Valerian Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Valerian against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Valerian is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for insomnia and poor sleep, anxiety and stress, restlessness.Based on those ingredients, 904 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian Root Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Valerian by Herbal Terra
Ask about any prescription or over-the-counter medication and we check it for interactions with Valerian by Herbal Terra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Valerian by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient, valerian root extract (dry), which is the part of the valerian plant used for its calming properties. Its listed role in the product is as the sole active ingredient.
The inactive ingredients are alcohol, water, and glycerin. These are the carriers and solvents that make up the liquid, not active ingredients.
Does it work?
Moderate evidence
For insomnia (trouble falling or staying asleep), valerian is rated Possibly Effective. The evidence for restless legs syndrome, pre-procedural anxiety, stress, and menstrual cramps (dysmenorrhea) is rated Insufficient Reliable Evidence To Rate, which means we do not yet have enough reliable data to judge whether it helps for those uses.
How safe is it?
Well-documented data
Valerian is generally well tolerated for short-term use, but long-term safety has not been well studied. Common side effects include dizziness, drowsiness, and mental slowness, along with headache, stomach upset, excitability, and vivid dreams.
After regular use, stopping abruptly may bring on withdrawal symptoms such as a racing heartbeat, anxiety, irritability, and insomnia, so tapering slowly is advised. Our safety data advises against using valerian during pregnancy, because its safety has not been established.
It also advises against use while breastfeeding, because there is not enough safety information. Talk with your own doctor or pharmacist about your situation before deciding anything.
Meds to double-check
Moderate interaction found
Double-check with your own doctor or pharmacist before taking this product if you use CNS depressants or alprazolam (Xanax), since both carry Moderate-rated sedation interactions. Alcohol and glucuronidated drugs also carry Moderate ratings, and CYP2D6 and CYP3A4 substrates carry Minor ratings.
We do not hold data showing that any of these interactions are absent.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Valerian may be worth considering if your main goal is occasional sleeplessness, since that is the use with the strongest rating in our data. If you take sedating medications, drink alcohol, or are pregnant or breastfeeding, you should be especially careful.
Please talk it over with your own doctor or pharmacist before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Valerian, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 7238360709308 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 325481 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Valerian by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Valerian Root Extract, Dry | 983 mg | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.
Precautions
We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!
Do not use if you are allergic to any ingredients.
Storage
Store in a cool, dry, dark place.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Sugar free
Expertly extracted 100% natural Premium product
Organic alcohol
No artificial ingredients, color additives, fillers or binders.
Natural Gluten free
Formula
Valeriana officinalis
Organic alcohol
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Valerian by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Valerian by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Valerian Root Extract, Dry
Interacts with904 drugs
Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...
Valerian Root Extract, Dry monograph & interactionsOther (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Valerian by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Herbal Terra Valerian is a liquid whose single active ingredient, valerian root extract, has documented interactions with several drug types.
The most serious of these is Moderate-rated: valerian root extract can add to the sedative effects of CNS depressants (drugs that slow the brain and nervous system), so the combined drowsiness can be stronger than either alone.
Read the full breakdown — every affected drug type, severity by severity
Valerian root extract also carries Moderate-rated interactions with glucuronidated drugs (medications cleared by liver enzymes called UGT1A1 and UGT2B7), where it may weakly raise their levels. Its interactions with alprazolam (Xanax) and with alcohol are also Moderate, mainly because of added sedation.
Minor-rated interactions are listed for CYP2D6 and CYP3A4 substrates (drugs processed by two other liver enzymes), but clinical studies suggest valerian has little real effect on those.
Altogether, these interactions span 905 individual medications. If you take any prescription or over-the-counter medicine, talk it over with your own doctor or pharmacist before combining it with this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Valerian?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Valerian interact with 904 drugs. Click any drug to see the details.
1 of the 1 ingredient in Valerian interact with drugs. Each result below shows which ingredient is responsible. Valerian Root Extract, Dry
Gabapentin EnacarbilHorizant
How Gabapentin Enacarbil interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Gabapentin Enacarbil interactionGamma Hydroxybutyrate (prescription Drug)GHB
How Gamma Hydroxybutyrate (prescription Drug) interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Gamma Hydroxybutyrate (prescription Drug) interactionGanaxoloneZtalmy
How Ganaxolone interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract, Dry + Ganaxolone interactionGlutethimideDoriden
How Glutethimide interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Glutethimide interactionGuaifenesin, HydrocodoneEntuss, Pneumotussin
How Guaifenesin, Hydrocodone interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Guaifenesin, Hydrocodone interactionGuaifenesin, Hydrocodone BitartrateFlowtuss, Obredon
How Guaifenesin, Hydrocodone Bitartrate interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract, Dry + Guaifenesin, Hydrocodone Bitartrate interactionGuaifenesin, Hydrocodone Bitartrate, Pseudoephedrine HydrochlorideHycofenix
How Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride interactionGuaifenesin, Hydrocodone, PseudoephedrineEntuss-D, Tussi-Organidin DM NR
How Guaifenesin, Hydrocodone, Pseudoephedrine interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract, Dry + Guaifenesin, Hydrocodone, Pseudoephedrine interactionHeroinHeroin
How Heroin interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Heroin interactionHexobarbitalHexobarbital, Sombulex
How Hexobarbital interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Hexobarbital interactionHomatropine Methylbromide, HydrocodoneHycodan, Tussigon
How Homatropine Methylbromide, Hydrocodone interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Homatropine Methylbromide, Hydrocodone interactionHydrocodoneHydrocodone, Zohydro ER
How Hydrocodone interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract, Dry + Hydrocodone interactionHydrocodone BitartrateHysingla, Vantrela ER
How Hydrocodone Bitartrate interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Hydrocodone Bitartrate interactionHydrocodone, IbuprofenVicoprofen
How Hydrocodone, Ibuprofen interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract, Dry + Hydrocodone, Ibuprofen interactionHydrocodone, PseudoephedrineP-V-Tussin, Rezira
How Hydrocodone, Pseudoephedrine interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Hydrocodone, Pseudoephedrine interactionHydrocodone, Pseudoephedrine, ChlorpheniramineZutripro
How Hydrocodone, Pseudoephedrine, Chlorpheniramine interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract, Dry + Hydrocodone, Pseudoephedrine, Chlorpheniramine interactionHydrocodone/chlorpheniramineTussionex
How Hydrocodone/chlorpheniramine interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract, Dry + Hydrocodone/chlorpheniramine interactionHydromorphoneDilaudid, Hydromorph Contin, Palladone
How Hydromorphone interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Hydromorphone interactionHyoscyamine, PhenobarbitalLevsin Pb, Levsinex Pb Timecaps
How Hyoscyamine, Phenobarbital interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Hyoscyamine, Phenobarbital interactionIbuprofen, AcetaminophenAdvil Dual Action
How Ibuprofen, Acetaminophen interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract, Dry + Ibuprofen, Acetaminophen interactionIbuprofen, HydrocodoneIbucodone
How Ibuprofen, Hydrocodone interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract, Dry + Ibuprofen, Hydrocodone interactionIbuprofen, OxycodoneCombunox
How Ibuprofen, Oxycodone interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Ibuprofen, Oxycodone interactionIndiplonIndiplon
How Indiplon interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Indiplon interactionIrinotecanCamptosar, Onivyde
How Irinotecan interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract, Dry + Irinotecan interactionIrinotecan Hydrochloride
How Irinotecan Hydrochloride interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract, Dry + Irinotecan Hydrochloride interactionKetazolamLoftran
How Ketazolam interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Ketazolam interactionLamivudine, RaltegravirDutrebis
How Lamivudine, Raltegravir interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract, Dry + Lamivudine, Raltegravir interactionLamotrigineLamictal
How Lamotrigine interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryGlucuronidated Drugs, Cns Depressants Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract, Dry + Lamotrigine interactionLasmiditan SuccinateReyvow
How Lasmiditan Succinate interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract, Dry + Lasmiditan Succinate interactionLemborexantDayvigo
How Lemborexant interacts with Valerian — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract, Dry + Lemborexant interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Valerian with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Valerian Root Extract, Dry
Alcohol (Ethanol)
Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.
Alprazolam (Xanax)
Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.
Cns Depressants
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.
Glucuronidated Drugs
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.
Brand information
Manufacturer and brand details for Valerian, from the product label.
Herbal Terra
See all Herbal Terra products- Name
- Herbal Terra LLC
- Phone Number
- +18083857868
- Web Address
- herbalterra.com
Valerian by Herbal Terra: Common Questions
Does Valerian by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Valerian’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Valerian's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 38 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Valerian 38 references
- Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
- Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
- Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
- Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 1999;51:505-12. PubMed
- Garges HP, Varia I, Doraiswamy PM. Cardiac complications and delirium associated with Valerian root withdrawal. [Letter to the Editor]. JAMA 1998;280:1566-7. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- MacGregor FB, Abernethy VE, Dahabra S, et al. Hepatotoxicity of herbal remedies. BMJ 1989;299:1156-7. PubMed
- Leathwood PD, Chauffard F. Aqueous extract of valerian reduces latency to fall asleep in man. Planta Med 1985;2:144-8. PubMed
- Hadley S, Petry JJ. Valerian. Am Fam Physician 2003;67:1755-8..
- Glass JR, Sproule BA, Herrmann N, et al. Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects. J Clin Psychopharmacol 2003;23:260-8. PubMed
- Lefebvre T, Foster BC, Drouin CE, et al. In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. J Pharm Pharmaceut Sci 2004;7:265-73.
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