Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Triple Potency Liver Ingredients & Drug Interactions

by Healthy 'N Fit

Triple Potency Liver label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Triple Potency Liver against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Triple Potency Liver is a dietary supplement by Healthy 'N Fit with 5 active ingredients. Its ingredients are commonly taken for high cholesterol, vitamin b3 deficiency (pellagra), heart health support.Based on those ingredients, 749 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Niacin, Vitamin B12, Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Triple Potency Liver by Healthy 'N Fit

Ask about any prescription or over-the-counter medication and we check it for interactions with Triple Potency Liver by Healthy 'N Fit — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Triple Potency Liver by Healthy 'N Fit

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Triple Potency Liver contains 4 active ingredients: niacin, vitamin B12, choline, and riboflavin. Niacin is a B vitamin that your body uses for energy and cell repair, though at high supplement doses it's also used to help manage cholesterol and blood pressure.

Vitamin B12 supports your nervous system and helps your body make red blood cells and DNA. Choline is a nutrient needed for cell membranes and brain function.

Riboflavin, another B vitamin, helps your body convert food into energy. The product also contains several inactive ingredients, including a desiccated beef liver extract, along with common tablet fillers and binders.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Complete protein and amino acids for athletes.
  • We looked for evidence on: Athletic performance, Physical performance, Muscle recovery, Strength training support, Endurance performance.
  • The closest evidence on file: Choline is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Ineffective" for Physical performance.
  • Also on file: Niacin is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

Niacin is likely effective for preventing and treating pellagra (a disease from severe niacin deficiency), and possibly effective for improving cholesterol and fat levels in people with HIV/AIDS-related dyslipidemia and metabolic syndrome. Vitamin B12 is effective for treating B12 deficiency and Imerslund-Grasbeck disease, likely effective for cyanide poisoning, and possibly effective for canker sores and postherpetic neuralgia (nerve pain after shingles).

For choline and riboflavin, the evidence we hold doesn't establish effectiveness for the conditions listed — choline shows insufficient reliable evidence for most uses, and riboflavin has no effectiveness ratings on file. Talk with your pharmacist about whether this product matches what you're actually looking to address.

The evidence, ingredient by ingredient Niacin Vitamin B12 Choline Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Niacin in normal dietary amounts is safe, but high-dose supplements like those in this product can cause flushing (warmth and redness of the face and upper body), stomach upset, and at higher doses, liver problems. Up to 70% of people taking niacin for treatment report flushing.

The most common side effects are flushing, gastrointestinal distress (nausea, vomiting, heartburn, abdominal pain, constipation, or diarrhea), and elevated liver enzymes; rare but serious effects include liver damage, muscle breakdown, and low platelet counts. Vitamin B12 is generally well tolerated orally with no established upper limit — your body removes excess in urine.

Choline is safe in food amounts but at high supplement doses (over 3.5 grams daily) can cause fishy body odor, nausea, vomiting, and diarrhea. Riboflavin is very safe; excess is removed in urine, though high doses may cause nausea and bright yellow urine.

Niacin, vitamin B12, and choline are rated likely safe in pregnancy and lactation at recommended amounts, but high-dose niacin should be avoided during pregnancy unless prescribed; check with your doctor before using any high-dose supplements.

Side effects, ingredient by ingredient Niacin Vitamin B12 Choline Riboflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Choline, Niacin, Vitamin B12, Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 750 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take any blood pressure medications, diabetes medications, blood thinners or antiplatelet drugs, cholesterol-lowering statins, gout medications (allopurinol or probenecid), bile acid sequestrants for cholesterol, medications that affect your liver, metformin, tetracycline antibiotics, or atropine. Most of these interactions are Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for people who want to support liver function with B vitamins and choline, and it's specifically useful if you have a niacin or B12 deficiency. You should be careful if you take blood pressure medications, diabetes drugs, blood thinners, statins, gout medications, tetracycline antibiotics, or metformin.

Talk with your pharmacist before starting — the niacin in particular has enough interactions that a quick medication check is worth your time.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Triple Potency Liver, straight from the product label.

Brand Healthy 'N Fit
Barcode (UPC) 799750001466
Net contents 250 Tablet(s)
Market status On market
Date entered into DSLD Feb 23, 2016
DSLD ID 56984
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Triple Potency Liver by Healthy 'N Fit, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Tablet(s)
Maximum serving Sizes:
4 Tablet(s)
Servings per container
62
UPC/BARCODE
799750001466
IngredientAmount% DV
Calories20 {Calories}--
Calories from Fat0 {Calories}--
Niacin60 NP30%
Protein5 Gram(s)--
Vitamin B12100 mcg1667%
Total Fat0 Gram(s)--
Choline60 mg--
Riboflavin300 mcg18%

Other ingredients: desiccated defatted Beef Liver extract, Microcrystalline Cellulose, Glucose Polymers, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Silica, Food Glaze, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Triple Potency Liver contains 6000 mgs of the Highest Quality 100% Pure Argentine Beef Liver, which is Hormone-Free and Defatted.

For decades, Triple Potency Liver has played an important role in the supplement regimens of many athletes, bodybuilders, and those seeking to add extra high quality complete protein/amino acids and important nutrients to their diet.

CONTAINING 100% BEEF PROTEIN/AMINO ACIDS

Naturally high in Vitamins and Minerals including blood-building Iron, plus fortified with a mega dose of Vitamin B-12

~ LOADED WITH BCAA’S, EAA’S, AND B VITAMINS ~ MADE FROM DEFATTED HORMONE FREE ARGENTINE BEEF LIVER

Formulation

Triple Potency Liver contains 6000 mgs of the Highest Quality 100% Pure Argentine Beef Liver, which is Hormone-Free and Defatted.

Triple Potency Liver is produced under low heat to help preserve the extensive nutrient profile, and contains NO added hormones. It is also important to note that Triple Potency Liver contains no fillers (such as whey, gelatin, or collagen) as seen in competing brands, and is triple the potency of other liver tablets at a very affordable price.

Brand IP Statement(s)

Triple Potency Liver is an excellent source of naturally occurring vitamins, minerals, and other nutrients.

2014, 1980 HEALTHY ‘N FIT INTERNATIONAL INC.

Healthy ‘N Fit has Developed and Implemented More Successful Technologies Than Any Other Brand in Over a Dozen Product Categories

General Statements

AMINO ACID PROFILE Typical Analysis, mgs per 100g of protein Alanine 5790 mg Arginine 6205 mg Aspartic acid 9485 mg Cystine 1810 mg Glutamic acid 12785 mg Glycine 5810 mg Histidine 3015 mg Isoleucine^ (BCAA) 4735 mg Leucine^ (BCAA) 9450 mg Lysine^ 8035 mg Methionine^ 2615 mg Phenylalanine^ 5340 mg Proline 4700 mg Serine 4415 mg Threonine^ 4245 mg Tryptophan^ (naturally occurring) 1315 mg Tyrosine 4005 mg Valine^ (BCAA) 6245 mg ^Essential Amino Acids

~ NUTRITIONALLY SUPPORTS ANABOLISM AND RECOVERY

MORE CONCENTRATED THAN STEAK

THE QUALITY AND POTENCY OF THIS PRODUCT HAS BEEN LABORATORY TESTED AND ASSAYED

This is a natural product and the appearance may vary. A proper diet and exercise program are essential for reaching your training goals.

USA DIST.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

ADVANCED DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, beginner or intermediate athletes should take 1 serving (4 tablets) daily. Advanced athletes should take 1-2 servings (4-8 tablets) daily. Best when taken between meals or after workouts to help maintain a positive nitrogen balance and anabolic activity.

Precautions

As a reminder, it is always recommended to check with your physician before taking any dietary supplements, changing your diet, or starting an exercise program, especially if you are pregnant, nursing, taking any medications, or have a medical condition.

This product is formulated for adults, KEEP OUT OF THE REACH OF CHILDREN.

If this product or any product does not agree with you, stop taking them.

Storage

Store in a cool, dry place. Do not refrigerate.

General

14660914US

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Triple Potency Liver by Healthy 'N Fit label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Triple Potency Liver label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Triple Potency Liver by Healthy 'N Fit

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container62 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Niacin

Interacts with
727 drugs
60 NP per serving

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

Protein

5 Gram(s) per serving

Vitamin B12

Interacts with
20 drugs
100 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Choline

Interacts with
16 drugs
60 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Riboflavin

Interacts with
20 drugs
300 mcg per serving

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Other (inactive) ingredients: Desiccated defatted Beef Liver extract, Microcrystalline Cellulose, Glucose Polymers, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Silica, Food Glaze, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Triple Potency Liver by Healthy 'N Fit Drug Interactions

Want to check YOUR meds against Triple Potency Liver?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
749Drugs
733 Moderate 16 Minor

Ingredients driving the most interactions

Niacin 727
Vitamin B12 20
Riboflavin 20
Choline 16

Individual Drug Interactions

The ingredients in Triple Potency Liver interact with 749 drugs. Click any drug to see the details.

4 of the 5 ingredients in Triple Potency Liver interact with drugs. Each result below shows which ingredient is responsible. Niacin Vitamin B12 Riboflavin Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Triple Potency Liver with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Niacin full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Triple Potency Liver, from the product label.

Healthy 'N Fit

See all Healthy 'N Fit products
Name
Healthy 'N Fit International, Inc.
State
NY
Phone Number
800-338-5200
Web Address
www.behealthynfit.com
Pharmacist Counseling Corner

Triple Potency Liver by Healthy 'N Fit: Common Questions

Does Triple Potency Liver by Healthy 'N Fit interact with any medications?
Yes. Based on its ingredients, Triple Potency Liver has a known interaction with 749 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Triple Potency Liver contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this cause the flushing I've heard about with niacin?
Flushing is common — up to 70% of people taking niacin for treatment experience it. It's a warmth and redness of the face and upper body caused by blood vessel dilation. It's more common at higher doses and may be worse with time-release niacin. You can try taking it with food or an antacid, and it usually improves within two weeks, but flushing can happen even at lower doses.
Is this safe if I'm pregnant or breastfeeding?
Niacin, vitamin B12, choline, and riboflavin are all rated likely safe at normal recommended amounts during pregnancy and lactation. However, high-dose niacin should be avoided unless your doctor prescribes it, and you should check with your provider before using any high-dose supplements.
Can this product damage my liver?
Niacin has been associated with liver toxicity, especially at high supplement doses — the risk is higher with sustained-release forms. It's also theoretically risky if you take other drugs that stress the liver. Your doctor can monitor your liver enzymes if you use this product, and you should report any unusual tiredness, yellowing of skin or eyes, or dark urine.
What does each ingredient actually do in this product?
Niacin supports energy and cell repair and is used at higher doses for cholesterol and blood pressure. Vitamin B12 maintains your nervous system, helps make red blood cells, and supports DNA. Choline is needed for cell membranes and brain function. Riboflavin helps convert food into energy. All four are B vitamins that support basic body functions.
Will this work for liver support?
The effectiveness data we hold doesn't cover whether these specific ingredients support liver health in the way marketing claims. We know niacin and the B vitamins have defined roles in your body, but we'd need more evidence to confirm whether this product does what it claims for liver function specifically. Ask your pharmacist whether it matches your actual health goal.
Why does my urine turn bright yellow after taking this?
That's the riboflavin. High doses of riboflavin cause bright yellow urine as excess is removed by your kidneys — it's harmless and should fade when you stop or lower your dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Triple Potency Liver label
Go deeper

The Full Monographs Behind Triple Potency Liver’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

Triple Potency Liver's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 115 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Niacin 66 references
  1. Garg R, Malinow MR, Pettinger M, et al. Niacin treatment increases plasma homocysteine levels. Am Heart J 1999;138:1082-7.
  2. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  3. Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987;2:10-32. PubMed
  4. Guyton JR, Blazing MA, Hagar J, et al. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group. Arch Intern Med 2000;160:1177-84. PubMed
  5. Gibbons LW, Gonzalez V, Gordon N, Grundy S. The prevalence of side effects with regular and sustained-release nicotinic acid. Am J Med 1995;99:378-85. PubMed
  6. Whelan AM, Price SO, Fowler SF, Hainer BL. The effect of aspirin on niacin-induced cutaneous reactions. J Fam Pract 1992;34:165-8.
  7. Jungnickel PW, Maloley PA, Vander Tuin EL, et al. Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions. J Gen Intern Med 1997;12:591-6. PubMed
  8. Capuzzi DM, Guyton JR, Morgan JM, et al. Efficacy and safety of an extended-release niacin (Niaspan): a long-term study. Am J Cardiol 1998;82:74-81;disc. 85U-6U. PubMed
  9. Gray DR, Morgan T, Chretien SD, Kashyap ML. Efficacy and safety of controlled-release niacin in dyslipoproteinemic veterans. Ann Intern Med 1994;121:252-8. PubMed
  10. McKenney JM, Proctor JD, Harris S, Chinchili VM. A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients. JAMA 1994;271:672-7. DOI
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Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
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  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
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  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
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  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
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  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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