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Dietary supplement

Vitamin K2 50 mcg Ingredients & Drug Interactions

by Epic 4 Health

Vitamin K2 50 mcg label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin K2 50 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vitamin K2 50 mcg is a dietary supplement by Epic 4 Health with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin K2 50 mcg by Epic 4 Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin K2 50 mcg by Epic 4 Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin K2 50 mcg by Epic 4 Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains one active ingredient: vitamin K2 at 50 micrograms per capsule. Vitamin K2 is a fat-soluble vitamin that supports blood clotting and bone health.

The capsule also holds several inactive ingredients — sunflower seed oil, gelatin, glycerin, purified water, and annatto suspension — which help deliver and preserve the vitamin.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Vitamin K for blood clotting and bone health.
  • We looked for evidence on: Hemorrhagic disease, Hypoprothrombinemia, Intraventricular hemorrhage, Osteoporosis, Vitamin K-dependent clotting factors deficiency (VKCFD), Warfarin anticoagulation — and 2 related terms.
  • The strongest evidence on file: Vitamin K is rated "Effective" for Hemorrhagic disease (Natural Medicines).
  • Also on file: Vitamin K is rated "Effective" for Hypoprothrombinemia, Warfarin anticoagulation, Vitamin K-dependent clotting factors deficiency (VKCFD).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.

Vitamin K2 is effective for treating vitamin K deficiency disorders, including low levels of vitamin K-dependent clotting factors and a condition called hypoprothrombinemia (a blood-clotting disorder). It's also effective for reversing warfarin anticoagulation and hemorrhagic disease.

For osteoporosis, the evidence suggests it may be helpful, though the data is still developing.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, vitamin K2 is generally well tolerated. The most common side effects are mild — nausea, diarrhea, abdominal pain, and stomach upset — and occur in a small number of people.

Vitamin K is considered likely safe during pregnancy and breastfeeding. That said, normal dietary amounts are fine, but you should check with your doctor or pharmacist before starting any supplement, especially if you take blood thinners or have a bleeding disorder.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check whether you use warfarin (Coumadin) or any other anticoagulant — vitamin K2 can antagonize and reverse their effects (Major interaction). Run your exact medications through the tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Vitamin K2 works well for clotting disorders and may help bone health. If you take warfarin or another anticoagulant, you must talk to your doctor before using this product — it can directly reduce how your blood thinner works.

For everyone else, it's generally well tolerated, but a quick check-in with your pharmacist is smart.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin K2 50 mcg, straight from the product label.

Brand Epic 4 Health
Barcode (UPC) 850000851023
Net contents 150 Softgel(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 229907
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin K2 50 mcg by Epic 4 Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
850000851023
IngredientAmount% DV
Vitamin K250 mcg--

Other ingredients: Sunflower seed Oil, Gelatin, Glycerin, purified Water, Annatto suspension

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free of: milk, egg, fish, shellfish, tree nuts, wheat, peanuts, soybeans and corn. Gluten free, soy free

Manufactured in a cGMP Certified U.S.A. Facility.

Sustained bioavailability Promotes skeletal density Supports healthy cardiovascular system

Precautions

Caution: Before using any dietary supplement, pregnant or lactating women should consult with a physician or health professional. Individuals taking anticoagulants (e.g. warfarin, heparin) or aspirin and other salicylates should consult with their physician before taking supplements containing Vitamin K.

Keep out of reach of children.

Do not use if safety seal is broken or missing.

To report a serious adverse event or to obtain product information contact 1-800-866-0978.

Storage

Keep bottle tightly closed. Store between 15 degrees - 30 degrees C (59 degrees - 86 degrees F).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

MenaQ7 is a registered trademark of NattoPharma, Norway; Patented in the United States and Canada. (US Patent Numbers 8,728,553 & 8,354,129; Canada Patent Number 2,347,387).

Formula

Natural as MenaQ7 Vitamin K2 as MK-7

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults: Take one (1) softgel daily as a dietary supplement or as recommended by your healthcare professional.

Seals/Symbols

GMP Quality Assured

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin K2 50 mcg by Epic 4 Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin K2 50 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin K2 50 mcg by Epic 4 Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Vitamin K2

Interacts with
2 drugs
50 mcg per serving Form: MenaQ7, Menaquinone

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K2 monograph & interactions

Other (inactive) ingredients: Sunflower seed Oil, Gelatin, Glycerin, Purified Water, Annatto suspension. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin K2 50 mcg by Epic 4 Health Drug Interactions

Want to check YOUR meds against Vitamin K2 50 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K2 2

Individual Drug Interactions

The ingredients in Vitamin K2 50 mcg interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin K2 50 mcg interact with drugs. Each result below shows which ingredient is responsible. Vitamin K2

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin K2 50 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin K2 50 mcg, from the product label.

Epic 4 Health

See all Epic 4 Health products
Name
Epic 4 Health
Street Address
30 New York Avenue
City
Westbury
State
NY
ZipCode
11590
Phone Number
1-800-866-0978
Web Address
www.Epic4Health.com
Pharmacist Counseling Corner

Vitamin K2 50 mcg by Epic 4 Health: Common Questions

Does Vitamin K2 50 mcg by Epic 4 Health interact with any medications?
Yes. Based on its ingredients, Vitamin K2 50 mcg has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin K2 50 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interfere with my warfarin?
Yes — this is a serious interaction. Vitamin K2 can block warfarin's blood-thinning effect. Do not take this supplement unless your doctor adjusts your warfarin dose or okays it first. Check with your doctor or pharmacist before starting.
What side effects does vitamin K2 have?
Taken by mouth, it's usually well tolerated. The most common mild effects are nausea, diarrhea, abdominal pain, and stomach upset. Serious side effects are very rare with oral doses.
Is vitamin K2 safe during pregnancy?
Yes — vitamin K is rated likely safe during pregnancy and breastfeeding. That said, always let your doctor or pharmacist know about any supplement you're taking or considering.
What does this product actually do?
Vitamin K2 supports blood clotting and may help bone strength. It's effective for treating vitamin K deficiency disorders and for reversing warfarin anticoagulation when medically necessary. For osteoporosis, the research suggests it may be helpful, though more data is still being gathered.
Can I take this with other medications?
Vitamin K2 can interfere with blood thinners like warfarin. For any other medications you take, run them through the checker on this page — or ask your pharmacist — before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin K2 50 mcg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin K2 50 mcg label
Go deeper

The Full Monographs Behind Vitamin K2 50 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Vitamin K2 50 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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