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Dietary supplement

Water-Soluble Pumpkin Seed Extract Ingredients & Drug Interactions

by Life Extension

Water-Soluble Pumpkin Seed Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Water-Soluble Pumpkin Seed Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Water-Soluble Pumpkin Seed Extract is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pumpkin Seed Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Water-Soluble Pumpkin Seed Extract by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Water-Soluble Pumpkin Seed Extract by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Water-Soluble Pumpkin Seed Extract by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pumpkin seed extract, which is a concentrated form of compounds from pumpkin seeds. The capsule also contains inactive ingredients—microcrystalline cellulose, cellulose, stearic acid, stearate, and silica—which are standard fillers and binders that help form and hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Benign prostatic hyperplasia and urinary health.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Overactive bladder, Prostate health, Urinary frequency, Nocturia.
  • The strongest evidence on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Pumpkin is rated "Insufficient Reliable Evidence To Rate" for Overactive bladder.

Pumpkin seed extract is possibly effective for benign prostatic hyperplasia (BPH)—that's the noncancerous enlargement of the prostate gland that can cause urinary symptoms in older men. For other uses listed in our data—androgenic alopecia (male-pattern hair loss), interstitial cystitis (bladder pain), intestinal parasites, and urinary tract infections—the evidence isn't established; we don't have enough reliable information to rate it either way.

The evidence, ingredient by ingredient Pumpkin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pumpkin seed products are generally well tolerated when taken by mouth. The most common side effects are mild: abdominal discomfort, diarrhea, nausea, and vomiting.

A rare serious reaction, anaphylaxis (a severe allergic reaction), has been reported. There are also two case reports of temporary hair loss after eating bitter-tasting pumpkin or squash with high levels of cucurbitacin, a naturally occurring compound in wild pumpkins.

During pregnancy, there isn't enough data on concentrated seed supplements to know whether they're safe—talk with your doctor or pharmacist before use. The same applies to breastfeeding; safety data is limited.

Side effects, ingredient by ingredient Pumpkin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pumpkin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take lithium, you'll need to check with your doctor or pharmacist before using this product. Pumpkin seed extract may reduce lithium excretion and raise its levels in your blood, potentially requiring a dose adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have benign prostate enlargement and want to try a supplement with some evidence behind it, pumpkin seed extract is worth discussing with your pharmacist. Anyone taking lithium should check with their pharmacist or doctor first—this product could affect how your body handles that medication.

Always run your exact medications through the checker on this page before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Water-Soluble Pumpkin Seed Extract, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870120964
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 328798
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Water-Soluble Pumpkin Seed Extract by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
737870120964
IngredientAmount% DV
Pumpkin Seed Extract262 mg--

Other ingredients: Microcrystalline Cellulose, Cellulose, Stearic Acid, Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for more info

Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule three times daily for the first two weeks. After two weeks, reduce to two (2) capsules daily or as recommended by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

Precautions

Warnings: Keep out of reach of children.

Read the entire label and follow directions carefully prior to use. Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with you physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-800-280-2852.

Formulation

Water-soluble

Gluten free Non GMO LE Certified

For prostate and urinary tract heatlh

Seals/Symbols

Non GMO LE Certified

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Water-Soluble Pumpkin Seed Extract by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Water-Soluble Pumpkin Seed Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Water-Soluble Pumpkin Seed Extract by Life Extension

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Pumpkin Seed Extract

Interacts with
1 drug
262 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin Seed Extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Cellulose, Stearic Acid, Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Water-Soluble Pumpkin Seed Extract by Life Extension Drug Interactions

Want to check YOUR meds against Water-Soluble Pumpkin Seed Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Pumpkin Seed Extract 1

Individual Drug Interactions

The ingredients in Water-Soluble Pumpkin Seed Extract interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Water-Soluble Pumpkin Seed Extract interact with drugs. Each result below shows which ingredient is responsible. Pumpkin Seed Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Water-Soluble Pumpkin Seed Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pumpkin Seed Extract1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin Seed Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Water-Soluble Pumpkin Seed Extract, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Water-Soluble Pumpkin Seed Extract by Life Extension: Common Questions

Does Water-Soluble Pumpkin Seed Extract by Life Extension interact with any medications?
Yes. Based on its ingredients, Water-Soluble Pumpkin Seed Extract has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Water-Soluble Pumpkin Seed Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does pumpkin seed extract actually help with prostate problems?
The evidence says possibly—it's considered possibly effective for benign prostatic hyperplasia, the noncancerous prostate enlargement that causes urinary symptoms. That doesn't mean it works for everyone, so talk with your doctor about whether it's right for your situation.
What are the side effects I might experience?
Most people tolerate it well. The most common side effects are mild: abdominal discomfort, diarrhea, nausea, and vomiting. Rarely, anaphylaxis (a severe allergic reaction) has been reported. There are also two case reports of temporary hair loss after eating pumpkin with high cucurbitacin content—a compound found in wild pumpkins.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data on concentrated pumpkin seed supplements during pregnancy or breastfeeding to know either way. Talk with your doctor or pharmacist for personalized advice before using it.
Is this product just ground-up pumpkin seeds, or something more concentrated?
This is a concentrated extract of pumpkin seeds, not the same as eating whole seeds or pumpkin. The safety and effectiveness of this concentrated form may differ from the whole food.
What are the inactive ingredients in the capsule?
The capsule contains microcrystalline cellulose, cellulose, stearic acid, stearate, and silica. These are standard binders and fillers that help form the capsule and hold it together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Water-Soluble Pumpkin Seed Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Water-Soluble Pumpkin Seed Extract label
Go deeper

The Full Monographs Behind Water-Soluble Pumpkin Seed Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph →
Sources

Sources & How We Checked

Water-Soluble Pumpkin Seed Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
  4. Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
  5. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed

See these in context on the Pumpkin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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