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Resveratrol at typical supplement doses is generally well tolerated. At higher doses, the most common side effects are diarrhea, gastrointestinal discomfort, and loose stools.

There's one case report of a skin rash that resolved after stopping the supplement. A few patients on peritoneal dialysis reported headache, fatigue, and memory loss while taking resveratrol, though whether resveratrol caused these isn't certain.

Long-term safety at high doses isn't fully established. We don't have enough safety data to recommend this supplement during pregnancy or while breastfeeding.

Talk with your doctor or pharmacist if you're pregnant, nursing, or planning either.

Side effects, ingredient by ingredient Resveratrol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Resveratrol.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 823 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist if you're on blood thinners or antiplatelet drugs like warfarin or aspirin — resveratrol may increase bleeding risk. Also check if you take any medications metabolized by CYP2C19, CYP1A2, CYP3A4, or CYP2E1 enzymes, since resveratrol may raise their levels, though this hasn't been proven in most people.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Resveratrol may help with obesity and hay fever, though the evidence is early. If you take blood thinners, antiplatelet drugs, or medications metabolized by your liver's CYP enzymes, check your exact medications with our tool before starting.

The interaction data here is mostly theoretical — your pharmacist can tell you whether it matters for your specific prescriptions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Transmax Trans-Resveratrol 500 mg, straight from the product label.

Brand Biotivia
Barcode (UPC) 094922257659
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 33096
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Transmax Trans-Resveratrol 500 mg by Biotivia, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
094922257659
IngredientAmount% DV
98% Trans-Resveratrol Polygonum cuspidatum rhizome extract510 mg--
500 mg of Trans-Resveratrol500 mg--

Other ingredients: Hydroxypropyl methyl cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Committment to Excellence: Biotivia will not compromise in the relentless pursuit of human health.

~Unique formulation and processing technology greatly increases Bio availability.

~Manufactured in accordance with GMP standards for quality assurance. ~Protected against Oxidation by Patented Oxygen elimination active packaging system.

Bio Enhanced

Laboratory Grade! Energy! Longevity! Endurance! Weight Management!

Conforms to recent scientific studies.

LONGEVITY BIOCEUTICALS RELENTLESS DEVOTION TO HUMAN HEALTH

Brand IP Statement(s)

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Formula

Capsule shell consists of all vegetable Hydroxypropyl methyl cellulose and are Kosher, Vegan, and Halal certified.

Capsule shell consists of all vegetable Hydroxypropyl methyl cellulose and are Kosher, Vegan, and Halal certified.

Capsule shell consists of all vegetable Hydroxypropyl methyl cellulose and are Kosher, Vegan, and Halal certified.

Formulation

Capsule shell consists of all vegetable Hydroxypropyl methyl cellulose and are Kosher, Vegan, and Halal certified.

No additives, fillers or glidants.

~Contains no animal products.

Certified Vegan

No additives, fillers, GMO's or glidants.

Suggested/Recommended/Usage/Directions

Usage Instructions: For 12 years of age or older take one or two capsules before breakfast.

Precautions

Not to be used by children under the age of 12 or by pregnant or lactating women without the recommendation of one's physician.

Not to be used by children under the age of 12 or by pregnant or lactating women without the recommendation of one's physician.

Storage

Storage Instructions: Keep in cool dark place or refrigerate. Replace cap tightly after use.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

CERTIFIED VEGAN AVA American Vegan Association

FDA Statement of Identity

Dietary supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Transmax Trans-Resveratrol 500 mg by Biotivia label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Transmax Trans-Resveratrol 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Transmax Trans-Resveratrol 500 mg by Biotivia

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

98% Trans-Resveratrol Polygonum cuspidatum rhizome extract

Interacts with
822 drugs
510 mg per serving

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

98% Trans-Resveratrol Polygonum cuspidatum rhizome extract monograph & interactions

Other (inactive) ingredients: Hydroxypropyl methyl cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Transmax Trans-Resveratrol 500 mg by Biotivia Drug Interactions

Want to check YOUR meds against Transmax Trans-Resveratrol 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
822Drugs
822 Moderate

Ingredients driving the most interactions

98% Trans-Resveratrol Polygonum cuspidatum rhizome extract 822

Individual Drug Interactions

The ingredients in Transmax Trans-Resveratrol 500 mg interact with 822 drugs. Click any drug to see the details.

1 of the 1 ingredient in Transmax Trans-Resveratrol 500 mg interact with drugs. Each result below shows which ingredient is responsible. 98% Trans-Resveratrol Polygonum cuspidatum rhizome extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Transmax Trans-Resveratrol 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

98% Trans-Resveratrol Polygonum cuspidatum rhizome extract5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
98% Trans-Resveratrol Polygonum cuspidatum rhizome extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Transmax Trans-Resveratrol 500 mg, from the product label.

Biotivia

See all Biotivia products
Name
Biotivia LLC
Street Address
2503D N. Harrison Street, #13
City
Arlington
State
VA
ZipCode
22207
Phone Number
1-866-459-2773
Web Address
www.Biotivia.com
Pharmacist Counseling Corner

Transmax Trans-Resveratrol 500 mg by Biotivia: Common Questions

Does Transmax Trans-Resveratrol 500 mg by Biotivia interact with any medications?
Yes. Based on its ingredients, Transmax Trans-Resveratrol 500 mg has a known interaction with 822 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Transmax Trans-Resveratrol 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is resveratrol, and where does it come from?
Resveratrol is a plant compound called a polyphenol. This product extracts it from Polygonum cuspidatum rhizome (Japanese knotweed root) and standardizes it to 98% purity. You'll also find resveratrol naturally in red grapes and red wine, but in much smaller amounts.
Can I take this if I'm pregnant or breastfeeding?
We don't have enough safety data to say it's okay. Talk with your doctor or pharmacist before using it if you're pregnant, nursing, or planning to become pregnant.
What side effects might I experience?
At typical doses, resveratrol is usually well tolerated. Higher doses may cause diarrhea, loose stools, or digestive discomfort. Rarely, a skin rash or headache has been reported. If you notice anything unusual, stop and talk to your pharmacist.
Does resveratrol really help with weight loss or allergies?
The evidence is promising but not definitive. Resveratrol is rated possibly effective for both obesity and hay fever, meaning there's some early research support, but we don't have solid proof yet.
Is this the same as red wine or grape seed extract?
No. Red wine and grapes contain resveratrol naturally, but in tiny amounts. This product is a concentrated extract — 500 mg per capsule — much higher than you'd get from food. That's why it carries different safety and interaction considerations.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Transmax Trans-Resveratrol 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Transmax Trans-Resveratrol 500 mg label
Go deeper

The Full Monographs Behind Transmax Trans-Resveratrol 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Resveratrol

Interacts with 822 drugs

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...

Read the full Resveratrol monograph →
Sources

Sources & How We Checked

Transmax Trans-Resveratrol 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Resveratrol 24 references
  1. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113.
  2. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  3. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  4. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  5. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  6. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  7. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  8. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  9. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  10. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  11. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  12. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  13. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  14. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  15. la, Porte C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D., Singhal, N., and Cameron, D. W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Cli PubMed
  16. Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive
  17. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
  18. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
  19. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
  20. Lin CT, Sun XY, Lin AX. Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study. Ren Fail. 2016;38(2):214-21. PubMed
  21. Li Q, Yang G, Xu H, Tang S, Lee WY. Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther 2021;21(1):214. PubMed
  22. McCreary MR, Schnell PM, Rhoda DA. Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19). Sci Rep 2022;12(1):10978. PubMed
  23. Abdelhaleem IA, Brakat AM, Adayel HM, Asla MM, Rizk MA, Aboalfetoh AY. The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis. Med Clin (Barc) 2022;158(12):576-585. PubMed
  24. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Contact Dermatitis 2022.

See these in context on the Resveratrol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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