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Dietary supplement

Nopal Cactus 1000 (Opuntia) 1,000 mg Ingredients & Drug Interactions

by Only Natural

Nopal Cactus 1000 (Opuntia) 1,000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nopal Cactus 1000 (Opuntia) 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nopal Cactus 1000 (Opuntia) 1,000 mg is a dietary supplement by Only Natural with 1 active ingredient. Its ingredients are commonly taken for blood sugar control, high cholesterol, hangover symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nopal Cactus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nopal Cactus 1000 (Opuntia) 1,000 mg by Only Natural

Ask about any prescription or over-the-counter medication and we check it for interactions with Nopal Cactus 1000 (Opuntia) 1,000 mg by Only Natural — and tell you which ingredient is responsible.

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Computed from our clinical databases

HelloPharmacist Scorecard of Nopal Cactus 1000 (Opuntia) 1,000 mg by Only Natural

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.
Known Interaction Concern
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Prickly Pear Cactus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nopal Cactus 1000 (Opuntia) 1,000 mg, straight from the product label.

Brand Only Natural
Barcode (UPC) 0-27413-00000-0
Net contents 90 Veggie Capsule(s)
Market status Off market
Date entered into DSLD Mar 25, 2013
DSLD ID 19812
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nopal Cactus 1000 (Opuntia) 1,000 mg by Only Natural, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
UPC/BARCODE
0-27413-00000-0
IngredientAmount% DV
Nopal Cactus1000 mg--

Other ingredients: Vegetable Stearate, Vegetable Cellulose, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take two (2) capsules with a meal up to three (3) times a day or as directed by a health care professional.

General Statements

Description: Nopal cactus has been used as a natural alternative to relive inflammation and to promote healthy blood sugar levels.

Made in USA

Est. 1986

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Vegetarian

FDA Statement of Identity

Dietary Supplement

Formulation

GUARANTEED FREE OF: yeast, corn, wheat, gluten, milk, salt, sugar, starch preservatives, artificial flavor & color

Storage

STORE IN A COOL, DRY PLACE

Precautions

KEEP OUT OF THE REACH OF CHILDREN

TAMPER RESISTANT - DO NOT USE IF SEAL IS DAMAGED OR MISSING

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nopal Cactus 1000 (Opuntia) 1,000 mg by Only Natural label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nopal Cactus 1000 (Opuntia) 1,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nopal Cactus 1000 (Opuntia) 1,000 mg by Only Natural

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Nopal Cactus

Interacts with
86 drugs
1000 mg per serving

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hango...

Nopal Cactus monograph & interactions

Other (inactive) ingredients: Vegetable Stearate, Vegetable Cellulose, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nopal Cactus 1000 (Opuntia) 1,000 mg by Only Natural Drug Interactions

Nopal Cactus 1000 (Opuntia) 1,000 mg contains a single active ingredient, and it has known interactions with 86 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Nopal Cactus 1000 (Opuntia) 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Nopal Cactus 86

Individual Drug Interactions

The ingredients in Nopal Cactus 1000 (Opuntia) 1,000 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nopal Cactus 1000 (Opuntia) 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. Nopal Cactus

Each ingredient & the kinds of drugs it affects

For each ingredient in Nopal Cactus 1000 (Opuntia) 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nopal Cactus1 drug type · 86 drugs

Antidiabetes Drugs

Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.
Case reports show that combining prickly pear cactus with antidiabetes drugs such as chlorpropamide, glyburide, glipizide, and metformin can increase the risk of hypoglycemia in patients with type 2 diabetes. Advise patients to monitor glucose levels closely. Dose adjustments may be necessary.

Likelihood Probable Evidence D
Nopal Cactus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nopal Cactus 1000 (Opuntia) 1,000 mg, from the product label.

Only Natural

See all Only Natural products
Name
Only Natural, Inc.
City
Island Park
State
NY
ZipCode
11558
Pharmacist Counseling Corner

Nopal Cactus 1000 (Opuntia) 1,000 mg by Only Natural: Common Questions

Does Nopal Cactus 1000 (Opuntia) 1,000 mg by Only Natural interact with any medications?
Yes. Based on its ingredients, Nopal Cactus 1000 (Opuntia) 1,000 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nopal Cactus 1000 (Opuntia) 1,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nopal Cactus 1000 (Opuntia) 1,000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nopal Cactus 1000 (Opuntia) 1,000 mg label
Go deeper

The Full Monographs Behind Nopal Cactus 1000 (Opuntia) 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Prickly Pear Cactus

Interacts with 86 drugs

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hangover symptoms. Some small studies suggest...

Read the full Prickly Pear Cactus monograph →
Sources

Sources & How We Checked

Nopal Cactus 1000 (Opuntia) 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Prickly Pear Cactus 9 references
  1. Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.
  2. Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
  3. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  4. Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. PubMed
  5. Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
  6. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
  7. Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118.
  8. Onakpoya IJ, O'Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. PubMed
  9. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11

See these in context on the Prickly Pear Cactus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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