Wild Lettuce and Dogwood Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Wild Lettuce and Dogwood against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Wild Lettuce and Dogwood is a dietary supplement by Herbal Terra with 2 active ingredients. Its ingredients are commonly taken for constipation, bowel cleansing before procedures, hemorrhoids.Based on those ingredients, 997 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dogwood Bark Extract, Dry, Wild Lettuce Herb Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Wild Lettuce and Dogwood by Herbal Terra
Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce and Dogwood by Herbal Terra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Wild Lettuce and Dogwood by Herbal Terra
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.
Why this rating?
- The label discloses an exact amount for 0 of its 2 active ingredients.
- “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (983 mg) without saying how much of each component you get.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 2 of the 2 matched ingredients can interact with medications — Wild Lettuce, Cascara Sagrada.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
- For scale: 998 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
- Pregnancy & breastfeeding safety ratings cover 2 of 2.
- General safety write-ups exist for 2 of 2.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Wild Lettuce and Dogwood, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 7439500734758 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2025 |
| DSLD ID | 325511 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Wild Lettuce and Dogwood by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Blend | 983 mg | -- |
| Dogwood Bark Extract, Dry | 0 NP | -- |
| Wild Lettuce Herb Extract, Dry | 0 NP | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.
Precautions
We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!
Do not use if you are allergic to any ingredients.
Storage
Store in a cool, dry, dark place.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Sugar free
Expertly extracted 100% natural Premium product
Organic alcohol
No artificial ingredients, color additives, fillers or binders.
Natural Gluten free
Formula
Organic alcohol
FDA Statement of Identity
Herbal Supplement
General Statements
Extraction rate: about 1/3-4 (up to 333 mg of dry raw material per 1 ml of extract).
Seals/Symbols
Made in USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Wild Lettuce and Dogwood by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Wild Lettuce and Dogwood by Herbal Terra
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Wild Lettuce and Dogwood by Herbal Terra Drug Interactions
Wild Lettuce and Dogwood contains 2 ingredients, and 2 of them have known drug interactions. Altogether they interact with 997 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Wild Lettuce and Dogwood?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Wild Lettuce and Dogwood interact with 997 drugs. Click any drug to see the details.
2 of the 2 ingredients in Wild Lettuce and Dogwood interact with drugs. Each result below shows which ingredient is responsible. Dogwood Bark Extract, Dry Wild Lettuce Herb Extract, Dry
AcepromazineAtravet
How Acepromazine interacts with Wild Lettuce and Dogwood — through 1 ingredient. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs, Cns Depressants Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acepromazine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Butalbital, Caffeine, Codeine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Wild Lettuce and Dogwood — through 1 ingredient. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Wild Lettuce and Dogwood — through 1 ingredient. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Caffeine, Codeine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Caffeine, Codeine, Salicylamide interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Caffeine, Dihydrocodeine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Dogwood Bark Extract, DryDiuretic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Caffeine, Pyrilamine interactionWild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs, Cns Depressants Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylephrine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs, Cns Depressants Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Wild Lettuce and Dogwood — through 1 ingredient. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Wild Lettuce and Dogwood — through 1 ingredient. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Wild Lettuce and Dogwood — through 1 ingredient. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Wild Lettuce and Dogwood — through 1 ingredient. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Wild Lettuce and Dogwood — through 2 ingredients. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDogwood Bark Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dogwood Bark Extract, Dry + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Wild Lettuce and Dogwood — through 1 ingredient. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Wild Lettuce and Dogwood — through 1 ingredient. Tap an ingredient for the detail:
Wild Lettuce Herb Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce Herb Extract, Dry + Acetaminophen, Dichloralphenazone, Isometheptene interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Wild Lettuce and Dogwood with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dogwood Bark Extract, Dry
Corticosteroids
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Digoxin (Lanoxin)
Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Diuretic Drugs
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Stimulant Laxatives
Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Cascara sagrada has stimulant laxative effects and might compound fluid and electrolyte losses when taken with stimulant laxatives.
Warfarin (Coumadin)
Theoretically, cascara sagrada might increase the risk of bleeding when taken with warfarin.
Cascara sagrada has stimulant laxative effects. In some people, cascara sagrada can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
In vitro research suggests that cascara sagrada can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.
Wild Lettuce Herb Extract, Dry
Anticholinergic Drugs
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.
Cns Depressants
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Brand information
Manufacturer and brand details for Wild Lettuce and Dogwood, from the product label.
Herbal Terra
See all Herbal Terra products- Name
- Herbal Terra LLC
- Phone Number
- +18083857868
- Web Address
- herbalterra.com
Wild Lettuce and Dogwood by Herbal Terra: Common Questions
Does Wild Lettuce and Dogwood by Herbal Terra interact with any medications?
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Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Wild Lettuce and Dogwood’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Cascara Sagrada
Interacts with 745 drugsCascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Because it can cause cramping, dehydration, an...
Read the full Cascara Sagrada monograph → Herb & supplement monographWild Lettuce
Interacts with 393 drugsWild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...
Read the full Wild Lettuce monograph →Sources & How We Checked
Wild Lettuce and Dogwood's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cascara Sagrada 9 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Nadir A, Reddy D, Van Thiel DH. Cascara-sagrada induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity. Am J Gastroenterol 2000;95:3634-7. PubMed
- Nakasone ES, Tokeshi J. A serendipitous find: a case of cholangiocarcinoma identified incidentally after acute liver injury due to cascara sagrada ingestion. Hawaii J Med Public Health 2015;74(6):200-2.
- Cirillo C, Capasso R. Constipation and botanical medicines: an overview. Phytother Res 2015;29(10):1488-93. PubMed
- Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed
Wild Lettuce 5 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
- Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC