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Dietary supplement

Wild Lettuce Lactuca Spp. Ingredients & Drug Interactions

by Wise Woman Herbals

Wild Lettuce Lactuca Spp. label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Lettuce Lactuca Spp. against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Lettuce Lactuca Spp. is a dietary supplement by Wise Woman Herbals with 1 active ingredient. Its ingredients are commonly taken for insomnia and trouble sleeping, anxiety and restlessness, pain relief.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Lettuce. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Lettuce Lactuca Spp. by Wise Woman Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce Lactuca Spp. by Wise Woman Herbals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Wild Lettuce Lactuca Spp. by Wise Woman Herbals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1.50 mL) without saying how much of each component you get.

This product contains one active ingredient: wild lettuce, a plant traditionally used in herbal preparations. The liquid form also includes alcohol and water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Wild Lettuce product and its label doesn't state a use — see Wild Lettuce's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness data for wild lettuce in our monograph. The evidence for what this herb does isn't established in the information available to us.

The evidence, ingredient by ingredient Wild Lettuce

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Safety data on wild lettuce are limited, and high doses have been linked to side effects. Large amounts — or prematurely harvested wild lettuce — have been reported to cause sweating, rapid breathing, rapid heartbeat, dilated pupils, dizziness, ringing in the ears, vision changes, pressure in the head, drowsiness, agitation, difficulty breathing, and in severe cases, coma and death.

Topically, it can cause contact dermatitis (skin irritation). Don't use this product during pregnancy — there isn't enough safety information.

Avoid it while breastfeeding as well; reliable safety data don't exist for nursing.

Side effects, ingredient by ingredient Wild Lettuce

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Lettuce.
  • The most serious interaction on file is rated Moderate.
  • For scale: 393 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check whether you use central nervous system depressants (Moderate severity) — sedatives, sleeping pills, anti-anxiety drugs, or opioid painkillers — or anticholinergic drugs (Moderate severity), which block certain nerve signals. Use the medication checker below with your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild lettuce is a traditional herbal product with very limited human safety data and no established effectiveness in our records. It's not right for pregnancy or breastfeeding.

If you take sedatives, sleeping pills, opioids, or anticholinergic medications, talk to your pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Lettuce Lactuca Spp., straight from the product label.

Brand Wise Woman Herbals
Barcode (UPC) 748840147683
Net contents 2 Fluid oz.; 60 mL
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 284857
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Lettuce Lactuca Spp. by Wise Woman Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
15 Drop(s)
Maximum serving Sizes:
30 Drop(s)
Servings per container
40
UPC/BARCODE
748840147683
IngredientAmount% DV
Proprietary Blend1.5 mL--
Wild Lettuce0 NP--

Other ingredients: Alcohol, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Add 15-30 drops to water, 1-4 times per day as needed.

Precautions

Caution: Not for use during pregnancy.

May cause drowsiness or increased sleep times.

Keep out of the reach of children.

General Statements

Botanical formula

FDA Statement of Identity

Dietary supplement

Storage

Store in a cool, dry area away from direct sunlight with the lid tightly sealed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Lettuce Lactuca Spp. by Wise Woman Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Lettuce Lactuca Spp. label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Lettuce Lactuca Spp. by Wise Woman Herbals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size15 Drop(s) Dosage formLiquid Servings per container40 Amounts shown are per serving.

Proprietary Blend

1.5 mL per serving

Other (inactive) ingredients: Alcohol, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Lettuce Lactuca Spp. by Wise Woman Herbals Drug Interactions

Want to check YOUR meds against Wild Lettuce Lactuca Spp.?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
393Drugs
393 Moderate

Ingredients driving the most interactions

Wild Lettuce 393

Individual Drug Interactions

The ingredients in Wild Lettuce Lactuca Spp. interact with 393 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Lettuce Lactuca Spp. interact with drugs. Each result below shows which ingredient is responsible. Wild Lettuce

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Lettuce Lactuca Spp. with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Lettuce2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
Wild Lettuce full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Lettuce Lactuca Spp., from the product label.

Wise Woman Herbals

See all Wise Woman Herbals products
Name
Wise Woman Herbals
City
Creswell
State
OR
ZipCode
97426
Phone Number
541.895.5152
Web Address
wisewomanherbals.com
Pharmacist Counseling Corner

Wild Lettuce Lactuca Spp. by Wise Woman Herbals: Common Questions

Does Wild Lettuce Lactuca Spp. by Wise Woman Herbals interact with any medications?
Yes. Based on its ingredients, Wild Lettuce Lactuca Spp. has a known interaction with 393 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Lettuce Lactuca Spp. contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does wild lettuce do?
We don't have established effectiveness data for wild lettuce in our records. It's a traditional herbal ingredient, but we can't tell you from our information what conditions it's intended to treat or how well it works.
Can I take this while pregnant or breastfeeding?
No — the safety data advise against it. There isn't enough safety information during pregnancy, and there's no reliable data for breastfeeding. Talk with your doctor or pharmacist before considering it.
What side effects can wild lettuce cause?
Large amounts have been reported to cause sweating, rapid heartbeat, dizziness, ringing in the ears, vision changes, drowsiness, and agitation. In severe cases, difficulty breathing, coma, and death have occurred. It can also cause skin irritation if applied topically.
Is it safe to take large doses of this product?
No. High doses have been linked to side effects, and large amounts of wild lettuce or prematurely harvested material carry a real risk of serious adverse effects. Stick to the dose on the label and talk to your pharmacist if you're tempted to increase it.
Does wild lettuce contain anticholinergic compounds?
Studies show mixed evidence, but if it does, the amount is very small. However, case reports exist of people taking large amounts experiencing anticholinergic side effects like dry mouth, constipation, and dizziness — so dose matters.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Lettuce Lactuca Spp. is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Lettuce Lactuca Spp. label
Go deeper

The Full Monographs Behind Wild Lettuce Lactuca Spp.’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph →
Sources

Sources & How We Checked

Wild Lettuce Lactuca Spp.'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
  5. Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.

See these in context on the Wild Lettuce monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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