Valerian Root Liquid Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Valerian Root Liquid Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Valerian Root Liquid Extract is a dietary supplement by Planetary Herbals with 1 active ingredient. Its ingredients are commonly taken for insomnia and poor sleep, anxiety and stress, restlessness.Based on those ingredients, 902 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Valerian Root Liquid Extract by Planetary Herbals
Ask about any prescription or over-the-counter medication and we check it for interactions with Valerian Root Liquid Extract by Planetary Herbals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Valerian Root Liquid Extract by Planetary Herbals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: valerian root extract. Valerian is an herbal sedative traditionally used to help with sleep and calm.
The liquid also contains grain alcohol and purified water as inactive ingredients.
Does it work?
Moderate evidence
Valerian is possibly effective for insomnia based on available evidence. For restless legs syndrome, pre-procedural anxiety, stress, and period pain (dysmenorrhea), the evidence isn't strong enough to rate it reliably.
If sleep is what you're after, valerian may help, but results vary from person to person.
How safe is it?
Well-documented data
Valerian is generally well tolerated in the short term, though long-term safety hasn't been well studied. Common side effects include dizziness, drowsiness, mental slowness, headache, and gastrointestinal upset.
Some people report vivid dreams or feel more excitable instead of calm. If you use it for a long time and stop suddenly, you may experience withdrawal symptoms—anxiety, irritability, insomnia, or even rapid heart rate—so taper your dose slowly when you're ready to stop.
There have been rare case reports of liver problems tied to multi-ingredient products containing valerian, though a single-ingredient extract carries less risk. Safety data advises against valerian in pregnancy and while breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your pharmacist if you're on CNS depressants (sedating drugs, sleep aids, narcotic painkillers), Alprazolam (Xanax), drugs metabolized by glucuronidation, or if you drink alcohol regularly. Even though interactions with CYP2D6 and CYP3A4 substrates are Minor, mention those too if you take them—we can help sort it out.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Valerian may help if you're struggling with sleep, but it's a sedative, so it'll add to the sleepiness of any other calming drugs you're on—including alcohol. If you're pregnant or nursing, skip it.
Check your medications with the tool on this page before you start, and let your pharmacist know you're thinking about adding it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 20, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Valerian Root Liquid Extract, straight from the product label.
| Brand | Planetary Herbals |
|---|---|
| Barcode (UPC) | 021078101314 |
| Net contents | 4 fl. Oz.; 118.28 mL |
| Market status | On market |
| Date entered into DSLD | Nov 20, 2017 |
| DSLD ID | 80565 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Valerian Root Liquid Extract by Planetary Herbals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| Valerian root extract | 1.5 mL | -- |
Other ingredients: Grain Alcohol, purified Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Herbal Supplement
General Statements
Approved by Michael Tierra L.Ac, O.M.D
Planetary Herbals Valerian Root Liquid Extract is carefully prepared from freshly harvested roots to prevent the degradation of valerian’s sensitive constituents.
Suggested/Recommended/Usage/Directions
Suggested Use: 60 drops (approx. 1/4 tsp.) as needed up to 3 times before bedtime in water or juice.
Precautions
Warning: Do not use if you are pregnant, may become pregnant, or breastfeeding.
Do not use if tamper-evident seal is broken or missing.
Keep out of the reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
Planetary Herbals, LLC
General
PF0131 REV E141
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Valerian Root Liquid Extract by Planetary Herbals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Valerian Root Liquid Extract by Planetary Herbals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1.5 mL Dosage formLiquid Servings per container78 Amounts shown are per serving.
Valerian root extract
Interacts with902 drugs
Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...
Valerian root extract monograph & interactionsOther (inactive) ingredients: Grain Alcohol, Purified Water. These complete the product’s ingredient list but are not active constituents.
Valerian Root Liquid Extract by Planetary Herbals Drug Interactions
HelloPharmacist Interaction Report
Planetary Herbals Valerian Root Liquid Extract does interact with several medication types, so you'll want to check your specific prescriptions before starting it.
Read the full breakdown — every affected drug type, severity by severity
The main concern is with CNS depressants—that's sedating drugs like sleep aids, anti-anxiety medications, or narcotic painkillers. Valerian adds to their drowsy effect, and the interaction is Moderate severity.
Alprazolam (Xanax) falls into this category and gets a Moderate flag of its own because valerian can amplify its sedation and may modestly raise its blood levels. Alcohol is another Moderate interaction: mixing valerian with drinking can intensify sleepiness and mental cloudiness.
Valerian also may weakly inhibit a liver enzyme called glucuronidation (UGT1A1 and UGT2B7), which could raise levels of drugs that depend on it to clear from your body—that's Moderate severity. On the lighter side, valerian shows only Minor interactions with drugs broken down by two other liver enzymes (CYP2D6 and CYP3A4); clinical studies suggest it doesn't meaningfully affect them.
Altogether, these interactions span 891 individual medications. Use the search tool below to check your exact medications before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Valerian Root Liquid Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Valerian Root Liquid Extract interact with 902 drugs. Click any drug to see the details.
1 of the 1 ingredient in Valerian Root Liquid Extract interact with drugs. Each result below shows which ingredient is responsible. Valerian root extract
Aspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Glucuronidated Drugs Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
How Aspirin, Meprobamate interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Aspirin, Meprobamate interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Aspirin, Pentazocine interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Atorvastatin Calcium interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Atropine, Phenobarbital interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Atropine, Meperidine interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract + Atropine, Morphine Sulfate interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionBelinostatBeleodaq
How Belinostat interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Belinostat interactionBelladona Extract, PhenobarbitalChardonna-2
How Belladona Extract, Phenobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Belladona Extract, Phenobarbital interactionBelladonna Alkaloids, Ergotamine Tartrate, PhenobarbitalBel Tabs, Bellamine-S, Bellaphen-S, Duragal S, Phenarbal S, Spastrin
How Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBelladonna Alkaloids, PhenobarbitalBarbidonna, Donnatal
How Belladonna Alkaloids, Phenobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Belladonna Alkaloids, Phenobarbital interactionBelladonna Extract, PhenobarbitalBelap
How Belladonna Extract, Phenobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Belladonna Extract, Phenobarbital interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBelladonna, Ergotamine Tartrate, Phenobarbital
How Belladonna, Ergotamine Tartrate, Phenobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Belladonna, Ergotamine Tartrate, Phenobarbital interactionBelladonna, Ergotamine, PhenobarbitalBellergal-S
How Belladonna, Ergotamine, Phenobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Belladonna, Ergotamine, Phenobarbital interactionBelladonna, OpiumB & O Supprettes
How Belladonna, Opium interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Belladonna, Opium interactionBelladonna, PhenobarbitalBellophen, Susano
How Belladonna, Phenobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Belladonna, Phenobarbital interactionBellafoline, Caffeine, Ergotamine Tartrate, PentobarbitalCafergot PB
How Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionBellafoline, PhenobarbitalBelladenal, Belladenal-S
How Bellafoline, Phenobarbital interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Bellafoline, Phenobarbital interactionBelzutifanWelireg
How Belzutifan interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Belzutifan interactionBenactyzine, MeprobamateDeprol
How Benactyzine, Meprobamate interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs, Cns Depressants Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Benactyzine, Meprobamate interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with Valerian Root Liquid Extract — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Glucuronidated Drugs +2 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Benzhydrocodone, Acetaminophen interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Valerian Root Liquid Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Valerian root extract
Alcohol (Ethanol)
Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.
Alprazolam (Xanax)
Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.
Cns Depressants
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.
Glucuronidated Drugs
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.
Brand information
Manufacturer and brand details for Valerian Root Liquid Extract, from the product label.
Planetary Herbals
See all Planetary Herbals products- Name
- Planetary Herbals, LLC
- Street Address
- P.O. Box 1760
- City
- Soquel
- State
- CA
- ZipCode
- 95073
- Web Address
- www.planetaryherbals.com
Valerian Root Liquid Extract by Planetary Herbals: Common Questions
Does Valerian Root Liquid Extract by Planetary Herbals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take valerian if I'm pregnant or breastfeeding?
What are the most common side effects?
What happens if I stop taking valerian suddenly after using it long-term?
Is valerian actually proven to work for sleep?
Does valerian interact with my liver medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Valerian Root Liquid Extract is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Valerian Root Liquid Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Valerian Root Liquid Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Valerian 37 references
- Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
- Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
- Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
- Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 1999;51:505-12. PubMed
- Garges HP, Varia I, Doraiswamy PM. Cardiac complications and delirium associated with Valerian root withdrawal. [Letter to the Editor]. JAMA 1998;280:1566-7. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- MacGregor FB, Abernethy VE, Dahabra S, et al. Hepatotoxicity of herbal remedies. BMJ 1989;299:1156-7. PubMed
- Leathwood PD, Chauffard F. Aqueous extract of valerian reduces latency to fall asleep in man. Planta Med 1985;2:144-8. PubMed
- Hadley S, Petry JJ. Valerian. Am Fam Physician 2003;67:1755-8..
- Glass JR, Sproule BA, Herrmann N, et al. Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects. J Clin Psychopharmacol 2003;23:260-8. PubMed
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