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Dietary supplement

Xanthium Chinese 1000 mg Ingredients & Drug Interactions

by GM Germa

Xanthium Chinese 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Xanthium Chinese 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Xanthium Chinese 1000 mg is a dietary supplement by GM Germa with 1 active ingredient. Its ingredients are commonly taken for nasal congestion and sinus problems, allergic rhinitis (hay fever), headache.Based on those ingredients, 662 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Xanthium Chinese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Xanthium Chinese 1000 mg by GM Germa

Ask about any prescription or over-the-counter medication and we check it for interactions with Xanthium Chinese 1000 mg by GM Germa — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Xanthium Chinese 1000 mg by GM Germa

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This capsule contains one active ingredient: Siberian cocklebur (Xanthium Chinese) at 1000 mg per dose. The capsule also includes inactive ingredients—magnesium stearate, microcrystalline cellulose, and gelatin—which are binders and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Siberian Cocklebur product and its label doesn't state a use — see Siberian Cocklebur's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

No effectiveness ratings are available in our data for Siberian cocklebur.

The evidence, ingredient by ingredient Siberian Cocklebur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Siberian cocklebur is regarded as unsafe for use. The fruit contains toxic compounds and has caused serious poisoning; it requires careful processing and professional oversight that this product may not guarantee.

The adverse effects documented with oral consumption include abdominal pain, nausea, vomiting, severe low blood sugar, elevated liver function tests, increased bleeding risk, drowsiness, dizziness, shortness of breath, sweating, fever, and heart palpitations. In severe cases, symptoms have progressed to metabolic acidosis and worsening blood-sugar swings.

Heart rhythm problems (arrhythmias) can occur within hours of taking it, and there have been reports of heart muscle damage in fatal cases. The supplement can also increase bleeding risk, primarily through liver damage.

Do not use this product during pregnancy or while breastfeeding. The safety data advises against it due to potential toxicity and insufficient safety information.

Side effects, ingredient by ingredient Siberian Cocklebur

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Siberian Cocklebur.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 663 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Do not take this product if you are on blood-sugar-lowering medications (antidiabetes drugs), drugs that can harm the liver (hepatotoxic drugs), or drugs that can harm the kidneys (nephrotoxic drugs). These carry Major-severity interactions.

Talk to your pharmacist or doctor before combining this supplement with any prescription medication.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

We cannot recommend this product. Siberian cocklebur carries serious safety concerns — it's been linked to liver failure, severe low blood sugar, heart rhythm problems, and bleeding — and it interacts with a very large number of medications across three major categories.

If you're considering it for any reason, you must talk with your doctor or pharmacist first; this is not a product to start on your own.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Xanthium Chinese 1000 mg, straight from the product label.

Brand GM Germa
Barcode (UPC) 790933502107
Net contents 100 Cap(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 303184
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Xanthium Chinese 1000 mg by GM Germa, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
790933502107
IngredientAmount% DV
Xanthium Chinese500 mg--

Other ingredients: Magnesium Stearate, Microcrystalline Cellulose, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Natural product, free of sugar, sodium, starch, preservatives and artificial color & flavors.

Promotes urinary tract health.

No sugar No starch No artificial color No artificial flavor No preservatives

Suggested/Recommended/Usage/Directions

Suggested use: Use as a dietary supplement. Take two capsules a day, preferably with food or as directed by your doctor.

Precautions

Warning: Do not use if pregnant or nursing, ask a physician before use if taking any medication or have any medical condition, if allergic to any of the ingredients, if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of the reach of children

In case of accidental overdose, get medical help or contact a poison control center immediately. Do not use if either seal is broken or missing

Warning: Do not use if pregnant or nursing, ask a physician before use if taking any medication or have any medical condition, if allergic to any of the ingredients, if any adverse reactions occur.

Storage

Store at controlled room temperature between 15 degrees and 30 degrees C (59 degrees - 86 degrees F).

Seals/Symbols

Made in USA

General Statements

Please recycle

Questions or Comments: 1-305-278-0033, M-F, 9-5 Eastern

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Xanthium Chinese 1000mg per serving

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Xanthium Chinese 1000 mg by GM Germa label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Xanthium Chinese 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Xanthium Chinese 1000 mg by GM Germa

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Xanthium Chinese

Interacts with
662 drugs
500 mg per serving

Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and allergies. H...

Xanthium Chinese monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Microcrystalline Cellulose, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Xanthium Chinese 1000 mg by GM Germa Drug Interactions

Want to check YOUR meds against Xanthium Chinese 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
662Drugs
662 Major

Ingredients driving the most interactions

Xanthium Chinese 662

Individual Drug Interactions

The ingredients in Xanthium Chinese 1000 mg interact with 662 drugs. Click any drug to see the details.

1 of the 1 ingredient in Xanthium Chinese 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Xanthium Chinese

Each ingredient & the kinds of drugs it affects

For each ingredient in Xanthium Chinese 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Xanthium Chinese3 drug types · 662 drugs

Antidiabetes Drugs

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans. Hypoglycemia occurs soon after consumption and worsens with time in most cases. Do not use Siberian cocklebur in people taking medications that also lower blood glucose.
Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Likely Evidence B
Hepatotoxic Drugs

Siberian cocklebur can adversely affect the liver. It has been linked to many cases of hepatotoxicity and some cases of liver failure. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (TriCor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo).

Likelihood Likely Evidence B
Nephrotoxic Drugs

Siberian cocklebur can adversely affect the kidney. Theoretically, combining Siberian cocklebur with potentially nephrotoxic drugs might have additive harmful effects on kidney function.
Some potentially nephrotoxic drugs include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others.

Likelihood Likely Evidence B
Xanthium Chinese full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Xanthium Chinese 1000 mg, from the product label.

GM Germa

See all GM Germa products
Name
Germa Products, LLC
Street Address
13121 SW 122 Avenue
City
Miami
State
FL
ZipCode
33186
Phone Number
1-305-278-0033
Web Address
www.germa.net
Pharmacist Counseling Corner

Xanthium Chinese 1000 mg by GM Germa: Common Questions

Does Xanthium Chinese 1000 mg by GM Germa interact with any medications?
Yes. Based on its ingredients, Xanthium Chinese 1000 mg has a known interaction with 662 medications, including 662 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Xanthium Chinese 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this if I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy and while breastfeeding due to potential toxicity and unknown safety. Talk to your doctor or pharmacist before considering this product.
What are the main side effects I should watch for?
Common early effects include stomach pain, nausea, vomiting, and severe low blood sugar. More serious effects can include heart palpitations or irregular heartbeat (starting as soon as 3 hours after taking it), increased bleeding, shortness of breath, fever, dizziness, and in severe cases, metabolic acidosis and heart damage.
Why is this product considered unsafe?
Siberian cocklebur seeds and seedlings contain toxic compounds that can seriously damage the liver and kidneys, cause dangerous drops in blood sugar, trigger heart rhythm problems, and increase bleeding risk. The fruit requires careful professional processing, and the risks may outweigh any benefits.
Can I take this with my blood-pressure or cholesterol medication?
This product carries Major-severity interactions with medications that can harm the liver and kidneys — categories that include some blood-pressure and cholesterol drugs. Do not take it without checking your exact medications with your pharmacist or doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Xanthium Chinese 1000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Xanthium Chinese 1000 mg label
Go deeper

The Full Monographs Behind Xanthium Chinese 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Siberian Cocklebur

Interacts with 662 drugs

Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and allergies. Human evidence is very limited, and the p...

Read the full Siberian Cocklebur monograph →
Sources

Sources & How We Checked

Xanthium Chinese 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Siberian Cocklebur 4 references
  1. Wu, M. L., Wang, C. P., and Deng, J. F. Fatal hepatic failure due to fructus xanthii in a child. Abstracts of the 2005 North American Congress of Clinical Toxicology Annual Meeting. Clin Toxicol 2005;43:639. DOI
  2. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756. PubMed
  3. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
  4. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.

See these in context on the Siberian Cocklebur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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