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Dietary supplement

Grape Seed Extract Plus Resveratrol 325 mg Ingredients & Drug Interactions

by ResVitale

Grape Seed Extract Plus Resveratrol 325 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Grape Seed Extract Plus Resveratrol 325 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Grape Seed Extract Plus Resveratrol 325 mg is a dietary supplement by ResVitale with 2 active ingredients. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, anti-aging.Based on those ingredients, 925 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Grape Seed extract, Resveratrol Polyphenol Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Grape Seed Extract Plus Resveratrol 325 mg by ResVitale

Ask about any prescription or over-the-counter medication and we check it for interactions with Grape Seed Extract Plus Resveratrol 325 mg by ResVitale — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Grape Seed Extract Plus Resveratrol 325 mg by ResVitale

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 5 active ingredients.
  • “Resveratrol Polyphenol Complex” is a proprietary blend — the label gives one combined amount (100 mg) without saying how much of each component you get.

This capsule contains five active ingredients. The Resveratrol Polyphenol Complex is a blend of resveratrol compounds; the product is standardized to deliver 25 mg of trans-resveratrol, the most studied form.

Organic French Whole Red Grape Wine Grape and Grape Seed Extract are two sources of grape polyphenols (plant compounds believed to support blood vessel health). Organic Muscadine is another grape variety.

Wildcrafted Japanese Knotweed (hu zhang) adds additional resveratrol. The inactive ingredients are a vegetarian capsule, rice bran, and silica.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: antioxidant protection and healthy aging support.
  • We looked for evidence on: oxidative stress, free radical damage, cellular aging.
  • The closest evidence on file: Resveratrol is rated "Insufficient Reliable Evidence To Rate" for Aging skin (Natural Medicines).
  • Also on file: Grape is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Ocular stress.

The data we hold shows that grape seed extract is possibly effective for chronic venous insufficiency (CVI) — a condition where veins struggle to return blood from the legs — though more research would strengthen that claim. For chemotherapy-induced nausea and vomiting, hay fever, and obesity, the evidence rates as possibly ineffective.

Resveratrol shows mixed results: possibly effective for obesity and hay fever, but possibly ineffective for cardiovascular disease and high cholesterol. Japanese knotweed has insufficient evidence to rate for hepatitis, rheumatoid arthritis, wound healing, gout, osteoarthritis, and unstable angina.

The evidence, ingredient by ingredient Resveratrol Grape Hu Zhang

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Grape extracts are generally well tolerated in studies; the most common side effects from oral use are abdominal pain, diarrhea, dry mouth, indigestion, headache, joint pain, and nausea. Rarely, anaphylaxis to grape skin has been reported.

Resveratrol at typical supplement doses is also generally well tolerated, though higher doses may cause diarrhea, gastrointestinal discomfort, or loose stools. A few cases of rash have been reported in trials.

During pregnancy, the data advises against concentrated grape supplements and resveratrol — whole grapes as food are fine, but supplements carry limited safety data. There isn't enough information to know whether concentrated grape supplements or resveratrol are safe while breastfeeding; talk with your doctor or pharmacist.

Japanese knotweed should be avoided in pregnancy and breastfeeding due to insufficient safety information.

Side effects, ingredient by ingredient Resveratrol Grape Hu Zhang

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Resveratrol, Grape, Hu Zhang.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 926 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take blood thinners (such as warfarin) or antiplatelet drugs (such as aspirin or clopidogrel). Also confirm use if you take medications broken down by liver enzymes (CYP1A2, CYP2D6, CYP2E1, or CYP3A4 substrates), cyclosporine, midazolam, carbamazepine, or estrogen replacement therapy.

The product may alter how these drugs work, and dosing adjustments might be needed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with leg swelling and poor circulation from chronic venous insufficiency, though the evidence is modest. If you take any blood thinners, sedatives, cyclosporine, estrogen, or medications processed by your liver, you need to check with your doctor or pharmacist first — the grape and resveratrol content can interact.

Skip it if you're pregnant or breastfeeding. Talk it over with your own healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Grape Seed Extract Plus Resveratrol 325 mg, straight from the product label.

Brand ResVitale
Net contents 75 Veggie Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2014
DSLD ID 31962
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Grape Seed Extract Plus Resveratrol 325 mg by ResVitale, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
75
IngredientAmount% DV
Resveratrol Polyphenol Complex100 mg--
Organic French Whole Red Grape Wine Grape0 NP--
Wildcrafted Japanese Knotweed extract0 NP--
organic Muscadine0 NP--
Grape Seed extract325 mg--
standardized to contain 25 mg of trans-Resveratrol25 mg--

Other ingredients: vegetarian Capsule, Rice Bran, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

THE ART Our powerful dual-ingredient blend of Grape Seed Extract and trans-Resveratrol delivers important antioxidant protection.

Together, Grape Seed Extract and Resveratrol deliver a powerful concentration of polyphenols from red wine vineyards. In addition to red wine grapes, our Resveratrol complex features muscadine grapes and Polygonum cuspidatum for a superior resveratrol product.

Provides powerful dual-ingredient antioxidant activity protection Protects against free radicals Helps provide cellular protection against oxidative stress Provides supplemental polyphenols

Dual-ingredient antioxidant protection Protects against free radicals Helps protect cells against oxidative stress Provides supplemental polyphenols

Resveratrol is a powerful polyphenol found in red wine grapes shown to be an important antioxidant for cellular health. THE SCIENCE Grape Seed Extract is a botanical that has a concentrated source of numerous naturally occuring polyphenols and bioflavonols. The bioflavonoids in grape seed extract help protect cell membranes from oxidative damage caused by free radicals.*

BONUS SIZE 25% MORE FREE LIMITED TIME OFFER

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 capsule daily with food or as recommended by your healthcare practitioner.

Storage

Store tightly in a cool, dry place.

Precautions

Consult your healthcare professional before using this product if you are pregnant, nursing, on medication or under a doctor's care.

KEEP OUT OF REACH OF CHILDREN.

DO NOT GIVE TO PETS.

Discontinue use two weeks before surgery. WARNING: DO NOT USE IF SEAL IS BROKEN OR MISSING.

Brand IP Statement(s)

THE BENEFITS Grape Seed Extract is combined with our special Resveratrol Polyphenol Complex(TM) for healthy aging support.

PURE YOUTH ACTIVATING(TM)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Formula

Standardized Extract 95% polyphenols

Formulation

Does not contain: Soy, yeast, lactose, citrus, milk, egg or fish products, sugar, salt, starch, artificial coloring or flavoring, or preservatives.

No artificial colors or flavors. Gluten free.

General

VC1711 VA1710

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Grape Seed Extract Plus Resveratrol 325 mg by ResVitale label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Grape Seed Extract Plus Resveratrol 325 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Grape Seed Extract Plus Resveratrol 325 mg by ResVitale

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container75 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Resveratrol Polyphenol Complex

Interacts with
822 drugs
100 mg per serving

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

Resveratrol Polyphenol Complex monograph & interactions

Grape Seed extract

Interacts with
910 drugs
325 mg per serving Form: polyphenols

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...

Grape Seed extract monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Rice Bran, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Grape Seed Extract Plus Resveratrol 325 mg by ResVitale Drug Interactions

Want to check YOUR meds against Grape Seed Extract Plus Resveratrol 325 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
925Drugs
888 Moderate 37 Minor

Ingredients driving the most interactions

Grape Seed extract 910
Resveratrol Polyphenol Complex 822

Individual Drug Interactions

The ingredients in Grape Seed Extract Plus Resveratrol 325 mg interact with 925 drugs. Click any drug to see the details.

2 of the 2 ingredients in Grape Seed Extract Plus Resveratrol 325 mg interact with drugs. Each result below shows which ingredient is responsible. Grape Seed extract Resveratrol Polyphenol Complex

Each ingredient & the kinds of drugs it affects

For each ingredient in Grape Seed Extract Plus Resveratrol 325 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Grape Seed extract9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Grape Seed extract full monograph & interactions

Resveratrol Polyphenol Complex5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Resveratrol Polyphenol Complex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Grape Seed Extract Plus Resveratrol 325 mg, from the product label.

ResVitale

See all ResVitale products
Name
RESVITALE
Street Address
701 S. Howard Ave., Suite 106-310
City
Tampa
State
FL
ZipCode
33606
Phone Number
1-877-787-5454
Web Address
www.resvitale.com
Pharmacist Counseling Corner

Grape Seed Extract Plus Resveratrol 325 mg by ResVitale: Common Questions

Does Grape Seed Extract Plus Resveratrol 325 mg by ResVitale interact with any medications?
Yes. Based on its ingredients, Grape Seed Extract Plus Resveratrol 325 mg has a known interaction with 925 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Grape Seed Extract Plus Resveratrol 325 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin?
Not without checking first. Grape extracts and resveratrol in this product may thin your blood further, raising bleeding risk. Your doctor or pharmacist needs to know you're considering it and may need to adjust your therapy or monitor you more closely.
What is this product supposed to help with?
It's designed mainly for chronic venous insufficiency — the feeling of heaviness, swelling, or poor circulation in your legs. The grape seed and resveratrol in it have modest evidence supporting that use. For nausea from chemo, hay fever, or weight loss, the evidence doesn't support benefit.
Is it safe to take while I'm pregnant?
No. The safety data advises against concentrated grape supplements and resveratrol during pregnancy. Whole grapes as food are fine, but this concentrated supplement form should be avoided. Talk with your doctor about safer options.
What are the most common side effects?
Stomach upset — abdominal pain, diarrhea, indigestion, and nausea — are the side effects most often reported. Dry mouth, headache, and joint pain have also been seen. These are usually mild and uncommon at typical doses.
What is resveratrol?
Resveratrol is a polyphenol (a type of plant compound) found naturally in grapes, wine, and berries. This product is standardized to 25 mg of trans-resveratrol, the form studied most in research, and it's thought to support blood vessel function and reduce inflammation.
Why are there both grape seed extract and Japanese knotweed in the same capsule?
Both are sources of resveratrol and other polyphenols believed to support circulation and vascular health. The combination aims to give you multiple polyphenol sources in one dose, though the evidence for added benefit from combining them isn't established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Grape Seed Extract Plus Resveratrol 325 mg label
Go deeper

The Full Monographs Behind Grape Seed Extract Plus Resveratrol 325 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Resveratrol

Interacts with 822 drugs

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...

Read the full Resveratrol monograph → Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph → Herb & supplement monograph

Hu Zhang

Interacts with 826 drugs

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for...

Read the full Hu Zhang monograph →
Sources

Sources & How We Checked

Grape Seed Extract Plus Resveratrol 325 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 77 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Resveratrol 24 references
  1. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113.
  2. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  3. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  4. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  5. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  6. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  7. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  8. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  9. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  10. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  11. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  12. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  13. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  14. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  15. la, Porte C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D., Singhal, N., and Cameron, D. W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Cli PubMed
  16. Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive
  17. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
  18. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
  19. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
  20. Lin CT, Sun XY, Lin AX. Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study. Ren Fail. 2016;38(2):214-21. PubMed
  21. Li Q, Yang G, Xu H, Tang S, Lee WY. Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther 2021;21(1):214. PubMed
  22. McCreary MR, Schnell PM, Rhoda DA. Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19). Sci Rep 2022;12(1):10978. PubMed
  23. Abdelhaleem IA, Brakat AM, Adayel HM, Asla MM, Rizk MA, Aboalfetoh AY. The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis. Med Clin (Barc) 2022;158(12):576-585. PubMed
  24. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Contact Dermatitis 2022.

See these in context on the Resveratrol monograph →

Grape 34 references
  1. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  2. Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. PubMed
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See these in context on the Grape monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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