Vitamin D-3 50 mcg (2000 IU) Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Vitamin D-3 50 mcg (2000 IU) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Vitamin D-3 50 mcg (2000 IU) is a dietary supplement by Basic Vitamins with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Vitamin D-3 50 mcg (2000 IU) by Basic Vitamins
Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin D-3 50 mcg (2000 IU) by Basic Vitamins — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Vitamin D-3 50 mcg (2000 IU) by Basic Vitamins
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: vitamin D3, the form of vitamin D your body produces when skin is exposed to sunlight. Vitamin D3 is used to treat and prevent deficiencies and is effective for several conditions including rickets, osteomalacia (soft bones), renal bone disease, hypoparathyroidism, and familial hypophosphatemia.
The tablet also contains inactive ingredients — cellulose, hydroxypropyl methylcellulose, silicon dioxide, croscarmellose sodium, magnesium stearate, triacetin, and titanium dioxide — which serve as binders, flow agents, and coating.
Does it work?
Strong evidence
Vitamin D3 is established as effective for rickets, osteomalacia, renal osteodystrophy, hypoparathyroidism, and familial hypophosphatemia — conditions where vitamin D deficiency or poor absorption plays a role. The evidence we hold does not address whether this supplement is effective for general health maintenance or prevention of deficiency in people without these diagnosed conditions.
How safe is it?
Well-documented data
Vitamin D is generally well tolerated at recommended doses like the 2000 IU in this product. Very high doses taken over time can cause vitamin D toxicity, with symptoms that may include high blood calcium (hypercalcemia), weak bones in adults, poor growth in children, eye inflammation, and sensitivity to light.
In rare cases, excessive doses can also lead to kidney damage and anemia. The safety data suggests vitamin D is often used during pregnancy and breastfeeding at recommended amounts, but you should only take it under your doctor's guidance — there isn't enough information on file to make blanket statements about higher doses in these situations.
Meds to double-check
Moderate interaction found
Check before taking this product if you use digoxin (Lanoxin) for heart rhythm — high-dose vitamin D raises blood calcium, which increases the risk of serious heart arrhythmias. Also double-check with your pharmacist if you take thiazide diuretics, verapamil (Calan), diltiazem (Cardizem), atorvastatin (Lipitor), or calcipotriene (Dovonex).
Altogether, these interactions span 705 individual medications.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product makes sense if your doctor has diagnosed you with vitamin D deficiency or one of the conditions it treats — rickets, osteomalacia, hypoparathyroidism, or renal bone disease. If you take any heart rhythm medications, blood pressure drugs, or cholesterol medications, check with your pharmacist first.
At this dose, the risk is lower than at high supplementation, but it's worth a quick medication review before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Vitamin D-3 50 mcg (2000 IU), straight from the product label.
| Brand | Basic Vitamins |
|---|---|
| Barcode (UPC) | 307610168404 |
| Net contents | 200 Film Coated Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2021 |
| DSLD ID | 251004 |
| Product type | Vitamin |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Vitamin D-3 50 mcg (2000 IU) by Basic Vitamins, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin D3 | 50 mcg | 250% |
Other ingredients: Cellulose, Hydroxypropyl Methylcellulose, Silicon Dioxide, Croscarmellose Sodium, Magnesium Stearate, Triacetin, Titanium Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Keep out of the reach of children.
Do not use if inner seal is missing or broken.
Warning: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Storage
Store in cool, dry place.
General Statements
Basic's
High quality basics
FDA Statement of Identity
Dietary Supplement
Formulation
Gluten Free
Contains No: Sugar, starch, preservatives, artificial colors or flavors. Gluten free.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one (1) tablet daily, preferably with a meal.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Vitamin D-3 50 mcg (2000 IU) by Basic Vitamins label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Vitamin D-3 50 mcg (2000 IU) by Basic Vitamins
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container200 Amounts shown are per serving.
Vitamin D3
Interacts with715 drugs
Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...
Vitamin D3 monograph & interactionsOther (inactive) ingredients: Cellulose, Hydroxypropyl Methylcellulose, Silicon Dioxide, Croscarmellose Sodium, Magnesium Stearate, Triacetin, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.
Vitamin D-3 50 mcg (2000 IU) by Basic Vitamins Drug Interactions
HelloPharmacist Interaction Report
Vitamin D-3 50 mcg by Basic Vitamins interacts with a number of medications, primarily through its effect on calcium levels in your blood.
The most serious concerns involve heart rhythm drugs: high-dose vitamin D can raise blood calcium (hypercalcemia), which increases the risk of dangerous heart rhythms with digoxin (Lanoxin) — a Moderate severity interaction that warrants avoiding vitamin D doses above 4000 IU daily and monitoring blood calcium if you take this drug.
Read the full breakdown — every affected drug type, severity by severity
Other Moderate interactions include thiazide diuretics (which reduce how much calcium your body gets rid of in urine, and could lead to elevated blood calcium when combined with vitamin D), calcium channel blockers like verapamil (Calan) and diltiazem (Cardizem) — where high-dose vitamin D may reduce their effectiveness for heart rhythm control — and atorvastatin (Lipitor), where vitamin D may reduce how much of the statin your body absorbs. Vitamin D can also theoretically increase aluminum absorption in people with kidney failure, and raises the risk of high blood calcium if you use calcipotriene (Dovonex), a vitamin D-like skin treatment for psoriasis.
A Minor interaction exists with CYP3A4 substrates, a broad class of medications that vitamin D might affect through liver enzyme changes.
Although this product's dose of 2000 IU is below the upper safe limit of 4000 IU for adults, you should run your exact medications through the checker below before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Vitamin D-3 50 mcg (2000 IU)?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Vitamin D-3 50 mcg (2000 IU) interact with 715 drugs. Click any drug to see the details.
1 of the 1 ingredient in Vitamin D-3 50 mcg (2000 IU) interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3
Chlorpheniramine, Phenylephrine, PhenyltoloxamineCom Time, Comhist, Comhist LA, Linhist LA, Q Hist LA
How Chlorpheniramine, Phenylephrine, Phenyltoloxamine interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Chlorpheniramine, Phenylephrine, Phenyltoloxamine interactionChlorpheniramine, Phenylephrine, PyrilamineTanamine
How Chlorpheniramine, Phenylephrine, Pyrilamine interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Chlorpheniramine, Phenylephrine, Pyrilamine interactionChlorpheniramine, PhenylpropanolamineAler-Releaf, Conex DA, Contac, Dehist, Histabid Duracaps, Ornade +1 more
How Chlorpheniramine, Phenylpropanolamine interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Chlorpheniramine, Phenylpropanolamine interactionChlorpheniramine, Pheylephrine, PyrilaminePhena-Plus
How Chlorpheniramine, Pheylephrine, Pyrilamine interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Chlorpheniramine, Pheylephrine, Pyrilamine interactionChlorpheniramine, PseudoephedrineA.R.M., Anamine TD, Atrohist, Atrohist Ped, Brexin LA, Children's Deconamine +26 more
How Chlorpheniramine, Pseudoephedrine interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Chlorpheniramine, Pseudoephedrine interactionChlorpheniramine, Pyrilamine, PhenylephrineDuphrene
How Chlorpheniramine, Pyrilamine, Phenylephrine interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Chlorpheniramine, Pyrilamine, Phenylephrine interactionCiclesonideAlvesco, Omnaris, Zetonna
How Ciclesonide interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Ciclesonide interactionCilostazolPletal
How Cilostazol interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Cilostazol interactionCisapridePropulsid
How Cisapride interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Cisapride interactionCitalopramCelexa
How Citalopram interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Citalopram interactionClarithromycinBiaxin, Biaxin XL
How Clarithromycin interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Clarithromycin interactionClindamycinCleocin, Cleocin T Gel, ClindaMax, Clindesse, Dalacin C
How Clindamycin interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Clindamycin interactionClomipramineAnafranil, Anafranil SR
How Clomipramine interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Clomipramine interactionClonazepamCeberclon, Klonopin, Rivotril
How Clonazepam interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Clonazepam interactionClopidogrelPlavix
How Clopidogrel interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Clopidogrel interactionCobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide FumarateGenvoya
How Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interactionCobimetinib FumarateCotellic
How Cobimetinib Fumarate interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Cobimetinib Fumarate interactionCocaine Hydrochloride (prescription Drug)Goprelto, Numbrin
How Cocaine Hydrochloride (prescription Drug) interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Cocaine Hydrochloride (prescription Drug) interactionColchicineColchicine, Colcrys, Colsalide Improved, Gloperba, Lodoco, Mitigare
How Colchicine interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Colchicine interactionColchicine, ProbenecidColBenemid
How Colchicine, Probenecid interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Colchicine, Probenecid interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Conjugated Estrogens, Methyltestosterone interactionCopanlisibAliqopa
How Copanlisib interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Copanlisib interactionCrinecerfontCrenessity
How Crinecerfont interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Crinecerfont interactionCrizotinibXalkori
How Crizotinib interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Crizotinib interactionCyclobenzaprineCyclobenzaprine, Cycloprine, Flexeril
How Cyclobenzaprine interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Cyclobenzaprine interactionCyclophosphamideCytoxan, Neosar
How Cyclophosphamide interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Cyclophosphamide interactionCyclosporineCequa, Ciclosporine, Gengraf, Neoral, Sandimmune, Verkazia +1 more
How Cyclosporine interacts with Vitamin D-3 50 mcg (2000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Cyclosporine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Vitamin D-3 50 mcg (2000 IU) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin D3
Aluminum
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.
Atorvastatin (Lipitor)
Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.
Calcipotriene (Dovonex)
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.
Diltiazem (Cardizem, Others)
Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.
Thiazide Diuretics
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.
Verapamil (Calan, Others)
Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.
Brand information
Manufacturer and brand details for Vitamin D-3 50 mcg (2000 IU), from the product label.
Basic Vitamins
See all Basic Vitamins products- Name
- Basic Drugs, Inc.
- City
- Vandalia
- State
- OH
- ZipCode
- 45377
- Phone Number
- 937-898-4010
- Web Address
- www.basicvitamins.com
Vitamin D-3 50 mcg (2000 IU) by Basic Vitamins: Common Questions
Does Vitamin D-3 50 mcg (2000 IU) by Basic Vitamins interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is 2000 IU a safe dose of vitamin D?
Can I take this while pregnant or breastfeeding?
What does vitamin D3 do in the body?
Will this interact with my blood pressure medicine?
What are the side effects?
Does this product contain any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Vitamin D-3 50 mcg (2000 IU) is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Vitamin D-3 50 mcg (2000 IU)’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Vitamin D-3 50 mcg (2000 IU)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin D 26 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
- Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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