Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Ultra Collagen Enhance Ingredients & Drug Interactions

by ResVitale

Ultra Collagen Enhance label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Collagen Enhance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultra Collagen Enhance is a dietary supplement by ResVitale with 5 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, joint stiffness, cartilage support.Based on those ingredients, 822 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Resveratrol Polyphenol Complex(TM), Chondroitin Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultra Collagen Enhance by ResVitale

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Collagen Enhance by ResVitale — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultra Collagen Enhance by ResVitale

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “BioCell Collagen” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Ultra Collagen Enhance contains 5 active ingredients. Chondroitin sulfate and Hydrolyzed Collagen Type II are structural compounds that support joint and skin health.

BioCell Collagen is a proprietary collagen blend. Hyaluronic acid is a natural substance that holds water in skin and tissues.

Resveratrol Polyphenol Complex is a plant-derived antioxidant extracted from grapes and other sources. The product also contains inactive ingredients: a vegetarian capsule, rice bran, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Reduce appearance of lines and wrinkles.
  • We looked for evidence on: Aging skin, Skin elasticity, Skin hydration, Collagen support.
  • The strongest evidence on file: Collagen Peptides is rated "Possibly Effective" for Aging skin (Natural Medicines).
  • Also on file: Resveratrol is rated "Insufficient Reliable Evidence To Rate" for Aging skin.
  • Also on file: Chondroitin Sulfate is rated "Insufficient Reliable Evidence To Rate" for Aging skin.

Chondroitin sulfate is possibly effective for cataracts and osteoarthritis, but evidence is insufficient to rate it for aging skin, osteoporosis, high cholesterol, or colorectal polyp prevention. Hyaluronic acid is possibly effective for dry eye and venous leg ulcers, though evidence is insufficient for aging skin, hay fever, and sexual dysfunction.

Resveratrol is possibly effective for obesity and hay fever, but appears possibly ineffective for heart disease and high cholesterol. We have no established evidence in our data for the other ingredients or the product as a whole.

The evidence, ingredient by ingredient Chondroitin Sulfate Hyaluronic Acid Collagen Peptides Resveratrol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chondroitin sulfate is generally well tolerated short-term, though quality varies. Common side effects include abdominal pain, bloating, constipation, diarrhea, heartburn, and nausea.

Rare cases of liver damage and skin reactions (swelling, hair loss, rash) have been reported, as has one case of asthma flare. Hyaluronic acid appears well tolerated orally and topically in most adults, with topical use occasionally causing eczema, redness, or itching.

Resveratrol is generally well tolerated at typical doses but may cause diarrhea, stomach discomfort, or loose stools at higher doses. Rare skin rash has been reported.

Safety data is insufficient for oral hyaluronic acid and resveratrol supplements in pregnancy and lactation — the facts advise against use unless your doctor advises otherwise. Chondroitin should be avoided in pregnancy and lactation due to lack of safety information.

Side effects, ingredient by ingredient Chondroitin Sulfate Hyaluronic Acid Collagen Peptides Resveratrol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Resveratrol, Chondroitin Sulfate.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 823 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take warfarin or other anticoagulants (blood thinners) or antiplatelet drugs like aspirin or clopidogrel — chondroitin and resveratrol may increase bleeding risk. Also double-check any medications your liver breaks down, including drugs metabolized by CYP2C19, CYP1A2, CYP2E1, or CYP3A4 enzymes, since resveratrol may theoretically raise their blood levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines collagen, joint-support, and skin ingredients that appeal to those managing joint health or skin aging. If you take warfarin or other blood thinners, or medications processed through your liver, you'll need to check your specific drugs with us first — resveratrol and chondroitin both carry interaction potential.

Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or on regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Collagen Enhance, straight from the product label.

Brand ResVitale
Net contents 90 Veggie Capsule(s)
Market status On market
Date entered into DSLD Oct 25, 2012
DSLD ID 14019
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Collagen Enhance by ResVitale, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Vegetarian Capsule(s)
Maximum serving Sizes:
3 Vegetarian Capsule(s)
Servings per container
30
IngredientAmount% DV
Chondroitin Sulfate200 mg--
Hyaluronic Acid100 mg--
Hydrolyzed Collagen Type II600 mg--
BioCell Collagen1000 mg--
Resveratrol Polyphenol Complex(TM)400 mg--
Dermaval(TM)500 mg--

Other ingredients: vegetarian Capsule, Rice Bran, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Ultra intensive beauty protein builder Reduces the look of lines and wrinkles Preserves skin's radiance and texture

Enjoy a natural plump effect through three revolutionary ingredients.

Trans-Resveratrol promotes youthful cellular activity.

- Collagen-enhancing formula boosts skin's luminosity, texture and firmness

Brand IP Statement(s)

THE ART An alliance of nature and science delivers skin-deep youth protection. French red wine Resveratrol – organic, wild and potent – is combined with Polygonum cuspidatum and beauty powerhouses Dermaval(TM) and BioCell Collagen(R) to form a superior nutritional skin barrier against cellular aging.

THE BENEFITS BioCell Collagen(R) uses hyaluronic acid and chondroitin to plump and reduce the appearance of lines and wrinkles from within while replenishing lost collagen. Dermaval(TM) helps preserve the elasticity and glow of youthful skin.

THE PROOF Skincare scientists have discovered a way to help maintain skin’s elasticity. Dermaval(TM) has shown the ability to retain your youthful skin tone and texture.

Dermaval(TM), VitaGranate(R), VitaBerry(R) Tropical are trademarks of VDF FutureCeuticals, Inc., used under license. BioCell Collagen(R) is a registered trademark of BioCell Technology, LLC Newport Beach California, USA (US Patent Pending 6,025,327; 6,323,319; 7,780,841; 7,091,180; 7,799,348 other US and foreign patents pending).

ULTRA COLLAGEN ENHANCE(TM)

BioCell Collagen(R) helps replenish collagen proteins vital for smoothing the looks of lines and wrinkles, while clinically tested Dermaval(TM) helps maintain elasticity for ageless contours and a lifted appearance.

- Ultra firming Dermaval(TM) has been clinically tested and helps retain elasticity of the skin.

PURE YOUTH ACTIVATING(TM)

FDA Statement of Identity

DIETARY SUPPLEMENT

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 3 capsules daily. Product can be taken on an empty stomach, with food or as recommended by your healthcare practitioner.

Formulation

Does not contain: Corn, soy, wheat, yeast, lactose, citrus, milk, egg or fish products, sugar, salt, starch, artificial coloring, flavoring or preservatives. Gluten free.

Seals/Symbols

BioCell Collagen(R)

General

VC1341

Precautions

CALIFORNIA PROPOSITION 65 WARNING WARNING: This product contains chemicals known to the state of California to cause cancer and birth defects or reproductive harm.

Storage

Store tightly in a cool, dry place.

Formula

with Dermaval for skin's youthful elasticity

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Collagen Enhance by ResVitale label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Collagen Enhance label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Collagen Enhance by ResVitale

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

BioCell Collagen

1000 mg per serving

Resveratrol Polyphenol Complex(TM)

Interacts with
822 drugs
400 mg per serving Form: natural wild Polygonum cuspidatum, Organic French red whole grape (skin, vine, stem, seeds) (Vitis vinifera) full spectrum polyphenol profile, USDA certified organic Muscadine red whole Grape

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

Resveratrol Polyphenol Complex(TM) monograph & interactions

Dermaval(TM)

500 mg per serving Form: Green Garden Asparagus Asparagus officinalis Concentrate, Okra Abelmoschus esculentus Concentrate, VitaBerry(R) Tropical, VitaGranate(R) BioActive Pomegranate Punica granatum Extract

Other (inactive) ingredients: Vegetarian Capsule, Rice Bran, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Collagen Enhance by ResVitale Drug Interactions

Want to check YOUR meds against Ultra Collagen Enhance?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
822Drugs
822 Moderate

Ingredients driving the most interactions

Resveratrol Polyphenol Complex(TM) 822
Chondroitin Sulfate 2

Individual Drug Interactions

The ingredients in Ultra Collagen Enhance interact with 822 drugs. Click any drug to see the details.

2 of the 5 ingredients in Ultra Collagen Enhance interact with drugs. Each result below shows which ingredient is responsible. Resveratrol Polyphenol Complex(TM) Chondroitin Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Collagen Enhance with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Resveratrol Polyphenol Complex(TM)5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Resveratrol Polyphenol Complex(TM) full monograph & interactions

Chondroitin Sulfate1 drug type · 2 drugs

Warfarin (Coumadin)

Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.

Likelihood Unlikely Evidence D
Chondroitin Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Collagen Enhance, from the product label.

ResVitale

See all ResVitale products
Name
ResVitale
Pharmacist Counseling Corner

Ultra Collagen Enhance by ResVitale: Common Questions

Does Ultra Collagen Enhance by ResVitale interact with any medications?
Yes. Based on its ingredients, Ultra Collagen Enhance has a known interaction with 822 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Collagen Enhance contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Chondroitin should be avoided in both pregnancy and breastfeeding — the safety data isn't there. Resveratrol and hyaluronic acid also lack sufficient safety information during pregnancy and lactation. Talk with your doctor or pharmacist before taking this product if you're pregnant, planning to become pregnant, or breastfeeding.
What are the most common side effects?
Chondroitin commonly causes digestive upset: bloating, constipation, diarrhea, heartburn, and nausea. Resveratrol may cause diarrhea or loose stools at higher doses. Hyaluronic acid is well tolerated in most people. Skin reactions like rash have been rarely reported.
Does chondroitin actually work for joint pain?
Chondroitin is possibly effective for osteoarthritis and cataracts based on our data. For aging skin, osteoporosis, and other uses, we don't have enough reliable evidence to say whether it works.
What is hyaluronic acid doing in a collagen product?
Hyaluronic acid draws water into skin and tissues, helping maintain hydration and plumpness — it works alongside collagen to support skin moisture and elasticity.
Is resveratrol safe to take every day?
Resveratrol is generally well tolerated at typical supplement doses, though long-term safety isn't fully studied. At very high doses, digestive upset can occur. Your pharmacist can help you decide if daily use is right for your situation.
Why does this product have so many ingredients?
Each ingredient targets different aspects of collagen, skin, and joint support — chondroitin and collagen for structure, hyaluronic acid for hydration, and resveratrol for antioxidant effects. The blend is designed to work on multiple levels.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultra Collagen Enhance is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Collagen Enhance label
Go deeper

The Full Monographs Behind Ultra Collagen Enhance’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Collagen Peptides

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...

Read the full Collagen Peptides monograph → Herb & supplement monograph

Resveratrol

Interacts with 822 drugs

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...

Read the full Resveratrol monograph →
Sources

Sources & How We Checked

Ultra Collagen Enhance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 52 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chondroitin Sulfate 22 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  3. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  4. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  5. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
  6. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
  7. Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
  8. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  9. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
  10. Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
  11. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
  12. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  13. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
  14. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
  15. Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
  16. Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
  17. von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
  18. Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
  19. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  20. Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
  21. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
  22. Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed

See these in context on the Chondroitin Sulfate monograph →

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Collagen Peptides 2 references
  1. Trc T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35(3):341-8. PubMed
  2. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. PubMed

See these in context on the Collagen Peptides monograph →

Resveratrol 24 references
  1. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113.
  2. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  3. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
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  16. Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive
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  18. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
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  24. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Contact Dermatitis 2022.

See these in context on the Resveratrol monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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