Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Omega Krill Oil 600 mg Ingredients & Drug Interactions

by NaturesPlus

Omega Krill Oil 600 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Omega Krill Oil 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Omega Krill Oil 600 mg is a dietary supplement by NaturesPlus with 5 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Antarctic Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Omega Krill Oil 600 mg by NaturesPlus

Ask about any prescription or over-the-counter medication and we check it for interactions with Omega Krill Oil 600 mg by NaturesPlus — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Omega Krill Oil 600 mg by NaturesPlus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 5 active ingredients. Krill oil itself provides eicosapentaenoic acid and docosahexaenoic acid — two omega-3 fatty acids — plus phospholipids, which help your body absorb them.

Astaxanthin is a carotenoid antioxidant also derived from krill. The remaining inactive ingredients are gelatin (the capsule), water, fatty acids, rosemary extract, and mineral salts (phosphorus, sodium chloride, potassium chloride, magnesium oxide, and calcium).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: healthy heart function, brain function, and inflammation control.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertriglyceridemia, Heart failure, Hypertension, Stroke — and 4 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Heart failure, Hyperlipidemia, Hypertension, and more.

Krill oil shows possibly effective evidence for dry eye — the main use backed by research for this product. For aging skin, Alzheimer's disease, cancer prevention, high cholesterol (hyperlipidemia), and cognitive function, the evidence is insufficient to rate, so we don't know yet whether it works.

Astaxanthin's effectiveness for age-related cognitive decline, macular degeneration, aging skin, Alzheimer's disease, athletic performance, and carpal tunnel syndrome is also insufficiently established in the data we hold.

The evidence, ingredient by ingredient Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Krill oil is generally well tolerated at doses up to 4 grams daily, though some people report bloating, diarrhea, fishy burps, heartburn, nausea, and stomach upset — these side effects tend to be milder with krill oil than with fish oil. Headache, tiredness, and dizziness have been reported rarely.

Avoid krill oil if you have a shellfish allergy and use caution if you have a bleeding disorder. Astaxanthin is also generally well tolerated in studies, with the most common side effects being abdominal pain, diarrhea, and red-colored stools; long-term safety data are limited.

There isn't enough safety data to know whether krill oil is safe during pregnancy or breastfeeding — talk with your doctor or pharmacist before using it in either situation. The same applies to astaxanthin, for which the safety data recommend avoiding it during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Krill Oil Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Astaxanthin, Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 839 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take anticoagulants or antiplatelets (blood thinners like warfarin, dabigatran, apixaban, or aspirin) — krill oil may increase bleeding risk. Antidiabetes drugs should also be reviewed, as krill oil might lower blood sugar.

Additionally, medications broken down by your liver's CYP3A4 or CYP2B6 enzymes — including some statins and immunosuppressants — could theoretically be affected by astaxanthin, though this hasn't been confirmed in people.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help dry eye symptoms, though evidence is limited for other uses. If you take blood thinners, diabetes medications, or certain drugs processed by your liver, check with your own doctor or pharmacist before starting — the interactions are moderate and worth reviewing with your medications in hand.

Generally well tolerated, but digestive upset and a shellfish allergy are things to watch for.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Omega Krill Oil 600 mg, straight from the product label.

Brand NaturesPlus
Barcode (UPC) 097467039728
Net contents 60 Liquid-Filled Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 298566
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Omega Krill Oil 600 mg by NaturesPlus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Liquid-Filled Capsule(s)
Maximum serving Sizes:
2 Liquid-Filled Capsule(s)
Servings per container
30
UPC/BARCODE
097467039728
IngredientAmount% DV
Calories15 Calorie(s), 9 Calorie(s)--
Eicosapentaenoic Acid154 mg, 77 mg--
Docosahexaenoic Acid70 mg, 35 mg--
Total Fat1.5 Gram(s), 1 Gram(s)2%, 1%
Phospholipids500 mg, 250 mg--
Antarctic Krill Oil1200 mg, 600 mg--
Astaxanthin6 mg, 3 mg--

Other ingredients: Gelatin, Water, Fatty Acids, Pure Assure Rosemary, Phosphorus, Sodium Chloride, Potassium Chloride, Magnesium Oxide, Calcium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Nutritional Support for: healthy heart function, healthy brain function, healthy inflammation control, free radical defense, anti-aging processes, overall well-being

NaturesPlus encapsulates only the world's purest Krill, sustainably harvested from pristine Antarctic waters. Pure Assure potency preservation technology including complete nitrogen flush, rosemary extract and high-density, fish-gelatin capsules, guarantees maximum bioavailability. NaturesPlus Omega Krill Oil Liquid-Filled Capsules deliver benefits you can feel!

Free from artificial colors and preservatives. Free from yeast, milk, eggs, soy, tree nuts, peanuts and wheat. Gluten Free.

Formula

Discover the amazing benefits of NaturesPlus Omega Krill Oil, the most effective Krill Omega-3 EFA phospholipids ever developed, with 30% to 100% better EFA absorption than fish oils.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, 1-2 capsules daily.

Storage

Keep tightly closed in a cool, dry place.

Precautions

Keep out of reach of children.

Contains fish (gelatin) and shellfish (krill).

Contains Fish and Crustacean

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright Natural Organics

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Omega Krill Oil 600 mg by NaturesPlus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Omega Krill Oil 600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Omega Krill Oil 600 mg by NaturesPlus

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Liquid-Filled Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Eicosapentaenoic Acid

154 mg per serving

Docosahexaenoic Acid

70 mg per serving

Phospholipids

500 mg per serving

Antarctic Krill Oil

Interacts with
208 drugs
1200 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Antarctic Krill Oil monograph & interactions

Astaxanthin

Interacts with
671 drugs
6 mg per serving Form: Krill

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Other (inactive) ingredients: Gelatin, Water, Fatty Acids, Pure Assure Rosemary, Phosphorus, Sodium Chloride, Potassium Chloride, Magnesium Oxide, Calcium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Omega Krill Oil 600 mg by NaturesPlus Drug Interactions

Want to check YOUR meds against Omega Krill Oil 600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Astaxanthin 671
Antarctic Krill Oil 208

Individual Drug Interactions

The ingredients in Omega Krill Oil 600 mg interact with 838 drugs. Click any drug to see the details.

2 of the 5 ingredients in Omega Krill Oil 600 mg interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Antarctic Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Omega Krill Oil 600 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Antarctic Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Antarctic Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Omega Krill Oil 600 mg, from the product label.

NaturesPlus

See all NaturesPlus products
Name
NaturesPlus Div. of Natural Organics, Inc.
Street Address
548 Broadhollow Rd.
City
Melville
State
NY
ZipCode
11747
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Omega Krill Oil 600 mg by NaturesPlus: Common Questions

Does Omega Krill Oil 600 mg by NaturesPlus interact with any medications?
Yes. Based on its ingredients, Omega Krill Oil 600 mg has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Omega Krill Oil 600 mg contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does krill oil really help dry eye?
Yes — krill oil is rated possibly effective for dry eye, making it the best-supported use for this product. That said, the evidence is still evolving, so results vary from person to person.
What's the difference between krill oil and fish oil?
Both contain omega-3 fatty acids, but krill oil's omega-3s are bound to phospholipids, which may make them easier to absorb. The gastrointestinal side effects (like fishy burps and bloating) also tend to be milder with krill oil than fish oil.
Can I take this if I have a shellfish allergy?
No — krill oil comes from Antarctic krill, a crustacean, so it poses an allergy risk if you're sensitive to shellfish. Check with your doctor before using it.
What are the most common side effects?
Bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, and mild stomach discomfort are the most frequently reported. Headache, tiredness, and dizziness are rare. These usually improve with time or when taken with food.
Is it safe to take during pregnancy or breastfeeding?
There isn't enough safety data to know. Talk with your doctor or pharmacist before using it if you're pregnant or breastfeeding — they can weigh the potential benefits against any risks for your situation.
Can I take this with my other supplements?
That depends on what they are — supplement combinations aren't addressed in the data we hold. Your pharmacist can help you sort out potential interactions between this product and everything else you're taking.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Omega Krill Oil 600 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Omega Krill Oil 600 mg label
Go deeper

The Full Monographs Behind Omega Krill Oil 600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Omega Krill Oil 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team