Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Wild Lettuce Ingredients & Drug Interactions

by Herbalist & Alchemist

Wild Lettuce label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Lettuce against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Lettuce is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for insomnia and trouble sleeping, anxiety and restlessness, pain relief.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are fresh Wild Lettuce herb extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Wild Lettuce by Herbalist & Alchemist

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce by Herbalist & Alchemist — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Wild Lettuce by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: fresh wild lettuce herb extract. It's prepared with ethyl alcohol and distilled water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: promotes restful sleep.
  • We looked for evidence on: insomnia, sleep quality, sleep onset.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We hold no effectiveness ratings for wild lettuce in our data, so the evidence for what it may do isn't established here.

The evidence, ingredient by ingredient Wild Lettuce

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild lettuce comes with important safety cautions. Limited human safety data exist, and high doses have been tied to side effects.

Large amounts—or prematurely harvested wild lettuce—have been reported to cause sweating, rapid breathing, rapid heartbeat, dizziness, ringing in the ears, vision problems, pressure in the head, sleepiness, agitation, slowed breathing, and in severe cases, coma or death. Topically, it can cause contact dermatitis (skin irritation).

The safety data advises against use during pregnancy and breastfeeding, so talk with your pharmacist or doctor if you're pregnant, trying to conceive, or nursing.

Side effects, ingredient by ingredient Wild Lettuce

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Lettuce.
  • The most serious interaction on file is rated Moderate.
  • For scale: 393 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you use CNS depressants (sedatives, sleep aids, narcotic pain relievers, anti-anxiety medications) or anticholinergic drugs (certain antihistamines, antidepressants, or bladder medications). The moderate interaction risk with these drug types means dosing adjustments or monitoring may be needed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild Lettuce is an herbal extract with limited safety data and notable interactions with sedatives and anticholinergic medications. If you take any prescription drugs—especially sleep aids, anxiety medications, or drugs affecting nerve signals—check with your pharmacist before starting.

Pregnant and nursing people should avoid it entirely.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Lettuce, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056129941
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Jul 25, 2018
DSLD ID 175871
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Lettuce by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.5 mL
Maximum serving Sizes:
2 mL
Servings per container
30
UPC/BARCODE
667056129941
IngredientAmount% DV
fresh Wild Lettuce herb extract2 mL--

Other ingredients: Ethyl Alcohol, distilled Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Lactuca spp.

OK

General Statements

Promotes restful sleep

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 30-40 drops (1.5-2 mL) in juice or water. Take 3 times per day. Shake well before using.

General

Botanical preparation ratio 1:2.14

NO. WLT-2 1748FR

Precautions

Keep out of children's reach

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

OK

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Lettuce by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Lettuce label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Lettuce by Herbalist & Alchemist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.5 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Fresh Wild Lettuce herb extract

Interacts with
393 drugs
2 mL per serving

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because i...

Fresh Wild Lettuce herb extract monograph & interactions

Other (inactive) ingredients: Ethyl Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Lettuce by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against Wild Lettuce?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
393Drugs
393 Moderate

Ingredients driving the most interactions

fresh Wild Lettuce herb extract 393

Individual Drug Interactions

The ingredients in Wild Lettuce interact with 393 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Lettuce interact with drugs. Each result below shows which ingredient is responsible. fresh Wild Lettuce herb extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Lettuce with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

fresh Wild Lettuce herb extract2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
fresh Wild Lettuce herb extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Lettuce, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

Wild Lettuce by Herbalist & Alchemist: Common Questions

Does Wild Lettuce by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, Wild Lettuce has a known interaction with 393 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Lettuce contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the side effects of wild lettuce at high doses?
Large amounts have been reported to cause sweating, rapid breathing, rapid heartbeat, dizziness, ringing in the ears, vision problems, pressure in the head, sleepiness, agitation, and in severe cases, slowed breathing, coma, or death. Topically, it can cause skin irritation.
Is wild lettuce safe during pregnancy or breastfeeding?
No. The safety data advises against use during pregnancy and breastfeeding. If you're pregnant, trying to conceive, or nursing, talk with your pharmacist or doctor before considering this product.
Can I take wild lettuce with my sleep medication?
No—not without checking with your pharmacist first. Wild lettuce has a documented moderate interaction with CNS depressants like sleep aids, which can add to drowsiness and other sedative effects. Your pharmacist can advise you on safety or dosing.
Does wild lettuce contain anticholinergic compounds?
Studies show mixed evidence. Wild lettuce may contain tiny amounts of an anticholinergic compound, but case reports exist of people taking large doses experiencing anticholinergic side effects like constipation and dry mouth. Use caution if you're on anticholinergic medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Lettuce is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Lettuce label
Go deeper

The Full Monographs Behind Wild Lettuce’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph →
Sources

Sources & How We Checked

Wild Lettuce's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
  5. Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.

See these in context on the Wild Lettuce monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team