Varicose Health & Circulation Ingredients & Drug Interactions
by New Sun
What is this page for?
First and foremost: checking Varicose Health & Circulation against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Varicose Health & Circulation is a dietary supplement by New Sun with 7 active ingredients. Its ingredients are commonly taken for diarrhea, sore throat and mouth irritation, minor skin inflammation and wounds.Based on those ingredients, 362 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Butcher's Broom, Horse Chestnut, Rutin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Varicose Health & Circulation by New Sun
Ask about any prescription or over-the-counter medication and we check it for interactions with Varicose Health & Circulation by New Sun — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Varicose Health & Circulation by New Sun
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Varicose Health & Circulation contains 7 ingredients total, though the Proprietary Blend's contents are not disclosed on the label and we can't assess it. The active ingredients we can identify are white oak (a plant traditionally used for circulation), butcher's broom (used to support vein health), two forms of horse chestnut (a seed extract for chronic venous insufficiency), and rutin (a plant compound).
The inactive ingredients are gelatin, rice flour, magnesium stearate, and silica — common capsule fillers and binders.
Does it work?
Moderate evidence
For chronic venous insufficiency (the heaviness or swelling in the legs from damaged veins), butcher's broom and both horse chestnut forms are rated possibly effective. Rutin and white oak have no established effectiveness ratings in our data.
For other conditions on the label — hemorrhoids, diabetic retinopathy, orthostatic hypotension (dizziness on standing), lymphedema, irritable bowel syndrome, and kidney stones — the evidence we hold is insufficient to rate any of these ingredients.
How safe is it?
Well-documented data
Butcher's broom and horse chestnut are generally well tolerated short-term in healthy adults, though long-term safety data are limited. The most common side effects from butcher's broom are digestive complaints: diarrhea, nausea, vomiting, heartburn, and indigestion.
Horse chestnut may cause dizziness, headache, gastrointestinal upset, or itching. Rutin may cause headache, flushing, or rashes in some people.
White oak has high tannin content and can irritate the digestive tract — it's meant for short-term use only. During pregnancy, white oak, butcher's broom, and horse chestnut safety data advise against use.
Rutin is rated likely safe in pregnancy, but there isn't enough data for supplement doses. While breastfeeding, white oak, butcher's broom, and horse chestnut are best avoided.
Rutin safety while breastfeeding is unknown. If you're pregnant or nursing, talk with your doctor or pharmacist before taking this product.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, apixaban, aspirin, or clopidogrel) — horse chestnut may increase bleeding risk. Also check if you take alpha-adrenergic antagonists for blood pressure or urinary symptoms (like doxazosin or terazosin) or alpha-adrenergic agonists (like pseudoephedrine or phenylephrine), or diabetes medications — butcher's broom and rutin may theoretically affect how these work.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product targets circulation and vein health with ingredients that have modest evidence for chronic venous insufficiency, but it interacts with blood thinners, some blood pressure medications, and diabetes drugs — and we can't check two of its ingredients. If you take any prescription medication, especially blood thinners, blood pressure meds, or diabetes drugs, check with your doctor or pharmacist before starting.
It's meant for short-term use and isn't recommended in pregnancy or while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Varicose Health & Circulation, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Varicose Health & Circulation by New Sun, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1200 mg | -- |
| White Oak | 0 NP | -- |
| Butcher's Broom | 0 NP | -- |
| Horse Chestnut | 0 NP | -- |
| Horse Chestnut (seed) Concentrate | 0 NP | -- |
| Rutin | 0 NP | -- |
| Enzyme Blend | 0 NP | -- |
Other ingredients: Gelatin, Rice Flour, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Helps support healthy circulation.*
Precautions
Keep out of reach of children.
Do not use if safety seal is missing or broken.
Warning: If you are pregnant, nursing, taking any medications, or experiencing health issues, consult your doctor before use.
Storage
Store in a cool, dry place.
Suggested/Recommended/Usage/Directions
Recommendation: As a dietary supplement, take two capsules with meala twice daily.
FDA Disclaimer Statement
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General
Product No. 39-3 V3.0
FDA Statement of Identity
Dietary Supplement
Formulation
This product does not contain: yeast, corn, wheat, egg, starch, preservatives, artificial coloring or sweeteners.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Varicose Health & Circulation by New Sun label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Varicose Health & Circulation by New Sun
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
White Oak
No knowninteractions
White oak bark is a traditional herbal remedy rich in tannins, used mostly as a tea or skin wash for diarrhea, sore throat, and minor skin problems. S...
White Oak monograph & interactionsButcher's Broom
Interacts with158 drugs
Butcher's broom is a plant extract most often used for circulation problems in the legs, such as chronic venous insufficiency, where some evidence sug...
Butcher's Broom monograph & interactionsHorse Chestnut
Interacts with122 drugs
Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and h...
Horse Chestnut monograph & interactionsHorse Chestnut (seed) Concentrate
Interacts with122 drugs
Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and h...
Horse Chestnut (seed) Concentrate monograph & interactionsRutin
Interacts with86 drugs
Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...
Rutin monograph & interactionsEnzyme Blend
Other (inactive) ingredients: Gelatin, Rice Flour, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Varicose Health & Circulation by New Sun Drug Interactions
HelloPharmacist Interaction Report
Varicose Health & Circulation by New Sun has documented interactions with several types of medications, most seriously through its horse chestnut content and blood thinners (anticoagulants/antiplatelet drugs).
Horse chestnut may increase bleeding risk when combined with blood thinners or antiplatelet medications like warfarin or aspirin because it contains a compound called esculin with antiplatelet effects. This interaction is rated Moderate severity.
Read the full breakdown — every affected drug type, severity by severity
Butcher's broom may theoretically reduce the effects of alpha-adrenergic antagonists (medications that relax blood vessel muscles, like doxazosin or terazosin) or increase the effects of alpha-adrenergic agonists (stimulants like pseudoephedrine or phenylephrine). Rutin may theoretically increase the risk of low blood sugar (hypoglycemia) if combined with diabetes medications.
All three of these interactions are rated Moderate.
We could not check the Proprietary Blend or Enzyme Blend for interactions — we hold no data on those. Before you start, run your exact medications through the checker below to see what applies to you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Varicose Health & Circulation?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Varicose Health & Circulation interact with 362 drugs. Click any drug to see the details.
3 of the 7 ingredients in Varicose Health & Circulation interact with drugs. Each result below shows which ingredient is responsible. Butcher's Broom Horse Chestnut Rutin
"phentolamineOraVerse, Rogitine, Ryzumvi
How "phentolamine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Antagonists Moderate
Interaction Summary
Theoretically, butcher's broom might reduce the effects of alpha-adrenergic antagonists.
Read the full Butcher's Broom + "phentolamine interactionAbciximabReoPro
How Abciximab interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Horse Chestnut (seed) ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Horse Chestnut (seed) Concentrate + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Horse Chestnut (seed) ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Horse Chestnut (seed) Concentrate + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
RutinAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rutin + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Horse Chestnut (seed) ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Horse Chestnut (seed) Concentrate + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Horse Chestnut (seed) ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Horse Chestnut (seed) Concentrate + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Horse Chestnut (seed) ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Horse Chestnut (seed) Concentrate + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime
How Acetaminophen, Doxylamine, Pseudoephedrine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Doxylamine, Pseudoephedrine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Horse Chestnut (seed) ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Horse Chestnut (seed) Concentrate + Acetaminophen, Ibuprofen interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Varicose Health & Circulation — through 1 ingredient. Tap an ingredient for the detail:
Butcher's BroomAlpha-adrenergic Agonists Moderate
Interaction Summary
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Phenylephrine, Chlorpheniramine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Varicose Health & Circulation with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Butcher's Broom
Alpha-Adrenergic Agonists
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Animal and in vitro studies show that butcher's broom has alpha-adrenergic agonist effects.
Alpha-Adrenergic Antagonists
Theoretically, butcher's broom might reduce the effects of alpha-adrenergic antagonists.
Animal and in vitro studies show that butcher's broom has alpha-adrenergic agonist effects.
Horse Chestnut
Anticoagulant/Antiplatelet Drugs
Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.
Rutin
Antidiabetes Drugs
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.
Brand information
Manufacturer and brand details for Varicose Health & Circulation, from the product label.
New Sun
See all New Sun products- Name
- New Sun
- City
- Hendersonville
- State
- NC
- ZipCode
- 28792
- Phone Number
- 1-800-544-0777
- Web Address
- www.newsun.net
Varicose Health & Circulation by New Sun: Common Questions
Does Varicose Health & Circulation by New Sun interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this work for varicose veins?
Can I take this if I'm pregnant?
What side effects should I watch for?
Can I take this long-term?
What is horse chestnut and why is it in here?
What's in the Proprietary Blend?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Varicose Health & Circulation is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Varicose Health & Circulation’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
White Oak
White oak bark is a traditional herbal remedy rich in tannins, used mostly as a tea or skin wash for diarrhea, sore throat, and minor skin problems. Solid human evidence is very limited, and...
Read the full White Oak monograph → Herb & supplement monographButcher's Broom
Interacts with 158 drugsButcher's broom is a plant extract most often used for circulation problems in the legs, such as chronic venous insufficiency, where some evidence suggests it may help reduce swelling and di...
Read the full Butcher's Broom monograph → Herb & supplement monographHorse Chestnut
Interacts with 122 drugsHorse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...
Read the full Horse Chestnut monograph → Herb & supplement monographRutin
Interacts with 86 drugsRutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...
Read the full Rutin monograph →Sources & How We Checked
Varicose Health & Circulation's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
White Oak 2 references
Butcher's Broom 8 references
- Beltramino R, Penenory A, Buceta AM. An open-label, randomized multicenter study comparing the efficacy and safety of Cyclo 3 Fort versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. Angiology 2000;51:535-44.. PubMed
- Redman DA. Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report. J Altern Complement Med 2000;6:539-49..
- Landa, N., Aguirre, A., Goday, J., Raton, J. A., and Diaz-Perez, J. L. Allergic contact dermatitis from a vasoconstrictor cream. Contact Dermatitis 1990;22(5):290-291. PubMed
- Cluzan, R. V., Alliot, F., Ghabboun, S., and Pascot, M. Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT. Lymphology 1996;29(1):29-35.
- Parrado F, Buzzi A. A study of the efficacy and tolerability of a preparation containing Ruscus aculeatus in the treatment of chronic venous insufficiency of the lower limbs. Clin Drug Invest 1999;18(4):255-61. DOI
- Sadarmin PP, Timperley J. An unusual case of Butcher's Broom precipitating diabetic ketoacidosis. J Emerg Med 2013;45(3):e63-e65. PubMed
- Ramirez-Hernandez M, Garcia-Selles J, Merida-Fernandez C, Martinez-Escribano JA. Allergic contact dermatitis to ruscogenins. Contact Dermatitis 2006;54(1):60. PubMed
- European Medicines Agency. Assessment report on Ruscus Aculeatus L rhizome. EMEA/HMPC/261939/2007. London, September 4, 2008. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_HMPC_assessment_report/2009/12/WC500018288.pdf. Acces
Horse Chestnut 21 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Greeske K, Pohlmann BK. Horse chestnut seed extract-an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency. Fortschr Med 1996;114:196-200.
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Takegoshi K, Tohyama T, Okuda K, et al. A case of Venoplant-induced hepatic injury. Gastroenterol Jpn 1986;21:62-5.
- Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
- Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children. Allergy 1992;47:380-3.
- Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
- Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103:507-13. PubMed
- Comaish JS, Kersey PJ. Contact dermatitis to extract of horse chestnut (esculin). Contact Dermatitis 1980;6:150-1. PubMed
- Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd. PubMed
- Ottillinger, B. and Greeske, K. Rational therapy of chronic venous insufficiency--chances and limits of the therapeutic use of horse-chestnut seeds extract. BMC.Cardiovasc.Disord. 2001;1(1):5. PubMed
- Pittler, M. H. and Ernst, E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane.Database.Syst.Rev. 2004;(2):CD003230. PubMed
- Fang, Y., Zhao, L., Yan, F., Xia, X., Xu, D., and Cui, X. Escin improves sperm quality in male patients with varicocele-associated infertility. Phytomedicine. 2010;17(3-4):192-196. PubMed
- De Smet, P. A., Van den Eertwegh, A. J., Lesterhuis, W., and Stricker, B. H. Hepatotoxicity associated with herbal tablets. BMJ 7-13-1996;313(7049):92.
- Rehn, D., Unkauf, M., Klein, P., Jost, V., and Lucker, P. W. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Arzneimittelforschung 1996;46(5):483-487.
- Edem E, Kahyaoglu B, Çakar MA. Acute Effusive Pericarditis due to Horse Chestnut Consumption. Am J Case Rep. 2016;17:305-8. PubMed
- Costa Santos D, Lérias G, Madruga I. Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement. Eur J Case Rep Intern Med 2021;8(3):002389. PubMed
- Yi HY, Lee JY. Poisoning due to consumption of horse chestnut seed. Clin Exp Emerg Med 2021;8(4):333-335. PubMed
Rutin 2 references
- Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
- Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.
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