Interactions on record — worth a quick check against your medications. Based on 2 of 7 ingredients. Check your meds →
Dietary supplement

TropinexAQ Ingredients & Drug Interactions

by Image Sports

TropinexAQ label
See full label image
Tablet Or Pill Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TropinexAQ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TropinexAQ is a dietary supplement by Image Sports with 7 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 1,083 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3, Pueraria thumbergiana B.. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TropinexAQ by Image Sports

Ask about any prescription or over-the-counter medication and we check it for interactions with TropinexAQ by Image Sports — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of TropinexAQ by Image Sports

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 7 active ingredients.
  • “Body and Mind Matrix(TM) (Proprietary Blend)” is a proprietary blend — the label gives one combined amount (855 mg) without saying how much of each component you get.
  • “Pituitary Growth Matrix(TM) (Proprietary Blend)” is a proprietary blend — the label doesn't break down how much of each component you get.

TropinexAQ contains 7 ingredients: vitamin D3 for bone and calcium regulation; Pueraria thumbbergiana (kudzu), a plant traditionally used for various conditions; and five others — Alseodaphne andersonii, Alstonia macrophylla, Sambucus australis, Eucommiae cortex, and Ficus bengalensis — which we cannot fully describe because we don't hold detailed data on them. The tablet also contains several inactive ingredients (fillers, binders, and capsule materials) including calcium carbonate, cellulose, magnesium stearate, and others that aid tablet formation and stability.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Lean muscle, body fat, skin, energy, well-being.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle strength, Menopausal symptoms, Body composition, Physical stamina — and 2 related terms.
  • The closest evidence on file: Kudzu is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Kudzu is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms.
  • Also on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength, Exercise-induced muscle damage.

Vitamin D3 is effective for treating vitamin D deficiency conditions including familial hypophosphatemia, osteomalacia (soft bones from vitamin D lack), renal bone disease, rickets, and hypoparathyroidism. Kudzu is possibly effective for alcohol use disorder but has insufficient reliable evidence for hay fever, angina, back pain, and other uses.

We don't hold effectiveness data for the other ingredients in this product.

The evidence, ingredient by ingredient Vitamin D Kudzu

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D3 is generally well tolerated at recommended doses, though very high doses taken over time can cause toxicity — symptoms include high blood calcium (hypercalcemia), bone loss in adults, and slow growth in children. It's often used during pregnancy and breastfeeding at normal amounts, but only under your doctor's guidance.

Kudzu is generally well tolerated short-term but long-term safety isn't established; it should be avoided in pregnancy because of possible hormone-like effects and insufficient safety data for breastfeeding. Clinical trials of kudzu reported nausea, indigestion, bloating, hives, and dizziness at rates no higher than placebo, though rare allergic reactions have been reported.

Side effects, ingredient by ingredient Vitamin D Kudzu

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Kudzu, Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,084 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking TropinexAQ, double-check with your pharmacist if you take thiazide water pills, heart-rhythm drugs (verapamil, diltiazem, digoxin), atorvastatin, blood thinners or antiplatelet drugs, estrogen or tamoxifen, methotrexate, diabetes medications, caffeine-containing products, or any drug that's toxic to the liver. These are Moderate-severity interactions at minimum.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

TropinexAQ is designed for growth and hormonal support using vitamin D3 and kudzu, but it carries substantial interaction potential — especially if you take heart rhythm drugs, blood thinners, diabetes medications, or estrogen therapy. Talk to your pharmacist before starting, particularly if you're on any prescription medication or have liver concerns.

If you're pregnant or breastfeeding, check with your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TropinexAQ, straight from the product label.

Brand Image Sports
Barcode (UPC) 859123003067
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18329
Product type Botanical With Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TropinexAQ by Image Sports, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
859123003067
IngredientAmount% DV
Vitamin D3450 IU113%
Body and Mind Matrix(TM) (Proprietary Blend)855 mg--
Alseodaphne andersonii0 NP--
Alstonia macrophylla W.0 NP--
Sambucus australis0 NP--
Pituitary Growth Matrix(TM) (Proprietary Blend)0 NP--
Ficus bengalensis0 NP--
Pueraria thumbergiana B.0 NP--
Eucommiae cortex0 NP--

Other ingredients: Calcium Carbonate, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Natural & Artificial flavor, Zanthoxylum piperitum, Triacetin, Maltodextrin, Hydroxypropyl Methylcellulose, Starch, Dextrose, Sodium Carboxymethylcellulose, Titanium Dioxide, Polydextrose, Talc, FD&C Blue No. 2, Mica-based Pearlescent Pigment, Medium Chain Triglycerides, Soy Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

i

R.E.A.L

General Statements

Beneficial Effects Associated With Optimal Growth Factor Levels: Increased Lean Muscle* Decreased Body Fat* Healthier / Youthful Appearing Skin* Enhanced Energy and Stamina* Improved Overall Well-being*

450I.U.

{Growth Factor Releasing Peptides (AQ)}

Recombinant Endothelium Active Liposomal When combined with a proper exercise and nutrition regimen. Statements based on early-stage independent 3rd party in vivo and / or in vitro model scientific research data findings.

Increased (GFr) and insulin-like growth factor 1 (IGF-1) levels are desirable for those looking to improve physique. Growth factor peptide-releasing agents have been shown to support immune function, particularly in advanced subjects, as well as anti-aging effects.* Bodybuilders and athletes utilize (GFr) agents, along with their nutrition and training regimens, in an effort to build more muscle and burn fat.* To promote anabolism, optimally dose in the morning, on an empty stomach.*

PLATINUM EDITION INCLUDES FREE WELLNESS NUTRITION PLAN

Precautions

Keep this product and all supplements out of the reach of children.

Please read entire label before use.

Warnings: Not intended for use by persons under age 18.

Do not exceed recommended dose.

Do not exceed recommended dose. Get the consent of a licensed physician before using this product, especially if you are taking medication, have a medical condition, you are pregnant, nursing or thinking about becoming pregnant.

Storage

DO NOT REFRIGERATE

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

General

Rev. 01-001-TAQ001 12/11

Brand IP Statement(s)

Who is TropinexAQ(TM) for? Growth Factor Releasing Peptide – TropinexAQ(TM) is a peptide-releasing matrix, developed to modulate the pituitary growth family.* Constituent studies show that the agents in this matrix can provide a strong effect on growth factor release (GFr) in a specific and dose-related manner.* Research demonstrates that Growth Factor peptide-releasing agents influence targeted signaling pathway(s) to promote growth factor secretion.*

How does TropinexAQ(TM) work? TropinexAQ(TM) may help to promote and support an increase in strength, muscle mass, body fat loss, promote healthy joints, connective tissue and bone mass.* Healthy growth factor secretion also can lead to the liver secreting more (IGF-1), a protein which is indicated to be a primary anabolic mechanism of action for (GFr).*

Suggested/Recommended/Usage/Directions

Suggested Use: Take one (1) tablet in the morning on an empty stomach or as directed by a qualified healthcare practitioner. Not designed to be cycled — take daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TropinexAQ by Image Sports label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TropinexAQ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TropinexAQ by Image Sports

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D3

Interacts with
715 drugs
450 IU per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

Body and Mind Matrix(TM) (Proprietary Blend)

855 mg per serving
  • › Alseodaphne andersonii
  • › Alstonia macrophylla W.
  • › Sambucus australis

Pituitary Growth Matrix(TM) (Proprietary Blend)

0 NP per serving

Other (inactive) ingredients: Calcium Carbonate, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Natural & Artificial flavor, Zanthoxylum piperitum, Triacetin, Maltodextrin, Hydroxypropyl Methylcellulose, Starch, Dextrose, Sodium Carboxymethylcellulose, Titanium Dioxide, Polydextrose, Talc, FD&C Blue No. 2, Mica-based Pearlescent Pigment, Medium Chain Triglycerides, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

TropinexAQ by Image Sports Drug Interactions

Want to check YOUR meds against TropinexAQ?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,083Drugs
580 Moderate 503 Minor

Ingredients driving the most interactions

Vitamin D3 715
Pueraria thumbergiana B. 584

Individual Drug Interactions

The ingredients in TropinexAQ interact with 1,083 drugs. Click any drug to see the details.

2 of the 7 ingredients in TropinexAQ interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3 Pueraria thumbergiana B.

Each ingredient & the kinds of drugs it affects

For each ingredient in TropinexAQ with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D38 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D3 full monograph & interactions

Pueraria thumbergiana B.7 drug types · 584 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Kudzu isoflavones are reported to have antiplatelet activity.

Likelihood Possible Evidence D
Caffeine

Theoretically, taking kudzu with caffeine might increase levels of caffeine.
In healthy males injected with the kudzu constituent puerarin, caffeine clearance and metabolism is inhibited. This effect has been attributed to inhibition of cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if taking kudzu orally would have this same effect.

Likelihood Probable Evidence D
Estrogens

Theoretically, kudzu might alter the effects of estrogen therapy.
Some research suggests that kudzu has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
There is some concern that kudzu can adversely affect the liver.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Theoretically, taking kudzu with methotrexate might increase the risk of methotrexate toxicity.
Preclinical research suggests that kudzu extract greatly reduces the elimination and increases the toxicity of methotrexate. Kudzu might inhibit organic anion transporters (OATs) that are responsible for hepatobiliary and renal excretion of anions, similar to the interaction between methotrexate and non-steroidal anti-inflammatory drugs (NSAIDs).

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, kudzu might interfere with tamoxifen activity.
Some research suggests that kudzu may have estrogenic effects.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Kudzu might lower blood glucose levels and have additive effects in patients treated with antidiabetic agents. The dose of diabetes medications might need to be adjusted.

Likelihood Unlikely Evidence D
Pueraria thumbergiana B. full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TropinexAQ, from the product label.

Image Sports

See all Image Sports products
Name
Image Sports
City
Fort Lauderdale
State
FL
ZipCode
33301
Pharmacist Counseling Corner

TropinexAQ by Image Sports: Common Questions

Does TropinexAQ by Image Sports interact with any medications?
Yes. Based on its ingredients, TropinexAQ has a known interaction with 1,083 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TropinexAQ contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is vitamin D3 safe if I take a thiazide water pill?
Not without checking first. High-dose vitamin D with thiazide diuretics can raise your blood calcium too much, which is risky. Your pharmacist or doctor will want to know what dose of vitamin D is in this product and whether it's safe for you.
Can I take this if I'm on a blood thinner?
The kudzu in TropinexAQ may increase bleeding risk with anticoagulants and antiplatelet drugs. Don't start it without talking to your pharmacist — they'll know your specific medication and risk level.
Is this product safe in pregnancy?
Vitamin D3 is often used during pregnancy at normal doses under a doctor's supervision, but kudzu should be avoided because there isn't enough safety data and it may have hormone-like effects. Talk to your doctor before using this product if you're pregnant.
What does the kudzu in this do?
Kudzu is possibly effective for alcohol use disorder. For other uses like hay fever or back pain, we don't have enough reliable evidence to say it works.
Can I take this with my diabetes medication?
Kudzu may lower blood sugar, so there's a theoretical risk of it working together with your diabetes drug and causing low blood sugar. Your doctor or pharmacist may need to adjust your diabetes medication dose.
What are the side effects?
Vitamin D is well tolerated, but very high doses can cause toxicity — symptoms include high blood calcium, weak bones, and slow growth in children. Kudzu may cause nausea, indigestion, bloating, dizziness, or hives at about the same rate as placebo in trials, though rare allergic reactions have occurred.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TropinexAQ label
Go deeper

The Full Monographs Behind TropinexAQ’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Kudzu

Interacts with 584 drugs

Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Early research is promising for cutting back...

Read the full Kudzu monograph →
Sources

Sources & How We Checked

TropinexAQ's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 47 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Kudzu 21 references
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  4. Lee KT, Sohn IC, Kim DH, et al. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro. Arch Pharm Res 2000;23:461-6.
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  9. Hsu, H. H., Chang, C. K., Su, H. C., Liu, I. M., and Cheng, J. T. Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. Planta Med 2002;68(11):999-1003.
  10. Zheng, G., Zhang, X., Zheng, J., Meng, Q., and Zheng, D. [Estrogen-like effects of puerarin and total isoflavones from Pueraria lobata]. Zhong.Yao Cai. 2002;25(8):566-568.
  11. Qi, B. L. and Qi, B. M. [Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats]. Zhongguo Zhong.Yao Za Zhi. 2002;27(11):850-852.
  12. Akita, H., Sowa, J., Makiura, M., Akamatsu, H., and Matsunaga, K. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact Dermatitis 2003;48(6):348-349. PubMed
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  14. Chandeying, V. and Sangthawan, M. Efficacy comparison of Pueraria mirifica (PM) against conjugated equine estrogen (CEE) with/without medroxyprogesterone acetate (MPA) in the treatment of climacteric symptoms in perimenopausal women: phase III study. J M
  15. Virojchaiwong, P., Suvithayasiri, V., and Itharat, A. Comparison of Pueraria mirifica 25 and 50 mg for menopausal symptoms. Arch.Gynecol.Obstet. 2011;284(2):411-419. PubMed
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  17. Kim HJ, Kim H, Ahn JH, Suk JH. Liver injury induced by herbal extracts containing mistletoe and kudzu. J Altern Complement Med 2015;21(3):180-5. PubMed
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See these in context on the Kudzu monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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