Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Ultimate Strength Raspberry Ketone Super Flush Ingredients & Drug Interactions

by New Health Corp.

Ultimate Strength Raspberry Ketone Super Flush label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultimate Strength Raspberry Ketone Super Flush against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultimate Strength Raspberry Ketone Super Flush is a dietary supplement by New Health Corp. with 4 active ingredients. Its ingredients are commonly taken for weight loss, fat burning, boosting metabolism.Based on those ingredients, 933 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cascara Sagrada bark powder, Raspberry Ketone, Senna leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ultimate Strength Raspberry Ketone Super Flush by New Health Corp.

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate Strength Raspberry Ketone Super Flush by New Health Corp. — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ultimate Strength Raspberry Ketone Super Flush by New Health Corp.

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains four active ingredients. Raspberry ketone is derived from raspberry and has been studied for weight and hair loss, though evidence is insufficient.

Cascara sagrada bark powder and senna leaf extract are both stimulant laxatives intended to promote bowel movements. Raspberry fruit powder comes from the whole fruit and is included for its nutritional profile.

The capsules also contain inactive ingredients—gelatin, microcrystalline cellulose, rice flour, crosscarmelose sodium, and magnesium stearate—which are common binders and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: natural weight loss support.
  • We looked for evidence on: Obesity, Weight management, Metabolic support, Fat reduction.
  • The closest evidence on file: Red Raspberry is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Raspberry Ketone is rated "Insufficient Reliable Evidence To Rate" for Obesity.

The evidence for this product's main uses is limited. Raspberry ketone has insufficient evidence to support its use for hair loss or weight loss.

Senna leaf extract is likely effective for constipation and possibly effective for bowel preparation. Cascara sagrada is possibly ineffective for bowel preparation and has insufficient evidence for constipation.

Raspberry fruit powder has insufficient evidence for aging skin, heart health, respiratory infections, heart failure, and diabetes.

The evidence, ingredient by ingredient Raspberry Ketone Cascara Sagrada Red Raspberry Senna

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Raspberry ketone is used safely in foods, but human safety data for high supplement doses is very limited. Case reports describe heart palpitations, rapid heartbeat, elevated blood pressure, and in rare cases, serious arrhythmias.

A small number of people have also reported sweating, diarrhea, and shakiness. Cascara sagrada and senna are generally well tolerated for short-term use but carry real risks with long-term use, including liver damage, kidney problems, and severe depletion of body reserves.

Both can cause mild abdominal discomfort and cramping. Raspberry fruit is generally well tolerated, though diarrhea and stomach upset may occur at higher doses.

During pregnancy, avoid concentrated supplements of raspberry ketone—safety data is too limited. Cascara sagrada and senna are not recommended in pregnancy.

Raspberry fruit powder is often used in late pregnancy but safety is not well established; use only if your doctor advises it. For breastfeeding, avoid raspberry ketone and cascara sagrada.

Safety information is not available for raspberry fruit powder while nursing.

Side effects, ingredient by ingredient Raspberry Ketone Cascara Sagrada Red Raspberry Senna

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Red Raspberry, Senna, Cascara Sagrada, Raspberry Ketone.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 934 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you're on stimulant drugs (like decongestants or ADHD medications), warfarin or other blood thinners, antiplatelet drugs like aspirin or clopidogrel, insulin or diabetes medications, corticosteroids, diuretics, digoxin, or any medications processed by the liver (CYP3A4 substrates). The stimulant laxatives in this formula create additional risks with potassium-affecting drugs and heart medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines a weight-loss ingredient with two stimulant laxatives, neither of which has strong evidence for the stated uses. If you take any blood thinners, heart medications, diabetes medications, or diuretics, you need to check this product with your pharmacist or doctor first.

The stimulant laxatives carry particular risks with long-term use. Talk to your pharmacist about whether this product is right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate Strength Raspberry Ketone Super Flush, straight from the product label.

Brand New Health Corp.
Barcode (UPC) 713757664417
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2013
DSLD ID 25580
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate Strength Raspberry Ketone Super Flush by New Health Corp., sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
713757664417
IngredientAmount% DV
Raspberry Ketone200 mg--
Cascara Sagrada bark powder250 mg--
Raspberry fruit powder50 mg--
Senna leaf extract50 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Rice Flour, crosscarmelose sodium, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

CAUTION: This product contains cascara. Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stools, abdominal pain, or intestinal obstruction, hemorrhoids or are menstruating.

Consult your physician if you have frequent diarrhea, are pregnant, nursing, taking medication or have a medical condition.

Individuals with a history of kidney stones should use this cautiously. Do not take for more than seven consecutive days.

This product is not for persons under 12 years of age. KEEP OUT OF THE REACH OF CHILDREN.

DO NOT USE IF INNER SAFETY SEAL IS BROKEN.

Storage

STORE AT ROOM TEMPERATURE.

General Statements

Fax: 813-489-2504

NATURAL WEIGHT LOSS SUPPORT

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement, take one (1) capsule 1 hour before sleep with a full glass of water. If needed, you may take an additional daily dose.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultimate Strength Raspberry Ketone Super Flush by New Health Corp. label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultimate Strength Raspberry Ketone Super Flush label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultimate Strength Raspberry Ketone Super Flush by New Health Corp.

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Raspberry Ketone

Interacts with
174 drugs
200 mg per serving

Raspberry ketone is a natural aroma compound found in red raspberries that is heavily marketed for weight loss, but there is no good human evidence th...

Raspberry Ketone monograph & interactions

Cascara Sagrada bark powder

Interacts with
745 drugs
250 mg per serving

Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Becaus...

Cascara Sagrada bark powder monograph & interactions

Raspberry fruit powder

Interacts with
135 drugs
50 mg per serving

Red raspberry leaf is a traditional herbal remedy most often used as a tea in late pregnancy and for menstrual discomfort, but solid scientific eviden...

Raspberry fruit powder monograph & interactions

Senna leaf extract

Interacts with
140 drugs
50 mg per serving

Senna is a plant-based stimulant laxative that is widely used and generally effective for short-term relief of constipation. It is best used occasiona...

Senna leaf extract monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Rice Flour, Crosscarmelose sodium, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate Strength Raspberry Ketone Super Flush by New Health Corp. Drug Interactions

Want to check YOUR meds against Ultimate Strength Raspberry Ketone Super Flush?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
933Drugs
448 Moderate 485 Minor

Ingredients driving the most interactions

Cascara Sagrada bark powder 745
Raspberry Ketone 174
Senna leaf extract 140
Raspberry fruit powder 135

Individual Drug Interactions

The ingredients in Ultimate Strength Raspberry Ketone Super Flush interact with 933 drugs. Click any drug to see the details.

4 of the 4 ingredients in Ultimate Strength Raspberry Ketone Super Flush interact with drugs. Each result below shows which ingredient is responsible. Cascara Sagrada bark powder Raspberry Ketone Senna leaf extract Raspberry fruit powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate Strength Raspberry Ketone Super Flush with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Cascara Sagrada bark powder6 drug types · 745 drugs

Corticosteroids

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Cascara sagrada has stimulant laxative effects and might compound fluid and electrolyte losses when taken with stimulant laxatives.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cascara sagrada might increase the risk of bleeding when taken with warfarin.
Cascara sagrada has stimulant laxative effects. In some people, cascara sagrada can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
In vitro research suggests that cascara sagrada can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Cascara Sagrada bark powder full monograph & interactions

Raspberry Ketone2 drug types · 174 drugs

Stimulant Drugs

Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Structurally, raspberry ketone resembles synephrine, a known stimulant agent. Heart palpitations, elevated blood pressure, coronary vasospasm, pulseless electrical activity arrest, and resistant polymorphic ventricular tachycardia have been reported in patients taking raspberry ketone.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, raspberry ketone might increase warfarin dose requirements.
In one case report, a patient taking warfarin 55 mg per week had a decrease in INR over a period of one month while taking raspberry ketone 250 mg daily. A warfarin dose increase to 70 mg per week was necessary to maintain a therapeutic INR while taking raspberry ketone. The mechanism for this potential interaction is not known.

Likelihood Possible Evidence D
Raspberry Ketone full monograph & interactions

Senna leaf extract5 drug types · 140 drugs

Digoxin (Lanoxin)

Theoretically, senna might increase the risk of adverse effects when taken with digoxin.
Overuse/abuse of senna increases the risk of adverse effects from cardiac glycosides, such as digoxin, due to potassium depletion.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of senna might compound diuretic-induced potassium loss and increase the risk for hypokalemia.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking senna may interfere with the absorption of exogenous estrogens.
Some preliminary clinical evidence suggests that senna reduces the absorption of estradiol and decreases serum concentrations of estrone and estrone sulfate by decreasing intestinal transit time.

Likelihood Possible Evidence B
Stimulant Laxatives

Theoretically, senna might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Senna is a stimulant laxative; concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of senna might increase the effects of warfarin.
Senna has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. In one case report, excessive use of senna for 3 weeks resulted in diarrhea, bloody stools, and an elevated INR of 11.9.

Likelihood Possible Evidence D
Senna leaf extract full monograph & interactions

Raspberry fruit powder2 drug types · 135 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
In vitro research suggests that red raspberry leaf extract has antiplatelet activity and enhances the in vitro effects of the antiplatelet medication cangrelor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Insulin

Red raspberry leaf might reduce glucose levels in patients being treated with insulin.
In one case report, a 38-year-old patient with gestational diabetes, whose blood glucose was being controlled with medical nutrition therapy and insulin, developed hypoglycemia after consuming two servings of raspberry leaf tea daily for 3 days beginning at 32 weeks' gestation. The patient required an insulin dose reduction. The hypoglycemia was considered to be probably related to use of red raspberry leaf tea.

Likelihood Possible Evidence D
Raspberry fruit powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultimate Strength Raspberry Ketone Super Flush, from the product label.

New Health Corp.

See all New Health Corp. products
Name
New Health Corp(TM)
Street Address
7345 International Pl., Unit 101
City
Sarasota
State
FL
ZipCode
34240
Phone Number
941-893-4296
Web Address
NewHealthCorp.com
Pharmacist Counseling Corner

Ultimate Strength Raspberry Ketone Super Flush by New Health Corp.: Common Questions

Does Ultimate Strength Raspberry Ketone Super Flush by New Health Corp. interact with any medications?
Yes. Based on its ingredients, Ultimate Strength Raspberry Ketone Super Flush has a known interaction with 933 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate Strength Raspberry Ketone Super Flush contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does raspberry ketone actually work for weight loss?
The evidence isn't there yet. Our data shows insufficient reliable evidence to rate raspberry ketone for weight loss. It's been studied, but we don't have solid proof it works.
Can I take this if I'm on warfarin?
No—not without talking to your doctor first. Both raspberry ketone and the laxatives in this product interact with warfarin. Raspberry ketone may require a higher dose of your blood thinner, and the laxatives increase bleeding risk. Your doctor may need to adjust your dose or choose a different product.
Is this safe to use long-term?
The laxatives in here—cascara sagrada and senna—are not recommended for daily long-term use. They carry real risks with extended use, including liver and kidney problems. Short-term occasional use under medical guidance is safer. The raspberry ketone data is limited for any duration.
What are the most common side effects?
The laxatives typically cause mild abdominal cramping and discomfort. Raspberry ketone is not well studied in humans, but case reports describe heart palpitations, rapid heartbeat, elevated blood pressure, and a small number of people reported sweating, shakiness, and diarrhea.
Can I take this while pregnant or breastfeeding?
No. Raspberry ketone, cascara sagrada, and senna should all be avoided during pregnancy and breastfeeding—there isn't enough safety data, or the data advises against it. Talk to your doctor if you need a bowel-support product while pregnant or nursing.
Will this slow down how my body processes other medications?
Possibly. Cascara sagrada may slow the breakdown of certain medications processed by your liver (CYP3A4 substrates), which could make them work longer or stronger. Your pharmacist can tell you if any of your medications are affected.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultimate Strength Raspberry Ketone Super Flush is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate Strength Raspberry Ketone Super Flush label
Go deeper

The Full Monographs Behind Ultimate Strength Raspberry Ketone Super Flush’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Raspberry Ketone

Interacts with 174 drugs

Raspberry ketone is a natural aroma compound found in red raspberries that is heavily marketed for weight loss, but there is no good human evidence that it helps people lose weight. Most cla...

Read the full Raspberry Ketone monograph → Herb & supplement monograph

Cascara Sagrada

Interacts with 745 drugs

Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Because it can cause cramping, dehydration, an...

Read the full Cascara Sagrada monograph → Herb & supplement monograph

Red Raspberry

Interacts with 135 drugs

Red raspberry leaf is a traditional herbal remedy most often used as a tea in late pregnancy and for menstrual discomfort, but solid scientific evidence for these uses is limited. It is gene...

Read the full Red Raspberry monograph → Herb & supplement monograph

Senna

Interacts with 140 drugs

Senna is a plant-based stimulant laxative that is widely used and generally effective for short-term relief of constipation. It is best used occasionally and for only a few days at a time, s...

Read the full Senna monograph →
Sources

Sources & How We Checked

Ultimate Strength Raspberry Ketone Super Flush's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 63 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Raspberry Ketone 4 references
  1. Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
  2. Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
  3. Ansari SA, Patel F, Ashouri D, Dhaliwal JSS, Desai A. Resistant Polymorphic Ventricular Tachycardia in a Patient Taking Raspberry Ketones Weight Loss Supplement. Cureus 2022;14(12):e33089. PubMed
  4. Khattar A, Beeton I. Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Anatol J Cardiol. 2020;24(3):205-208.

See these in context on the Raspberry Ketone monograph →

Cascara Sagrada 9 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  5. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  6. Nadir A, Reddy D, Van Thiel DH. Cascara-sagrada induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity. Am J Gastroenterol 2000;95:3634-7. PubMed
  7. Nakasone ES, Tokeshi J. A serendipitous find: a case of cholangiocarcinoma identified incidentally after acute liver injury due to cascara sagrada ingestion. Hawaii J Med Public Health 2015;74(6):200-2.
  8. Cirillo C, Capasso R. Constipation and botanical medicines: an overview. Phytother Res 2015;29(10):1488-93. PubMed
  9. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Cascara Sagrada monograph →

Red Raspberry 8 references
  1. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  2. Parsons M, Simpson M, Ponton T. Raspberry leaf and its effects on labour: safety and efficacy. Aust Coll Midwives Inc J 1999;12:20-5.
  3. Simpson M, Parsons M, Greenwood J, Wade K. Raspberry leaf in pregnancy: its safety and efficacy in labor. J Midwifery Womens Health 2001;46:51-9.. PubMed
  4. Mullen W, McGinn J, Lean ME, et al. Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. J Agric Food Chem 2002;50:5191-6.. PubMed
  5. Sherson, D., Andersen, B., Hansen, I., and Kjoller, H. Occupational asthma due to freeze-dried raspberry. Ann Allergy Asthma Immunol. 2003;90(6):660-663. PubMed
  6. Cheang KI, Nguyen TT, Karjane NW, Salley KE. Raspberry Leaf and Hypoglycemia in Gestational Diabetes Mellitus. Obstet Gynecol. 2016;128(6):1421-4. PubMed
  7. Dudzinska D, Bednarska K, Boncler M, Luzak B, Watala C. The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils. Platelets. 2016;27(5):433-9.
  8. Henrotin Y, Cozannet RL, Fança-Berthon P, et al. Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial. BMC Musculoskelet Disord 2022;23(1):650. PubMed

See these in context on the Red Raspberry monograph →

Senna 42 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89. PubMed
  4. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  5. Seybold U, Landauer N, Hillebrand S, Goebel FD. Senna-induced hepatitis in a poor metabolizer. Ann Intern Med 2004;141:650-1. PubMed
  6. Vanderperren B, Rizzo M, Angenot L, et al. Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides. Ann Pharmacother 2005;39:1353-7. PubMed
  7. Xing JH, Soffer EE. Adverse effects of laxatives. Dis Colon Rectum 2001;44:1201-9. PubMed
  8. Prior J, White I. Tetany and clubbing in patient who ingested large quantities of senna. Lancet 1978;2:947. PubMed
  9. Langmead L, Rampton DS. Review article: herbal treatment in gastrointestinal and liver disease--benefits and dangers. Aliment Pharmacol Ther 2001;15:1239-52. PubMed
  10. Joo JS, Ehrenpreis ED, Gonzalez L, et al. Alterations in colonic anatomy induced by chronic stimulant laxatives: the cathartic colon revisited. J Clin Gastroenterol 1998;26:283-6. PubMed
  11. Godding EW. Laxatives and the special role of senna. Pharmacology 1988;36:230-6. PubMed
  12. van Os FH. Anthraquinone derivatives in vegetable laxatives. Pharmacology 1976;14:7-17. PubMed
  13. Sondheimer JM, Gervaise EP. Lubricant versus laxative in the treatment of chronic functional constipation of children: a comparative study. J Pediatr Gastroenterol Nutr 1982;1:223-6. DOI
  14. Perkin JM. Constipation in childhood: a controlled comparison between lactulose and standardized senna. Curr Med Res Opin 1977;4:540-3. PubMed
  15. Shelton MG. Standardized senna in the management of constipation in the puerperium: A clinical trial. S Afr Med J 1980;57:78-80.
  16. [No authors listed] Senna in the puerperium. Pharmacology 1992;44:23-5. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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