Triphala Ingredients & Drug Interactions
by Herbadiet
What is this page for?
First and foremost: checking Triphala against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Triphala is a dietary supplement by Herbadiet with 3 active ingredients. Its ingredients are commonly taken for antioxidant support, cholesterol and heart health, immune support.Based on those ingredients, 933 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bibhitaki (Bahera) fruit powder, Amalaki (Amla) fruit powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Triphala by Herbadiet
Ask about any prescription or over-the-counter medication and we check it for interactions with Triphala by Herbadiet — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Triphala by Herbadiet
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Triphala is a traditional Ayurvedic blend of three dried fruit powders: amalaki (Indian gooseberry), bibhitaki (Terminalia bellirica), and haritaki (Terminalia chebula). This product has 3 active ingredients and no inactive fillers or excipients listed.
Each fruit brings its own phytochemicals—tannins, vitamin C, and other compounds—that are thought to work together as a digestive and detoxifying agent in traditional medicine. Western research has focused mainly on amalaki and bibhitaki; haritaki's chemistry hasn't been formally checked in our data.
Does it work?
Couldn't assess
The evidence for Triphala or its individual fruits is limited in the studies we hold. Amalaki shows possibly effective ratings for GERD (gastroesophageal reflux disease, or acid reflux) and dyslipidemia (abnormal blood lipids), but the other conditions studied—high cholesterol, hair loss—lack reliable evidence to rate.
Bibhitaki's effectiveness for obesity, high blood pressure, high cholesterol, and angina is rated insufficient evidence to rate. We don't hold effectiveness data for haritaki on file.
How safe is it?
Well-documented data
Amalaki is generally well tolerated when used as a food, though supplement-dose safety is less studied. A small number of trial participants reported upset stomach (epigastric discomfort), fatigue, or muscle and joint pain, but these were uncommon.
Bibhitaki is generally well tolerated short-term in studies, though long-term safety varies by product quality. During pregnancy, the safety data advises against using amalaki and bibhitaki because there isn't enough information to know they're safe.
The same applies to breastfeeding. No safety data on file covers haritaki in pregnancy or while breastfeeding.
Talk with your doctor or pharmacist before using this product if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before taking Triphala, check with your doctor or pharmacist if you take blood thinners (anticoagulants) or antiplatelet drugs like clopidogrel (Plavix), aspirin, diabetes medications, the muscle relaxant chlorzoxazone (Parafon Forte, Paraflex), the acid reducer omeprazole (Prilosec), or any drug your liver metabolizes through the CYP3A4, CYP2D6, or CYP2C9 enzymes—all carry moderate-severity interactions with this product's ingredients.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Triphala is traditionally used for digestion and detoxification, but it carries moderate-severity interactions with blood thinners, diabetes drugs, aspirin, and several other medications—and its individual ingredients can slow how your liver processes a wide range of drugs. If you take any prescription medication, especially blood thinners or diabetes pills, check your exact drugs with the tool on this page before starting.
Talk with your doctor or pharmacist to see if it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Triphala, straight from the product label.
| Brand | Herbadiet |
|---|---|
| Net contents | 0 Not Present |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2021 |
| DSLD ID | 243627 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Triphala by Herbadiet, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amalaki (Amla) fruit powder | 667 mg | -- |
| Bibhitaki (Bahera) fruit powder | 667 mg | -- |
| Haritaki (Harad) fruit powder | 667 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Standardized powder derived from Emblica officinalis, Terminalia bellirica & Terminali chebula fruit
Formulation
Rejuvenates body & enhances immunity
No sugar, no artificial colors, no artificial flavors, no sodium, no wheat, no gluten, no soy, no dairy, no yeast.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take up to 4000mg daily, or as directed by physician.
Precautions
Keep out of reach of children.
Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women, consult your physician before use.
Keep of reach of children
Storage
Store in a dry, cool & dark.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Triphala by Herbadiet label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Triphala by Herbadiet
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Gram(s) Dosage formPowder Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Amalaki (Amla) fruit powder
Interacts with208 drugs
Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion...
Amalaki (Amla) fruit powder monograph & interactionsBibhitaki (Bahera) fruit powder
Interacts with933 drugs
Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes....
Bibhitaki (Bahera) fruit powder monograph & interactionsHaritaki (Harad) fruit powder
Triphala by Herbadiet Drug Interactions
HelloPharmacist Interaction Report
Triphala by Herbadiet contains three fruit powders, and two of them—amalaki and bibhitaki—carry documented interactions with medications.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs: amalaki may increase bleeding risk by reducing how quickly your blood clots, an effect seen in clinical trials at moderate severity.
Read the full breakdown — every affected drug type, severity by severity
Amalaki also interacts with diabetes medications and aspirin at moderate severity, raising the risk of low blood sugar (hypoglycemia) and bleeding. Clopidogrel (Plavix), a blood thinner, faces the same moderate bleeding risk from amalaki as other antiplatelet drugs.
Bibhitaki adds a different layer of concern: it may slow how your liver breaks down certain medications through enzyme inhibition (CYP3A4, CYP2D6, and CYP2C9 substrates), potentially raising their blood levels and side effects—all moderate severity. It also interacts with anticoagulants, antidiabetes drugs, chlorzoxazone (a muscle relaxant), and omeprazole (an acid reducer), again at moderate severity.
Altogether, these interactions span 934 individual medications.
We could not check haritaki for interactions—no data is on file for it. Use the medication checker on this page to look up your exact drugs before starting this product, and talk with your doctor or pharmacist about whether it's right for you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Triphala?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Triphala interact with 933 drugs. Click any drug to see the details.
2 of the 3 ingredients in Triphala interact with drugs. Each result below shows which ingredient is responsible. Bibhitaki (Bahera) fruit powder Amalaki (Amla) fruit powder
ChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Triphala — through 2 ingredients. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 2d6 (cyp2d6) Substrates, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Chlorpropamide interactionAmalaki (amla) Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Amalaki (amla) Fruit Powder + Chlorpropamide interactionChlorzoxazoneParaflex, Parafon Forte DSC
How Chlorzoxazone interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderChlorzoxazone (parafon Forte, Paraflex) Moderate
Interaction Summary
Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.
Read the full Bibhitaki (bahera) Fruit Powder + Chlorzoxazone interactionCiclesonideAlvesco, Omnaris, Zetonna
How Ciclesonide interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Ciclesonide interactionCilostazolPletal
How Cilostazol interacts with Triphala — through 2 ingredients. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Bibhitaki (bahera) Fruit Powder + Cilostazol interactionAmalaki (amla) Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Amalaki (amla) Fruit Powder + Cilostazol interactionCisapridePropulsid
How Cisapride interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Cisapride interactionCitalopramCelexa
How Citalopram interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Citalopram interactionClarithromycinBiaxin, Biaxin XL
How Clarithromycin interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Clarithromycin interactionClindamycinCleocin, Cleocin T Gel, ClindaMax, Clindesse, Dalacin C
How Clindamycin interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Clindamycin interactionClomipramineAnafranil, Anafranil SR
How Clomipramine interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Clomipramine interactionClonazepamCeberclon, Klonopin, Rivotril
How Clonazepam interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Clonazepam interactionClopidogrelPlavix
How Clopidogrel interacts with Triphala — through 2 ingredients. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Clopidogrel interactionAmalaki (amla) Fruit PowderAnticoagulant/antiplatelet Drugs, Clopidogrel (plavix) Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Amalaki (amla) Fruit Powder + Clopidogrel interactionClozapineClozaril, Versacloz
How Clozapine interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Clozapine interactionCobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide FumarateGenvoya
How Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interactionCobimetinib FumarateCotellic
How Cobimetinib Fumarate interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Cobimetinib Fumarate interactionCocaine Hydrochloride (prescription Drug)Goprelto, Numbrin
How Cocaine Hydrochloride (prescription Drug) interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Cocaine Hydrochloride (prescription Drug) interactionCodeine PhosphateCodeine
How Codeine Phosphate interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Codeine Phosphate interactionCodeine Phosphate, GuaifenesinBrontex, Robitussin AC
How Codeine Phosphate, Guaifenesin interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Codeine Phosphate, Guaifenesin interactionCodeine Phosphate, PseudoephedrineKg Fed, Nucofed
How Codeine Phosphate, Pseudoephedrine interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Codeine Phosphate, Pseudoephedrine interactionCodeine Phosphate, Pseudoephedrine, TriprolidineCoActifed
How Codeine Phosphate, Pseudoephedrine, Triprolidine interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Codeine Phosphate, Pseudoephedrine, Triprolidine interactionCodeine SulfateCodeine Sulfate
How Codeine Sulfate interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Codeine Sulfate interactionCodeine, PapaverineCopavin
How Codeine, Papaverine interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Codeine, Papaverine interactionCodeine, ParacetamolCo-codamol
How Codeine, Paracetamol interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Codeine, Paracetamol interactionColchicineColchicine, Colcrys, Colsalide Improved, Gloperba, Lodoco, Mitigare
How Colchicine interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Colchicine interactionColchicine, ProbenecidColBenemid
How Colchicine, Probenecid interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Colchicine, Probenecid interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Conjugated Estrogens, Methyltestosterone interactionCopanlisibAliqopa
How Copanlisib interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Copanlisib interactionCrinecerfontCrenessity
How Crinecerfont interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Bibhitaki (bahera) Fruit PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Bibhitaki (bahera) Fruit Powder + Crinecerfont interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Triphala with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Bibhitaki (Bahera) fruit powder
Anticoagulant/Antiplatelet Drugs
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
In vitro, Terminalia arjuna bark extract inhibits platelet aggregation, decreases platelet activation, and shows antithrombotic properties.
Antidiabetes Drugs
Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Animal and in vitro research shows that Terminalia bellirica and Terminalia chebula fruit and seed extract have hypoglycemic effects.
Chlorzoxazone (Parafon Forte, Paraflex)
Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of chlorzoxazone increases blood levels of chlorzoxazone and decreases chlorzoxazone clearance. It is speculated that Terminalia chebula reduces the metabolism of chlorzoxazone by inhibiting cytochrome P450 2E1.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2C9 enzymes and reduces CYP2C9 substrate metabolism.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2D6 enzymes and reduces CYP2D6 substrate metabolism.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP3A4 enzymes and reduces CYP3A4 substrate metabolism.
Omeprazole (Prilosec)
Theoretically, use of Terminalia chebula may increase the risk of adverse effects from omeprazole.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of omeprazole increases blood levels of omeprazole and decreases omeprazole clearance. It is speculated that Terminalia chebula reduces the metabolism of omeprazole by inhibiting cytochrome P450 2C19.
Amalaki (Amla) fruit powder
Anticoagulant/Antiplatelet Drugs
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking Indian gooseberry 500 mg along with clopidogrel 75 mg or ecosprin 75 mg, as a single dose or for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg or ecosprin 75 mg alone. Until more is known, use caution when taking Indian gooseberry in combination with anticoagulant/antiplatelet drugs.
Antidiabetes Drugs
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking Indian gooseberry fruit or fruit extract alone or in conjunction with antidiabetes medications can lower blood glucose levels. Dose adjustments to diabetes medications might be necessary.
Aspirin
Theoretically, Indian gooseberry may increase the risk of bleeding if used with aspirin; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with ecosprin 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus ecosprin 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with ecosprin 75 mg alone.
Clopidogrel (Plavix)
Theoretically, Indian gooseberry may increase the risk of bleeding if used with clopidogrel; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with clopidogrel 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus clopidogrel 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg alone.
Brand information
Manufacturer and brand details for Triphala, from the product label.
Herbadiet
See all Herbadiet products- Name
- Arkure Health Care
- Street Address
- 11, Sector - 14
- City
- Rohtak
- State
- Haryana
- ZipCode
- 124001
- Web Address
- www.herbadiet.in
Triphala by Herbadiet: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Triphala’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Indian Gooseberry
Interacts with 208 drugsIndian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some u...
Read the full Indian Gooseberry monograph → Herb & supplement monographTerminalia
Interacts with 933 drugsTerminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes. Some small studies suggest possible ben...
Read the full Terminalia monograph →Sources & How We Checked
Triphala's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 15 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Indian Gooseberry 6 references
- Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
- Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed
- Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro
- Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-16.
- Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed
- Majeed M, Mundkur L, Paulose S, Nagabhushanam K. Novel Emblica officinalis extract containing ß-glucogallin vs. metformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia. Food Fu
Terminalia 9 references
- Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
- Rao, N. K. and Nammi, S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC.Complement Altern.Med 2006;6:17. PubMed
- Murali, Y. K., Anand, P., Tandon, V., Singh, R., Chandra, R., and Murthy, P. S. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced
- Senthilkumar, G. P. and Subramanian, S. Evaluation of antioxidant potential of Terminalia chebula fruits studies in streptozotocin-induced diabetic rats. Pharmaceutical Biology (Netherlands) 2007;45:511-518.
- Malik N, Dhawan V, Bahl A, Kaul D. Inihbitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease. Platelets. 2009;20(3):183-1190.
- Varghese A, Savai J, Pandita N, Gaud RS. In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin, and arjungenin on CYP3A4, CYP2D6, and CYP2C9 enzyme activity in human liver microsomes. Toxicology Reports. 2015(2):806-16. PubMed
- Wu G, Dong Z, Dong J, et al. Effects of mongolian medicine Terminalia chebula Retz. on 6 CYP450 enzymes in rats. Int J Clin Exp Pathol 2020;13(12):3128-3138.
- Das A, Naveen J, Sreerama YN, Gnanesh Kumar BS, Baskaran V. Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit a-amylase, a-glucosidase and DPP-IV activity in high fat and low dose st
- Eltimamy M, Elshamarka M, Aboelsaad M, Sayed M, Moawad H. Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats. J Diabetes Metab Disord 2022;21(1):159-170. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC