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Dietary supplement

Upper Chamber Teapills Ingredients & Drug Interactions

by Plum Flower

Upper Chamber Teapills label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Upper Chamber Teapills against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Upper Chamber Teapills is a dietary supplement by Plum Flower with 4 active ingredients. Its ingredients are commonly taken for general wellness and longevity, antioxidant support, heart and cholesterol health.Based on those ingredients, 963 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Xanthium sibiricum Fruit Extract, Magnolia biondii Flower Extract, Angelica dahurica Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Upper Chamber Teapills by Plum Flower

Ask about any prescription or over-the-counter medication and we check it for interactions with Upper Chamber Teapills by Plum Flower — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Upper Chamber Teapills by Plum Flower

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (1,360 mg) without saying how much of each component you get.

Upper Chamber Teapills contains four active ingredients. Angelica dahurica root extract, Mentha haplocalyx herb extract (Japanese mint), Magnolia biondii flower extract, and Xanthium sibiricum fruit extract (Siberian cocklebur) are the components listed.

These are combined in a proprietary extract blend. The product also contains several inactive ingredients—magnesium silicate, dextrin, activated carbon, and china wax—which are binders, fillers, and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Gingivitis — rated "Possibly Effective" (Magnolia) (Natural Medicines).

The evidence for what this product actually does is very limited. Magnolia is rated possibly effective for gingivitis, but for its other claimed uses—hay fever, anxiety, and dental plaque—the evidence is insufficient to rate.

Angelica dahurica, Japanese mint, and Siberian cocklebur have either insufficient evidence or no established effectiveness ratings in the data we hold. This product's actual benefit is not well established.

The evidence, ingredient by ingredient Ashitaba Japanese Mint Magnolia Siberian Cocklebur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Siberian cocklebur is a major safety concern. It is regarded as generally unsafe—it has caused serious poisoning, including severe low blood sugar, liver and kidney damage, irregular heartbeat, and bleeding.

It requires careful professional processing and oversight. Angelica dahurica is likely safe as food but supplement safety hasn't been well studied.

Magnolia is generally well tolerated when taken by mouth, though long-term human safety data is limited. Japanese mint in food amounts is fine, but the concentrated oil can irritate or become toxic if misused.

All four ingredients carry warnings against use in pregnancy and breastfeeding due to insufficient safety data or potential harm.

Side effects, ingredient by ingredient Ashitaba Japanese Mint Magnolia Siberian Cocklebur

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Magnolia, Ashitaba, Siberian Cocklebur.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 964 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take any medication for diabetes or blood sugar control, any drug that affects the kidneys or liver, any blood thinner (anticoagulant) or antiplatelet drug, or any medication that makes you drowsy (CNS depressant). Siberian cocklebur carries Major-severity interactions with kidney drugs, liver drugs, and diabetes medications.

Magnolia and Angelica dahurica have Moderate interactions that could change how several other drugs work in your body.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

We cannot recommend this product without serious reservation. The presence of Siberian cocklebur—which is known to be toxic and to cause liver damage, kidney damage, severe low blood sugar, and heart problems—makes it a high-risk choice.

If you take any medication for blood sugar, kidney function, or liver function, or any blood thinner, you absolutely must talk to your pharmacist before considering this product. Even then, the safety profile and limited evidence of benefit make it hard to justify.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Upper Chamber Teapills, straight from the product label.

Brand Plum Flower
Barcode (UPC) 739934820162
Net contents 1.2 Ounce(s); 34 Gram(s); 200 Pill(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 331291
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Upper Chamber Teapills by Plum Flower, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Pill(s)
Maximum serving Sizes:
8 Pill(s)
Servings per container
25
UPC/BARCODE
739934820162
IngredientAmount% DV
Proprietary Extract Blend1360 mg--
Angelica dahurica Root Extract0 NP--
Mentha haplocalyx herb extract0 NP--
Magnolia biondii Flower Extract0 NP--
Xanthium sibiricum Fruit Extract0 NP--

Other ingredients: Magnesium Silicate, Hydrated, Dextrin, Carbon, Activated, China Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Take 8 pills 3 times daily or as directed by your health care practitioner

Precautions

Caution during pregnancy

Keep out of reach of children

Brand IP Statement(s)

US owned & operated since 1969. Made in China in partnership with the award-winning Lanzhou Foci Pharmaceutical Co. Ltd. Plum Flower Quality Guarantee

Formulation

No pharmaceuticals or dyes Unsulfured, preservative-free herbs when available Microbial and heavy metal tested

Scientifically authenticated herbs Produced at a Good Manufacturing Practices (GMP) certified factory

General Statements

Foci Pharmaceutical 1929 Foci Pharmaceutical

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Upper Chamber Teapills by Plum Flower label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Upper Chamber Teapills label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Upper Chamber Teapills by Plum Flower

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size8 Pill(s) Dosage formTablet Or Pill Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Magnesium Silicate, Hydrated, Dextrin, Carbon, Activated, China Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Upper Chamber Teapills by Plum Flower Drug Interactions

Want to check YOUR meds against Upper Chamber Teapills?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
963Drugs
662 Major 301 Moderate

Ingredients driving the most interactions

Xanthium sibiricum Fruit Extract 662
Magnolia biondii Flower Extract 351
Angelica dahurica Root Extract 186

Individual Drug Interactions

The ingredients in Upper Chamber Teapills interact with 963 drugs. Click any drug to see the details.

3 of the 4 ingredients in Upper Chamber Teapills interact with drugs. Each result below shows which ingredient is responsible. Xanthium sibiricum Fruit Extract Magnolia biondii Flower Extract Angelica dahurica Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Upper Chamber Teapills with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Xanthium sibiricum Fruit Extract3 drug types · 662 drugs

Antidiabetes Drugs

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans. Hypoglycemia occurs soon after consumption and worsens with time in most cases. Do not use Siberian cocklebur in people taking medications that also lower blood glucose.
Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Likely Evidence B
Hepatotoxic Drugs

Siberian cocklebur can adversely affect the liver. It has been linked to many cases of hepatotoxicity and some cases of liver failure. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (TriCor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo).

Likelihood Likely Evidence B
Nephrotoxic Drugs

Siberian cocklebur can adversely affect the kidney. Theoretically, combining Siberian cocklebur with potentially nephrotoxic drugs might have additive harmful effects on kidney function.
Some potentially nephrotoxic drugs include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others.

Likelihood Likely Evidence B
Xanthium sibiricum Fruit Extract full monograph & interactions

Magnolia biondii Flower Extract2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.

Likelihood Possible Evidence D
Magnolia biondii Flower Extract full monograph & interactions

Angelica dahurica Root Extract1 drug type · 186 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2. Theoretically, concomitant use of ashitaba with CYP1A2 substrates might decrease the clearance of these substrates and increase the risk for adverse effects. However, this interaction has yet to be reported in humans. Until more is known, use with caution.

Likelihood Possible Evidence D
Angelica dahurica Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Upper Chamber Teapills, from the product label.

Plum Flower

Name
Mayway Herbs
City
Oakland
State
CA
Web Address
www.plumflowerherbs.com
Pharmacist Counseling Corner

Upper Chamber Teapills by Plum Flower: Common Questions

Does Upper Chamber Teapills by Plum Flower interact with any medications?
Yes. Based on its ingredients, Upper Chamber Teapills has a known interaction with 963 medications, including 662 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Upper Chamber Teapills contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
No. All four active ingredients in this product advise against use during pregnancy and breastfeeding. The safety data is either absent or concerning enough that the recommendations are to avoid them. Talk to your doctor or pharmacist before taking any supplement while pregnant or nursing.
What is Siberian cocklebur, and why is it in this product?
Siberian cocklebur is the fruit of a plant. It's included in traditional formulas, but safety data shows it can cause serious harm—liver and kidney damage, severe low blood sugar, and heart problems—especially when concentrated. The product facts note it requires careful professional processing because of its toxic compounds.
Does this product actually work?
The evidence is very limited. Only magnolia has a solid rating—it's possibly effective for gingivitis. For everything else this product may be marketed for, the evidence is either insufficient or not rated. You'd be taking a high-risk product with unproven benefits.
Can I take this with my diabetes medication?
No, not without talking to your pharmacist first. Siberian cocklebur can cause severe low blood sugar on its own and carries a Major-severity interaction with diabetes drugs. Combining them could be dangerous.
What side effects has this product reported?
Siberian cocklebur has caused abdominal pain, nausea, vomiting, severe low blood sugar, liver damage, irregular heartbeat, dizziness, and bleeding. Japanese mint oil can trigger asthma-like attacks or respiratory problems if misused. Magnolia is generally well tolerated, though one person in a trial reported sexual dysfunction and another reported shaking hands and numbness—though it's unclear if magnolia caused these.
What if I'm taking a blood thinner—is this safe?
No. Magnolia may increase your bleeding risk when combined with blood thinners, and Siberian cocklebur can increase bleeding risk through liver damage. Talk to your pharmacist or doctor before using this product if you take any blood thinner.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Upper Chamber Teapills label
Go deeper

The Full Monographs Behind Upper Chamber Teapills’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ashitaba

Interacts with 186 drugs

Ashitaba is a leafy plant from Japan that is eaten as a vegetable and taken as a supplement for general health, antioxidant, and heart benefits. Most of the supporting research comes from la...

Read the full Ashitaba monograph → Herb & supplement monograph

Japanese Mint

Japanese mint is a menthol-rich plant used mainly for its essential oil in topical rubs, inhalants, and digestive remedies. There is some support for menthol's soothing and cooling effects,...

Read the full Japanese Mint monograph → Herb & supplement monograph

Magnolia

Interacts with 351 drugs

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human research is still limited, so we can't be...

Read the full Magnolia monograph → Herb & supplement monograph

Siberian Cocklebur

Interacts with 662 drugs

Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and allergies. Human evidence is very limited, and the p...

Read the full Siberian Cocklebur monograph →
Sources

Sources & How We Checked

Upper Chamber Teapills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ashitaba 2 references
  1. Kwon D, Yoon S, Carter O, Bailey GS, Dashwood RH. Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells. Biofactors. 2006;26(4):231
  2. Noh HM, Ahn EM, Yun JM, Cho BL, Paek YJ. Angelica keiskei Koidzumi extracts improve some markers of liver function in habitual alcohol drinkers: a randomized double-blind clinical trial. J Med Food. 2015;18(2):166-72.

See these in context on the Ashitaba monograph →

Japanese Mint 2 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Japanese Mint monograph →

Magnolia 9 references
  1. Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9. PubMed
  2. Tachikawa E, Takahashi M, Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000;60:433-40. PubMed
  3. Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-11.
  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  5. Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988;50:757-65. PubMed
  6. Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
  7. Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
  8. Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
  9. Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.

See these in context on the Magnolia monograph →

Siberian Cocklebur 4 references
  1. Wu, M. L., Wang, C. P., and Deng, J. F. Fatal hepatic failure due to fructus xanthii in a child. Abstracts of the 2005 North American Congress of Clinical Toxicology Annual Meeting. Clin Toxicol 2005;43:639. DOI
  2. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756. PubMed
  3. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
  4. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.

See these in context on the Siberian Cocklebur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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