Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Ultra Bromelain 1500 mg Ingredients & Drug Interactions

by NaturesPlus

Ultra Bromelain 1500 mg label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Bromelain 1500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultra Bromelain 1500 mg is a dietary supplement by NaturesPlus with 2 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultra Bromelain 1500 mg by NaturesPlus

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Bromelain 1500 mg by NaturesPlus — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultra Bromelain 1500 mg by NaturesPlus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Pineapple Fruit and Bromelain Digestion Blend” is a proprietary blend — the label gives one combined amount (1,500 mg) without saying how much of each component you get.

This product contains 2 active ingredients: bromelain (the main enzyme extracted from pineapple) and pineapple fruit. Bromelain is a protein-digesting enzyme traditionally used to support inflammation and tissue healing, though the evidence for many of its marketed uses remains limited.

The remaining ingredients are inactive fillers and binders — cellulose, dicalcium phosphate, microcrystalline cellulose, magnesium stearate, silica, stearic acid, and pharmaceutical glaze — that give the tablet its form and stability.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bromelain's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Digestive health, joint and muscle support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Exercise-induced muscle soreness, Knee pain, Osteoarthritis, Postoperative pain, Postoperative swelling — and 4 related terms.
  • The closest evidence on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Osteoarthritis, Knee pain, Rhinosinusitis, and more.

The evidence on bromelain for most of its common uses — hay fever, burns, cancer support, nerve pain from chemotherapy, vein circulation, and blood sugar — is not established in the data we hold. The product facts list these uses as having insufficient reliable evidence to rate.

If you're considering this supplement for a specific health concern, talk with your pharmacist or doctor about what the science actually supports for your situation.

The evidence, ingredient by ingredient Bromelain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated when taken by mouth short-term, though long-term safety data is limited. The most common side effects are digestive: diarrhea, flatulence, stomach upset, headache, nausea, vomiting, and abdominal pain.

Allergic reactions are possible — bromelain can trigger IgE-mediated reactions in sensitive people, and if inhaled (occupational exposure), it may cause asthma, throat itching, eye irritation, and difficulty swallowing. The safety data advises against bromelain during pregnancy and while breastfeeding, as there isn't enough evidence to know it's safe in either situation.

If you're pregnant, planning pregnancy, or nursing, talk with your pharmacist or doctor before taking this product.

Side effects, ingredient by ingredient Bromelain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood thinners and antiplatelet drugs (warfarin, apixaban, aspirin, clopidogrel, and similar medications) before taking this product — bromelain may increase bleeding risk with Moderate severity. Also double-check tetracycline antibiotics (doxycycline, minocycline, tetracycline), which bromelain may affect at Minor severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This bromelain supplement may be worth considering if you're interested in inflammation or tissue support and you don't take blood thinners or tetracycline antibiotics. If you do take any of those medications — or any prescription drug — check it against your exact medication list using the tool on this page before you start.

Anyone with a known pineapple or bromelain allergy should skip it. Pregnancy and breastfeeding are reasons to talk with your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Bromelain 1500 mg, straight from the product label.

Brand NaturesPlus
Barcode (UPC) 097467044067
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 298778
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Bromelain 1500 mg by NaturesPlus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
097467044067
IngredientAmount% DV
Bromelain0 NP--
Pineapple0 NP--
Pineapple Fruit and Bromelain Digestion Blend1500 mg--

Other ingredients: Cellulose, Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Silica, Stearic Acid, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Bromelain is a protein-digesting enzyme derived from pineapple with a wide range of benefits from digestive health to joint and muscle support.

Pineapple Enzyme Standardized 900 GDU

Formulation

Free from artificial colors, artificial preservatives and all of the major allergens identified in the U.S. Food Allergen Labeling and Consumer Protection Act.

Vegetarian

Gluten Free

Digestive Support

Storage

Keep tightly closed in a cool, dry place.

Precautions

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: One tablet daily. Tablets are designed to be swallowed, not chewed.

Brand IP Statement(s)

Copyright Natural Organics

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Bromelain 1500 mg by NaturesPlus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Bromelain 1500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Bromelain 1500 mg by NaturesPlus

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pineapple Fruit and Bromelain Digestion Blend

1500 mg per serving

Other (inactive) ingredients: Cellulose, Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Silica, Stearic Acid, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Bromelain 1500 mg by NaturesPlus Drug Interactions

Want to check YOUR meds against Ultra Bromelain 1500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141

Individual Drug Interactions

The ingredients in Ultra Bromelain 1500 mg interact with 141 drugs. Click any drug to see the details.

1 of the 2 ingredients in Ultra Bromelain 1500 mg interact with drugs. Each result below shows which ingredient is responsible. Bromelain

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Bromelain 1500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Bromelain 1500 mg, from the product label.

NaturesPlus

See all NaturesPlus products
Name
Natural Organics Laboratories, Inc. makers of NaturesPlus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Ultra Bromelain 1500 mg by NaturesPlus: Common Questions

Does Ultra Bromelain 1500 mg by NaturesPlus interact with any medications?
Yes. Based on its ingredients, Ultra Bromelain 1500 mg has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Bromelain 1500 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin or warfarin?
Not without checking with your pharmacist first. Bromelain may thin your blood and could raise your bleeding risk if combined with these drugs. Use the interaction checker on this page with your exact medication name, or call your pharmacy before you start.
What are the most common side effects?
The main ones are digestive: diarrhea, gas, stomach upset, and nausea. Headache can also occur. If your stomach gets too upset or diarrhea is severe, stop taking it and check in with us.
Is it safe to take long-term?
We have good safety data for short-term use, but long-term safety evidence is limited. If you're thinking of taking it regularly for months, it's worth discussing with your pharmacist or doctor first.
Can I take this while pregnant or breastfeeding?
The safety data advises against it during pregnancy and while breastfeeding — there isn't enough evidence to know it's safe in either situation. Talk with your doctor or pharmacist for personalized advice.
Does this actually work for inflammation or healing?
The evidence we have on bromelain for inflammation, burns, wounds, and similar uses is not established — the data rated it as having insufficient reliable evidence. If you're considering it for a specific health goal, ask your pharmacist or doctor what the science actually shows for your situation.
What if I'm allergic to pineapple?
Skip this product. Bromelain can trigger allergic reactions in people who are sensitive to it or pineapple, ranging from itching and hives to asthma and throat swelling.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultra Bromelain 1500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Bromelain 1500 mg label
Go deeper

The Full Monographs Behind Ultra Bromelain 1500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph →
Sources

Sources & How We Checked

Ultra Bromelain 1500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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