Wild Amazonian Formula Ingredients & Drug Interactions
by SuperSmart
What is this page for?
First and foremost: checking Wild Amazonian Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Wild Amazonian Formula is a dietary supplement by SuperSmart with 5 active ingredients. Its ingredients are commonly taken for osteoarthritis and rheumatoid arthritis, inflammation, immune support.Based on those ingredients, 962 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cat's Claw Bark Extract, Pau d'Arco Root Extract, Graviola leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Wild Amazonian Formula by SuperSmart
Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Amazonian Formula by SuperSmart — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Wild Amazonian Formula by SuperSmart
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Wild Amazonian Formula contains five ingredients. The active ones are Cat's Claw Bark Extract, Graviola leaf extract, Suma root extract, and Pau d'Arco Root Extract — traditional botanical extracts from South American plants.
The formula also contains two inactive ingredients (fillers): acacia gum and white rice flour, which help hold the capsule together.
Does it work?
Couldn't assess
The evidence for what these ingredients do isn't established in the data we hold. Cat's Claw has been studied for conditions like hay fever, Alzheimer disease, asthma, osteoporosis, and cancer, but the research so far is too limited or inconsistent to say it works.
The same goes for Graviola (studied for HPV, headache, and other uses) and Pau d'Arco (cancer, peptic ulcers, wound healing, period cramps). Suma root extract has no effectiveness ratings on file.
If you're considering this product for a specific health goal, your pharmacist or doctor can help you figure out what the real evidence says.
How safe is it?
Well-documented data
Cat's Claw is generally well tolerated short-term in healthy adults, but long-term safety isn't well studied. Some people in clinical trials reported anemia, fatigue, insomnia, and neuropathy, though those patients had advanced cancer so it's unclear what was caused by the herb.
A few case reports link it to kidney injury. Graviola raises concerns: lab studies suggest possible nerve toxicity with long-term use, and people taking it regularly have reported nausea and burning stomach pain.
In rare cases, it's been linked to movement disorders similar to Parkinson disease. Pau d'Arco at higher doses (above 1.5 grams daily) may cause anemia, bleeding, severe nausea, vomiting, and diarrhea.
Suma seems well tolerated, though safety data are limited. We don't have safety data on file for Mullaca.
Meds to double-check
Moderate interaction found
Before starting, double-check with your pharmacist if you take blood pressure medication (antihypertensives) or calcium channel blockers, blood thinners or antiplatelet drugs, CYP3A4 substrates (a broad category of medications), carbamazepine (Tegretol), immunosuppressants, or Paxlovid. All of these have Moderate-severity interactions documented with one or more ingredients in this formula.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you take blood pressure medication, blood thinners, seizure medication, immune-suppressing drugs, or Paxlovid, talk to your pharmacist before trying this product — interactions are documented. Even if you don't take any of those, it's smart to run your full medication list through the checker below.
This formula is not recommended during pregnancy or breastfeeding due to safety concerns with its ingredients.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Wild Amazonian Formula, straight from the product label.
| Brand | SuperSmart |
|---|---|
| Barcode (UPC) | 5453003827894 |
| Net contents | 120 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2025 |
| DSLD ID | 332547 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Wild Amazonian Formula by SuperSmart, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cat's Claw Bark Extract | 400 mg | -- |
| Graviola leaf extract | 400 mg | -- |
| Suma root extract | 400 mg | -- |
| Pau d'Arco Root Extract | 300 mg | -- |
| Mullaca, Powder | 300 mg | -- |
Other ingredients: Acacia Gum, White Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommended use: Adults. Take 2 capsules twice a day.
Precautions
Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.
Keep out of childrens' reach.
As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.
Storage
Store away from direct light, heat and humidity.
General Statements
EN: Wild harvested and manually collected plants
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Wild Amazonian Formula by SuperSmart label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Wild Amazonian Formula by SuperSmart
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Cat's Claw Bark Extract
Interacts with962 drugs
Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arth...
Cat's Claw Bark Extract monograph & interactionsGraviola leaf extract
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Graviola leaf extract monograph & interactionsSuma root extract
No knowninteractions
Suma is a South American root often marketed as a 'Brazilian ginseng' and used as an adaptogen for energy, stamina, and stress. Human evidence is very...
Suma root extract monograph & interactionsPau d'Arco Root Extract
Interacts with122 drugs
Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...
Pau d'Arco Root Extract monograph & interactionsMullaca, Powder
Other (inactive) ingredients: Acacia Gum, White Rice Flour. These complete the product’s ingredient list but are not active constituents.
Wild Amazonian Formula by SuperSmart Drug Interactions
HelloPharmacist Interaction Report
Wild Amazonian Formula by SuperSmart contains several ingredients that may interact with medications you're taking.
The most serious concern is Cat's Claw Bark Extract, which can theoretically lower your blood pressure if you're already on blood pressure medication (antihypertensives) or calcium channel blockers — both are Moderate severity interactions. It may also increase bleeding risk if you take blood thinners or antiplatelet drugs like aspirin or warfarin.
Read the full breakdown — every affected drug type, severity by severity
Cat's Claw can also affect how your body processes certain medications broken down by a liver enzyme called CYP3A4, potentially raising or lowering their levels. Additionally, it may interfere with immunosuppressive medications (drugs that calm your immune system) and could reduce how well Paxlovid works if you're taking that antiviral.
Graviola leaf extract carries a Moderate interaction with carbamazepine (Tegretol), a seizure and nerve pain medication, and may lower its levels. Pau d'Arco Root Extract also raises bleeding risk with blood thinners or antiplatelet drugs.
We could not check Mullaca, Powder — no data is on file for it.
Altogether, these interactions span 948 individual medications. Use the medication checker on this page to search your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Wild Amazonian Formula?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Wild Amazonian Formula interact with 962 drugs. Click any drug to see the details.
3 of the 5 ingredients in Wild Amazonian Formula interact with drugs. Each result below shows which ingredient is responsible. Cat's Claw Bark Extract Pau d'Arco Root Extract Graviola leaf extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, cat's claw might interfere with immunosuppressive therapy.
Read the full Cat's Claw Bark Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Wild Amazonian Formula — through 2 ingredients. Tap an ingredient for the detail:
Cat's Claw Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Cat's Claw Bark Extract + Abciximab interactionPau D'arco Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Pau D'arco Root Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Wild Amazonian Formula — through 2 ingredients. Tap an ingredient for the detail:
Pau D'arco Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Pau D'arco Root Extract + Abrocitinib interactionCat's Claw Bark ExtractAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Cat's Claw Bark Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acalabrutinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.
Read the full Cat's Claw Bark Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Wild Amazonian Formula — through 2 ingredients. Tap an ingredient for the detail:
Pau D'arco Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Pau D'arco Root Extract + Acenocoumarol interactionCat's Claw Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Cat's Claw Bark Extract + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Wild Amazonian Formula — through 2 ingredients. Tap an ingredient for the detail:
Cat's Claw Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Cat's Claw Bark Extract + Acetaminophen, Aspirin interactionPau D'arco Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Pau D'arco Root Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Wild Amazonian Formula — through 2 ingredients. Tap an ingredient for the detail:
Pau D'arco Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Pau D'arco Root Extract + Acetaminophen, Aspirin, Caffeine interactionCat's Claw Bark ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Cat's Claw Bark Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Wild Amazonian Formula — through 1 ingredient. Tap an ingredient for the detail:
Cat's Claw Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw Bark Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Wild Amazonian Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Cat's Claw Bark Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Cat's claw contains rhynchophylline and isorhynchophylline. Animal research suggests that these alkaloids can inhibit platelet aggregation. This interaction has not been reported in humans.
Antihypertensive Drugs
Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.
Cat's claw contains rhynchophylline. In vitro and animal research suggests that rhynchophylline can lower blood pressure. This interaction has not been reported in humans.
Calcium Channel Blockers
Theoretically, taking cat's claw with calcium channel blockers might increase the risk of hypotension.
Cat's claw contains various alkaloids, including rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxiene. Animal research suggests that these alkaloids can lower blood pressure by acting as calcium channel blockers. This interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Cat's claw may affect the clearance of drugs metabolized by CYP3A4. In vitro research shows that cat's claw can inhibit CYP3A4 enzymes. In one case report, a patient taking cat's claw (at an unspecified dose) experienced increased serum levels of atazanavir, ritonavir, and saquinavir, all of which are CYP3A4 substrates. Levels returned to normal 15 days after discontinuation of the cat's claw supplement, suggesting inhibition of CYP3A4 by cat's claw. In contrast, animal research suggests that rhynchophylline, an alkaloid contained in cat's claw, induces CYP3A expression and accelerates the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product.
Immunosuppressants
Theoretically, cat's claw might interfere with immunosuppressive therapy.
In human and laboratory research, cat's claw has been shown to have immunostimulating activity. It stimulates phagocytosis and increases respiratory cellular activity and the mobility of leukocytes. Theoretically, this could interfere with the activity of immunosuppressant medications.
Nirmatrelvir/Ritonavir (Paxlovid)
Theoretically, cat's claw may decrease the levels of nirmatrelvir.
Cat's claw contains rhynchophylline. Animal research suggests that this alkaloid induces CYP3A expression, thereby accelerating the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product. This interaction has not been reported in humans.
Pau d'Arco Root Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.
Graviola leaf extract
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Wild Amazonian Formula, from the product label.
SuperSmart
See all SuperSmart products- Name
- SN Worldwide Unipessoal, LDA
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Wild Amazonian Formula by SuperSmart: Common Questions
Does Wild Amazonian Formula by SuperSmart interact with any medications?
How can one product interact with so many drugs?
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What is Cat's Claw extract supposed to do?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Wild Amazonian Formula’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Cat's Claw
Interacts with 962 drugsCat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arthritis symptoms, but the overall evidence...
Read the full Cat's Claw monograph → Herb & supplement monographGraviola
Interacts with 1 drugGraviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...
Read the full Graviola monograph → Herb & supplement monographSuma
Suma is a South American root often marketed as a 'Brazilian ginseng' and used as an adaptogen for energy, stamina, and stress. Human evidence is very limited, and most claims come from trad...
Read the full Suma monograph → Herb & supplement monographPau D'arco
Interacts with 122 drugsPau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...
Read the full Pau D'arco monograph →Sources & How We Checked
Wild Amazonian Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 29 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cat's Claw 16 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
- Müller AC, Kanfer I. Potential pharmacokinetic interactions between antiretrovirals and medicinal plants used as complementary and African traditional medicines. Biopharm Drug Dispos. 2011;32(8):458-70. PubMed
- Sheng, Y., Bryngelsson, C., and Pero, R. W. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000;69(2):115-126. PubMed
- Lamm, S., Sheng, Y., and Pero, R. W. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine 2001;8(4):267-274.
- Sheng, Y., Li, L., Holmgren, K., and Pero, R. W. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001;8(4):275-282.
- Chen, C. X., Jin, R. M., Li, Y. K., Zhong, J., Yue, L., Chen, S. C., and Zhou, J. Y. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1992;13(2):126-130.
- Flythe, J. E., Rueda, J. F., Riscoe, M. K., and Watnick, S. Silicate nephrolithiasis after ingestion of supplements containing silica dioxide. Am.J.Kidney Dis. 2009;54(1):127-130. PubMed
- Zhou, J. and Zhou, S. Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity. J.Ethnopharmacol. 10-28-2010;132(1):15-27. PubMed
- Zhou, J. Y. and Zhou, S. W. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia 2012;83(4):617-626. PubMed
- Hemingway, S. R. and Phillipson, J. D. Proceedings: Alkaloids from S. American species of Uncaria (Rubiaceae). J.Pharm.Pharmacol. 1974;26 Suppl:113P.
- Hilepo, J. N., Bellucci, A. G., and Mossey, R. T. Acute renal failure caused by 'cat's claw' herbal remedy in a patient with systemic lupus erythematosus. Nephron 1997;77(3):361. PubMed
- De Paula LCL, Fonseca F, Perazzo F, et al. Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. J Altern Complement Med. 2015;21(1):22-30.
- Portalatin G, Shettigar S, Carrion-Rodriguez A, et al. Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis. Case Rep Nephrol Dial 2022;12(3):219-225.
- Lei S, Guo A, Lu J, et al. Activation of PXR causes drug interactions with Paxlovid in transgenic mice. Acta Pharm Sin B 2023;13(11):4502-4510. PubMed
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Suma 3 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. DOI
- Subiza, J., Subiza, J. L., Escribano, P. M., Hinojosa, M., Garcia, R., Jerez, M., and Subiza, E. Occupational asthma caused by Brazil ginseng dust. J Allergy Clin Immunol 1991;88(5):731-736. PubMed
Pau D'arco 6 references
- Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
- Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
- Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
- Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
- Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
- Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC