Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) Ingredients & Drug Interactions

by The Vitamin Shoppe

High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) is a dietary supplement by The Vitamin Shoppe with 4 active ingredients. Its ingredients are commonly taken for high cholesterol, digestive health and fiber, heart health support.Based on those ingredients, 764 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mixed Tocopherols, Mixed Tocotrienols. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Mixed Tocopherols” is listed as a grouped ingredient — the label gives one combined amount (565 mg) without saying how much of each component you get.

This supplement contains 5 active ingredients delivering vitamin E in multiple forms. The blend includes rice bran oil, mixed tocopherols, D-gamma-tocopherol, mixed tocotrienols, and additional vitamin E and D-beta and D-delta tocopherol—all forms of vitamin E that work as antioxidants in your body.

The total dose is 268 mg (400 IU). Vitamin E from food and supplements comes in several chemical forms (tocopherols and tocotrienols); this product delivers a mix of them, particularly emphasizing gamma-tocopherol rather than the alpha form found in many other supplements.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Cardiovascular health and immune support.
  • We looked for evidence on: Cardiovascular disease (CVD), Atherosclerosis, Angina, Congestive heart failure (CHF), Coronary artery bypass graft (CABG) surgery, Dyslipidemia — and 4 related terms.
  • The strongest evidence on file: Rice Bran is rated "Possibly Effective" for Dyslipidemia (Natural Medicines).
  • Also on file: Vitamin E is rated "Possibly Effective" for Nitrate tolerance.
  • Also on file: Vitamin E is rated "Possibly Ineffective" for Angina, Atherosclerosis, Congestive heart failure (CHF).

The vitamin E content here is Effective for preventing and treating vitamin E deficiency and a rare genetic disorder called ataxia with vitamin E deficiency (AVED). It's Possibly Effective for Alzheimer disease, beta-thalassemia, and G6PD deficiency (a genetic blood condition), and for intracranial hemorrhage.

Rice bran oil is Possibly Effective for dyslipidemia (abnormal blood lipid levels) but Possibly Ineffective for colorectal cancer; evidence for its use in alopecia areata (hair loss) is insufficient. Mixed tocotrienols are Possibly Effective for diabetes but Possibly Ineffective for high cholesterol; evidence for alopecia areata and breast cancer is insufficient.

The evidence, ingredient by ingredient Rice Bran Vitamin E Tocotrienols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E is generally well tolerated at usual dietary amounts, but long-term high-dose supplementation carries risks. High doses may increase the rare risk of bleeding, and there's been concern about a higher rate of hemorrhagic stroke (bleeding in the brain) in male smokers taking synthetic vitamin E for years—though other studies haven't confirmed this.

Rice bran can cause digestive effects like abdominal discomfort, gas, and irregular bowel habits, especially when first increasing intake; it can also rarely trigger allergic reactions including anaphylaxis. Tocotrienols appear well tolerated in trials with no reported adverse effects, though long-term safety data at supplement doses is limited.

For pregnancy, vitamin E is possibly safe and rice bran oil is likely safe, but tocotrienols have insufficient safety data and should be avoided unless your doctor advises otherwise. While breastfeeding, vitamin E and rice bran oil are likely or possibly safe, but tocotrienols safety is unclear—check with your doctor or pharmacist.

Side effects, ingredient by ingredient Rice Bran Vitamin E Tocotrienols

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Vitamin E, Tocotrienols.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 765 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you're on blood thinners (anticoagulants) or antiplatelet drugs—Moderate bleeding risk. Also check if you take warfarin (Coumadin), chemotherapy drugs, cyclosporine, or medications processed by your liver's CYP3A4 enzyme.

Niacin and this product together may reduce niacin's benefit on cholesterol—also worth confirming with your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is most useful if you have a vitamin E deficiency or one of the conditions where vitamin E shows benefit—talk with your doctor about whether that applies to you. If you take blood thinners, chemotherapy, warfarin, niacin, or any medications processed by your liver, check your exact medications against the interaction tool on this page before starting.

High-dose vitamin E over the long term carries a small bleeding risk and isn't appropriate for everyone, so confirm it's right for you with your own doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU), straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536018888
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 213806
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
766536018888
IngredientAmount% DV
Rice Bran Oil25 mg--
Mixed Tocopherols565 mg--
D-Gamma-Tocopherol440 mg--
Mixed Tocotrienols4 mg--
Vitamin E268 mg1788%
D-Beta and D-Delta Tocopherol125 mg--

Other ingredients: Gelatin, Glycerin, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Cardiovascular health Immune support

Gluten-free Dairy-free Nut-free Soy-free

Does not contain: Gluten, Sugar, salt, preservatives, artificial colors, artificial flavors.

General Statements

Vitamin

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Quality promise Tested & trusted

Precautions

Soy is used in the fermentation process, but is not present in the finished product.

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) softgel daily, preferably with a meal.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

It is important to take the complete Vitamin E family, which consists of tocopherols and tocotrienols, existing in the alpha, beta, delta and gamma forms. This product contains naturally sourced Vitamin E, as designated by d-Alpha which is twice as bioavailable as dl-Alpha, the synthetic form of Vitamin E.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) by The Vitamin Shoppe

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Rice Bran Oil

No known
interactions
25 mg per serving

Rice bran is the nutrient-rich outer layer of the rice grain and is a good source of fiber, healthy fats, and plant compounds. It is most studied for...

Rice Bran Oil monograph & interactions

Mixed Tocopherols

Interacts with
764 drugs
565 mg per serving

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Mixed Tocopherols monograph & interactions

Mixed Tocotrienols

Interacts with
122 drugs
4 mg per serving

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early resea...

Mixed Tocotrienols monograph & interactions

Vitamin E

Interacts with
764 drugs
268 mg per serving Form: D-Alpha-Tocopherol, D-Alpha-Tocopheryl Acetate

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
764Drugs
763 Moderate 1 Minor

Ingredients driving the most interactions

Mixed Tocopherols 764
Mixed Tocotrienols 122

Individual Drug Interactions

The ingredients in High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) interact with 764 drugs. Click any drug to see the details.

2 of the 4 ingredients in High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) interact with drugs. Each result below shows which ingredient is responsible. Mixed Tocopherols Mixed Tocotrienols

Each ingredient & the kinds of drugs it affects

For each ingredient in High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Mixed Tocopherols8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Mixed Tocopherols full monograph & interactions

Mixed Tocotrienols1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
Mixed Tocotrienols full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU), from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-866-293-3367
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) by The Vitamin Shoppe: Common Questions

Does High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) has a known interaction with 764 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this vitamin E supplement interact with my blood thinner?
Yes, there's a documented Moderate risk of increased bleeding. Vitamin E can weaken your blood's clotting ability at higher doses and may work against the clotting factors your blood thinner is meant to affect. Don't add this supplement without checking with your doctor or pharmacist first, especially if you take warfarin.
Can I take this if I'm on chemotherapy?
This needs a conversation with your oncologist. The concern is that vitamin E's antioxidant action might reduce how well chemotherapy drugs work, particularly alkylating agents and antitumor antibiotics. Your doctor knows your specific treatment and can advise whether it's safe.
What does the 'gamma' in the name mean?
Gamma-tocopherol is one of several forms of vitamin E found in nature. This product emphasizes gamma-tocopherol alongside other tocopherols and tocotrienols—different chemical forms that all act as antioxidants. Most other vitamin E supplements use mostly alpha-tocopherol.
Does this product work for high cholesterol?
Rice bran oil in this product is possibly effective for dyslipidemia (abnormal blood lipid levels), though the evidence is mixed. Tocotrienols are possibly ineffective for high cholesterol according to the data we hold. Talk with your doctor about whether this fits into your cholesterol management.
Can I take this while I'm pregnant or breastfeeding?
Vitamin E and rice bran oil are likely or possibly safe during these times, but tocotrienols have insufficient safety data, so it's best to avoid this product unless your doctor directs you to take it. The safety information available doesn't give us enough to know either way, so check with your doctor or pharmacist for personalized advice.
Will this cause digestive upset?
Rice bran in this supplement can cause abdominal discomfort, gas, and irregular bowel habits, especially when you first start taking it. These effects are usually temporary. If you're allergic to rice, there's a rare risk of serious allergic reactions, so stop and seek help immediately if you notice trouble breathing, swelling, or hives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU) label
Go deeper

The Full Monographs Behind High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rice Bran

Rice bran is the nutrient-rich outer layer of the rice grain and is a good source of fiber, healthy fats, and plant compounds. It is most studied for helping lower cholesterol, but for most...

Read the full Rice Bran monograph → Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph →
Sources

Sources & How We Checked

High Gamma Vitamin E with Mixed Tocopherols 268 mg (400 IU)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 75 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rice Bran 7 references
  1. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  2. Fujiwaki T, Furusho K. The effects of rice bran broth bathing in patients with atopic dermatitis. Acta Paediatr Jpn 1992;34:505-10.
  3. Uenotsuchi T, Satoh E, Kiryu H, Yano Y. Pyemotes dermatitis caused by indirect contact with husk rice. Br J Dermatol 2000;143:680-2. DOI
  4. Satoh R, Tsuge I, Tokuda R, Teshima R. Analysis of the distribution of rice allergens in brown rice grains and of the allergenicity of products containing rice bran. Food Chem. 2019;276:761-767. PubMed
  5. Togashi Y, Inomata N, Suzuki A, Hakuta A, Aihara M. Pediatric case with rice bran allergy induced by epicutaneous sensitization in a family rice shop. Allergol Int. 2019;68(1):117-118. PubMed
  6. So WKW, Chan JYW, Law BMH, et al. Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial. Nutrients 2021;13(2):526. PubMed
  7. Haneda Y, Kadowaki S, Furui M, Taketani T. A pediatric case of food-dependent exercise-induced anaphylaxis due to rice bran. Asia Pac Allergy 2021;11(1):e4. PubMed

See these in context on the Rice Bran monograph →

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed
  16. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-6.
  17. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  18. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  19. Liu M, Wallmon A, Olsson-Mortlock C, et al. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am J Clin Nutr 2003;77:700-6. PubMed
  20. Sokol RJ, Johnson KE, Karrer FM, et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991;338:212-4.. PubMed
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See these in context on the Vitamin E monograph →

Tocotrienols 4 references
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See these in context on the Tocotrienols monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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